Andrew Mark Pardoll

Professor

1976 …2019
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Research Output 1976 2019

2019

Divergent immune responses to synthetic and biological scaffolds

Sadtler, K., Wolf, M. T., Ganguly, S., Moad, C. A., Chung, L., Majumdar, S., Housseau, F., Pardoll, A. M. & Elisseeff, J. H., Feb 1 2019, In : Biomaterials. 192, p. 405-415 11 p.

Research output: Contribution to journalArticle

Cell engineering
Immunology
Cell Engineering
Tissue regeneration
Regenerative Medicine

The prognostic impact of pathologic lymph nodes in HPV-positive oropharyngeal cancers

El Asmar, M., Tsai, H. L., Fakhry, C., Maroun, C. A., Mandal, R., Pardoll, A. M. & Wang, H., Feb 1 2019, In : Oral Oncology. 89, p. 23-29 7 p.

Research output: Contribution to journalArticle

Oropharyngeal Neoplasms
Adjuvant Radiotherapy
Papillomavirus Infections
Head and Neck Neoplasms
Lymph Nodes
2018

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

Chung, L., Orberg, E. T., Geis, A., Chan, J. L., Fu, K., Shields, C. E. D. S., Dejea, C. M., Fathi, P., Chen, J., Finard, B. B., Tam, A. J., McAllister, F. M., Fan, H., Wu, X., Ganguly, S., Lebid, A., Metz, P., Van Meerbeke, S. W., Huso, D. L., Wick, E. C. & 5 othersPardoll, A. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Colon
Epithelial Cells
Carcinogenesis
Bacteroides fragilis
Myeloid Cells

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

Wilson, D. R., Sen, R., Sunshine, J. C., Pardoll, A. M., Green, J. & Kim, Y. J., Feb 1 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 2, p. 237-246 10 p.

Research output: Contribution to journalArticle

Immunotherapy
Nanoparticles
Interferons
Tumors
Neoplasms

Caspase-1 from human myeloid-derived suppressor cells can promote t cell–independent tumor proliferation

Zeng, Q., Fu, J., Korrer, M., Gorbounov, M., Murray, P. J., Pardoll, A. M., Masica, D. L. & Kim, Y. J., May 1 2018, In : Cancer immunology research. 6, 5, p. 566-577 12 p.

Research output: Contribution to journalArticle

Caspase 1
Neoplasms
Squamous Cell Carcinoma
Null Lymphocytes
T-Lymphocytes

Clinical Features and Therapeutic Outcomes in Men with Advanced Prostate Cancer and DNA Mismatch Repair Gene Mutations

Antonarakis, E., Shaukat, F., Isaacsson Velho, P., Kaur, H., Shenderov, E., Pardoll, A. M. & Lotan, T., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Prostatic Neoplasms
Mutation
Genes
Disease-Free Survival

Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system

Maxwell, R., Luksik, A. S., Garzon-Muvdi, T., Hung, A. L., Kim, E. S., Wu, A., Xia, Y., Belcaid, Z., Gorelick, N., Choi, J., Theodros, D., Jackson, C. M., Mathios, D., Ye, X., Tran, P. T., Redmond, K. A., Brem, H., Pardoll, A. M., Kleinberg, L. R. & Lim, M., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Immunotherapy
Histology
Adrenal Cortex Hormones
Central Nervous System
Neoplasms

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma

Garzon-Muvdi, T., Theodros, D., Luksik, A. S., Maxwell, R., Kim, E., Jackson, C. M., Belcaid, Z., Ganguly, S., Tyler, B. M., Brem, H., Pardoll, A. M. & Lim, M., Apr 17 2018, In : Oncotarget. 9, 29, p. 20681-20697 17 p.

Research output: Contribution to journalArticle

Glioblastoma
Immunotherapy
Dendritic Cells
Antigen Presentation
Neoplasms

Erratum: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells (Cell Host & Microbe (2018) 23(2) (203–214.e5) (S1931312818300428) (10.1016/j.chom.2018.01.007))

Chung, L., Orberg, E. T., Geis, A., Chan, J. L., Fu, K., DeStefano Shields, C. E., Dejea, C. M., Fathi, P., Chen, J., Finard, B. B., Tam, A. J., McAllister, F., Fan, H., Wu, X., Ganguly, S., Lebid, A., Metz, P., Van Meerbeke, S. W., Huso, D. L., Wick, E. C. & 5 othersPardoll, A. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F., Mar 14 2018, In : Cell Host and Microbe. 23, 3, 1 p.

Research output: Contribution to journalComment/debate

Names
Epithelial Cells
Bacteroides fragilis toxin

Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma

Harris-Bookman, S., Mathios, D., Martin, A., Xia, Y., Kim, E., Xu, H., Belcaid, Z., Polanczyk, M., Barberi, T., Theodros, D., Kim, J., Taube, J. M., Burger, P. C., Selby, M., Taitt, C., Korman, A., Ye, X., Drake, C. G., Brem, H., Pardoll, A. M. & 1 othersLim, M., Jan 1 2018, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Glioblastoma
Monoclonal Antibodies
Blocking Antibodies
Immunotherapy
Neoplasms

Neoadjuvant PD-1 blockade in resectable lung cancer

Forde, P., Chaft, J. E., Smith, K., Anagnostou, V., Cottrell, T. R., Hellmann, M. D., Zahurak, M., Broderick, S., Yang, S. C., Jones, D. R., Battafarano, R. J., Velez, M. J., Rekhtman, N., Olah, Z., Verde, F., Naidoo, J., Marrone, K., Guo, H., Sidhom, J. W., Zhang, J. & 15 othersCaushi, J. X., Chan, H. Y., Scharpf, R. B., White, J., Gabrielson, E., Wang, H., Rosner, G., Rusch, V., Wolchok, J. D., Merghoub, T., Taube, J. M., Velculescu, V. E., Topalian, S., Brahmer, J. & Pardoll, A. M., May 24 2018, In : New England Journal of Medicine. 378, 21, p. 1976-1986 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Clone Cells
Neoplasms
Non-Small Cell Lung Carcinoma
T-Lymphocytes

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

Forde, P., Chaft, J. E. & Pardoll, A. M., Aug 30 2018, In : The New England journal of medicine. 379, 9, p. e14

Research output: Contribution to journalLetter

Lung Neoplasms

Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A

Chan, J. L., Wu, S., Geis, A., Chan, G. V., Gomes, T. A. M., Beck, S., Wu, X., Fan, H., Tam, A. J., Chung, L., Ding, H., Wang, H., Pardoll, A. M., Housseau, F. & Sears, C. L., Jan 1 2018, (Accepted/In press) In : Mucosal Immunology.

Research output: Contribution to journalArticle

Bacteroides fragilis
Colitis
Polysaccharides
Bacteria
Interleukin-17

Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: A proposal for quantitative immune-related pathologic response criteria (irPRC)

Cottrell, T. R., Thompson, E., Forde, P. M., Stein, J. E., Duffield, A. S., Anagnostou, V., Rekhtman, N., Anders, R. A., Cuda, J. D., Illei, P. B., Gabrielson, E., Askin, F. B., Niknafs, N., Smith, K., Velez, M. J., Sauter, J. L., Isbell, J. M., Jones, D. R., Battafarano, R. J., Yang, S. C. & 10 othersDanilova, L. V., Wolchok, J. D., Topalian, S., Velculescu, V. E., Pardoll, A. M., Brahmer, J. R., Hellmann, M. D., Chaft, J. E., Cimino-Mathews, A. & Taube, J. M., Jan 1 2018, In : Annals of Oncology. 29, 8, p. 1853-1860 8 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Non-Small Cell Lung Carcinoma
Neoplasms
Tumor-Infiltrating Lymphocytes
Neoadjuvant Therapy

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., Anders, R. A., Giardiello, F. M., Wick, E. C., Wang, H., Wu, S., Pardoll, A. M., Housseau, F. & Sears, C. L., Feb 2 2018, In : Science. 359, 6375, p. 592-597 6 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Biofilms
Bacteroides fragilis
Bacteria
Colorectal Neoplasms

PD-L1 expression in medulloblastoma: An evaluation by subgroup

Martin, A., Nirschl, C. J., Polanczyk, M. J., Bell, W. R., Nirschl, T. R., Harris-Bookman, S., Phallen, J., Hicks, J., Martinez, D., Ogurtsova, A., Xu, H., Sullivan, L. M., Meeker, A. K., Raabe, E., Cohen, K. J., Eberhart, C. G., Burger, P. C., Santi, M., Taube, J. M., Pardoll, A. M. & 2 othersDrake, C. G. & Lim, M., Apr 10 2018, In : Oncotarget. 9, 27, p. 19177-19191 15 p.

Research output: Contribution to journalArticle

Medulloblastoma
Biomarkers
Cell Line
Tumor Microenvironment
Gamma Rays

The intestinal microbiome influences checkpoint blockade

Sears, C. L. & Pardoll, A. M., Mar 6 2018, In : Nature Medicine. 24, 3, p. 254-255 2 p.

Research output: Contribution to journalArticle

Gastrointestinal Microbiome

The mutation-associated neoantigen functional expansion of specific T cells (MANAFEST) assay: A sensitive platform for monitoring antitumor immunity

Danilova, L. V., Anagnostou, V., Caushi, J. X., Sidhom, J. W., Guo, H., Chan, H. Y., Suri, P., Tam, A., Zhang, J., Asmar, M. E., Marrone, K., Naidoo, J., Brahmer, J., Forde, P., Baras, A., Cope, L., Velculescu, V. E., Pardoll, A. M., Housseau, F. & Smith, K., Aug 1 2018, In : Cancer immunology research. 6, 8, p. 888-899 12 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Mutation
Antigens
Cytokines

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

Hung, A. L., Maxwell, R., Theodros, D., Belcaid, Z., Mathios, D., Luksik, A. S., Kim, E., Wu, A., Xia, Y., Garzon-Muvdi, T., Jackson, C., Ye, X., Tyler, B. M., Selby, M., Korman, A., Barnhart, B., Park, S. M., Youn, J. I., Chowdhury, T., Park, C. K. & 3 othersBrem, H., Pardoll, A. M. & Lim, M., May 23 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Glioblastoma
Immunity
Survival
Therapeutics
T-Lymphocytes

TNFa and radioresistant stromal cells are essential for therapeutic efficacy of cyclic dinucleotide STING agonists in nonimmunogenic tumors

Francica, B. J., Ghasemzadeh, A., Desbien, A. L., Theodros, D., Sivick, K. E., Reiner, G. L., Glickman, L. H., Marciscano, A. E., Sharabi, A. B., Leong, M. L., McWhirter, S. M., Dubensky, T. W., Pardoll, A. M. & Drake, C. G., Apr 1 2018, In : Cancer immunology research. 6, 4, p. 422-433 12 p.

Research output: Contribution to journalArticle

Stromal Cells
Neoplasms
Therapeutics
Necrosis
Bone Marrow

YAP is essential for treg-mediated suppression of antitumor immunity

Ni, X., Tao, J., Barbi, J., Chen, Q., Park, B. V., Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., Zheng, Y., Zhang, X., Wu, X., Vignali, P., Yang, C. P., Li, H., Pardoll, A. M., Lu, L., Pan, D. & Pan, F., Aug 1 2018, In : Cancer discovery. 8, 8, p. 1026-1043 18 p.

Research output: Contribution to journalArticle

Immunity
Activins
Activin Receptors
Self Tolerance
Regulatory T-Lymphocytes
2017

Autologous reconstitution of human cancer and immune system in vivo

Fu, J., Sen, R., Masica, D. L., Karchin, R., Pardoll, A. M., Walter, V., Hayes, D. N., Chung, C. H. & Kim, Y. J., 2017, In : Oncotarget. 8, 2, p. 2053-2068 16 p.

Research output: Contribution to journalArticle

Immune System
Tumor Microenvironment
Neoplasms
Human Trafficking
Tumor-Infiltrating Lymphocytes

Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas

Kim, J. E., Patel, M. A., Mangraviti, A., Kim, E. S., Theodros, D., Velarde, E., Liu, A., Sankey, E. W., Tam, A., Xu, H., Mathios, D., Jackson, C. M., Harris-Bookman, S., Garzon-Muvdi, T., Sheu, M., Martin, A., Tyler, B. M., Tran, P. T., Ye, X., Olivi, A. & 6 othersTaube, J. M., Burger, P. C., Drake, C. G., Brem, H., Pardoll, A. M. & Lim, M., Jan 1 2017, In : Clinical Cancer Research. 23, 1, p. 124-136 13 p.

Research output: Contribution to journalArticle

Mucin-3
Glioma
Immunoglobulins
Radiation
T-Lymphocytes

Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 162(5) (974–986) (S009286741500848X) (10.1016/j.cell.2015.07.011))

Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L., Snyder, A., Makarov, V., Budhu, S., Slamon, D. J., Wolchok, J. D., Pardoll, A. M., Beckmann, M. W., Zahnow, C., Merghoub, T., Chan, T. A., Baylin, S. B. & 1 othersStrick, R., Apr 6 2017, In : Cell. 169, 2, p. 361 1 p.

Research output: Contribution to journalComment/debate

Endogenous Retroviruses
Organized Financing
DNA Methylation
Interferons
Health

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V., Smith, K., Forde, P., Niknafs, N., Bhattacharya, R., White, J., Zhang, T., Adleff, V., Phallen, J., Wali, N., Hruban, C., Guthrie, V. B., Rodgers, K., Naidoo, J., Kang, H., Sharfman, W., Georgiades, C. S., Verde, F., Illei, P. B., Li, Q. K. & 9 othersGabrielson, E., Brock, M. V., Zahnow, C., Baylin, S. B., Scharpf, R. B., Brahmer, J., Karchin, R., Pardoll, A. M. & Velculescu, V. E., Mar 1 2017, In : Cancer Discovery. 7, 3, p. 264-276 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
T-Lymphocytes
Mutation
T-Cell Antigen Receptor

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D., Uram, J., Smith, K., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N., Rucki, A. A., Laheru, D., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Greten, T. F. & 26 othersDuffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L. V., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K. M., Nickles Fader, A. N., Taube, J. M., Housseau, F., Spetzler, D., Xiao, N., Pardoll, A. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J., Vogelstein, B., Anders, R. A. & Diaz, L. A., Jul 28 2017, In : Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journalArticle

Death Domain Receptors
DNA Mismatch Repair
Neoplasms
Disease-Free Survival
Turcot syndrome

Prediction of response to immune checkpoint inhibitor therapy using early-time-point 18F-FDG PET/CT imaging in patients with advanced melanoma

Cho, S. Y., Lipson, E., Im, H. J., Rowe, S., Gonzalez, E. M., Blackford, A., Chirindel, A., Pardoll, A. M., Topalian, S. & Wahl, R. L., Sep 1 2017, In : Journal of Nuclear Medicine. 58, 9, p. 1421-1428 8 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Melanoma
Organizations
Neoplasms
Research

Primary resistance to PD-1 blockade mediated by JAK1/2 mutations

Shin, D. S., Zaretsky, J. M., Escuin-Ordinas, H., Garcia-Diaz, A., Hu-Lieskovan, S., Kalbasi, A., Grasso, C. S., Hugo, W., Sandoval, S., Torrejon, D. Y., Palaskas, N., Abril-Rodriguez, G., Parisi, G., Azhdam, A., Chmielowski, B., Cherry, G., Seja, E., Berent-Maoz, B., Shintaku, I. P., Le, D. & 7 othersPardoll, A. M., Diaz, L. A., Tumeh, P. C., Graeber, T. G., Lo, R. S., Comin-Anduix, B. & Ribas, A., Feb 1 2017, In : Cancer Discovery. 7, 2, p. 188-201 14 p.

Research output: Contribution to journalArticle

Mutation
Interferon-gamma
Melanoma
Neoplasms
Therapeutics

Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment

Muroyama, Y., Nirschl, T. R., Kochel, C. M., Lopez-Bujanda, Z., Theodros, D., Mao, W., Carrera-Haro, M. A., Ghasemzadeh, A., Marciscano, A. E., Velarde, E., Tam, A. J., Thoburn, C. J., Uddin, M., Meeker, A. K., Anders, R. A., Pardoll, A. M. & Drake, C. G., Nov 1 2017, In : Cancer immunology research. 5, 11, p. 992-1004 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Regulatory T-Lymphocytes
Radiotherapy
Tumor-Infiltrating Lymphocytes
Neoplasms

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

Thiele Orberg, E., Fan, H., Tam, A. J., Dejea, C. M., Destefano Shields, C. E., Wu, S., Chung, L., Finard, B. B., Wu, X., Fathi, P., Ganguly, S., Fu, J., Pardoll, A. M., Sears, C. L. & Housseau, F., Mar 1 2017, In : Mucosal Immunology. 10, 2, p. 421-433 13 p.

Research output: Contribution to journalArticle

Bacteroides fragilis
Colon
Carcinogenesis
Interleukin-17
Myeloid Cells

The Scaffold Immune Microenvironment: Biomaterial-Mediated Immune Polarization in Traumatic and Nontraumatic Applications

Sadtler, K., Allen, B. W., Estrellas, K., Housseau, F., Pardoll, A. M. & Elisseeff, J. H., Oct 1 2017, In : Tissue Engineering - Part A. 23, 19-20, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Biomaterials
Scaffolds
Macrophages
Polarization

Transcriptional mechanisms of resistance to anti-PD-1 therapy

Ascierto, M. L., Makohon-Moore, A., Lipson, E., Taube, J. M., McMiller, T. L., Berger, A. E., Fan, J., Kaunitz, G. J., Cottrell, T. R., Kohutek, Z. A., Favorov, A., Makarov, V., Riaz, N., Chan, T. A., Cope, L., Hruban, R. H., Pardoll, A. M., Taylor, B. S., Solit, D. B., Iacobuzio-Donahue, C. A. & 1 othersTopalian, S., Jun 15 2017, In : Clinical Cancer Research. 23, 12, p. 3168-3180 13 p.

Research output: Contribution to journalArticle

Melanoma
Biomarkers
Clonal Evolution
Neoplasm Metastasis
Exome
2016

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

Patel, M. A., Kim, J. E., Theodros, D., Tam, A., Velarde, E., Kochel, C. M., Francica, B., Nirschl, T. R., Ghasemzadeh, A., Mathios, D., Harris-Bookman, S., Jackson, C. C., Jackson, C., Ye, X., Tran, P. T., Tyler, B. M., Coric, V., Selby, M., Brem, H., Drake, C. G. & 2 othersPardoll, A. M. & Lim, M., May 17 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 28.

Research output: Contribution to journalArticle

Radiosurgery
Glioma
Monoclonal Antibodies
Radiation
Glioblastoma

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

Mathios, D., Kim, J. E., Mangraviti, A., Phallen, J., Park, C. K., Jackson, C. M., Garzon-Muvdi, T., Kim, E., Theodros, D., Polanczyk, M., Martin, A., Suk, I., Ye, X., Tyler, B. M., Bettegowda, C., Brem, H., Pardoll, A. M. & Lim, M., Dec 21 2016, In : Science Translational Medicine. 8, 370, 370ra180.

Research output: Contribution to journalArticle

Immunity
Drug Therapy
Glioblastoma
Immunotherapy
Programmed Cell Death 1 Receptor

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

Danilova, L. V., Wang, H., Sunshine, J., Kaunitz, G. J., Cottrell, T. R., Xu, H., Esandrio, J., Anders, R. A., Cope, L., Pardoll, A. M., Drake, C. G. & Taube, J. M., Nov 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. E7769-E7777

Research output: Contribution to journalArticle

Melanoma
Programmed Cell Death 1 Ligand 2 Protein
Neoplasms
Ligands
Programmed Cell Death 1 Receptor

Design, clinical translation and immunological response of biomaterials in regenerative medicine

Sadtler, K., Singh, A., Wolf, M. T., Wang, X., Pardoll, A. M. & Elisseeff, J. H., Jun 7 2016, In : Nature Reviews Materials. 1, 7, 16040.

Research output: Contribution to journalReview article

Biocompatible Materials
Biomaterials
Tissue
Scaffolds
Repair

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Sadtler, K., Estrellas, K., Allen, B. W., Wolf, M. T., Fan, H., Tam, A. J., Patel, C. H., Luber, B. S., Wang, H., Wagner, K. R., Powell, J., Housseau, F., Pardoll, A. M. & Elisseeff, J. H., Apr 15 2016, In : Science. 352, 6283, p. 366-370 5 p.

Research output: Contribution to journalArticle

Th2 Cells
Biocompatible Materials
Regeneration
Muscles
Interleukin-4

Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 152 (974-986))

Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L., Snyder, A., Makarov, V., Budhu, S., Slamon, D. J., Wolchok, J. D., Pardoll, A. M., Beckmann, M. W., Zahnow, C., Merghoub, T., Chan, T. A., Baylin, S. B. & 1 othersStrick, R., Feb 25 2016, In : Cell. 164, 5, p. 1073 1 p.

Research output: Contribution to journalArticle

Erratum to: PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment

Mathios, D., Ruzevick, J., Jackson, C. M., Xu, H., Shah, S. R., Taube, J. M., Burger, P. C., McCarthy, E. F., Quinones-Hinojosa, A., Pardoll, A. M. & Lim, M., May 9 2016, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1 1 p.

Research output: Contribution to journalArticle

Chordoma

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma [J Immunothera Cancer, 4, (2016), (28)] DOI:10.1186/s40425-016-0132-2

Patel, M. A., Kim, J. E., Theodros, D., Tam, A., Velarde, E., Kochel, C. M., Francica, B., Nirschl, T. R., Ghasemzadeh, A., Mathios, D., Harris-Bookman, S., Jackson, C. C., Jackson, C., Ye, X., Tran, P. T., Tyler, B. M., Coric, V., Selby, M., Brem, H., Drake, C. G. & 2 othersPardoll, A. M. & Lim, M., Nov 4 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 74.

Research output: Contribution to journalComment/debate

Financial Support
Glioma
Publications
Monoclonal Antibodies
Radiation

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Topalian, S., Taube, J. M., Anders, R. A. & Pardoll, A. M., Apr 26 2016, In : Nature Reviews Cancer. 16, 5, p. 275-287 13 p.

Research output: Contribution to journalArticle

CTLA-4 Antigen
Kidney Neoplasms
Biomarkers
Programmed Cell Death 1 Receptor
Neoplasms

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Yang, H. Y., Barbi, J., Wu, C. Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J. H., Park, B. V., Bandara, S., Novack, L., Ni, X., Yang, X., Chang, K. Y., Wu, R. C., Zhang, J., Yang, C. W., Pardoll, A. M., Li, H. & Pan, F., Jul 19 2016, In : Immunity. 45, 1, p. 83-93 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
MicroRNAs
Transcription Factors
Interleukin-6
Cytokines

PD-1 blockade with pembrolizumab in advanced merkel-cell carcinoma

Nghiem, P. T., Bhatia, S., Lipson, E., Kudchadkar, R. R., Miller, N. J., Annamalai, L., Berry, S., Chartash, E. K., Daud, A., Fling, S. P., Friedlander, P. A., Kluger, H. M., Kohrt, H. E., Lundgren, L., Margolin, K., Mitchell, A., Olencki, T., Pardoll, A. M., Reddy, S. A., Shantha, E. M. & 11 othersSharfman, W., Sharon, E., Shemanski, L. R., Shinohara, M. M., Sunshine, J. C., Taube, J. M., Thompson, J. A., Townson, S. M., Yearley, J. H., Topalian, S. & Cheever, M. A., Jun 30 2016, In : New England Journal of Medicine. 374, 26, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Merkel Cell Carcinoma
Oncogenic Viruses
Merkel cell polyomavirus
pembrolizumab
Confidence Intervals

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N., Smith, K., Tam, A., Ganguly, S., Wanyiri, J. W., Iyadorai, T., Malik, A. A., Roslani, A. C., Vadivelu, J. S., Van Meerbeke, S., Huso, D. L., Pardoll, A. M. & Sears, C. L., Apr 15 2016, In : Cancer Research. 76, 8, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Th17 Cells
Colon
Carcinogenesis
Bacteroides fragilis
T-Lymphocytes

Systemic tolerance mediated by melanoma brain tumors is reversible by radiotherapy and vaccination

Jackson, C. M., Kochel, C. M., Nirschl, C. J., Durham, N. M., Ruzevick, J., Alme, A., Francica, B. J., Elias, J., Daniels, A., Dubensky, T. W., Lauer, P., Brockstedt, D. G., Baxi, E. G., Calabresi, P., Taube, J. M., Pardo-Villamizar, C. A., Brem, H., Pardoll, A. M., Lim, M. & Drake, C. G., Mar 1 2016, In : Clinical Cancer Research. 22, 5, p. 1161-1172 12 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
Brain Neoplasms
Melanoma
Vaccination
Radiotherapy

TGFβ1-mediated SMAD3 enhances PD-1 expression on antigen-specific T cells in cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S. J., Pan, F., Pardoll, A. M. & Cox, A., Dec 1 2016, In : Cancer Discovery. 6, 12, p. 1366-1381 16 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Neoplasms
Tumor Microenvironment
Up-Regulation

The intratumoral balance between metabolic and immunologic gene expression is associated with anti-PD-1 response in patients with renal cell carcinoma

Ascierto, M. L., McMiller, T. L., Berger, A. E., Danilova, L. V., Anders, R. A., Netto, G. J., Xu, H., Pritchard, T. S., Fan, J., Cheadle, C., Cope, L., Drake, C. G., Pardoll, A. M., Taube, J. M. & Topalian, S., Sep 1 2016, In : Cancer immunology research. 4, 9, p. 726-733 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Gene Expression
Neoplasms
Therapeutics
Intrinsic Factor

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

Mathios, D., Park, C. K., Marcus, W. D., Alter, S., Rhode, P. R., Jeng, E. K., Wong, H. C., Pardoll, A. M. & Lim, M., Jan 1 2016, In : International Journal of Cancer. 138, 1, p. 187-194 8 p.

Research output: Contribution to journalArticle

Interleukin-15
Glioblastoma
Survival
Neoplasms
Therapeutics

Tumor regression and allograft rejection after administration of anti-PD-1

Lipson, E., Bagnasco, S. M., Moore, J., Jang, S., Patel, M., Zachary, A. A., Pardoll, A. M., Taube, J. M. & Drake, C. G., Mar 3 2016, In : New England Journal of Medicine. 374, 9, p. 896-898 3 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Graft Rejection
Immunocompromised Host
Skin Neoplasms
Antineoplastic Agents
2015
Adoptive Transfer
Multiple Myeloma
Immunity
Bone Marrow
Lymphocytes