Andrew Horti

Professor

1992 …2020

Research output per year

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Research Output

2020
2019

High-potency ligands for DREADD imaging and activation in rodents and monkeys

Bonaventura, J., Eldridge, M. A. G., Hu, F., Gomez, J. L., Sanchez-Soto, M., Abramyan, A. M., Lam, S., Boehm, M. A., Ruiz, C., Farrell, M. R., Moreno, A., Galal Faress, I. M., Andersen, N., Lin, J. Y., Moaddel, R., Morris, P. J., Shi, L., Sibley, D. R., Mahler, S. V., Nabavi, S. & 5 others, Pomper, M. G., Bonci, A., Horti, A. G., Richmond, B. J. & Michaelides, M., Dec 1 2019, In : Nature communications. 10, 1, 4627.

Research output: Contribution to journalArticle

Open Access

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

Horti, A., Naik, R., Foss, C., Minn, I., Misheneva, V., Du, Y., Wang, Y., Mathews, W. B., Wu, Y., Hall, A., LaCourse, C., Ahn, H. H., Nam, H., Lesniak, W., Valentine, H., Pletnikova, O., Troncoso, J. C., Smith, M. D., Calabresi, P., Savonenko, A. & 3 others, Dannals, R. F., Pletnikov, M. & Pomper, M. G., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

2018

18F-XTRA PET for enhanced imaging of the extrathalamic α4β2 nicotinic acetylcholine receptor

Coughlin, J. M., Slania, S., Du, Y., Rosenthal, H. B., Lesniak, W., Minn, I., Smith, G., Dannals, R. F., Kuwabara, H., Wong, D. F., Wang, Y., Horti, A. & Pomper, M. G., Oct 1 2018, In : Journal of Nuclear Medicine. 59, 10, p. 1603-1608 6 p.

Research output: Contribution to journalArticle

Brain PET imaging of α7-nAChR with [18F]ASEM: Reproducibility, occupancy, receptor density, and changes in schizophrenia

Wong, D. F., Kuwabara, H., Horti, A. G., Roberts, J. M., Nandi, A., Cascella, N., Brasic, J., Weerts, E. M., Kitzmiller, K., Phan, J. A., Gapasin, L., Sawa, A., Valentine, H., Wand, G., Mishra, C., George, N., McDonald, M., Lesniak, W., Holt, D. P., Azad, B. B. & 4 others, Dannals, R. F., Kem, W., Freedman, R. & Gjedde, A., Jan 1 2018, In : International Journal of Neuropsychopharmacology. 21, 7, p. 656-667 12 p.

Research output: Contribution to journalArticle

Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach

Valenta, I., Varga, Z. V., Valentine, H., Cinar, R., Horti, A., Mathews, W. B., Dannals, R. F., Steele, K., Kunos, G., Wahl, R. L., Pomper, M. G., Wong, D. F., Pacher, P. & Schindler, T. H., Feb 1 2018, In : JACC: Cardiovascular Imaging. 11, 2P2, p. 320-332 13 p.

Research output: Contribution to journalArticle

Synthesis and Evaluation of a New 18F-Labeled Radiotracer for Studying the GABAB Receptor in the Mouse Brain

Naik, R., Valentine, H., Dannals, R. F., Wong, D. F. & Horti, A., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1453-1461 9 p.

Research output: Contribution to journalArticle

The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [18F]ASEM

Coughlin, J. M., Du, Y., Rosenthal, H. B., Slania, S., Min Koo, S., Park, A., Solomon, G., Vranesic, M., Antonsdottir, I., Speck, C. L., Rootes-Murdy, K., Lerner, A., Rowe, S., Wang, Y., Lesniak, W., Minn, I., Bakker, A., Smith, G., Dannals, R. F., Kuwabara, H. & 3 others, Horti, A., Wong, D. F. & Pomper, M. G., Jan 15 2018, In : NeuroImage. 165, p. 118-124 7 p.

Research output: Contribution to journalArticle

2017

Development of a radioligand for imaging V1a vasopressin receptors with PET

Naik, R., Valentine, H., Hall, A., Mathews, W. B., Harris, J. C. O., Carter, C. S., Dannals, R. F., Wong, D. F. & Horti, A., Oct 20 2017, In : European Journal of Medicinal Chemistry. 139, p. 644-656 13 p.

Research output: Contribution to journalArticle

Synthesis and preliminary biological evaluation of indol-3-yl-oxoacetamides as potent cannabinoid receptor type 2 ligands

Moldovan, R. P., Deuther-Conrad, W., Horti, A. & Brust, P., Jan 1 2017, In : Molecules. 22, 1, 77.

Research output: Contribution to journalArticle

2016

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase

Horti, A., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N. J., Dannals, R. F. & Pomper, M. G., Nov 1 2016, In : Journal of Nuclear Medicine. 57, 11, p. 1817-1822 6 p.

Research output: Contribution to journalArticle

Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

Moldovan, R. P., Teodoro, R., Gao, Y., Deuther-Conrad, W., Kranz, M., Wang, Y., Kuwabara, H., Nakano, M., Valentine, H., Fischer, S., Pomper, M. G., Wong, D. F., Dannals, R. F., Brust, P. & Horti, A., Sep 8 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 7840-7855 16 p.

Research output: Contribution to journalArticle

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain

Tamborini, L., Chen, Y., Foss, C. A., Pinto, A., Horti, A. G., Traynelis, S. F., De Micheli, C., Mease, R. C., Hansen, K. B., Conti, P. & Pomper, M. G., Dec 22 2016, In : Journal of medicinal chemistry. 59, 24, p. 11110-11119 10 p.

Research output: Contribution to journalArticle

2015

[125I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR

Gao, Y., Mease, R. C., Olson, T. T., Kellar, K. J., Dannals, R. F., Pomper, M. G. & Horti, A. G., May 1 2015, In : Nuclear Medicine and Biology. 42, 5, p. 488-493 6 p.

Research output: Contribution to journalArticle

AT-1001 Is a partial agonist with high affinity and selectivity at human and rat α3β4 nicotinic cholinergic receptors

Tuan, E. W., Horti, A. G., Olson, T. T., Gao, Y., Stockmeier, C. A., Al-Muhtasib, N., Dalley, C. B., Lewin, A. E., Wolfe, B. B., Sahibzada, N., Xiao, Y. & Kellar, K. J., Oct 1 2015, In : Molecular Pharmacology. 88, 4, p. 640-649 10 p.

Research output: Contribution to journalArticle

Cannabinoid CB2 receptors in a mouse model of Aβ amyloidosis: Immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation

Savonenko, A. V., Melnikova, T., Wang, Y., Ravert, H., Gao, Y., Koppel, J., Lee, D., Pletnikova, O., Cho, E., Sayyida, N., Hiatt, A., Troncoso, J., Davies, P., Dannals, R. F., Pomper, M. G. & Horti, A. G., Jun 18 2015, In : PloS one. 10, 6, e0129618.

Research output: Contribution to journalArticle

2014

18F-ASEM, a radiolabeled antagonist for imaging the aα7-nicotinic acetylcholine receptor with PET

Horti, A. G., Gao, Y., Kuwabara, H., Wang, Y., Abazyan, S., Yasuda, R. P., Tran, T., Xiao, Y., Sahibzada, N., Holt, D. P., Kellar, K. J., Pletnikov, M. V., Pomper, M. G., Wong, D. F. & Dannals, R. F., Apr 1 2014, In : Journal of Nuclear Medicine. 55, 4, p. 672-677 6 p.

Research output: Contribution to journalArticle

Brain PET Imaging in the Cannabinoid System

Wong, D. F., Nandi, A., Zaidi, E., Gean, E., Horti, A., Frolov, B., George, N. & Brasic, J. R., Jan 1 2014, Imaging of the Human Brain in Health and Disease. Elsevier Inc., p. 27-36 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy

Wong, D. F., Kuwabara, H., Pomper, M., Holt, D. P., Brasic, J. R., George, N., Frolov, B., Willis, W., Gao, Y., Valentine, H., Nandi, A., Gapasin, L., Dannals, R. F. & Horti, A. G., Jan 1 2014, In : Molecular Imaging and Biology. 16, 5, p. 730-738 9 p.

Research output: Contribution to journalArticle

PET imaging of endocannabinoid system

Horti, A. G., Raymont, V. & Terry, G. E., Jan 1 2014, PET and SPECT of Neurobiological Systems. Springer Berlin Heidelberg, p. 249-319 71 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Reciprocal alterations in cortical cannabinoid receptor 1 binding relative to protein immunoreactivity and transcript levels in schizophrenia

Volk, D. W., Eggan, S. M., Horti, A. G., Wong, D. F. & Lewis, D. A., Oct 1 2014, In : Schizophrenia Research. 159, 1, p. 124-129 6 p.

Research output: Contribution to journalArticle

2013

Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors

Gao, Y., Kellar, K. J., Yasuda, R. P., Tran, T., Xiao, Y., Dannals, R. F. & Horti, A. G., Oct 10 2013, In : Journal of medicinal chemistry. 56, 19, p. 7574-7589 16 p.

Research output: Contribution to journalArticle

PET imaging of high-affinity a4b2 nicotinic acetylcholine receptors in humans with 18F-AZAN, a radioligand with optimal brain kinetics

Wong, D. F., Kuwabara, H., Kim, J., Brašić, J. R., Chamroonrat, W., Gao, Y., Valentine, H., Willis, W., Mathur, A., McCaul, M. E., Wand, G., Gean, E. G., Dannals, R. F. & Horti, A. G., Aug 1 2013, In : Journal of Nuclear Medicine. 54, 8, p. 1308-1314 7 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of new radioligands [11C]A-833834 and [11C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors

Horti, A. G., Ravert, H. T., Gao, Y., Holt, D. P., Bunnelle, W. H., Schrimpf, M. R., Li, T., Ji, J., Valentine, H., Scheffel, U., Kuwabara, H., Wong, D. F. & Dannals, R. F., Apr 1 2013, In : Nuclear Medicine and Biology. 40, 3, p. 395-402 8 p.

Research output: Contribution to journalArticle

2012

5-(5-(6-[11C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin- 2-yl)-1H-indole as a potential PET radioligand for imaging cerebral α7-nAChR in mice

Gao, Y., Ravert, H. T., Valentine, H., Scheffel, U., Finley, P., Wong, D. F., Dannals, R. F. & Horti, A. G., Jun 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 12, p. 3698-3702 5 p.

Research output: Contribution to journalArticle

Positron emission tomography experience with 2-[ 18F]fluoro-3-(2(s)-azetidinylmethoxy)pyridine (2-[ 18F]fa) in the living human brain of smokers with paranoid schizophrenia

Brašić, J. R., Cascella, N., Kumar, A., Zhou, Y., Hilton, J., Raymont, V., Crabb, A., Guevara, M. R., Horti, A. G. & Wong, D. F., Apr 1 2012, In : Synapse. 66, 4, p. 352-368 17 p.

Research output: Contribution to journalArticle

2011
2010

68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer

Banerjee, S. R., Pullambhatla, M., Byun, Y., Nimmagadda, S., Green, G., Fox, J. J., Horti, A., Mease, R. C. & Pomper, M. G., Jul 22 2010, In : Journal of medicinal chemistry. 53, 14, p. 5333-5341 9 p.

Research output: Contribution to journalArticle

Editorial

Horti, A. G. & Dannals, R. F., Oct 22 2010, In : Current topics in medicinal chemistry. 10, 15, 1 p.

Research output: Contribution to journalEditorial

Editorial

Horti, A. G. & Dannals, R. F., Dec 1 2010, In : Current topics in medicinal chemistry. 10, 16, 1 p.

Research output: Contribution to journalEditorial

Editorial

Horti, A. G. & Dannals, R. F., Oct 22 2010, In : Current topics in medicinal chemistry. 10, 16, 1 p.

Research output: Contribution to journalEditorial

Improved syntheses of precursors for PET radioligands [18F]XTRA and [18F]AZAN

Gao, Y., Wang, H., Mease, R. C., Pomper, M. G. & Horti, A. G., Oct 6 2010, In : Tetrahedron Letters. 51, 40, p. 5333-5335 3 p.

Research output: Contribution to journalArticle

Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR

Wong, D. F., Kuwabara, H., Horti, A. G., Raymont, V., Brasic, J., Guevara, M., Ye, W., Dannals, R. F., Ravert, H. T., Nandi, A., Rahmim, A., Ming, J. E., Grachev, I., Roy, C. & Cascella, N., Oct 1 2010, In : NeuroImage. 52, 4, p. 1505-1513 9 p.

Research output: Contribution to journalArticle

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

Horti, A. G., Gao, Y., Ravert, H. T., Finley, P., Valentine, H., Wong, D. F., Endres, C. J., Savonenko, A. V. & Dannals, R. F., Jul 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 5202-5207 6 p.

Research output: Contribution to journalArticle

2009

Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): Development of ligands with optimized lipophilicity and binding affinity

Fan, H., Kotsikorou, E., Hoffman, A. F., Ravert, H. T., Holt, D., Hurst, D. P., Lupica, C. R., Reggio, P. H., Dannals, R. F. & Horti, A. G., Feb 1 2009, In : European Journal of Medicinal Chemistry. 44, 2, p. 593-608 16 p.

Research output: Contribution to journalArticle

Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors

Horti, A. G. & Wong, D. F., Jan 1 2009, In : PET Clinics. 4, 1, p. 89-100 12 p.

Research output: Contribution to journalReview article

2008

Development of radioligands for in vivo imaging of type 1 cannbinoid receptors (CB1) in human brain

Horti, A. G. & Van Laere, K., Nov 1 2008, In : Current pharmaceutical design. 14, 31, p. 3363-3383 21 p.

Research output: Contribution to journalReview article