Andrew Horti

Professor

1992 …2020

Research output per year

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Research Output

[125/123I]IPH: A radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors

Musachio, J. L., Villemagne, V. L., Scheffel, U., Stathis, M., Finley, P., Horti, A., London, E. D. & Dannals, R. F., Aug 1 1997, In : Synapse. 26, 4, p. 392-399 8 p.

Research output: Contribution to journalArticle

[125I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR

Gao, Y., Mease, R. C., Olson, T. T., Kellar, K. J., Dannals, R. F., Pomper, M. G. & Horti, A. G., May 1 2015, In : Nuclear Medicine and Biology. 42, 5, p. 488-493 6 p.

Research output: Contribution to journalArticle

[125i]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors

Dávila-García, M. I., Musachio, J. L., Perry, D. C., Xiao, Y., Horti, A., London, E. D., Dannals, R. F. & Kellar, K. J., Jul 1 1997, In : Journal of Pharmacology and Experimental Therapeutics. 282, 1, p. 445-451 7 p.

Research output: Contribution to journalArticle

11C-JHU75528: A radiotracer for PET imaging of CB1 cannabinoid receptors

Horti, A. G., Fan, H., Kuwabara, H., Hilton, J., Ravert, H. T., Holt, D. P., Alexander, M., Kumar, A., Rahmim, A., Scheffel, U., Wong, D. F. & Dannals, R. F., Oct 1 2006, In : Journal of Nuclear Medicine. 47, 10, p. 1689-1696 8 p.

Research output: Contribution to journalArticle

18F-ASEM, a radiolabeled antagonist for imaging the aα7-nicotinic acetylcholine receptor with PET

Horti, A. G., Gao, Y., Kuwabara, H., Wang, Y., Abazyan, S., Yasuda, R. P., Tran, T., Xiao, Y., Sahibzada, N., Holt, D. P., Kellar, K. J., Pletnikov, M. V., Pomper, M. G., Wong, D. F. & Dannals, R. F., Apr 1 2014, In : Journal of Nuclear Medicine. 55, 4, p. 672-677 6 p.

Research output: Contribution to journalArticle

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase

Horti, A., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N. J., Dannals, R. F. & Pomper, M. G., Nov 1 2016, In : Journal of Nuclear Medicine. 57, 11, p. 1817-1822 6 p.

Research output: Contribution to journalArticle

18F-XTRA PET for enhanced imaging of the extrathalamic α4β2 nicotinic acetylcholine receptor

Coughlin, J. M., Slania, S., Du, Y., Rosenthal, H. B., Lesniak, W., Minn, I., Smith, G., Dannals, R. F., Kuwabara, H., Wong, D. F., Wang, Y., Horti, A. & Pomper, M. G., Oct 1 2018, In : Journal of Nuclear Medicine. 59, 10, p. 1603-1608 6 p.

Research output: Contribution to journalArticle

2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: Synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling

Koren, A. O., Horti, A. G., Mukhin, A. G., Gündisch, D., Kimes, A. S., Dannals, R. F. & London, E. D., Sep 10 1998, In : Journal of medicinal chemistry. 41, 19, p. 3690-3698 9 p.

Research output: Contribution to journalArticle

2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans.

Kimes, A. S., Horti, A. G., London, E. D., Chefer, S. I., Contoreggi, C., Ernst, M., Friello, P., Koren, A. O., Kurian, V., Matochik, J. A., Pavlova, O., Vaupel, D. B. & Mukhin, A. G., Jul 2003, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 10, p. 1331-1333 3 p.

Research output: Contribution to journalArticle

2-[18F]F-A-85380: A PET radioligand for α4β2 nicotinic acetylcholine receptors

Chefer, S. I., Horti, A. G., Koren, A. O., Gündisch, D., Links, J. M., Kurian, V., Dannals, R. F., Mukhin, A. G. & London, E. D., Sep 9 1999, In : Neuroreport. 10, 13, p. 2715-2721 7 p.

Research output: Contribution to journalArticle

2-[18F]fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors

Horti, A. G., Scheffel, U., Koren, A. O., Ravert, H. T., Mathews, W. B., Musachio, J. L., Finley, P. A., London, E. D. & Dannals, R. F., Oct 1 1998, In : Nuclear Medicine and Biology. 25, 7, p. 599-603 5 p.

Research output: Contribution to journalArticle

5-(5-(6-[11C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin- 2-yl)-1H-indole as a potential PET radioligand for imaging cerebral α7-nAChR in mice

Gao, Y., Ravert, H. T., Valentine, H., Scheffel, U., Finley, P., Wong, D. F., Dannals, R. F. & Horti, A. G., Jun 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 12, p. 3698-3702 5 p.

Research output: Contribution to journalArticle

5-iodo-a-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors

Mukhin, A. G., Gündisch, D., Horti, A. G., Koren, A. O., Tamagnan, G., Kimes, A. S., Chambers, J., Vaupel, D. B., King, S. L., Picciotto, M. R., Innis, R. B. & London, E. D., Jan 1 2000, In : Molecular Pharmacology. 57, 3, p. 642-649 8 p.

Research output: Contribution to journalArticle

6-[18F]fluoro-A-85380: An in vivo tracer for the nicotinic acetylcholine receptor

Scheffel, U., Horti, A. G., Koren, A. O., Ravert, H. T., Banta, J. P., Finley, P. A., London, E. D. & Dannals, R. F., Jan 1 2000, In : Nuclear Medicine and Biology. 27, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors

Horti, A. G., Chefer, S. I., Mukhin, A. G., Koren, A. O., Gündisch, D., Links, J. M., Kurian, V., Dannals, R. F. & London, E. D., Jun 16 2000, In : Life Sciences. 67, 4, p. 463-469 7 p.

Research output: Contribution to journalArticle

68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer

Banerjee, S. R., Pullambhatla, M., Byun, Y., Nimmagadda, S., Green, G., Fox, J. J., Horti, A., Mease, R. C. & Pomper, M. G., Jul 22 2010, In : Journal of medicinal chemistry. 53, 14, p. 5333-5341 9 p.

Research output: Contribution to journalArticle

Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): Development of ligands with optimized lipophilicity and binding affinity

Fan, H., Kotsikorou, E., Hoffman, A. F., Ravert, H. T., Holt, D., Hurst, D. P., Lupica, C. R., Reggio, P. H., Dannals, R. F. & Horti, A. G., Feb 1 2009, In : European Journal of Medicinal Chemistry. 44, 2, p. 593-608 16 p.

Research output: Contribution to journalArticle

AT-1001 Is a partial agonist with high affinity and selectivity at human and rat α3β4 nicotinic cholinergic receptors

Tuan, E. W., Horti, A. G., Olson, T. T., Gao, Y., Stockmeier, C. A., Al-Muhtasib, N., Dalley, C. B., Lewin, A. E., Wolfe, B. B., Sahibzada, N., Xiao, Y. & Kellar, K. J., Oct 1 2015, In : Molecular Pharmacology. 88, 4, p. 640-649 10 p.

Research output: Contribution to journalArticle

Brain PET Imaging in the Cannabinoid System

Wong, D. F., Nandi, A., Zaidi, E., Gean, E., Horti, A., Frolov, B., George, N. & Brasic, J. R., Jan 1 2014, Imaging of the Human Brain in Health and Disease. Elsevier Inc., p. 27-36 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain PET imaging of α7-nAChR with [18F]ASEM: Reproducibility, occupancy, receptor density, and changes in schizophrenia

Wong, D. F., Kuwabara, H., Horti, A. G., Roberts, J. M., Nandi, A., Cascella, N., Brasic, J., Weerts, E. M., Kitzmiller, K., Phan, J. A., Gapasin, L., Sawa, A., Valentine, H., Wand, G., Mishra, C., George, N., McDonald, M., Lesniak, W., Holt, D. P., Azad, B. B. & 4 others, Dannals, R. F., Kem, W., Freedman, R. & Gjedde, A., Jan 1 2018, In : International Journal of Neuropsychopharmacology. 21, 7, p. 656-667 12 p.

Research output: Contribution to journalArticle

Cannabinoid CB2 receptors in a mouse model of Aβ amyloidosis: Immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation

Savonenko, A. V., Melnikova, T., Wang, Y., Ravert, H., Gao, Y., Koppel, J., Lee, D., Pletnikova, O., Cho, E., Sayyida, N., Hiatt, A., Troncoso, J., Davies, P., Dannals, R. F., Pomper, M. G. & Horti, A. G., Jun 18 2015, In : PloS one. 10, 6, e0129618.

Research output: Contribution to journalArticle

Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors

Horti, A. G. & Wong, D. F., Jan 1 2009, In : PET Clinics. 4, 1, p. 89-100 12 p.

Research output: Contribution to journalReview article

Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors

Gao, Y., Kellar, K. J., Yasuda, R. P., Tran, T., Xiao, Y., Dannals, R. F. & Horti, A. G., Oct 10 2013, In : Journal of medicinal chemistry. 56, 19, p. 7574-7589 16 p.

Research output: Contribution to journalArticle

Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

Moldovan, R. P., Teodoro, R., Gao, Y., Deuther-Conrad, W., Kranz, M., Wang, Y., Kuwabara, H., Nakano, M., Valentine, H., Fischer, S., Pomper, M. G., Wong, D. F., Dannals, R. F., Brust, P. & Horti, A., Sep 8 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 7840-7855 16 p.

Research output: Contribution to journalArticle

Development of a radioligand for imaging V1a vasopressin receptors with PET

Naik, R., Valentine, H., Hall, A., Mathews, W. B., Harris, J. C. O., Carter, C. S., Dannals, R. F., Wong, D. F. & Horti, A., Oct 20 2017, In : European Journal of Medicinal Chemistry. 139, p. 644-656 13 p.

Research output: Contribution to journalArticle

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain

Tamborini, L., Chen, Y., Foss, C., Pinto, A., Horti, A., Traynelis, S. F., De Micheli, C., Mease, R., Hansen, K. B., Conti, P. & Pomper, M. G., Dec 22 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11110-11119 10 p.

Research output: Contribution to journalArticle

Development of radioligands for in vivo imaging of type 1 cannbinoid receptors (CB1) in human brain

Horti, A. G. & Van Laere, K., Nov 1 2008, In : Current pharmaceutical design. 14, 31, p. 3363-3383 21 p.

Research output: Contribution to journalReview article

Editorial

Horti, A. G. & Dannals, R. F., Oct 22 2010, In : Current topics in medicinal chemistry. 10, 15, 1 p.

Research output: Contribution to journalEditorial

Editorial

Horti, A. G. & Dannals, R. F., Dec 1 2010, In : Current topics in medicinal chemistry. 10, 16, 1 p.

Research output: Contribution to journalEditorial

Editorial

Horti, A. G. & Dannals, R. F., Oct 22 2010, In : Current topics in medicinal chemistry. 10, 16, 1 p.

Research output: Contribution to journalEditorial

Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian monkeys

Chefer, S. I., Kimes, A. S., Matochik, J. A., Horti, A. G., Kurian, V., Shumway, D., Domino, E. F., London, E. D. & Mukhin, A. G., Jan 1 2008, In : Neuropsychopharmacology. 33, 2, p. 270-278 9 p.

Research output: Contribution to journalArticle

Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)- pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors

Brown, L. V., Chefer, S., Pavlova, O., Vaupel, D. B., Koren, A. O., Kimes, A. S., Horti, A. G. & Mukhin, A. G., Nov 1 2004, In : Journal of Neurochemistry. 91, 3, p. 600-612 13 p.

Research output: Contribution to journalArticle

Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach

Valenta, I., Varga, Z. V., Valentine, H., Cinar, R., Horti, A., Mathews, W. B., Dannals, R. F., Steele, K., Kunos, G., Wahl, R. L., Pomper, M. G., Wong, D. F., Pacher, P. & Schindler, T. H., Feb 1 2018, In : JACC: Cardiovascular Imaging. 11, 2P2, p. 320-332 13 p.

Research output: Contribution to journalArticle

Fluorine-18-FPH for PET imaging of nicotinic acetylcholine receptors

Horti, A., Scheffel, U., Stathis, M., Finley, P., Ravert, H. T., London, E. D. & Dannais, R. F., Aug 20 1997, In : Journal of Nuclear Medicine. 38, 8, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain

Chefer, S. I., London, E. D., Koren, A. O., Pavlova, O. A., Kurian, V., Kimes, A. S., Horti, A. G. & Mukhin, A. G., Apr 1 2003, In : Synapse. 48, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: A PET study with 2-18F-FA-85380

Mukhin, A. G., Kimes, A. S., Chefer, S. I., Matochik, J. A., Contoreggi, C. S., Horti, A. G., Vaupel, D. B., Pavlova, O. & Stein, E. A., Oct 1 2008, In : Journal of Nuclear Medicine. 49, 10, p. 1628-1635 8 p.

Research output: Contribution to journalArticle

High-potency ligands for DREADD imaging and activation in rodents and monkeys

Bonaventura, J., Eldridge, M. A. G., Hu, F., Gomez, J. L., Sanchez-Soto, M., Abramyan, A. M., Lam, S., Boehm, M. A., Ruiz, C., Farrell, M. R., Moreno, A., Galal Faress, I. M., Andersen, N., Lin, J. Y., Moaddel, R., Morris, P. J., Shi, L., Sibley, D. R., Mahler, S. V., Nabavi, S. & 5 others, Pomper, M. G., Bonci, A., Horti, A. G., Richmond, B. J. & Michaelides, M., Dec 1 2019, In : Nature communications. 10, 1, 4627.

Research output: Contribution to journalArticle

Open Access

Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy

Wong, D. F., Kuwabara, H., Pomper, M., Holt, D. P., Brasic, J. R., George, N., Frolov, B., Willis, W., Gao, Y., Valentine, H., Nandi, A., Gapasin, L., Dannals, R. F. & Horti, A. G., Jan 1 2014, In : Molecular Imaging and Biology. 16, 5, p. 730-738 9 p.

Research output: Contribution to journalArticle

Imaging nicotinic acetylcholine receptors with fluorine-18-FPH, an epibatidine analog

Villemagne, V. L., Horti, A., Scheffel, U., Ravert, H. T., Finley, P., Clough, D. J., London, E. D., Wagner, H. N. & Dannals, R. F., Nov 1 1997, In : Journal of Nuclear Medicine. 38, 11, p. 1737-1741 5 p.

Research output: Contribution to journalArticle