Andrew Horti

Professor

1992 …2020

Research output per year

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Research Output

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Article
1992

Synthesis of N‐[11C]‐methyl‐L‐DOPA

Horti, A., Ravert, H. T., Dannals, R. F. & Wagner, H. N., Dec 1992, In : Journal of Labelled Compounds and Radiopharmaceuticals. 31, 12, p. 1029-1036 8 p.

Research output: Contribution to journalArticle

1995

Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil

Baldwin, R. M., Horti, A. G., Bremner, J. D., Stratton, M. D., Dannals, R. F., Ravert, H. T., Zea-Ponce, Y., Ng, C. K., Dey, H. M., Soufer, R., Charney, D. S., Mazza, S. M., Sparks, R. B., Stubbs, J. B. & Innis, R. B., Jul 1995, In : Nuclear Medicine and Biology. 22, 5, p. 659-665 7 p.

Research output: Contribution to journalArticle

1996
1997

[125/123I]IPH: A radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors

Musachio, J. L., Villemagne, V. L., Scheffel, U., Stathis, M., Finley, P., Horti, A., London, E. D. & Dannals, R. F., Aug 1 1997, In : Synapse. 26, 4, p. 392-399 8 p.

Research output: Contribution to journalArticle

[125i]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors

Dávila-García, M. I., Musachio, J. L., Perry, D. C., Xiao, Y., Horti, A., London, E. D., Dannals, R. F. & Kellar, K. J., Jul 1 1997, In : Journal of Pharmacology and Experimental Therapeutics. 282, 1, p. 445-451 7 p.

Research output: Contribution to journalArticle

Fluorine-18-FPH for PET imaging of nicotinic acetylcholine receptors

Horti, A., Scheffel, U., Stathis, M., Finley, P., Ravert, H. T., London, E. D. & Dannais, R. F., Aug 20 1997, In : Journal of Nuclear Medicine. 38, 8, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

Imaging nicotinic acetylcholine receptors with fluorine-18-FPH, an epibatidine analog

Villemagne, V. L., Horti, A., Scheffel, U., Ravert, H. T., Finley, P., Clough, D. J., London, E. D., Wagner, H. N. & Dannals, R. F., Nov 1 1997, In : Journal of Nuclear Medicine. 38, 11, p. 1737-1741 5 p.

Research output: Contribution to journalArticle

1998

2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: Synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling

Koren, A. O., Horti, A. G., Mukhin, A. G., Gündisch, D., Kimes, A. S., Dannals, R. F. & London, E. D., Sep 10 1998, In : Journal of medicinal chemistry. 41, 19, p. 3690-3698 9 p.

Research output: Contribution to journalArticle

2-[18F]fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors

Horti, A. G., Scheffel, U., Koren, A. O., Ravert, H. T., Mathews, W. B., Musachio, J. L., Finley, P. A., London, E. D. & Dannals, R. F., Oct 1 1998, In : Nuclear Medicine and Biology. 25, 7, p. 599-603 5 p.

Research output: Contribution to journalArticle

In vivo imaging of brain nicotinic acetylcholine receptors with 5- [123I]iodo-A-85380 using single photon emission computed tomography

Chefer, S. I., Horti, A. G., Lee, K. S., Koren, A. O., Jones, D. W., Gorey, J. G., Links, J. M., Mukhin, A. G., Weinberger, D. R. & London, E. D., Nov 13 1998, In : Life Sciences. 63, 25, p. PL355-PL360

Research output: Contribution to journalArticle

In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand

Vaupel, D. B., Mukhin, A. G., Kimes, A. S., Horti, A. G., Koren, A. O. & London, E. D., Jul 13 1998, In : Neuroreport. 9, 10, p. 2311-2317 7 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors

Horti, A. G., Scheffel, U., Kimes, A. S., Musachio, J. L., Ravert, H. T., Mathews, W. B., Zhan, Y., Finley, P. A., London, E. D. & Dannals, R. F., Oct 23 1998, In : Journal of medicinal chemistry. 41, 22, p. 4199-4206 8 p.

Research output: Contribution to journalArticle

Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A- 85380)

Horti, A. G., Koren, A. O., Ravert, H. T., Musachio, J. L., Mathews, W. B., London, E. D. & Dannals, R. F., Apr 1998, In : Journal of Labelled Compounds and Radiopharmaceuticals. 41, 4, p. 309-318 10 p.

Research output: Contribution to journalArticle

1999

2-[18F]F-A-85380: A PET radioligand for α4β2 nicotinic acetylcholine receptors

Chefer, S. I., Horti, A. G., Koren, A. O., Gündisch, D., Links, J. M., Kurian, V., Dannals, R. F., Mukhin, A. G. & London, E. D., Sep 9 1999, In : Neuroreport. 10, 13, p. 2715-2721 7 p.

Research output: Contribution to journalArticle

Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects

Bremner, J. D., Baldwin, R., Horti, A., Staib, L. H., Ng, C. K., Tan, P. Z., Zea-Ponce, Y., Zoghbi, S., Seibyl, J. P., Soufer, R., Charney, D. S. & Innis, R. B., Aug 31 1999, In : Psychiatry Research - Neuroimaging. 91, 2, p. 79-91 13 p.

Research output: Contribution to journalArticle

Radiosynthesis and in vivo evaluation of 6-[18F]FA, a novel tracer for the nicotinic acetylcholine receptor

Scheffel, U., Horti, A. G., Koren, A. O., Ravert, H. T., Banta, J. P., Finley, P. A., London, E. D. & Dannals, R. F., Jan 1 1999, In : Journal of Labelled Compounds and Radiopharmaceuticals. 42, SUPPL. 1, p. S188-S190

Research output: Contribution to journalArticle

Radiosynthesis and preliminary evaluation of 5-[(123/125)I]iodo-3- (2(S)-azetidinylmethoxy)pyridine: A radioligand for nicotinic acetylcholine receptors

Horti, A. G., Koren, A. O., Lee, K. S., Mukhin, A. G., Vaupel, D. B., Kimes, A. S., Stratton, M. & London, E. D., Feb 1 1999, In : Nuclear Medicine and Biology. 26, 2, p. 175-182 8 p.

Research output: Contribution to journalArticle

Synthesis and characterization of binding of 5-[76Br]bromo-3-[[2(S)- azetidinyl]methoxy]pyridine, a novel nicotinic acetylcholine receptor ligand, in rat brain

Sihver, W., Fasth, K. J., Horti, A. G., Koren, A. O., Bergström, M., Lu, L., Hagberg, G., Lundqvist, H., Donnals, R. F., London, E. D., Nordberg, A. & Långström, B., Aug 30 1999, In : Journal of Neurochemistry. 73, 3, p. 1264-1272 9 p.

Research output: Contribution to journalArticle

2000

5-iodo-a-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors

Mukhin, A. G., Gündisch, D., Horti, A. G., Koren, A. O., Tamagnan, G., Kimes, A. S., Chambers, J., Vaupel, D. B., King, S. L., Picciotto, M. R., Innis, R. B. & London, E. D., Jan 1 2000, In : Molecular Pharmacology. 57, 3, p. 642-649 8 p.

Research output: Contribution to journalArticle

6-[18F]fluoro-A-85380: An in vivo tracer for the nicotinic acetylcholine receptor

Scheffel, U., Horti, A. G., Koren, A. O., Ravert, H. T., Banta, J. P., Finley, P. A., London, E. D. & Dannals, R. F., Jan 1 2000, In : Nuclear Medicine and Biology. 27, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors

Horti, A. G., Chefer, S. I., Mukhin, A. G., Koren, A. O., Gündisch, D., Links, J. M., Kurian, V., Dannals, R. F. & London, E. D., Jun 16 2000, In : Life Sciences. 67, 4, p. 463-469 7 p.

Research output: Contribution to journalArticle

Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]iomazenil in healthy human subjects

Bremner, J. D., Horti, A., Staib, L. H., Zea-Ponce, Y., Soufer, R., Charney, D. S. & Baldwin, R., Jan 1 2000, In : Synapse. 35, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Radiohalogenated analogs of A-85380: Potential ligands for mapping α4β2 nicotinic receptors in human brain

Mukhin, A. G., Chefer, S. I., Horti, A. G., Koren, A. O., Vaupel, D. B., Gündisch, D., Pavlova, O. I., Kurian, V., Kimes, A. S. & London, E. D., Dec 1 2000, In : NeuroImage. 11, 6 PART II, p. S50

Research output: Contribution to journalArticle

2001
2002

Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)- 3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors

Brown, L. V. L., Kulkarni, S., Pavlova, O. A., Koren, A. O., Mukhin, A. G., Newman, A. H. & Horti, A. G., Jun 20 2002, In : Journal of medicinal chemistry. 45, 13, p. 2841-2849 9 p.

Research output: Contribution to journalArticle

Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5-I-A-85380 in healthy human subjects

Fujita, M., Seibyl, J. P., Vaupel, B. D., Tamagnan, G., Early, M., Zoghbi, S. S., Baldwin, R. M., Horti, A. G., Koren, A. O., Mukhin, A. G., Khan, S., Bozkurt, A., Kimes, A. S., London, E. D. & Innis, R. B., Feb 23 2002, In : European Journal of Nuclear Medicine. 29, 2, p. 183-190 8 p.

Research output: Contribution to journalArticle

2003

2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans.

Kimes, A. S., Horti, A. G., London, E. D., Chefer, S. I., Contoreggi, C., Ernst, M., Friello, P., Koren, A. O., Kurian, V., Matochik, J. A., Pavlova, O., Vaupel, D. B. & Mukhin, A. G., Jul 2003, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 10, p. 1331-1333 3 p.

Research output: Contribution to journalArticle

Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain

Chefer, S. I., London, E. D., Koren, A. O., Pavlova, O. A., Kurian, V., Kimes, A. S., Horti, A. G. & Mukhin, A. G., Apr 1 2003, In : Synapse. 48, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

Pharmacology, toxicology, and radiation dosimetry evaluation of [123I] 5-I-A-85380, a radioligand for in vivo imaging of cerebral neuronal nicotinic acetylcholine receptors in humans

Vaupel, D. B., Tella, S. R., Huso, D. L., Mukhin, A. G., Baum, I., Wagner, V. O., Horti, A. G., London, E. D., Koren, A. O. & Kimes, A. S., Feb 1 2003, In : Drug Development Research. 58, 2, p. 149-168 20 p.

Research output: Contribution to journalArticle

Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET

Fujita, M., Ichise, M., Van Dyck, C. H., Zoghbi, S. S., Tamagnan, G., Mukhin, A. G., Bozkurt, A., Seneca, N., Tipre, D., DeNucci, C. C., Iida, H., Vaupel, D. B., Horti, A. G., Koren, A. O., Kimes, A. S., London, E. D., Seibyl, J. P., Baldwin, R. M. & Innis, R. B., Dec 1 2003, In : European Journal of Nuclear Medicine and Molecular Imaging. 30, 12, p. 1620-1629 10 p.

Research output: Contribution to journalArticle

Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand

Willis, P. G., Katoch-Rouse, R. & Horti, A. G., Aug 2003, In : Journal of Labelled Compounds and Radiopharmaceuticals. 46, 9, p. 799-804 6 p.

Research output: Contribution to journalArticle

Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: Development of central cannabinoid receptor ligands with lower lipophilicity

Katoch-Rouse, R., Pavlova, O. A., Caulder, T., Hoffman, A. F., Mukhin, A. G. & Horti, A. G., Feb 13 2003, In : Journal of medicinal chemistry. 46, 4, p. 642-645 4 p.

Research output: Contribution to journalArticle

2004

Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)- pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors

Brown, L. V., Chefer, S., Pavlova, O., Vaupel, D. B., Koren, A. O., Kimes, A. S., Horti, A. G. & Mukhin, A. G., Nov 1 2004, In : Journal of Neurochemistry. 91, 3, p. 600-612 13 p.

Research output: Contribution to journalArticle

2005

In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for α4β2* nicotinic acetylcholine receptors

Gündisch, D., Koren, A. O., Horti, A. G., Pavlova, O. A., Kimes, A. S., Mukhin, A. G. & London, E. D., Feb 1 2005, In : Synapse. 55, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)- azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography

Vaupel, D. B., Tella, S. R., Huso, D. L., Wagner, V. O., Mukhin, A. G., Chefer, S. I., Horti, A. G., London, E. D., Koren, A. O. & Kimes, A. S., Jan 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 1, p. 355-365 11 p.

Research output: Contribution to journalArticle

Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography

Willis, P. G., Pavlova, O. A., Chefer, S. I., Vaupel, D. B., Mukhin, A. G. & Horti, A. G., Sep 8 2005, In : Journal of medicinal chemistry. 48, 18, p. 5813-5822 10 p.

Research output: Contribution to journalArticle

2006

11C-JHU75528: A radiotracer for PET imaging of CB1 cannabinoid receptors

Horti, A. G., Fan, H., Kuwabara, H., Hilton, J., Ravert, H. T., Holt, D. P., Alexander, M., Kumar, A., Rahmim, A., Scheffel, U., Wong, D. F. & Dannals, R. F., Oct 1 2006, In : Journal of Nuclear Medicine. 47, 10, p. 1689-1696 8 p.

Research output: Contribution to journalArticle

Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET

Horti, A. G., Ravert, H. T., Mathews, W. B., Abraham, E. H., Wahl, R. L. & Dannals, R. F., Aug 1 2006, In : Journal of Labelled Compounds and Radiopharmaceuticals. 49, 9, p. 811-815 5 p.

Research output: Contribution to journalArticle