Andrew Ewald

Professor

19982020
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Research Output 1998 2020

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Article
2020

Twist1-induced epithelial dissemination requires PRKD1 signaling

Georgess, D., Padmanaban, V., Sirka, O. K., Coutinho, K., Choi, A., Frid, G., Neumann, N. M., Inoue, T. & Ewald, A. J., Jan 15 2020, In : Cancer Research. 80, 2, p. 204-218 15 p.

Research output: Contribution to journalArticle

Protein Kinases
Breast Neoplasms
Phosphorylation
Extracellular Matrix
Breast
2019

3D Analysis of Multi-cellular Responses to Chemoattractant Gradients

Kang, T. Y., Ellison, D., Lee, S. H., Ewald, A. & Levchenko, A., May 24 2019, In : Journal of visualized experiments : JoVE. 147

Research output: Contribution to journalArticle

Chemotactic Factors
Organoids
Cell culture
Epidermal Growth Factor
Tissue

Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy

Hickey, J. W., Dong, Y., Chung, J. W., Salathe, S. F., Pruitt, H. C., Li, X., Chang, C., Fraser, A. K., Bessell, C. A., Ewald, A., Gerecht, S., Mao, H. Q. & Schneck, J. P., Jan 1 2019, In : Advanced Materials. 1807359.

Research output: Contribution to journalArticle

T-cells
Tumors
Cell signaling
Hyaluronic acid
Hydrogel
Organoids
Genetic engineering
Genetic Engineering
Gene expression
Nanoparticles

Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

Li, L., Knutsdottir, H., Hui, K., Weiss, M. J., He, J., Philosophe, B., Cameron, A. M., Wolfgang, C. L., Pawlik, T. M., Ghiaur, G., Ewald, A. J., Mezey, E., Bader, J. S. & Selaru, F. M., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
Organoids
Liver Neoplasms
Pharmaceutical Preparations
Neoplasms
Drug Therapy

Microscale pressure measurements based on an immiscible fluid/fluid interface

Yang, J., Duan, X., Fraser, A. K., Choudhury, M. I., Ewald, A. J., Li, R. & Sun, S. X., Dec 1 2019, In : Scientific reports. 9, 1, 20044.

Research output: Contribution to journalArticle

Open Access
Pressure
Organoids
Hydrogel
Human Mammary Glands
Ion Channels
2018

Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread

Kim, D. H., Ewald, A., Park, J. S., Kshitiz, Kwak, M., Gray, R. S., Su, C. Y., Seo, J., An, S. & Levchenko, A., Dec 1 2018, In : Scientific Reports. 8, 1, 14210.

Research output: Contribution to journalArticle

Melanoma
Neoplasms
Traction
Cell Movement
Cues

Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation

Neumann, N. M., Perrone, M. C., Veldhuis, J. H., Huebner, R. J., Zhan, H., Devreotes, P. N., Brodland, G. W. & Ewald, A., Apr 9 2018, In : Developmental Cell. 45, 1, p. 67-82.e6

Research output: Contribution to journalArticle

Surface Tension
Receptor Protein-Tyrosine Kinases
Intercalation
Surface tension
Elongation

Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Ewald, A., Jan 1 2018, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Cells
Tissue
Neoplasm Metastasis
Seed
Neoplasms

Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids

Liu, X., Cheng, Y., Abraham, J. M., Wang, Z., Wang, Z., Ke, X., Yan, R., Shin, E., Ngamruengphong, S., Khashab, M., Zhang, G., McNamara, G., Ewald, A., Lin, D. C., Liu, Z. & Meltzer, S., Nov 1 2018, In : Cancer Letters. 436, p. 109-118 10 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Organoids
Barrett Esophagus
Neoplasms
Catenins

Myoepithelial cells are a dynamic barrier to epithelial dissemination

Sirka, O. K., Shamir, E. R. & Ewald, A., Oct 1 2018, In : The Journal of cell biology. 217, 10, p. 3368-3381 14 p.

Research output: Contribution to journalArticle

Smooth Muscle
Cadherins
Actins
Microscopy
Neoplasms
2017

A first-in-class twist1 inhibitor with activity in oncogene-driven lung cancer

Yochum, Z. A., Cades, J., Mazzacurati, L., Neumann, N. M., Khetarpal, S. K., Chatterjee, S., Wang, H., Attar, M. A., Huang, E. H. B., Chatley, S. N., Nugent, K., Somasundaram, A., Engh, J. A., Ewald, A., Cho, Y. J., Rudin, C. M., Tran, P. T. & Burns, T. F., Dec 1 2017, In : Molecular Cancer Research. 15, 12, p. 1764-1776 13 p.

Research output: Contribution to journalArticle

Harmine
Oncogenes
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Epithelial-Mesenchymal Transition

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

Xian, L., Georgess, D., Huso, T., Cope, L., Belton, A., Chang, Y. T., Kuang, W., Gu, Q., Zhang, X., Senger, S., Fasano, A., Huso, D. L., Ewald, A. & Smith Resar, L. M., Jan 1 2017, In : Nature Communications. 8, 15008.

Research output: Contribution to journalArticle

Paneth Cells
stem cells
compartments
Stem cells
Stem Cell Niche

Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation

Nguyen-Ngoc, K. V., Silvestri, V. L., Georgess, D., Fairchild, A. N. & Ewald, A., 2017, In : Journal of Cell Science. 130, 19, p. 3213-3221 9 p.

Research output: Contribution to journalArticle

Nonmuscle Myosin Type IIB
Nonmuscle Myosin Type IIA
Breast
Epithelium
Myosin Type II

MTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Asrani, K., Sood, A., Torres, A., Georgess, D., Phatak, P., Kaur, H., Dubin, A., Talbot, C. C., Elhelu, L., Ewald, A., Xiao, B., Worley, P. F. & Lotan, T., Nov 1 2017, In : Journal of Clinical Investigation. 127, 11, p. 4001-4017 17 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Epidermis
Cell Adhesion
mechanistic target of rapamycin complex 1
Keratinocytes

TRPV1 is a physiological regulator of μ-opioid receptors

Scherer, P. C., Zaccor, N. W., Neumann, N. M., Vasavda, C., Barrow, R. K., Ewald, A., Rao, F., Sumner, C. & Snyder, S. H., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13561-13566 6 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Opioid Receptors
Opioid Analgesics
GTP-Binding Proteins
Phosphorylation
2016

A collective route to metastasis: Seeding by tumor cell clusters

Cheung, K. J. & Ewald, A., Apr 8 2016, In : Science. 352, 6282, p. 167-169 3 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Neoplasms
Theoretical Models

Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis

Ellison, D., Mugler, A., Brennan, M. D., Lee, S. H., Huebner, R. J., Shamir, E. R., Woo, L. A., Kim, J., Amar, P., Nemenman, I., Ewald, A. & Levchenko, A., Feb 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. E679-E688

Research output: Contribution to journalArticle

Morphogenesis
Cell Communication
Cues
Aptitude
Gap Junctions

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

Lindberg, O. R., McKinney, A., Engler, J. R., Koshkakaryan, G., Gong, H., Robinson, A. E., Ewald, A., Huillard, E., James, C. D., Molinaro, A. M., Shieh, J. T. & Phillips, J. J., 2016, In : Oncotarget. 7, 48, p. 79101-79116 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Neoplasms
Cell-Matrix Junctions
Stem Cells

HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24

Teo, W. W., Merino, V., Cho, S., Korangath, P., Liang, X., Wu, R. C., Neumann, N. M., Ewald, A. & Sukumar, S., May 9 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Cadherins
Breast Neoplasms
Neoplasms
Tretinoin
Breast

Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration

Huebner, R. J., Neumann, N. M. & Ewald, A., Mar 15 2016, In : Development. 143, 6, p. 983-993 11 p.

Research output: Contribution to journalArticle

Cell Movement
Breast
Receptor Protein-Tyrosine Kinases
Mitogen-Activated Protein Kinase Kinases
Organoids

Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration

Huebner, R. J., Neumann, N. M. & Ewald, A., Apr 1 2016, In : Journal of Cell Science. 129, 7, p. 983-993 11 p.

Research output: Contribution to journalArticle

Cell Movement
Breast
Receptor Protein-Tyrosine Kinases
Mitogen-Activated Protein Kinase Kinases
Organoids

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

Cheung, K. J., Padmanaban, V., Silvestri, V., Schipper, K., Cohen, J. D., Fairchild, A. N., Gorin, M., Verdone, J. E., Pienta, K., Bader, J. S. & Ewald, A., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E854-E863

Research output: Contribution to journalArticle

Keratin-14
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Circulating Neoplastic Cells

Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination

Shamir, E. R., Coutinho, K., Georgess, D., Auer, M. & Ewald, A., Sep 15 2016, In : Biology Open. 5, 9, p. 1216-1228 13 p.

Research output: Contribution to journalArticle

Proteolysis
adhesives
Adhesives
epithelial cells
Epithelial Cells
2015

3D culture assays of murine mammary branching morphogenesis and epithelial invasion

Nguyen-Ngoc, K. V., Shamir, E. R., Huebner, R. J., Beck, J. N., Cheung, K. J. & Ewald, A., 2015, In : Methods in molecular biology (Clifton, N.J.). 1189, p. 135-162 28 p.

Research output: Contribution to journalArticle

Morphogenesis
Organoids
Breast
Human Mammary Glands
Fluorescent Antibody Technique

Adhesion in mammary development: Novel roles for E-cadherin in individual and collective cell migration

Shamir, E. R. & Ewald, A., 2015, In : Current Topics in Developmental Biology. 112, p. 353-382 30 p.

Research output: Contribution to journalArticle

Cadherins
Cell Movement
Breast
Cell Adhesion
Gene Knockdown Techniques

An Arresting Story about Basement Membrane Invasion

Ewald, A., Oct 26 2015, In : Developmental Cell. 35, 2, p. 143-144 2 p.

Research output: Contribution to journalArticle

Anchors
Basement Membrane
Demonstrations
Genes
Neoplasm Metastasis

p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway

Kim, M., Shewan, A. M., Ewald, A., Werb, Z. & Mostov, K. E., 2015, In : Journal of Cell Science. 128, 23, p. 4317-4327 11 p.

Research output: Contribution to journalArticle

Myosin Type II
Cell Movement
Hepatocyte Growth Factor
Cysts
Nonmuscle Myosin Type IIA
2014

A molecular switch for the orientation of epithelial cell polarization

Bryant, D. M., Roignot, J., Datta, A., Overeem, A. W., Kim, M., Yu, W., Peng, X., Eastburn, D. J., Ewald, A., Werb, Z. & Mostov, K. E., Oct 27 2014, In : Developmental Cell. 31, 2, p. 171-187 17 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Epithelial Cells
Switches
Polarization
Tissue

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A., Zahnow, C. & Pan, D., Mar 1 2014, In : Genes & development. 28, 5, p. 432-437 6 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Carcinogenesis
Growth
Molecular Targeted Therapy
Breast Neoplasms

Cancer: Sugar-coated cell signalling

Ewald, A. & Egeblad, M., 2014, In : Nature. 511, 7509, p. 298-299 2 p.

Research output: Contribution to journalArticle

cell organelle
Glycocalyx
genetic analysis
Genomics
Integrins

Cellular foundations of mammary tubulogenesis

Huebner, R. J. & Ewald, A., 2014, In : Seminars in Cell and Developmental Biology. 31, p. 124-131 8 p.

Research output: Contribution to journalArticle

Morphogenesis
Breast
Epithelium
Intercellular Junctions
Growth Factor Receptors

Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells

Huebner, R. J., Lechler, T. & Ewald, A., Mar 1 2014, In : Development. 141, 5, p. 1085-1094 10 p.

Research output: Contribution to journalArticle

Breast
Epithelium
Organoids
Cell Division
Tight Junctions

Illuminating breast cancer invasion: Diverse roles for cell-cell interactions

Cheung, K. J. & Ewald, A., 2014, In : Current Opinion in Cell Biology. 30, 1, p. 99-111 13 p.

Research output: Contribution to journalArticle

Cell Communication
Breast Neoplasms
Neoplasms
Paracrine Communication
Organoids

Invasive leader cells: Metastatic oncotarget

Cheung, K. J. & Ewald, A., 2014, In : Oncotarget. 5, 6, p. 1390-1391 2 p.

Research output: Contribution to journalArticle

Neoplasm Invasiveness
Tumor Microenvironment
Antineoplastic Agents
Extracellular Matrix
Neoplasm Metastasis

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

Chapiro, J., Sur, S., Savic, L. J., Ganapathy, S., Reyes, J., Duran, R., Thiruganasambandam, S. C., Moats, C. R., Lin, M., Luo, W., Tran, P. T., Herman, J. M., Semenza, G. L., Ewald, A., Vogelstein, B. & Geschwind, J. F., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6406-6417 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
gemcitabine
Therapeutics
Adenocarcinoma
Heterografts

Three-dimensional organotypic culture: Experimental models of mammalian biology and disease

Shamir, E. R. & Ewald, A., Jan 1 2014, In : Nature Reviews Molecular Cell Biology. 15, 10, p. 647-664 18 p.

Research output: Contribution to journalArticle

Theoretical Models
Culture Techniques
Aptitude
Time and Motion Studies
Morphogenesis

Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

Shamir, E. R., Pappalardo, E., Jorgens, D. M., Coutinho, K., Tsai, W. T., Aziz, K., Auer, M., Tran, P. T., Bader, J. S. & Ewald, A., 2014, In : Journal of Cell Biology. 204, 5, p. 839-856 18 p.

Research output: Contribution to journalArticle

Cadherins
Epithelial-Mesenchymal Transition
Epithelial Cells
Cell Adhesion
Cell-Matrix Junctions
2013

Collective invasion in breast cancer requires a conserved basal epithelial program

Cheung, K. J., Gabrielson, E., Werb, Z. & Ewald, A., Dec 19 2013, In : Cell. 155, 7, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

Cells
Breast Neoplasms
Genes
Tumors
Keratin-14

Isolation of mouse mammary organoids for long-term time-lapse imaging

Ewald, A., Feb 2013, In : Cold Spring Harbor Protocols. 8, 2, p. 130-133 4 p.

Research output: Contribution to journalArticle

Time-Lapse Imaging
Organoids
Breast
Epithelium
Tissue

Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix

Nguyen-Ngoc, K. V. & Ewald, A., Sep 2013, In : Journal of Microscopy. 251, 3, p. 212-223 12 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Breast
Collagen
Organoids
Morphogenesis
Time-Lapse Imaging
Morphogenesis
Epithelium
Imaging techniques
Optical Imaging

The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination

Beck, J. N., Singh, A., Rothenberg, A. R., Elisseeff, J. H. & Ewald, A., Dec 2013, In : Biomaterials. 34, 37, p. 9486-9495 10 p.

Research output: Contribution to journalArticle

Hydrogels
Adhesives
Polyethylene glycols
Adhesion
Collagen
2012

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

Nguyen-Ngoc, K. V., Cheung, K. J., Brenot, A., Shamir, E. R., Gray, R. S., Hines, W. C., Yaswen, P., Werb, Z. & Ewald, A., Sep 25 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 39

Research output: Contribution to journalArticle

Extracellular Matrix
Breast
Collagen
Epithelium
Basement Membrane

Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

Nakasone, E. S., Askautrud, H. A., Kees, T., Park, J. H., Plaks, V., Ewald, A., Fein, M., Rasch, M. G., Tan, Y. X., Qiu, J., Park, J., Sinha, P., Bissell, M. J., Frengen, E., Werb, Z. & Egeblad, M., Apr 17 2012, In : Cancer Cell. 21, 4, p. 488-503 16 p.

Research output: Contribution to journalArticle

Drug Therapy
Doxorubicin
Blood Vessels
Cell Death
Pharmaceutical Preparations

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium

Ewald, A., Huebner, R. J., Palsdottir, H., Lee, J. K., Perez, M. J., Jorgens, D. M., Tauscher, A. N., Cheung, K. J., Werb, Z. & Auer, M., Jun 1 2012, In : Journal of Cell Science. 125, 11, p. 2638-2654 17 p.

Research output: Contribution to journalArticle

Cell Movement
Breast
Morphogenesis
Epithelium
Intercellular Junctions
2011
Confocal microscopy
Confocal Microscopy
Tumors
Breast Neoplasms
Imaging techniques

Monitoring of vital signs for long-term survival of mice under anesthesia

Ewald, A., Werb, Z. & Egeblad, M., Feb 2011, In : Cold Spring Harbor Protocols. 6, 2

Research output: Contribution to journalArticle

Vital Signs
Anesthesia

Preparation of mice for long-term intravital imaging of the mammary gland

Ewald, A., Werb, Z. & Egeblad, M., Feb 2011, In : Cold Spring Harbor Protocols. 6, 2

Research output: Contribution to journalArticle

Human Mammary Glands
Intravital Microscopy
2010

Cellular mechanisms regulating epithelial morphogenesis and cancer invasion

Gray, R. S., Cheung, K. J. & Ewald, A., Oct 2010, In : Current Opinion in Cell Biology. 22, 5, p. 640-650 11 p.

Research output: Contribution to journalArticle

Morphogenesis
Neoplasms
Human Mammary Glands
Epithelium
Observation