Andrew Mark Pardoll

Professor

1976 …2018
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Research Output 1976 2018

2018

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

Chung, L. , Orberg, E. T. , Geis, A. L. , Chan, J. L. , Fu, K. , Shields, C. E. D. S. , Dejea, C. M. , Fathi, P. , Chen, J. , Finard, B. B. , Tam, A. J. , McAllister, F. M. , Fan, H. , Wu, X. , Ganguly, S. , Lebid, A. , Metz, P. , Van Meerbeke, S. W. , Huso, D. L. , Wick, E. C. & 5 others Pardoll, D. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F. Jan 1 2018 (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Colon
Epithelial Cells
Carcinogenesis
Bacteroides fragilis
Myeloid Cells

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

Wilson, D. R., Sen, R., Sunshine, J. C., Pardoll, D. M., Green, J. J. & Kim, Y. J. Feb 1 2018 In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 2, p. 237-246 10 p.

Research output: Contribution to journalArticle

Immunotherapy
Nanoparticles
Interferons
Tumors
Neoplasms

Caspase-1 from human myeloid-derived suppressor cells can promote t cell–independent tumor proliferation

Zeng, Q., Fu, J., Korrer, M., Gorbounov, M., Murray, P. J., Pardoll, D., Masica, D. L. & Kim, Y. J. May 1 2018 In : Cancer Immunology Research. 6, 5, p. 566-577 12 p.

Research output: Contribution to journalArticle

Caspase 1
Neoplasms
Squamous Cell Carcinoma
Null Lymphocytes
T-Lymphocytes

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma

Garzon-Muvdi, T., Theodros, D., Luksik, A. S., Maxwell, R., Kim, E., Jackson, C. M., Belcaid, Z., Ganguly, S., Tyler, B., Brem, H., Pardoll, D. M. & Lim, M. Apr 17 2018 In : Oncotarget. 9, 29, p. 20681-20697 17 p.

Research output: Contribution to journalArticle

Glioblastoma
Immunotherapy
Dendritic Cells
Antigen Presentation
Neoplasms

Erratum: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells (Cell Host & Microbe (2018) 23(2) (203–214.e5) (S1931312818300428) (10.1016/j.chom.2018.01.007))

Chung, L. , Orberg, E. T. , Geis, A. L. , Chan, J. L. , Fu, K. , DeStefano Shields, C. E. , Dejea, C. M. , Fathi, P. , Chen, J. , Finard, B. B. , Tam, A. J. , McAllister, F. , Fan, H. , Wu, X. , Ganguly, S. , Lebid, A. , Metz, P. , Van Meerbeke, S. W. , Huso, D. L. , Wick, E. C. & 5 others Pardoll, D. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F. Mar 14 2018 In : Cell Host and Microbe. 23, 3, 1 p.

Research output: Contribution to journalComment/debate

Names
Epithelial Cells
Bacteroides fragilis toxin

Neoadjuvant PD-1 blockade in resectable lung cancer

Forde, P. M. , Chaft, J. E. , Smith, K. N. , Anagnostou, V. , Cottrell, T. R. , Hellmann, M. D. , Zahurak, M. , Broderick, S. , Yang, S. C. , Jones, D. R. , Battafarano, R. J. , Velez, M. J. , Rekhtman, N. , Olah, Z. , Verde, F. , Naidoo, J. , Marrone, K. A. , Guo, H. , Sidhom, J. W. , Zhang, J. & 15 others Caushi, J. X., Chan, H. Y., Scharpf, R. B., White, J., Gabrielson, E., Wang, H., Rosner, G. L., Rusch, V., Wolchok, J. D., Merghoub, T., Taube, J. M., Velculescu, V. E., Topalian, S. L., Brahmer, J. R. & Pardoll, D. M. May 24 2018 In : New England Journal of Medicine. 378, 21, p. 1976-1986 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Clone Cells
Neoplasms
Non-Small Cell Lung Carcinoma
T-Lymphocytes

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., Anders, R. A., Giardiello, F. M., Wick, E. C., Wang, H., Wu, S., Pardoll, D. M., Housseau, F. & Sears, C. L. Feb 2 2018 In : Science. 359, 6375, p. 592-597 6 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Biofilms
Bacteroides fragilis
Bacteria
Colorectal Neoplasms

PD-L1 expression in medulloblastoma: An evaluation by subgroup

Martin, A. M. , Nirschl, C. J. , Polanczyk, M. J. , Bell, W. R. , Nirschl, T. R. , Harris-Bookman, S. , Phallen, J. , Hicks, J. , Martinez, D. , Ogurtsova, A. , Xu, H. , Sullivan, L. M. , Meeker, A. K. , Raabe, E. H. , Cohen, K. J. , Eberhart, C. G. , Burger, P. C. , Santi, M. , Taube, J. M. , Pardoll, D. M. & 2 others Drake, C. G. & Lim, M. Apr 10 2018 In : Oncotarget. 9, 27, p. 19177-19191 15 p.

Research output: Contribution to journalArticle

Medulloblastoma
Biomarkers
Cell Line
Tumor Microenvironment
Gamma Rays

The intestinal microbiome influences checkpoint blockade

Sears, C. L. & Pardoll, D. M. Mar 6 2018 In : Nature Medicine. 24, 3, p. 254-255 2 p.

Research output: Contribution to journalArticle

Gastrointestinal Microbiome

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

Hung, A. L. , Maxwell, R. , Theodros, D. , Belcaid, Z. , Mathios, D. , Luksik, A. S. , Kim, E. , Wu, A. , Xia, Y. , Garzon-Muvdi, T. , Jackson, C. , Ye, X. , Tyler, B. , Selby, M. , Korman, A. , Barnhart, B. , Park, S. M. , Youn, J. I. , Chowdhury, T. , Park, C. K. & 3 others Brem, H., Pardoll, D. M. & Lim, M. May 23 2018 (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Glioblastoma
Immunity
Survival
Therapeutics
T-Lymphocytes

TNFa and radioresistant stromal cells are essential for therapeutic efficacy of cyclic dinucleotide STING agonists in nonimmunogenic tumors

Francica, B. J., Ghasemzadeh, A., Desbien, A. L., Theodros, D., Sivick, K. E., Reiner, G. L., Glickman, L. H., Marciscano, A. E., Sharabi, A. B., Leong, M. L., McWhirter, S. M., Dubensky, T. W., Pardoll, D. M. & Drake, C. G. Apr 1 2018 In : Cancer Immunology Research. 6, 4, p. 422-433 12 p.

Research output: Contribution to journalArticle

Stromal Cells
Neoplasms
Therapeutics
Necrosis
Bone Marrow
2017

Autologous reconstitution of human cancer and immune system in vivo

Fu, J., Sen, R., Masica, D. L., Karchin, R., Pardoll, D., Walter, V., Hayes, D. N., Chung, C. H. & Kim, Y. J. 2017 In : Oncotarget. 8, 2, p. 2053-2068 16 p.

Research output: Contribution to journalArticle

Immune System
Tumor Microenvironment
Neoplasms
Human Trafficking
Tumor-Infiltrating Lymphocytes

Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas

Kim, J. E. , Patel, M. A. , Mangraviti, A. , Kim, E. S. , Theodros, D. , Velarde, E. , Liu, A. , Sankey, E. W. , Tam, A. , Xu, H. , Mathios, D. , Jackson, C. M. , Harris-Bookman, S. , Garzon-Muvdi, T. , Sheu, M. , Martin, A. M. , Tyler, B. M. , Tran, P. T. , Ye, X. , Olivi, A. & 6 others Taube, J. M., Burger, P. C., Drake, C. G., Brem, H., Pardoll, D. M. & Lim, M. Jan 1 2017 In : Clinical Cancer Research. 23, 1, p. 124-136 13 p.

Research output: Contribution to journalArticle

Mucin-3
Glioma
Immunoglobulins
Radiation
T-Lymphocytes

Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 162(5) (974–986) (S009286741500848X) (10.1016/j.cell.2015.07.011))

Chiappinelli, K. B. , Strissel, P. L. , Desrichard, A. , Li, H. , Henke, C. , Akman, B. , Hein, A. , Rote, N. S. , Cope, L. M. , Snyder, A. , Makarov, V. , Budhu, S. , Slamon, D. J. , Wolchok, J. D. , Pardoll, D. M. , Beckmann, M. W. , Zahnow, C. A. , Merghoub, T. , Chan, T. A. , Baylin, S. B. & 1 others Strick, R. Apr 6 2017 In : Cell. 169, 2, p. 361 1 p.

Research output: Contribution to journalComment/debate

Endogenous Retroviruses
Organized Financing
DNA Methylation
Interferons
Health

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V. , Smith, K. N. , Forde, P. M. , Niknafs, N. , Bhattacharya, R. , White, J. , Zhang, T. , Adleff, V. , Phallen, J. , Wali, N. , Hruban, C. , Guthrie, V. B. , Rodgers, K. , Naidoo, J. , Kang, H. , Sharfman, W. , Georgiades, C. , Verde, F. , Illei, P. , Li, Q. K. & 9 others Gabrielson, E., Brock, M. V., Zahnow, C. A., Baylin, S. B., Scharpf, R. B., Brahmer, J. R., Karchin, R., Pardoll, D. M. & Velculescu, V. E. Mar 1 2017 In : Cancer Discovery. 7, 3, p. 264-276 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
T-Lymphocytes
Mutation
T-Cell Antigen Receptor

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D. T. , Durham, J. N. , Smith, K. N. , Wang, H. , Bartlett, B. R. , Aulakh, L. K. , Lu, S. , Kemberling, H. , Wilt, C. , Luber, B. S. , Wong, F. , Azad, N. S. , Rucki, A. A. , Laheru, D. , Donehower, R. , Zaheer, A. , Fisher, G. A. , Crocenzi, T. S. , Lee, J. J. , Greten, T. F. & 26 others Duffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K. M., Fader, A. N., Taube, J., Housseau, F., Spetzler, D., Xiao, N., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J. R., Vogelstein, B., Anders, R. A. & Diaz, L. A. Jul 28 2017 In : Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journalArticle

Death Domain Receptors
DNA Mismatch Repair
Neoplasms
Disease-Free Survival
Turcot syndrome

Prediction of response to immune checkpoint inhibitor therapy using early-time-point 18F-FDG PET/CT imaging in patients with advanced melanoma

Cho, S. Y., Lipson, E. J., Im, H. J., Rowe, S. P., Gonzalez, E. M., Blackford, A., Chirindel, A., Pardoll, D. M., Topalian, S. L. & Wahl, R. L. Sep 1 2017 In : Journal of Nuclear Medicine. 58, 9, p. 1421-1428 8 p.

Research output: Contribution to journalArticle

Melanoma
Organizations
Neoplasms
Research
Therapeutics

Primary resistance to PD-1 blockade mediated by JAK1/2 mutations

Shin, D. S. , Zaretsky, J. M. , Escuin-Ordinas, H. , Garcia-Diaz, A. , Hu-Lieskovan, S. , Kalbasi, A. , Grasso, C. S. , Hugo, W. , Sandoval, S. , Torrejon, D. Y. , Palaskas, N. , Abril-Rodriguez, G. , Parisi, G. , Azhdam, A. , Chmielowski, B. , Cherry, G. , Seja, E. , Berent-Maoz, B. , Shintaku, I. P. , Le, D. T. & 7 others Pardoll, D. M., Diaz, L. A., Tumeh, P. C., Graeber, T. G., Lo, R. S., Comin-Anduix, B. & Ribas, A. Feb 1 2017 In : Cancer Discovery. 7, 2, p. 188-201 14 p.

Research output: Contribution to journalArticle

Mutation
Interferon-gamma
Melanoma
Neoplasms
Therapeutics

Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment

Muroyama, Y., Nirschl, T. R., Kochel, C. M., Lopez-Bujanda, Z., Theodros, D., Mao, W., Carrera-Haro, M. A., Ghasemzadeh, A., Marciscano, A. E., Velarde, E., Tam, A. J., Thoburn, C. J., Uddin, M., Meeker, A. K., Anders, R. A., Pardoll, D. M. & Drake, C. G. Nov 1 2017 In : Cancer Immunology Research. 5, 11, p. 992-1004 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Regulatory T-Lymphocytes
Radiotherapy
Tumor-Infiltrating Lymphocytes
Neoplasms

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

Thiele Orberg, E., Fan, H., Tam, A. J., Dejea, C. M., Destefano Shields, C. E., Wu, S., Chung, L., Finard, B. B., Wu, X., Fathi, P., Ganguly, S., Fu, J., Pardoll, D. M., Sears, C. L. & Housseau, F. Mar 1 2017 In : Mucosal Immunology. 10, 2, p. 421-433 13 p.

Research output: Contribution to journalArticle

Bacteroides fragilis
Colon
Carcinogenesis
Interleukin-17
Myeloid Cells

The Scaffold Immune Microenvironment: Biomaterial-Mediated Immune Polarization in Traumatic and Nontraumatic Applications

Sadtler, K., Allen, B. W., Estrellas, K., Housseau, F., Pardoll, D. M. & Elisseeff, J. H. Oct 1 2017 In : Tissue Engineering - Part A. 23, 19-20, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Biomaterials
Scaffolds
Macrophages
Polarization

Transcriptional mechanisms of resistance to anti-PD-1 therapy

Ascierto, M. L. , Makohon-Moore, A. , Lipson, E. J. , Taube, J. M. , McMiller, T. L. , Berger, A. E. , Fan, J. , Kaunitz, G. J. , Cottrell, T. R. , Kohutek, Z. A. , Favorov, A. , Makarov, V. , Riaz, N. , Chan, T. A. , Cope, L. , Hruban, R. H. , Pardoll, D. M. , Taylor, B. S. , Solit, D. B. , Iacobuzio-Donahue, C. A. & 1 others Topalian, S. L. Jun 15 2017 In : Clinical Cancer Research. 23, 12, p. 3168-3180 13 p.

Research output: Contribution to journalArticle

Melanoma
Biomarkers
Clonal Evolution
Neoplasm Metastasis
Exome
2016

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

Patel, M. A. , Kim, J. E. , Theodros, D. , Tam, A. , Velarde, E. , Kochel, C. M. , Francica, B. , Nirschl, T. R. , Ghasemzadeh, A. , Mathios, D. , Harris-Bookman, S. , Jackson, C. C. , Jackson, C. , Ye, X. , Tran, P. T. , Tyler, B. , Coric, V. , Selby, M. , Brem, H. , Drake, C. G. & 2 others Pardoll, D. M. & Lim, M. May 17 2016 In : Journal for ImmunoTherapy of Cancer. 4, 1, 28

Research output: Contribution to journalArticle

Radiosurgery
Glioma
Monoclonal Antibodies
Radiation
Glioblastoma

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

Mathios, D., Kim, J. E., Mangraviti, A., Phallen, J., Park, C. K., Jackson, C. M., Garzon-Muvdi, T., Kim, E., Theodros, D., Polanczyk, M., Martin, A. M., Suk, I., Ye, X., Tyler, B., Bettegowda, C., Brem, H., Pardoll, D. M. & Lim, M. Dec 21 2016 In : Science Translational Medicine. 8, 370, 370ra180

Research output: Contribution to journalArticle

Immunity
Drug Therapy
Glioblastoma
Immunotherapy
Programmed Cell Death 1 Receptor

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

Danilova, L., Wang, H., Sunshine, J., Kaunitz, G. J., Cottrell, T. R., Xu, H., Esandrio, J., Anders, R. A., Cope, L., Pardoll, D. M., Drake, C. G. & Taube, J. M. Nov 29 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. E7769-E7777

Research output: Contribution to journalArticle

Melanoma
Programmed Cell Death 1 Ligand 2 Protein
Neoplasms
Ligands
Programmed Cell Death 1 Receptor

Design, clinical translation and immunological response of biomaterials in regenerative medicine

Sadtler, K., Singh, A., Wolf, M. T., Wang, X., Pardoll, D. M. & Elisseeff, J. H. Jun 7 2016 In : Nature Reviews Materials. 1, 7, 16040

Research output: Contribution to journalReview article

Biocompatible Materials
Biomaterials
Tissue
Scaffolds
Repair

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Sadtler, K., Estrellas, K., Allen, B. W., Wolf, M. T., Fan, H., Tam, A. J., Patel, C. H., Luber, B. S., Wang, H., Wagner, K. R., Powell, J. D., Housseau, F., Pardoll, D. M. & Elisseeff, J. H. Apr 15 2016 In : Science. 352, 6283, p. 366-370 5 p.

Research output: Contribution to journalArticle

Th2 Cells
Biocompatible Materials
Regeneration
Muscles
Interleukin-4

Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 152 (974-986))

Chiappinelli, K. B. , Strissel, P. L. , Desrichard, A. , Li, H. , Henke, C. , Akman, B. , Hein, A. , Rote, N. S. , Cope, L. M. , Snyder, A. , Makarov, V. , Budhu, S. , Slamon, D. J. , Wolchok, J. D. , Pardoll, D. M. , Beckmann, M. W. , Zahnow, C. A. , Merghoub, T. , Chan, T. A. , Baylin, S. B. & 1 others Strick, R. Feb 25 2016 In : Cell. 164, 5, p. 1073 1 p.

Research output: Contribution to journalArticle

Erratum to: PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment

Mathios, D., Ruzevick, J., Jackson, C. M., Xu, H., Shah, S. R., Taube, J. M., Burger, P. C., McCarthy, E. F., Quinones-Hinojosa, A., Pardoll, D. M. & Lim, M. May 9 2016 (Accepted/In press) In : Journal of Neuro-Oncology. p. 1 1 p.

Research output: Contribution to journalArticle

Chordoma

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma [J Immunothera Cancer, 4, (2016), (28)] DOI:10.1186/s40425-016-0132-2

Patel, M. A. , Kim, J. E. , Theodros, D. , Tam, A. , Velarde, E. , Kochel, C. M. , Francica, B. , Nirschl, T. R. , Ghasemzadeh, A. , Mathios, D. , Harris-Bookman, S. , Jackson, C. C. , Jackson, C. , Ye, X. , Tran, P. T. , Tyler, B. , Coric, V. , Selby, M. , Brem, H. , Drake, C. G. & 2 others Pardoll, D. M. & Lim, M. Nov 4 2016 In : Journal for ImmunoTherapy of Cancer. 4, 1, 74

Research output: Contribution to journalComment/debate

Financial Support
Glioma
Publications
Monoclonal Antibodies
Radiation
CTLA-4 Antigen
Kidney Neoplasms
Biomarkers
Programmed Cell Death 1 Receptor
Neoplasms

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Yang, H. Y., Barbi, J., Wu, C. Y., Zheng, Y., Vignali, P. D. A., Wu, X., Tao, J. H., Park, B. V., Bandara, S., Novack, L., Ni, X., Yang, X., Chang, K. Y., Wu, R. C., Zhang, J., Yang, C. W., Pardoll, D. M., Li, H. & Pan, F. Jul 19 2016 In : Immunity. 45, 1, p. 83-93 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
MicroRNAs
Transcription Factors
Interleukin-6
Cytokines

PD-1 blockade with pembrolizumab in advanced merkel-cell carcinoma

Nghiem, P. T. , Bhatia, S. , Lipson, E. J. , Kudchadkar, R. R. , Miller, N. J. , Annamalai, L. , Berry, S. , Chartash, E. K. , Daud, A. , Fling, S. P. , Friedlander, P. A. , Kluger, H. M. , Kohrt, H. E. , Lundgren, L. , Margolin, K. , Mitchell, A. , Olencki, T. , Pardoll, D. M. , Reddy, S. A. , Shantha, E. M. & 11 others Sharfman, W. H., Sharon, E., Shemanski, L. R., Shinohara, M. M., Sunshine, J. C., Taube, J. M., Thompson, J. A., Townson, S. M., Yearley, J. H., Topalian, S. L. & Cheever, M. A. Jun 30 2016 In : New England Journal of Medicine. 374, 26, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Merkel Cell Carcinoma
Oncogenic Viruses
Merkel cell polyomavirus
pembrolizumab
Confidence Intervals

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N. J., Smith, K. N., Tam, A., Ganguly, S., Wanyiri, J. W., Iyadorai, T., Malik, A. A., Roslani, A. C., Vadivelu, J. S., Van Meerbeke, S., Huso, D. L., Pardoll, D. M. & Sears, C. L. Apr 15 2016 In : Cancer Research. 76, 8, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Th17 Cells
Colon
Carcinogenesis
Bacteroides fragilis
T-Lymphocytes

Systemic tolerance mediated by melanoma brain tumors is reversible by radiotherapy and vaccination

Jackson, C. M., Kochel, C. M., Nirschl, C. J., Durham, N. M., Ruzevick, J., Alme, A., Francica, B. J., Elias, J., Daniels, A., Dubensky, T. W., Lauer, P., Brockstedt, D. G., Baxi, E. G., Calabresi, P. A., Taube, J. M., Pardo, C. A., Brem, H., Pardoll, D. M., Lim, M. & Drake, C. G. Mar 1 2016 In : Clinical Cancer Research. 22, 5, p. 1161-1172 12 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
Brain Neoplasms
Melanoma
Vaccination
Radiotherapy

TGFβ1-mediated SMAD3 enhances PD-1 expression on antigen-specific T cells in cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S. J., Pan, F., Pardoll, D. M. & Cox, A. L. Dec 1 2016 In : Cancer Discovery. 6, 12, p. 1366-1381 16 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Neoplasms
Tumor Microenvironment
Up-Regulation

The intratumoral balance between metabolic and immunologic gene expression is associated with anti-PD-1 response in patients with renal cell carcinoma

Ascierto, M. L., McMiller, T. L., Berger, A. E., Danilova, L., Anders, R. A., Netto, G. J., Xu, H., Pritchard, T. S., Fan, J., Cheadle, C., Cope, L., Drake, C. G., Pardoll, D. M., Taube, J. M. & Topalian, S. L. Sep 1 2016 In : Cancer Immunology Research. 4, 9, p. 726-733 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Gene Expression
Neoplasms
Therapeutics
Intrinsic Factor

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

Mathios, D., Park, C. K., Marcus, W. D., Alter, S., Rhode, P. R., Jeng, E. K., Wong, H. C., Pardoll, D. M. & Lim, M. Jan 1 2016 In : International Journal of Cancer. 138, 1, p. 187-194 8 p.

Research output: Contribution to journalArticle

Interleukin-15
Glioblastoma
Survival
Neoplasms
Therapeutics

Tumor regression and allograft rejection after administration of anti-PD-1

Lipson, E. J., Bagnasco, S. M., Moore, J., Jang, S., Patel, M. J., Zachary, A. A., Pardoll, D. M., Taube, J. M. & Drake, C. G. Mar 3 2016 In : New England Journal of Medicine. 374, 9, p. 896-898 3 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Graft Rejection
Immunocompromised Host
Skin Neoplasms
Antineoplastic Agents
2015
Adoptive Transfer
Multiple Myeloma
Immunity
Bone Marrow
Lymphocytes

Cancer and Immune System: Basic Concepts and Targets for Intervention

Pardoll, D. Aug 1 2015 In : Seminars in Oncology. 42, 4, p. 523-538 16 p.

Research output: Contribution to journalArticle

Immune System Phenomena
Neoplasms
Vaccination
Vaccines
T-Lymphocytes

Combination immunotherapy: Where do we go from here?

Overacre, A. E., Kurtulus, S., Sznol, M., Pardoll, D. M., Anderson, A. & Vignali, D. A. A. Aug 18 2015 In : Journal for ImmunoTherapy of Cancer. 3, 1, 38

Research output: Contribution to journalArticle

Immunotherapy
Neoplasms
Education
Research
Therapeutics

Concepts of immunotherapy for glioma

Patel, M. A. & Pardoll, D. M. Jul 23 2015 In : Journal of Neuro-Oncology. 123, 3, p. 323-330 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Immunotherapy
Standard of Care
Neoplasms

Consensus nomenclature for CD8+ T cell phenotypes in cancer

Apetoh, L. , Smyth, M. J. , Drake, C. G. , Abastado, J. P. , Apte, R. N. , Ayyoub, M. , Blay, J. Y. , Bonneville, M. , Butterfield, L. H. , Caignard, A. , Castelli, C. , Cavallo, F. , Celis, E. , Chen, L. , Colombo, M. P. , Comin-Anduix, B. , Coukos, G. , Dhodapkar, M. V. , Dranoff, G. , Frazer, I. H. & 39 others Fridman, W. H., Gabrilovich, D. I., Gilboa, E., Gnjatic, S., Jäger, D., Kalinski, P., Kaufman, H. L., Kiessling, R., Kirkwood, J., Knuth, A., Liblau, R., Lotze, M. T., Lugli, E., Marincola, F., Melero, I., Melief, C. J., Mempel, T. R., Mittendorf, E. A., Odun, K., Overwijk, W. W., Palucka, A. K., Parmiani, G., Ribas, A., Romero, P., Schreiber, R. D., Schuler, G., Srivastava, P. K., Tartour, E., Valmori, D., van der Burg, S. H., van der Bruggen, P., van den Eynde, B. J., Wang, E., Zou, W., Whiteside, T. L., Speiser, D. E., Pardoll, D. M., Restifo, N. P. & Anderson, A. C. 2015 In : OncoImmunology. 4, 4

Research output: Contribution to journalArticle

Terminology
T-Lymphocytes
Phenotype
Neoplasms
Tumor Microenvironment

Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: Implications for PD-1 pathway blockade

Taube, J. M., Young, G. D., McMiller, T. L., Chen, S., Salas, J. T., Pritchard, T. S., Xu, H., Meeker, A. K., Fan, J., Cheadle, C., Berger, A. E., Pardoll, D. M. & Topalian, S. L. Sep 1 2015 In : Clinical Cancer Research. 21, 17, p. 3969-3976 8 p.

Research output: Contribution to journalArticle

Regulator Genes
Melanoma
Antigen Presentation
Immunosuppression
Interleukin-10

Distinct Mechanisms of Tumor Resistance to NK Killing: Of Mice and Men

Pardoll, D. M. Apr 21 2015 In : Immunity. 42, 4, p. 605-606 2 p.

Research output: Contribution to journalArticle

Innate Immunity
Natural Killer Cells
Natural Killer Cell Receptors
Ligands
Neoplasms

Expression profile and in vitro blockade of programmed death-1 in human papillomavirus-negative head and neck squamous cell carcinoma

Malm, I. J., Bruno, T. C., Fu, J., Zeng, Q., Taube, J. M., Westra, W., Pardoll, D., Drake, C. G. & Kim, Y. J. 2015 In : Head and Neck. 37, 8, p. 1088-1095 8 p.

Research output: Contribution to journalArticle

Ligands
Neoplasms
Lymphocytes
Mixed Lymphocyte Culture Test
Therapeutics

Immune checkpoint blockade: A common denominator approach to cancer therapy

Topalian, S. L., Drake, C. G. & Pardoll, D. M. Apr 13 2015 In : Cancer Cell. 27, 4, p. 451-461 11 p.

Research output: Contribution to journalArticle

Neoplasms
Self Tolerance
Therapeutics
Antigen-Antibody Complex
Pharmaceutical Preparations

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Chiappinelli, K. B. , Strissel, P. L. , Desrichard, A. , Li, H. , Henke, C. , Akman, B. , Hein, A. , Rote, N. S. , Cope, L. M. , Snyder, A. , Makarov, V. , Buhu, S. , Slamon, D. J. , Wolchok, J. D. , Pardoll, D. M. , Beckmann, M. W. , Zahnow, C. A. , Mergoub, T. , Chan, T. A. , Baylin, S. B. & 1 others Strick, R. Aug 27 2015 In : Cell. 162, 5, p. 974-986 13 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Double-Stranded RNA
Methyltransferases
DNA Methylation
Interferons

Integrating tissue microenvironment with scaffold design to promote immune-mediated regeneration

Sadtler, K., Housseau, F., Pardoll, D. & Elisseeff, J. H. Sep 4 2015 Biomaterials in Regenerative Medicine and the Immune System. Springer International Publishing, p. 35-51 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Scaffolds
Regeneration
Tissue