Andrew Ewald

Professor

19982020

Research output per year

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Research Output

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Article
2020

Between-tumor and within-tumor heterogeneity in invasive potential

Padmanaban, V., Tsehay, Y., Cheung, K. J., Ewald, A. J. & Bader, J. S., Jan 1 2020, In : PLoS computational biology. 16, 1, e1007464.

Research output: Contribution to journalArticle

Open Access

OrgDyn: feature- and model-based characterization of spatial and temporal organoid dynamics

Hasnain, Z., Fraser, A. K., Georgess, D., Choi, A., Macklin, P., Bader, J. S., Peyton, S. R., Ewald, A. J. & Newton, P. K., May 1 2020, In : Bioinformatics (Oxford, England). 36, 10, p. 3292-3294 3 p.

Research output: Contribution to journalArticle

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Jiao, Z., Cai, H., Long, Y., Sirka, O. K., Padmanaban, V., Ewald, A. J. & Devreotes, P. N., Feb 25 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4158-4168 11 p.

Research output: Contribution to journalArticle

Twist1-induced epithelial dissemination requires PRKD1 signaling

Georgess, D., Padmanaban, V., Sirka, O. K., Coutinho, K., Choi, A., Frid, G., Neumann, N. M., Inoue, T. & Ewald, A. J., Jan 15 2020, In : Cancer Research. 80, 2, p. 204-218 15 p.

Research output: Contribution to journalArticle

2019

3D Analysis of Multi-cellular Responses to Chemoattractant Gradients

Kang, T. Y., Ellison, D., Lee, S. H., Ewald, A. J. & Levchenko, A., May 24 2019, In : Journal of visualized experiments : JoVE. 147

Research output: Contribution to journalArticle

Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy

Hickey, J. W., Dong, Y., Chung, J. W., Salathe, S. F., Pruitt, H. C., Li, X., Chang, C., Fraser, A. K., Bessell, C. A., Ewald, A., Gerecht, S., Mao, H. Q. & Schneck, J. P., Jan 1 2019, In : Advanced Materials. 1807359.

Research output: Contribution to journalArticle

Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

Li, L., Knutsdottir, H., Hui, K., Weiss, M. J., He, J., Philosophe, B., Cameron, A. M., Wolfgang, C. L., Pawlik, T. M., Ghiaur, G., Ewald, A. J., Mezey, E., Bader, J. S. & Selaru, F. M., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access

Microscale pressure measurements based on an immiscible fluid/fluid interface

Yang, J., Duan, X., Fraser, A. K., Choudhury, M. I., Ewald, A. J., Li, R. & Sun, S. X., Dec 1 2019, In : Scientific reports. 9, 1, 20044.

Research output: Contribution to journalArticle

Open Access
2018

Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread

Kim, D. H., Ewald, A., Park, J. S., Kshitiz, Kwak, M., Gray, R. S., Su, C. Y., Seo, J., An, S. & Levchenko, A., Dec 1 2018, In : Scientific Reports. 8, 1, 14210.

Research output: Contribution to journalArticle

Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation

Neumann, N. M., Perrone, M. C., Veldhuis, J. H., Huebner, R. J., Zhan, H., Devreotes, P. N., Brodland, G. W. & Ewald, A., Apr 9 2018, In : Developmental Cell. 45, 1, p. 67-82.e6

Research output: Contribution to journalArticle

Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Ewald, A., Jan 1 2018, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids

Liu, X., Cheng, Y., Abraham, J. M., Wang, Z., Wang, Z., Ke, X., Yan, R., Shin, E., Ngamruengphong, S., Khashab, M., Zhang, G., McNamara, G., Ewald, A., Lin, D. C., Liu, Z. & Meltzer, S., Nov 1 2018, In : Cancer Letters. 436, p. 109-118 10 p.

Research output: Contribution to journalArticle

Myoepithelial cells are a dynamic barrier to epithelial dissemination

Sirka, O. K., Shamir, E. R. & Ewald, A. J., Oct 1 2018, In : Journal of Cell Biology. 217, 10, p. 3368-3381 14 p.

Research output: Contribution to journalArticle

Open Access
2017

A first-in-class twist1 inhibitor with activity in oncogene-driven lung cancer

Yochum, Z. A., Cades, J., Mazzacurati, L., Neumann, N. M., Khetarpal, S. K., Chatterjee, S., Wang, H., Attar, M. A., Huang, E. H. B., Chatley, S. N., Nugent, K., Somasundaram, A., Engh, J. A., Ewald, A. J., Cho, Y. J., Rudin, C. M., Tran, P. T. & Burns, T. F., Dec 2017, In : Molecular Cancer Research. 15, 12, p. 1764-1776 13 p.

Research output: Contribution to journalArticle

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

Xian, L., Georgess, D., Huso, T., Cope, L., Belton, A., Chang, Y. T., Kuang, W., Gu, Q., Zhang, X., Senger, S., Fasano, A., Huso, D. L., Ewald, A. & Smith Resar, L. M., Jan 1 2017, In : Nature Communications. 8, 15008.

Research output: Contribution to journalArticle

Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation

Nguyen-Ngoc, K. V., Silvestri, V. L., Georgess, D., Fairchild, A. N. & Ewald, A. J., Jan 1 2017, In : Journal of cell science. 130, 19, p. 3213-3221 9 p.

Research output: Contribution to journalArticle

MTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Asrani, K., Sood, A., Torres, A., Georgess, D., Phatak, P., Kaur, H., Dubin, A., Talbot, C. C., Elhelu, L., Ewald, A., Xiao, B., Worley, P. F. & Lotan, T., Nov 1 2017, In : Journal of Clinical Investigation. 127, 11, p. 4001-4017 17 p.

Research output: Contribution to journalArticle

TRPV1 is a physiological regulator of μ-opioid receptors

Scherer, P. C., Zaccor, N. W., Neumann, N. M., Vasavda, C., Barrow, R. K., Ewald, A., Rao, F., Sumner, C. & Snyder, S. H., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13561-13566 6 p.

Research output: Contribution to journalArticle

2016

A collective route to metastasis: Seeding by tumor cell clusters

Cheung, K. J. & Ewald, A., Apr 8 2016, In : Science. 352, 6282, p. 167-169 3 p.

Research output: Contribution to journalArticle

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

Lindberg, O. R., McKinney, A., Engler, J. R., Koshkakaryan, G., Gong, H., Robinson, A. E., Ewald, A. J., Huillard, E., James, C. D., Molinaro, A. M., Shieh, J. T. & Phillips, J. J., Jan 1 2016, In : Oncotarget. 7, 48, p. 79101-79116 16 p.

Research output: Contribution to journalArticle

HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24

Teo, W. W., Merino, V. F., Cho, S., Korangath, P., Liang, X., Wu, R. C., Neumann, N. M., Ewald, A. J. & Sukumar, S., Oct 20 2016, In : Oncogene. 35, 42, p. 5539-5551 13 p.

Research output: Contribution to journalArticle

Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration

Huebner, R. J., Neumann, N. M. & Ewald, A. J., Apr 1 2016, In : Journal of cell science. 129, 7, p. 983-993 11 p.

Research output: Contribution to journalArticle

Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration

Huebner, R. J., Neumann, N. M. & Ewald, A. J., Mar 15 2016, In : Development (Cambridge). 143, 6, p. 983-993 11 p.

Research output: Contribution to journalArticle

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

Cheung, K. J., Padmanaban, V., Silvestri, V., Schipper, K., Cohen, J. D., Fairchild, A. N., Gorin, M. A., Verdone, J. E., Pienta, K. J., Bader, J. S. & Ewald, A. J., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E854-E863

Research output: Contribution to journalArticle

Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination

Shamir, E. R., Coutinho, K., Georgess, D., Auer, M. & Ewald, A. J., Sep 15 2016, In : Biology Open. 5, 9, p. 1216-1228 13 p.

Research output: Contribution to journalArticle

2015

p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway

Kim, M., Shewan, A. M., Ewald, A. J., Werb, Z. & Mostov, K. E., Jan 1 2015, In : Journal of cell science. 128, 23, p. 4317-4327 11 p.

Research output: Contribution to journalArticle

2014

A molecular switch for the orientation of epithelial cell polarization

Bryant, D. M., Roignot, J., Datta, A., Overeem, A. W., Kim, M., Yu, W., Peng, X., Eastburn, D. J., Ewald, A. J., Werb, Z. & Mostov, K. E., Oct 27 2014, In : Developmental Cell. 31, 2, p. 171-187 17 p.

Research output: Contribution to journalArticle

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A. & Pan, D., Mar 1 2014, In : Genes and Development. 28, 5, p. 432-437 6 p.

Research output: Contribution to journalArticle

Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells

Huebner, R. J., Lechler, T. & Ewald, A. J., Mar 1 2014, In : Development (Cambridge). 141, 5, p. 1085-1094 10 p.

Research output: Contribution to journalArticle

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

Chapiro, J., Sur, S., Savic, L. J., Ganapathy-Kanniappan, S., Reyes, J., Duran, R., Thiruganasambandam, S. C., Moats, C. R., Lin, M. D., Luo, W., Tran, P. T., Herman, J. M., Semenza, G. L., Ewald, A. J., Vogelstein, B. & Geschwind, J. F., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6406-6417 12 p.

Research output: Contribution to journalArticle

Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

Shamir, E. R., Pappalardo, E., Jorgens, D. M., Coutinho, K., Tsai, W. T., Aziz, K., Auer, M., Tran, P. T., Bader, J. S. & Ewald, A. J., Mar 2014, In : Journal of Cell Biology. 204, 5, p. 839-856 18 p.

Research output: Contribution to journalArticle

2013

Collective invasion in breast cancer requires a conserved basal epithelial program

Cheung, K. J., Gabrielson, E., Werb, Z. & Ewald, A. J., Dec 19 2013, In : Cell. 155, 7, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

Isolation of mouse mammary organoids for long-term time-lapse imaging

Ewald, A. J., Feb 1 2013, In : Cold Spring Harbor Protocols. 8, 2, p. 130-133 4 p.

Research output: Contribution to journalArticle

Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix

Nguyen-Ngoc, K. V. & Ewald, A. J., Sep 1 2013, In : Journal of Microscopy. 251, 3, p. 212-223 12 p.

Research output: Contribution to journalArticle

The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination

Beck, J. N., Singh, A., Rothenberg, A. R., Elisseeff, J. H. & Ewald, A. J., Dec 1 2013, In : Biomaterials. 34, 37, p. 9486-9495 10 p.

Research output: Contribution to journalArticle

2012

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

Nguyen-Ngoc, K. V., Cheung, K. J., Brenot, A., Shamir, E. R., Gray, R. S., Hines, W. C., Yaswen, P., Werb, Z. & Ewald, A. J., Sep 25 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 39, p. E2595-E2604

Research output: Contribution to journalArticle

Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

Nakasone, E. S., Askautrud, H. A., Kees, T., Park, J. H., Plaks, V., Ewald, A. J., Fein, M., Rasch, M. G., Tan, Y. X., Qiu, J., Park, J., Sinha, P., Bissell, M. J., Frengen, E., Werb, Z. & Egeblad, M., Apr 17 2012, In : Cancer cell. 21, 4, p. 488-503 16 p.

Research output: Contribution to journalArticle

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium

Ewald, A. J., Huebner, R. J., Palsdottir, H., Lee, J. K., Perez, M. J., Jorgens, D. M., Tauscher, A. N., Cheung, K. J., Werb, Z. & Auer, M., Jun 1 2012, In : Journal of cell science. 125, 11, p. 2638-2654 17 p.

Research output: Contribution to journalArticle

Monitoring of vital signs for long-term survival of mice under anesthesia

Ewald, A. J., Werb, Z. & Egeblad, M., Feb 1 2011, In : Cold Spring Harbor Protocols. 6, 2

Research output: Contribution to journalArticle

Preparation of mice for long-term intravital imaging of the mammary gland

Ewald, A. J., Werb, Z. & Egeblad, M., Feb 1 2011, In : Cold Spring Harbor Protocols. 6, 2

Research output: Contribution to journalArticle

2010

The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures

Bhise, N. S., Gray, R. S., Sunshine, J. C., Htet, S., Ewald, A. J. & Green, J. J., Nov 1 2010, In : Biomaterials. 31, 31, p. 8088-8096 9 p.

Research output: Contribution to journalArticle

2008

Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis

Martín-Belmonte, F., Yu, W., Rodríguez-Fraticelli, A. E., Ewald, A., Werb, Z., Alonso, M. A. & Mostov, K., Apr 8 2008, In : Current Biology. 18, 7, p. 507-513 7 p.

Research output: Contribution to journalArticle

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

Ewald, A. J., Brenot, A., Duong, M., Chan, B. S. & Werb, Z., Apr 15 2008, In : Developmental Cell. 14, 4, p. 570-581 12 p.

Research output: Contribution to journalArticle

GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model

Kouros-Mehr, H., Bechis, S. K., Slorach, E. M., Littlepage, L. E., Egeblad, M., Ewald, A. J., Pai, S. Y., Ho, I. C. & Werb, Z., Feb 5 2008, In : Cancer cell. 13, 2, p. 141-152 12 p.

Research output: Contribution to journalArticle

Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis

Lu, P., Ewald, A. J., Martin, G. R. & Werb, Z., Sep 1 2008, In : Developmental biology. 321, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy

Egeblad, M., Ewald, A. J., Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F. & Werb, Z., Jan 1 2008, In : DMM Disease Models and Mechanisms. 1, 2-3, p. 155-167 13 p.

Research output: Contribution to journalArticle

2007

Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis

Yu, W., Fang, X., Ewald, A., Wong, K., Hunt, C. A., Werb, Z., Matthay, M. A. & Mostov, K., May 1 2007, In : Molecular biology of the cell. 18, 5, p. 1693-1700 8 p.

Research output: Contribution to journalArticle