Andrew Horti

Professor

1992 …2020

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NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: In vitro and in vivo evaluation

Chefer, S. I., Pavlova, O. A., Zhang, Y., Vaupel, D. B., Kimes, A. S., Horti, A. G., Stein, E. & Mukhin, A. G., Jan 1 2008, In : Journal of Neurochemistry. 104, 2, p. 306-315 10 p.

Research output: Contribution to journalArticle

PET imaging of high-affinity a4b2 nicotinic acetylcholine receptors in humans with 18F-AZAN, a radioligand with optimal brain kinetics

Wong, D. F., Kuwabara, H., Kim, J., Brašić, J. R., Chamroonrat, W., Gao, Y., Valentine, H., Willis, W., Mathur, A., McCaul, M. E., Wand, G., Gean, E. G., Dannals, R. F. & Horti, A. G., Aug 1 2013, In : Journal of Nuclear Medicine. 54, 8, p. 1308-1314 7 p.

Research output: Contribution to journalArticle

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

Horti, A., Naik, R., Foss, C., Minn, I., Misheneva, V., Du, Y., Wang, Y., Mathews, W. B., Wu, Y., Hall, A., LaCourse, C., Ahn, H. H., Nam, H., Lesniak, W., Valentine, H., Pletnikova, O., Troncoso, J. C., Smith, M. D., Calabresi, P., Savonenko, A. & 3 others, Dannals, R. F., Pletnikov, M. & Pomper, M. G., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)- azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography

Vaupel, D. B., Tella, S. R., Huso, D. L., Wagner, V. O., Mukhin, A. G., Chefer, S. I., Horti, A. G., London, E. D., Koren, A. O. & Kimes, A. S., Jan 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 1, p. 355-365 11 p.

Research output: Contribution to journalArticle

Pharmacology, toxicology, and radiation dosimetry evaluation of [123I] 5-I-A-85380, a radioligand for in vivo imaging of cerebral neuronal nicotinic acetylcholine receptors in humans

Vaupel, D. B., Tella, S. R., Huso, D. L., Mukhin, A. G., Baum, I., Wagner, V. O., Horti, A. G., London, E. D., Koren, A. O. & Kimes, A. S., Feb 1 2003, In : Drug Development Research. 58, 2, p. 149-168 20 p.

Research output: Contribution to journalArticle

Positron emission tomography experience with 2-[ 18F]fluoro-3-(2(s)-azetidinylmethoxy)pyridine (2-[ 18F]fa) in the living human brain of smokers with paranoid schizophrenia

Brašić, J. R., Cascella, N., Kumar, A., Zhou, Y., Hilton, J., Raymont, V., Crabb, A., Guevara, M. R., Horti, A. G. & Wong, D. F., Apr 1 2012, In : Synapse. 66, 4, p. 352-368 17 p.

Research output: Contribution to journalArticle

Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR

Wong, D. F., Kuwabara, H., Horti, A. G., Raymont, V., Brasic, J., Guevara, M., Ye, W., Dannals, R. F., Ravert, H. T., Nandi, A., Rahmim, A., Ming, J. E., Grachev, I., Roy, C. & Cascella, N., Oct 1 2010, In : NeuroImage. 52, 4, p. 1505-1513 9 p.

Research output: Contribution to journalArticle

Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET

Fujita, M., Ichise, M., Van Dyck, C. H., Zoghbi, S. S., Tamagnan, G., Mukhin, A. G., Bozkurt, A., Seneca, N., Tipre, D., DeNucci, C. C., Iida, H., Vaupel, D. B., Horti, A. G., Koren, A. O., Kimes, A. S., London, E. D., Seibyl, J. P., Baldwin, R. M. & Innis, R. B., Dec 1 2003, In : European Journal of Nuclear Medicine and Molecular Imaging. 30, 12, p. 1620-1629 10 p.

Research output: Contribution to journalArticle

Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects

Bremner, J. D., Baldwin, R., Horti, A., Staib, L. H., Ng, C. K., Tan, P. Z., Zea-Ponce, Y., Zoghbi, S., Seibyl, J. P., Soufer, R., Charney, D. S. & Innis, R. B., Aug 31 1999, In : Psychiatry Research - Neuroimaging. 91, 2, p. 79-91 13 p.

Research output: Contribution to journalArticle

Radiohalogenated analogs of A-85380: Potential ligands for mapping α4β2 nicotinic receptors in human brain

Mukhin, A. G., Chefer, S. I., Horti, A. G., Koren, A. O., Vaupel, D. B., Gündisch, D., Pavlova, O. I., Kurian, V., Kimes, A. S. & London, E. D., Dec 1 2000, In : NeuroImage. 11, 6 PART II, p. S50

Research output: Contribution to journalArticle

Radiosynthesis and in vivo evaluation of 6-[18F]FA, a novel tracer for the nicotinic acetylcholine receptor

Scheffel, U., Horti, A. G., Koren, A. O., Ravert, H. T., Banta, J. P., Finley, P. A., London, E. D. & Dannals, R. F., Jan 1 1999, In : Journal of Labelled Compounds and Radiopharmaceuticals. 42, SUPPL. 1, p. S188-S190

Research output: Contribution to journalArticle

Radiosynthesis and preliminary evaluation of 5-[(123/125)I]iodo-3- (2(S)-azetidinylmethoxy)pyridine: A radioligand for nicotinic acetylcholine receptors

Horti, A. G., Koren, A. O., Lee, K. S., Mukhin, A. G., Vaupel, D. B., Kimes, A. S., Stratton, M. & London, E. D., Feb 1 1999, In : Nuclear Medicine and Biology. 26, 2, p. 175-182 8 p.

Research output: Contribution to journalArticle

Reciprocal alterations in cortical cannabinoid receptor 1 binding relative to protein immunoreactivity and transcript levels in schizophrenia

Volk, D. W., Eggan, S. M., Horti, A. G., Wong, D. F. & Lewis, D. A., Oct 1 2014, In : Schizophrenia Research. 159, 1, p. 124-129 6 p.

Research output: Contribution to journalArticle

Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand

Willis, P. G., Katoch-Rouse, R. & Horti, A. G., Aug 2003, In : Journal of Labelled Compounds and Radiopharmaceuticals. 46, 9, p. 799-804 6 p.

Research output: Contribution to journalArticle

Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: Development of central cannabinoid receptor ligands with lower lipophilicity

Katoch-Rouse, R., Pavlova, O. A., Caulder, T., Hoffman, A. F., Mukhin, A. G. & Horti, A. G., Feb 13 2003, In : Journal of medicinal chemistry. 46, 4, p. 642-645 4 p.

Research output: Contribution to journalArticle

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

Horti, A. G., Gao, Y., Ravert, H. T., Finley, P., Valentine, H., Wong, D. F., Endres, C. J., Savonenko, A. V. & Dannals, R. F., Jul 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 5202-5207 6 p.

Research output: Contribution to journalArticle

Synthesis and characterization of binding of 5-[76Br]bromo-3-[[2(S)- azetidinyl]methoxy]pyridine, a novel nicotinic acetylcholine receptor ligand, in rat brain

Sihver, W., Fasth, K. J., Horti, A. G., Koren, A. O., Bergström, M., Lu, L., Hagberg, G., Lundqvist, H., Donnals, R. F., London, E. D., Nordberg, A. & Långström, B., Aug 30 1999, In : Journal of Neurochemistry. 73, 3, p. 1264-1272 9 p.

Research output: Contribution to journalArticle

Synthesis and Evaluation of a New 18F-Labeled Radiotracer for Studying the GABAB Receptor in the Mouse Brain

Naik, R., Valentine, H., Dannals, R. F., Wong, D. F. & Horti, A., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1453-1461 9 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)- 3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors

Brown, L. V. L., Kulkarni, S., Pavlova, O. A., Koren, A. O., Mukhin, A. G., Newman, A. H. & Horti, A. G., Jun 20 2002, In : Journal of medicinal chemistry. 45, 13, p. 2841-2849 9 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors

Horti, A. G., Scheffel, U., Kimes, A. S., Musachio, J. L., Ravert, H. T., Mathews, W. B., Zhan, Y., Finley, P. A., London, E. D. & Dannals, R. F., Oct 23 1998, In : Journal of medicinal chemistry. 41, 22, p. 4199-4206 8 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of new radioligands [11C]A-833834 and [11C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors

Horti, A. G., Ravert, H. T., Gao, Y., Holt, D. P., Bunnelle, W. H., Schrimpf, M. R., Li, T., Ji, J., Valentine, H., Scheffel, U., Kuwabara, H., Wong, D. F. & Dannals, R. F., Apr 1 2013, In : Nuclear Medicine and Biology. 40, 3, p. 395-402 8 p.

Research output: Contribution to journalArticle

Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil

Baldwin, R. M., Horti, A. G., Bremner, J. D., Stratton, M. D., Dannals, R. F., Ravert, H. T., Zea-Ponce, Y., Ng, C. K., Dey, H. M., Soufer, R., Charney, D. S., Mazza, S. M., Sparks, R. B., Stubbs, J. B. & Innis, R. B., Jul 1995, In : Nuclear Medicine and Biology. 22, 5, p. 659-665 7 p.

Research output: Contribution to journalArticle

Synthesis and preliminary biological evaluation of indol-3-yl-oxoacetamides as potent cannabinoid receptor type 2 ligands

Moldovan, R. P., Deuther-Conrad, W., Horti, A. & Brust, P., Jan 1 2017, In : Molecules. 22, 1, 77.

Research output: Contribution to journalArticle

Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography

Willis, P. G., Pavlova, O. A., Chefer, S. I., Vaupel, D. B., Mukhin, A. G. & Horti, A. G., Sep 8 2005, In : Journal of medicinal chemistry. 48, 18, p. 5813-5822 10 p.

Research output: Contribution to journalArticle

Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET

Horti, A. G., Ravert, H. T., Mathews, W. B., Abraham, E. H., Wahl, R. L. & Dannals, R. F., Aug 1 2006, In : Journal of Labelled Compounds and Radiopharmaceuticals. 49, 9, p. 811-815 5 p.

Research output: Contribution to journalArticle

Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A- 85380)

Horti, A. G., Koren, A. O., Ravert, H. T., Musachio, J. L., Mathews, W. B., London, E. D. & Dannals, R. F., Apr 1998, In : Journal of Labelled Compounds and Radiopharmaceuticals. 41, 4, p. 309-318 10 p.

Research output: Contribution to journalArticle

Synthesis of N‐[11C]‐methyl‐L‐DOPA

Horti, A., Ravert, H. T., Dannals, R. F. & Wagner, H. N., Dec 1992, In : Journal of Labelled Compounds and Radiopharmaceuticals. 31, 12, p. 1029-1036 8 p.

Research output: Contribution to journalArticle

The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [18F]ASEM

Coughlin, J. M., Du, Y., Rosenthal, H. B., Slania, S., Min Koo, S., Park, A., Solomon, G., Vranesic, M., Antonsdottir, I., Speck, C. L., Rootes-Murdy, K., Lerner, A., Rowe, S., Wang, Y., Lesniak, W., Minn, I., Bakker, A., Smith, G., Dannals, R. F., Kuwabara, H. & 3 others, Horti, A., Wong, D. F. & Pomper, M. G., Jan 15 2018, In : NeuroImage. 165, p. 118-124 7 p.

Research output: Contribution to journalArticle

Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5-I-A-85380 in healthy human subjects

Fujita, M., Seibyl, J. P., Vaupel, B. D., Tamagnan, G., Early, M., Zoghbi, S. S., Baldwin, R. M., Horti, A. G., Koren, A. O., Mukhin, A. G., Khan, S., Bozkurt, A., Kimes, A. S., London, E. D. & Innis, R. B., Feb 23 2002, In : European Journal of Nuclear Medicine. 29, 2, p. 183-190 8 p.

Research output: Contribution to journalArticle