Ana De Jesus-Acosta

Assistant Professor

20082019
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Research Output 2008 2019

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Article
2019

Effect of Gemcitabine and nab-Paclitaxel with or Without Hydroxychloroquine on Patients with Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial

Karasic, T. B., O'Hara, M. H., Loaiza-Bonilla, A., Reiss, K. A., Teitelbaum, U. R., Borazanci, E., De Jesus-Acosta, A., Redlinger, C., Burrell, J. A., Laheru, D., Von Hoff, D. D., Amaravadi, R. K., Drebin, J. A. & O'Dwyer, P. J., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalArticle

gemcitabine
Hydroxychloroquine
Pancreatic Neoplasms
Randomized Controlled Trials
Sulfates
Adenocarcinoma
Cell Death
Ligands
Survival
Biomarkers

The Significance of Ascites in Patients with Pancreatic Ductal Adenocarcinoma: A Case-Control Study

Baretti, M., Pulluri, B., Tsai, H. L., Blackford, A. L., Wolfgang, C., Laheru, D., Zheng, L., Herman, J., Le, D., Narang, A. & De Jesus-Acosta, A., Apr 1 2019, In : Pancreas. 48, 4, p. 585-589 5 p.

Research output: Contribution to journalArticle

Ascites
Case-Control Studies
Adenocarcinoma
Confidence Intervals
Survival
2018

A phase I trial of a guadecitabine (SGI-110) and irinotecan in metastatic colorectal cancer patients previously exposed to irinotecan

Lee, V., Wang, J., Zahurak, M., Gootjes, E., Verheul, H. M., Parkinson, R., Kerner, Z., Sharma, A., Rosner, G., De Jesus-Acosta, A., Laheru, D., Le, D., Oganesian, A., Lilly, E., Brown, T., Jones, P., Baylin, S. B., Ahuja, N. & Azad, N., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6160-6167 8 p.

Research output: Contribution to journalArticle

irinotecan
Colorectal Neoplasms
Intercellular Signaling Peptides and Proteins
Fever
Gastrointestinal Neoplasms
2017

Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer

Shrestha, B., Sun, Y., Faisal, F., Kim, V., Soares, K., Blair, A., Herman, J. M., Narang, A., Dholakia, A. S., Rosati, L., Hacker-Prietz, A., Chen, L., Laheru, D., De Jesus-Acosta, A., Le, D., Donehower, R. C., Azad, N., Diaz, L. A., Murphy, A., Lee, V. & 11 others, Fishman, E. K., Hruban, R. H., Liang, T., Cameron, J. L., Makary, M. A., Weiss, M. J., Ahuja, N., He, J., Wolfgang, C., Huang, C. Y. & Zheng, L., Jul 1 2017, In : Cancer Medicine. 6, 7, p. 1552-1562 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Drug Therapy
Neoadjuvant Therapy
Survival
Adenocarcinoma

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

Rao, A. D., Liu, Y., von Eyben, R., Hsu, C. C., Hu, C., Rosati, L. M., Parekh, A., Ng, K., Hacker-Prietz, A., Zheng, L., Pawlik, T. M., Laheru, D., Jaffee, E., Weiss, M. J., Le, D., Hruban, R. H., De Jesus-Acosta, A., Wolfgang, C., Narang, A., Chang, D. T. & 2 others, Koong, A. C. & Herman, J. M., Jan 1 2017, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

biomarkers
Pancreatic Neoplasms
Ligation
proximity
radiation therapy

Olaparib in combination with irinotecan, cisplatin, and mitomycin c in patients with advanced pancreatic cancer

Yarchoan, M., Myzak, M. C., Johnson, B. A., De Jesus-Acosta, A., Le, D., Jaffee, E., Azad, N., Donehower, R. C., Zheng, L., Oberstein, P. E., Fine, R. L., Laheru, D. & Goggins, M. S., 2017, In : Oncotarget. 8, 27, p. 44073-44081 9 p.

Research output: Contribution to journalArticle

irinotecan
Mitomycin
Pancreatic Neoplasms
Cisplatin
Adenocarcinoma

The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Begum, A., Ewachiw, T., Jung, C., Huang, A., Norberg, K. J., Marchionni, L., McMillan, R., Penchev, V., Rajeshkumar, N. V., Maitra, A., Wood, L. D., Wang, C., Wolfgang, C., De Jesus-Acosta, A., Laheru, D., Shapiro, I. M., Padval, M., Pachter, J. A., Weaver, D. T., Rasheed, Z. A. & 1 others, Matsui, W., Jul 1 2017, In : PLoS One. 12, 7, e0180181.

Research output: Contribution to journalArticle

non-specific protein-tyrosine kinase
Focal Adhesion Protein-Tyrosine Kinases
Neoplastic Stem Cells
adenocarcinoma
Stem cells
2016

A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET)

Viúdez, A., Carvalho, F. L. F., Maleki, Z., Zahurak, M., Laheru, D., Stark, A., Azad, N., Wolfgang, C., Baylin, S. B., Herman, J. G. & De Jesus-Acosta, A., May 1 2016, In : Oncotarget. 7, 18, p. 24950-24961 12 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Immunohistochemistry
Recurrence
Survival
Methyltransferases

Longer course of induction chemotherapy followed by chemoradiation favors better survival outcomes for patients with locally advanced pancreatic cancer

Faisal, F., Tsai, H. L., Blackford, A., Olino, K., Xia, C., De Jesus-Acosta, A., Le, D., Cosgrove, D., Azad, N., Rasheed, Z., Diaz, L. A., Donehower, R. C., Laheru, D., Hruban, R. H., Fishman, E. K., Edil, B. H., Schulick, R., Wolfgang, C., Herman, J. & Zheng, L., 2016, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 39, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
Pancreatic Neoplasms
Survival
Incidence
Drug Therapy

Pancreatic neuroendocrine tumors: Challenges in an underestimated disease

Viúdez, A., De Jesus-Acosta, A., Carvalho, F. L., Vera, R., Martín-Algarra, S. & Ramírez, N., May 1 2016, In : Critical Reviews in Oncology/Hematology. 101, p. 193-206 14 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Biomarkers
Molecular Targeted Therapy
Drug Therapy
Liver
2015

Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas

Wild, A. T., Dholakia, A. S., Fan, K. Y., Kumar, R., Moningi, S., Rosati, L. M., Laheru, D., Zheng, L., De Jesus-Acosta, A., Ellsworth, S. G., Hacker-Prietz, A., Voong, K., Tran, P. T., Hruban, R. H., Pawlik, T. M., Wolfgang, C. & Herman, J. M., 2015, In : Journal of Gastrointestinal Oncology. 6, 2, p. 115-125 11 p.

Research output: Contribution to journalArticle

Adenosquamous Carcinoma
Platinum
Pancreas
Drug Therapy
Survival

Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C. C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., De Jesus-Acosta, A., Sharma, P., Heidari, P., Mahmood, U., Chin, L., Moses, H. L., Weaver, V. M., Maitra, A., Allison, J. P., LeBleu, V. S. & 1 others, Kalluri, R., Dec 14 2015, In : Cancer Cell. 28, 6, p. 831-833 3 p.

Research output: Contribution to journalArticle

Resected pancreatic ductal adenocarcinomas with recurrence limited in lung have a significantly better prognosis than those with other recurrence patterns

Wangjam, T., Zhang, Z., Zhou, X. C., Lyer, L., Faisal, F., Soares, K. C., Fishman, E. K., Hruban, R. H., Herman, J. M., Laheru, D., Weiss, M. J., Li, M., De Jesus-Acosta, A., Wolfgang, C. & Zheng, L., 2015, In : Oncotarget. 6, 34, p. 36903-36910 8 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Recurrence
Lung
Pancreatic Neoplasms
Survival

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

Bever, K., Sugar, E., Bigelow, E., Sharma, R., Laheru, D., Wolfgang, C., Jaffee, E., Anders, R. A., De Jesus-Acosta, A. & Zheng, L., Apr 1 2015, In : HPB. 17, 4, p. 292-298 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Pancreatic Stellate Cells
Tissue Preservation
Therapeutics

The Role of Stereotactic Body Radiation Therapy for Pancreatic Cancer: A Single-Institution Experience

Moningi, S., Dholakia, A. S., Raman, S. P., Blackford, A., Cameron, J. L., Le, D., De Jesus-Acosta, A., Hacker-Prietz, A., Rosati, L. M., Assadi, R. K., Dipasquale, S., Pawlik, T. M., Zheng, L., Weiss, M. J., Laheru, D., Wolfgang, C. & Herman, J. M., Jul 8 2015, In : Annals of Surgical Oncology. 22, 7, p. 2352-2358 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Radiotherapy
Drug Therapy
Survival
Disease-Free Survival
2014

A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma

De Jesus-Acosta, A., Laheru, D., Maitra, A., Arcaroli, J., Rudek-Renaut, M., Dasari, A., Blatchford, P. J., Quackenbush, K. & Messersmith, W., 2014, In : Investigational New Drugs. 32, 4, p. 739-745 7 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Adenocarcinoma
Survival Rate
Pharmacokinetics
Survival

Baseline hemoglobin-A1c impacts clinical outcomes in patients with pancreatic cancer

Fan, K. Y., Dholakia, A. S., Wild, A. T., Su, Z., Hacker-Prietz, A., Kumar, R., Hodgin, M., Hsu, C. C., Le, D., De Jesus-Acosta, A., Diaz, L. A., Laheru, D., Hruban, R. H., Fishman, E. K., Brown, T. T., Pawlik, T. M., Wolfgang, C., Tran, P. T. & Herman, J. M., Jan 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 1, p. 50-57 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Hemoglobins
Adenocarcinoma
Pancreatic Diseases
Diabetes Mellitus

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: A dual-institutional follow-up with the RTOG 9704 trial

McAllister, F., Pineda, D. M., Jimbo, M., Lal, S., Burkhart, R., Moughan, J., Winter, K. A., Abdelmohsen, K., Gorospe, M., De Jesus-Acosta, A., Lankapalli, R. H., Winter, J. M., Yeo, C. J., Witkiewicz, A. K., Iacobuzio-Donahue, C. A., Laheru, D. & Brody, J. R., 2014, In : Cancer Biology and Therapy. 15, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

Deoxycytidine Kinase
Radiation Oncology
Pancreatic Neoplasms
Fluorouracil
Radiotherapy

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C. C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., De Jesus-Acosta, A., Sharma, P., Heidari, P., Mahmood, U., Chin, L., Moses, H. L., Weaver, V. M., Maitra, A., Allison, J. P., LeBleu, V. S. & 1 others, Kalluri, R., Jun 16 2014, In : Cancer Cell. 25, 6, p. 719-734 16 p.

Research output: Contribution to journalArticle

Myofibroblasts
Pancreatic Neoplasms
Immunosuppression
Fibrosis
Fibroblasts

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Zhou, W., Jubb, A. M., Lyle, K., Xiao, Q., Ong, C. C., Desai, R., Fu, L., Gnad, F., Song, Q., Haverty, P. M., Aust, D., Grützmann, R., Romero, M., Totpal, K., Neve, R. M., Yan, Y., Forrest, W. F., Wang, Y., Raja, R., Pilarsky, C. & 8 others, De Jesus-Acosta, A., Belvin, M., Friedman, L. S., Merchant, M., Jaffee, E., Zheng, L., Koeppen, H. & Hoeflich, K. P., Dec 1 2014, In : Journal of Pathology. 234, 4, p. 502-513 12 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Pancreatic Neoplasms
Cell Movement
Proto-Oncogene Proteins c-met
Adenocarcinoma
2013

Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer

Herman, J. M., Fan, K. Y., Wild, A. T., Hacker-Prietz, A., Wood, L. D., Blackford, A. L., Ellsworth, S., Zheng, L., Le, D., De Jesus-Acosta, A., Hidalgo, M., Donehower, R. C., Schulick, R. D., Edil, B. H., Choti, M. A., Hruban, R. H., Pawlik, T. M., Cameron, J. L., Laheru, D. & Wolfgang, C., Jul 15 2013, In : International Journal of Radiation Oncology, Biology, Physics. 86, 4, p. 678-685 8 p.

Research output: Contribution to journalArticle

chemotherapy
Adjuvant Chemotherapy
Pancreatic Neoplasms
cancer
Survival
2012

A multicenter analysis of GTX chemotherapy in patients with locally advanced and metastatic pancreatic adenocarcinoma

De Jesus-Acosta, A., Oliver, G. R., Blackford, A., Kinsman, K., Flores, E. I., Wilfong, L. S., Zheng, L., Donehower, R. C., Cosgrove, D., Laheru, D., Le, D., Chung, K. & Diaz, L. A., Feb 2012, In : Cancer Chemotherapy and Pharmacology. 69, 2, p. 415-424 10 p.

Research output: Contribution to journalArticle

gemcitabine
Chemotherapy
Adenocarcinoma
docetaxel
Drug Therapy

Predictive biomarkers and personalized medicine molecular determinants of retinoic acid sensitivity in pancreatic cancer

Gupta, S., Pramanik, D., Mukherjee, R., Campbell, N. R., Elumalai, S., De Wilde, R. F., Hong, S. M., Goggins, M. S., De Jesus-Acosta, A., Laheru, D. & Maitra, A., Jan 1 2012, In : Clinical Cancer Research. 18, 1, p. 280-289 10 p.

Research output: Contribution to journalArticle

Fatty Acid-Binding Proteins
Precision Medicine
Tretinoin
Pancreatic Neoplasms
Retinoic Acid Receptors
2011

Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer

Villarroel, M. C., Rajeshkumar, N. V., Garrido-Laguna, I., De Jesus-Acosta, A., Jones, S., Maitra, A., Hruban, R. H., Eshleman, J., Klein, A., Laheru, D., Donehower, R. C. & Hidalgo, M., Jan 2011, In : Molecular Cancer Therapeutics. 10, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
DNA
Genes
Neoplasms
2009
temozolomide
Opportunistic Infections
Cytomegalovirus
Brain Neoplasms
Immunosuppression
2008

Signal transduction proteins in tumors from puerto rican and caucasian gastric adenocarcinoma patients: Expression differences with potential for specific targeted therapies

Cangiano, J., Centeno, B. A., Garrett, C. R., Cáceres, W., De Jesus-Acosta, A., Lee, J. H., Pavía, O., Jove, R., Báez, L., Sullivan, D. M., Muro-Cacho, C. A. & Muñoz-Antonia, T., Aug 2008, In : Digestive Diseases and Sciences. 53, 8, p. 2090-2100 11 p.

Research output: Contribution to journalArticle

Signal Transduction
Stomach
Adenocarcinoma
Hispanic Americans
Epidermal Growth Factor