Research Output 2008 2017

2017

A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination

Goebbels, S., Wieser, G. L., Pieper, A., Spitzer, S., Weege, B., Yan, K., Edgar, J. M., Yagensky, O., Wichert, S. P., Agarwal, A., Karram, K., Renier, N., Tessier-Lavigne, M., Rossner, M. J., Káradóttir, R. T. & Nave, K. A. Jan 1 2017 In : Nature Neuroscience. 20, 1, p. 10-15 6 p.

Research output: Research - peer-reviewArticle

Oligodendroglia
Regulator Genes
Phosphatidylinositols
Axons
Cell Differentiation

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

Agarwal, A., Wu, P. H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D. & Bergles, D. E. Feb 8 2017 In : Neuron. 93, 3, p. 587-605.e7

Research output: Research - peer-reviewArticle

Astrocytes
Calcium
mitochondrial permeability transition pore
Mitochondria
Oxidative Phosphorylation
2016

Activity-dependent switch of gabaergic inhibition into glutamatergic excitation in astrocyte-neuron networks

Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., Díez, A., Fuenzalida, M., Agarwal, A., Bergles, D. E., Bettler, B., Manahan-Vaughan, D., Martín, E. D., Kirchhoff, F. & Araque, A. Dec 24 2016 In : eLife. 5, DECEMBER2016, e20362

Research output: Research - peer-reviewArticle

Astrocytes
Neurons
Switches
Interneurons
GABA Agents

Beware of your Cre-Ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory

Reichel, J. M., Bedenk, B. T., Gassen, N. C., Hafner, K., Bura, S. A., Almeida-Correa, S., Genewsky, A., Dedic, N., Giesert, F., Agarwal, A., Nave, K. A., Rein, T., Czisch, M., Deussing, J. M. & Wotjak, C. T. Oct 1 2016 In : Hippocampus. 26, 10, p. 1250-1264 15 p.

Research output: Research - peer-reviewArticle

Galactosidases
Transfection
Hippocampus
Population
Proteins

Cell calcium signaling mediates capillary regulation of blood flow in the Retina

Biesecker, K. R., Srienc, A. I., Shimoda, A. M., Agarwal, A., Bergles, D. E., Kofuji, P. & Newman, E. A. Sep 7 2016 In : Journal of Neuroscience. 36, 36, p. 9435-9445 11 p.

Research output: Research - peer-reviewArticle

Calcium Signaling
Neuroglia
Retina
Arterioles
Dilatation

Correction to NMDA Receptors Enhance Spontaneous Activity and Promote Neuronal Survival in the Developing Cochlea, [Neuron 89, (2016), 337-350]

Zhang-Hooks, Y., Agarwal, A., Mishina, M. & Bergles, D. E. Feb 3 2016 In : Neuron. 89, 3, p. 672 1 p.

Research output: Research - peer-reviewArticle

Cochlea
N-Methyl-D-Aspartate Receptors
Neurons

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

Kim, Y. S., Anderson, M., Park, K., Zheng, Q., Agarwal, A., Gong, C., Saijilafu, Young, L. A., He, S., LaVinka, P. C., Zhou, F., Bergles, D., Hanani, M., Guan, Y., Spray, D. C. & Dong, X. Sep 7 2016 In : Neuron. 91, 5, p. 1085-1096 12 p.

Research output: Research - peer-reviewArticle

Sensory Receptor Cells
Chronic Pain
Neurons
Diagnosis-Related Groups
Pain

NMDA Receptors Enhance Spontaneous Activity and Promote Neuronal Survival in the Developing Cochlea

Zhang-Hooks, Y., Agarwal, A., Mishina, M. & Bergles, D. E. 2016 In : Neuron. 89, 2, p. 337-350 14 p.

Research output: Research - peer-reviewArticle

Cochlea
N-Methyl-D-Aspartate Receptors
Neurons
Spiral Ganglion
Inner Auditory Hair Cells
2015

Calcium dynamics in astrocyte processes during neurovascular coupling

Otsu, Y., Couchman, K., Lyons, D. G., Collot, M., Agarwal, A., Mallet, J. M., Pfrieger, F. W., Bergles, D. E. & Charpak, S. Feb 17 2015 In : Nature Neuroscience. 18, 2, p. 210-218 9 p.

Research output: Research - peer-reviewArticle

Astrocytes
Calcium
Neurovascular Coupling
Hyperemia
Metabotropic Glutamate 5 Receptor

Neuron-glia signaling in developing retina mediated by neurotransmitter spillover

Rosa, J. M., Bos, R., Sack, G. S., Fortuny, C., Agarwal, A., Bergles, D. E., Flannery, J. G. & Feller, M. B. Aug 14 2015 In : eLife. 4, AUGUST2015, p. 1-20 20 p., e09590

Research output: Research - peer-reviewArticle

Neuroglia
Neurotransmitter Agents
Retina
Neurons
Calcium

Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells

Wang, H. C., Lin, C. C., Cheung, R., Zhang-Hooks, Y., Agarwal, A., Ellis-Davies, G., Rock, J. & Bergles, D. E. Dec 3 2015 In : Cell. 163, 6, p. 1348-1359 12 p.

Research output: Research - peer-reviewArticle

Adenosine Triphosphate
Cells
Fluids
Auditory Hair Cells
Fluids and Secretions
2014

Astrocyte morphology is controlled by neuron-derived FGF

Agarwal, A. & Bergles, D. E. Jul 16 2014 In : Neuron. 83, 2, p. 255-257 3 p.

Research output: Research - peer-reviewArticle

Astrocytes
Neurons
Drosophila
Homeostasis

Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity

Agarwal, A. , Zhang, M. , Trembak-Duff, I. , Unterbarnscheidt, T. , Radyushkin, K. , Dibaj, P. , Martins de Souza, D. , Boretius, S. , Brzózka, M. M. , Steffens, H. , Berning, S. , Teng, Z. , Gummert, M. N. , Tantra, M. , Guest, P. C. , Willig, K. I. , Frahm, J. , Hell, S. W. , Bahn, S. , Rossner, M. J. & 4 others Nave, K. A., Ehrenreich, H., Zhang, W. & Schwab, M. H. Aug 21 2014 In : Cell Reports. 8, 4, p. 1130-1145 16 p.

Research output: Research - peer-reviewArticle

Neuregulin-1
Neuronal Plasticity
Pyramidal Cells
Neurons
Plasticity

Multiscale Optical Ca2+ Imaging of Tonal Organization in Mouse Auditory Cortex

Issa, J. B., Haeffele, B. D., Agarwal, A., Bergles, D. E., Young, E. D. & Yue, D. T. Aug 20 2014 In : Neuron. 83, 4, p. 944-959 16 p.

Research output: Research - peer-reviewArticle

Auditory Cortex
Neurons
Photons
Microelectrodes
Transgenic Mice

Norepinephrine controls astroglial responsiveness to local circuit activity

Paukert, M., Agarwal, A., Cha, J., Doze, V. A., Kang, J. U. & Bergles, D. E. Jun 18 2014 In : Neuron. 82, 6, p. 1263-1270 8 p.

Research output: Research - peer-reviewArticle

Astrocytes
Norepinephrine
Light
Brain
Visual Cortex
2012

In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice

Agarwal, A., Dibaj, P., Kassmann, C. M., Goebbels, S., Nave, K. A. & Schwab, M. H. Jul 2012 In : Cerebral Cortex. 22, 7, p. 1473-1486 14 p.

Research output: Research - peer-reviewArticle

Pyramidal Cells
Neurons
Tamoxifen
Gene Expression
Homologous Recombination
2011

Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice

Sargin, D., El-Kordi, A., Agarwal, A., Müller, M., Wojcik, S. M., Hassouna, I., Sperling, S., Nave, K. A. & Ehrenreich, H. Apr 28 2011 In : BMC Biology. 9, 27

Research output: Research - peer-reviewArticle

Erythropoietin Receptors
Pyramidal Cells
Erythropoietin
Cognition
Hippocampus
2010

Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia

Ribes, S., Ebert, S., Regen, T., Agarwal, A., Tauber, S. C., Czesnik, D., Spreer, A., Bunkowski, S., Eiffert, H., Hanisch, U. K., Hammerschmidt, S. & Nau, R. Feb 2010 In : Infection and Immunity. 78, 2, p. 865-871 7 p.

Research output: Research - peer-reviewArticle

Toll-Like Receptors
Microglia
Streptococcus pneumoniae
Phagocytosis
Brain
2008

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A. N., Müller, T., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., Radyushkin, K., Goebbels, S., Fischer, T. M., Franklin, R. J., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M. H. & Nave, K. A. Aug 28 2008 In : Neuron. 59, 4, p. 581-595 15 p.

Research output: Research - peer-reviewArticle

Neuregulin-1
Peripheral Nervous System
Central Nervous System
Oligodendroglia
Myelin Sheath