Andrew Ewald

Professor

19982020

Research output per year

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Research Output

2020

Between-tumor and within-tumor heterogeneity in invasive potential

Padmanaban, V., Tsehay, Y., Cheung, K. J., Ewald, A. J. & Bader, J. S., Jan 1 2020, In : PLoS computational biology. 16, 1, e1007464.

Research output: Contribution to journalArticle

Open Access

OrgDyn: feature- and model-based characterization of spatial and temporal organoid dynamics

Hasnain, Z., Fraser, A. K., Georgess, D., Choi, A., Macklin, P., Bader, J. S., Peyton, S. R., Ewald, A. J. & Newton, P. K., May 1 2020, In : Bioinformatics (Oxford, England). 36, 10, p. 3292-3294 3 p.

Research output: Contribution to journalArticle

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Jiao, Z., Cai, H., Long, Y., Sirka, O. K., Padmanaban, V., Ewald, A. J. & Devreotes, P. N., Feb 25 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4158-4168 11 p.

Research output: Contribution to journalArticle

Twist1-induced epithelial dissemination requires PRKD1 signaling

Georgess, D., Padmanaban, V., Sirka, O. K., Coutinho, K., Choi, A., Frid, G., Neumann, N. M., Inoue, T. & Ewald, A. J., Jan 15 2020, In : Cancer Research. 80, 2, p. 204-218 15 p.

Research output: Contribution to journalArticle

2019

3D Analysis of Multi-cellular Responses to Chemoattractant Gradients

Kang, T. Y., Ellison, D., Lee, S. H., Ewald, A. J. & Levchenko, A., May 24 2019, In : Journal of visualized experiments : JoVE. 147

Research output: Contribution to journalArticle

E-cadherin is required for metastasis in multiple models of breast cancer

Padmanaban, V., Krol, I., Suhail, Y., Szczerba, B. M., Aceto, N., Bader, J. S. & Ewald, A., Jan 1 2019, (Accepted/In press) In : Nature.

Research output: Contribution to journalLetter

Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy

Hickey, J. W., Dong, Y., Chung, J. W., Salathe, S. F., Pruitt, H. C., Li, X., Chang, C., Fraser, A. K., Bessell, C. A., Ewald, A., Gerecht, S., Mao, H. Q. & Schneck, J. P., Jan 1 2019, In : Advanced Materials. 1807359.

Research output: Contribution to journalArticle

Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

Li, L., Knutsdottir, H., Hui, K., Weiss, M. J., He, J., Philosophe, B., Cameron, A. M., Wolfgang, C. L., Pawlik, T. M., Ghiaur, G., Ewald, A. J., Mezey, E., Bader, J. S. & Selaru, F. M., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access

Microscale pressure measurements based on an immiscible fluid/fluid interface

Yang, J., Duan, X., Fraser, A. K., Choudhury, M. I., Ewald, A. J., Li, R. & Sun, S. X., Dec 1 2019, In : Scientific reports. 9, 1, 20044.

Research output: Contribution to journalArticle

Open Access
2018

Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread

Kim, D. H., Ewald, A., Park, J. S., Kshitiz, Kwak, M., Gray, R. S., Su, C. Y., Seo, J., An, S. & Levchenko, A., Dec 1 2018, In : Scientific Reports. 8, 1, 14210.

Research output: Contribution to journalArticle

Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation

Neumann, N. M., Perrone, M. C., Veldhuis, J. H., Huebner, R. J., Zhan, H., Devreotes, P. N., Brodland, G. W. & Ewald, A., Apr 9 2018, In : Developmental Cell. 45, 1, p. 67-82.e6

Research output: Contribution to journalArticle

Editorial Overview: Integration of dynamic processes in cell behaviour and tissue architecture

Braga, V. MM. & Ewald, A., Oct 1 2018, In : Current Opinion in Cell Biology. 54, p. iii-v

Research output: Contribution to journalEditorial

Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Ewald, A., Jan 1 2018, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids

Liu, X., Cheng, Y., Abraham, J. M., Wang, Z., Wang, Z., Ke, X., Yan, R., Shin, E., Ngamruengphong, S., Khashab, M., Zhang, G., McNamara, G., Ewald, A., Lin, D. C., Liu, Z. & Meltzer, S., Nov 1 2018, In : Cancer Letters. 436, p. 109-118 10 p.

Research output: Contribution to journalArticle

Myoepithelial cells are a dynamic barrier to epithelial dissemination

Sirka, O. K., Shamir, E. R. & Ewald, A. J., Oct 1 2018, In : Journal of Cell Biology. 217, 10, p. 3368-3381 14 p.

Research output: Contribution to journalArticle

Open Access
2017

3D cell biology - The expanding frontier

Ewald, A. J., 2017, In : Journal of Cell Science. 130, 1, p. 1 1 p.

Research output: Contribution to journalEditorial

A first-in-class twist1 inhibitor with activity in oncogene-driven lung cancer

Yochum, Z. A., Cades, J., Mazzacurati, L., Neumann, N. M., Khetarpal, S. K., Chatterjee, S., Wang, H., Attar, M. A., Huang, E. H. B., Chatley, S. N., Nugent, K., Somasundaram, A., Engh, J. A., Ewald, A. J., Cho, Y. J., Rudin, C. M., Tran, P. T. & Burns, T. F., Dec 2017, In : Molecular Cancer Research. 15, 12, p. 1764-1776 13 p.

Research output: Contribution to journalArticle

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

Xian, L., Georgess, D., Huso, T., Cope, L., Belton, A., Chang, Y. T., Kuang, W., Gu, Q., Zhang, X., Senger, S., Fasano, A., Huso, D. L., Ewald, A. & Smith Resar, L. M., Jan 1 2017, In : Nature Communications. 8, 15008.

Research output: Contribution to journalArticle

Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation

Nguyen-Ngoc, K. V., Silvestri, V. L., Georgess, D., Fairchild, A. N. & Ewald, A. J., Jan 1 2017, In : Journal of cell science. 130, 19, p. 3213-3221 9 p.

Research output: Contribution to journalArticle

MTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Asrani, K., Sood, A., Torres, A., Georgess, D., Phatak, P., Kaur, H., Dubin, A., Talbot, C. C., Elhelu, L., Ewald, A., Xiao, B., Worley, P. F. & Lotan, T., Nov 1 2017, In : Journal of Clinical Investigation. 127, 11, p. 4001-4017 17 p.

Research output: Contribution to journalArticle

Pulling cells out of tumours

Ewald, A., Mar 1 2017, In : Nature Cell Biology. 19, 3, p. 147-149 3 p.

Research output: Contribution to journalShort survey

TRPV1 is a physiological regulator of μ-opioid receptors

Scherer, P. C., Zaccor, N. W., Neumann, N. M., Vasavda, C., Barrow, R. K., Ewald, A., Rao, F., Sumner, C. & Snyder, S. H., Dec 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 51, p. 13561-13566 6 p.

Research output: Contribution to journalArticle

2016

A collective route to metastasis: Seeding by tumor cell clusters

Cheung, K. J. & Ewald, A., Apr 8 2016, In : Science. 352, 6282, p. 167-169 3 p.

Research output: Contribution to journalArticle

Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis

Ellison, D., Mugler, A., Brennan, M. D., Lee, S. H., Huebner, R. J., Shamir, E. R., Woo, L. A., Kim, J., Amar, P., Nemenman, I., Ewald, A. J. & Levchenko, A., Feb 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. E679-E688

Research output: Contribution to journalReview article

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

Lindberg, O. R., McKinney, A., Engler, J. R., Koshkakaryan, G., Gong, H., Robinson, A. E., Ewald, A. J., Huillard, E., James, C. D., Molinaro, A. M., Shieh, J. T. & Phillips, J. J., Jan 1 2016, In : Oncotarget. 7, 48, p. 79101-79116 16 p.

Research output: Contribution to journalArticle

HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24

Teo, W. W., Merino, V. F., Cho, S., Korangath, P., Liang, X., Wu, R. C., Neumann, N. M., Ewald, A. J. & Sukumar, S., Oct 20 2016, In : Oncogene. 35, 42, p. 5539-5551 13 p.

Research output: Contribution to journalArticle

Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration

Huebner, R. J., Neumann, N. M. & Ewald, A. J., Apr 1 2016, In : Journal of cell science. 129, 7, p. 983-993 11 p.

Research output: Contribution to journalArticle

Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration

Huebner, R. J., Neumann, N. M. & Ewald, A. J., Mar 15 2016, In : Development (Cambridge). 143, 6, p. 983-993 11 p.

Research output: Contribution to journalArticle

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

Cheung, K. J., Padmanaban, V., Silvestri, V., Schipper, K., Cohen, J. D., Fairchild, A. N., Gorin, M. A., Verdone, J. E., Pienta, K. J., Bader, J. S. & Ewald, A. J., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E854-E863

Research output: Contribution to journalArticle

Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination

Shamir, E. R., Coutinho, K., Georgess, D., Auer, M. & Ewald, A. J., Sep 15 2016, In : Biology Open. 5, 9, p. 1216-1228 13 p.

Research output: Contribution to journalArticle

2015

Adhesion in mammary development: Novel roles for E-cadherin in individual and collective cell migration

Shamir, E. R. & Ewald, A. J., Jan 1 2015, Current Topics in Developmental Biology. Academic Press Inc., p. 353-382 30 p. (Current Topics in Developmental Biology; vol. 112).

Research output: Chapter in Book/Report/Conference proceedingChapter

An Arresting Story about Basement Membrane Invasion

Ewald, A. J., Oct 26 2015, In : Developmental Cell. 35, 2, p. 143-144 2 p.

Research output: Contribution to journalShort survey

p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway

Kim, M., Shewan, A. M., Ewald, A. J., Werb, Z. & Mostov, K. E., Jan 1 2015, In : Journal of cell science. 128, 23, p. 4317-4327 11 p.

Research output: Contribution to journalArticle

Quantitative real-time analysis of collective cancer invasion and dissemination

Ewald, A. J., Jan 1 2015, Independent Component Analyses, Compressive Sampling, Large Data Analyses (LDA), Neural Networks, Biosystems, and Nanoengineering XIII. Dai, L., Zheng, Y. & Szu, H. H. (eds.). SPIE, 94960P. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 9496).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2014

3D culture assays of murine mammary branching morphogenesis and epithelial invasion

Nguyen-Ngoc, K. V., Shamir, E. R., Huebner, R. J., Beck, J. N., Cheung, K. J. & Ewald, A. J., Sep 22 2014, Tissue Morphogenesis: Methods and Protocols. Springer New York, p. 135-162 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A molecular switch for the orientation of epithelial cell polarization

Bryant, D. M., Roignot, J., Datta, A., Overeem, A. W., Kim, M., Yu, W., Peng, X., Eastburn, D. J., Ewald, A. J., Werb, Z. & Mostov, K. E., Oct 27 2014, In : Developmental Cell. 31, 2, p. 171-187 17 p.

Research output: Contribution to journalArticle

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A. & Pan, D., Mar 1 2014, In : Genes and Development. 28, 5, p. 432-437 6 p.

Research output: Contribution to journalArticle

Cancer: Sugar-coated cell signalling

Ewald, A. J. & Egeblad, M., Jan 1 2014, In : Nature. 511, 7509, p. 298-299 2 p.

Research output: Contribution to journalShort survey

Cellular foundations of mammary tubulogenesis

Huebner, R. J. & Ewald, A. J., Jul 2014, In : Seminars in Cell and Developmental Biology. 31, p. 124-131 8 p.

Research output: Contribution to journalReview article

Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells

Huebner, R. J., Lechler, T. & Ewald, A. J., Mar 1 2014, In : Development (Cambridge). 141, 5, p. 1085-1094 10 p.

Research output: Contribution to journalArticle

Illuminating breast cancer invasion: Diverse roles for cell-cell interactions

Cheung, K. J. & Ewald, A. J., Oct 2014, In : Current Opinion in Cell Biology. 30, 1, p. 99-111 13 p.

Research output: Contribution to journalReview article

Invasive leader cells: Metastatic oncotarget

Cheung, K. J. & Ewald, A. J., 2014, In : Oncotarget. 5, 6, p. 1390-1391 2 p.

Research output: Contribution to journalEditorial

Open Access

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

Chapiro, J., Sur, S., Savic, L. J., Ganapathy-Kanniappan, S., Reyes, J., Duran, R., Thiruganasambandam, S. C., Moats, C. R., Lin, M. D., Luo, W., Tran, P. T., Herman, J. M., Semenza, G. L., Ewald, A. J., Vogelstein, B. & Geschwind, J. F., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6406-6417 12 p.

Research output: Contribution to journalArticle

Three-dimensional organotypic culture: Experimental models of mammalian biology and disease

Shamir, E. R. & Ewald, A. J., Jan 1 2014, In : Nature Reviews Molecular Cell Biology. 15, 10, p. 647-664 18 p.

Research output: Contribution to journalReview article

Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

Shamir, E. R., Pappalardo, E., Jorgens, D. M., Coutinho, K., Tsai, W. T., Aziz, K., Auer, M., Tran, P. T., Bader, J. S. & Ewald, A. J., Mar 2014, In : Journal of Cell Biology. 204, 5, p. 839-856 18 p.

Research output: Contribution to journalArticle

2013

Collective invasion in breast cancer requires a conserved basal epithelial program

Cheung, K. J., Gabrielson, E., Werb, Z. & Ewald, A. J., Dec 19 2013, In : Cell. 155, 7, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

Isolation of mouse mammary organoids for long-term time-lapse imaging

Ewald, A. J., Feb 1 2013, In : Cold Spring Harbor Protocols. 8, 2, p. 130-133 4 p.

Research output: Contribution to journalArticle

Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix

Nguyen-Ngoc, K. V. & Ewald, A. J., Sep 1 2013, In : Journal of Microscopy. 251, 3, p. 212-223 12 p.

Research output: Contribution to journalArticle