Ami Shah

Associate Professor

20062019
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Research Output 2006 2019

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Article
2019
Open Access
Immunotherapy
Referral and Consultation
Neoplasms
Odds Ratio
Educational Models

Anti–RNPC-3 (U11/U12) Antibodies in Systemic Sclerosis in Patients With Moderate-to-Severe Gastrointestinal Dysmotility

McMahan, Z., Domsic, R. T., Zhu, L., Medsger, T. A., Casciola Rosen, L. A. & Shah, A., Sep 1 2019, In : Arthritis Care and Research. 71, 9, p. 1164-1170 7 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Antibodies
Interstitial Lung Diseases
Gastrointestinal Diseases
African Americans
Open Access
HLA-DRB1 Chains
Arthritis
Epitopes
Alleles
Immunogenetics

Collaborative National Quality and Efficacy Registry (CONQUER) for Scleroderma: outcomes from a multicenter US-based systemic sclerosis registry

Shanmugam, V. K., Frech, T. M., Steen, V. D., Hummers, L. K., Shah, A. A., Bernstein, E. J., Khanna, D., Gordon, J. K., Castelino, F. V., Chung, L., Hant, F. N., Startup, E., VanBuren, J. M., Evnin, L. B. & Assassi, S., Jan 1 2019, (Accepted/In press) In : Clinical rheumatology.

Research output: Contribution to journalArticle

Systemic Scleroderma
Registries
Longitudinal Studies
Specimen Handling
Respiratory Function Tests

Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis

Shin, J. Y., Beckett, J. D., Bagirzadeh, R., Creamer, T. J., Shah, A. A., McMahan, Z., Paik, J. J., Sampedro, M. M., MacFarlane, E. G., Beer, M. A., Warren, D., Wigley, F. M. & Dietz, H. C., Jan 1 2019, In : Science translational medicine. 11, 497, eaaw0790.

Research output: Contribution to journalArticle

Systemic Scleroderma
Epigenomics
Fibrosis
Skin
Autocrine Communication

Estimating autoantibody signatures to detect autoimmune disease patient subsets

Wu, Z., Casciola Rosen, L. A., Shah, A., Rosen, A. & Zeger, S., Jan 1 2019, In : Biostatistics (Oxford, England). 20, 1, p. 30-47 18 p.

Research output: Contribution to journalArticle

Autoantibodies
Signature
Subset
Warping
Immune Response

Generation of a Core Set of Items to Develop Classification Criteria for Scleroderma Renal Crisis Using Consensus Methodology

the Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group, Jun 1 2019, In : Arthritis and Rheumatology. 71, 6, p. 964-971 8 p.

Research output: Contribution to journalArticle

Kidney
Hemolytic Anemia
Hemolysis
Proteinuria
Acute Kidney Injury

Immune checkpoint inhibitor-induced inflammatory arthritis persists after immunotherapy cessation

Braaten, T. J., Brahmer, J., Forde, P., Le, D., Lipson, E., Naidoo, J., Schollenberger, M., Zheng, L., Bingham, C., Shah, A. & Cappelli, L., Jan 1 2019, (Accepted/In press) In : Annals of the rheumatic diseases.

Research output: Contribution to journalArticle

Immunotherapy
Arthritis
Tumors
Immunosuppressive Agents
Logistics
Localized Scleroderma
Systemic Scleroderma
Skin Neoplasms
Melanoma
RNA Polymerase I
RNA Polymerase III
Antibodies
Neoplasms
Anti-Idiotypic Antibodies

Risk factors for mortality and cardiopulmonary hospitalization in systemic sclerosis patients at risk for pulmonary hypertension, in the pharos registry

Hsu, V. M., Chung, L., Hummers, L., Shah, A., Simms, R., Bolster, M., Hant, F. N., Silver, R. M., Fischer, A., Hinchcliff, M. E., Varga, J., Goldberg, A. Z., Derk, C. T., Schiopu, E., Khanna, D., Shapiro, L. S., Domsic, R. T., Medsger, T., Mayes, M. D., Furst, D. & 5 others, Csuka, M. E., Molitor, J. A., Saketkoo, L. A., Salazar, C. R. & Steen, V. D., Feb 1 2019, In : Journal of Rheumatology. 46, 2, p. 176-183 8 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pulmonary Hypertension
Registries
Hospitalization
Mortality

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Park, J. S., Oh, Y., Park, Y. J., Park, O., Yang, H., Slania, S., Hummers, L., Shah, A., An, H. T., Jang, J., Horton, M., Shin, J., Dietz, H. C., Song, E., Na, D. H., Park, E. J., Kim, K., Lee, K. C., Roschke, V. V., Hanes, J. S. & 2 others, Pomper, M. G. & Lee, S., Dec 1 2019, In : Nature communications. 10, 1, 1128.

Research output: Contribution to journalArticle

Open Access
TNF-Related Apoptosis-Inducing Ligand Receptors
fibrosis
Myofibroblasts
apoptosis
death
2018

ANCA-associated vasculitis in scleroderma: A renal perspective

Kant, S., Shah, A., Hummers, L., Wigley, F. & Geetha, D., Dec 1 2018, In : Clinical Nephrology. 90, 6, p. 413-418 6 p.

Research output: Contribution to journalArticle

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Kidney
Glomerulonephritis
Antineutrophil Cytoplasmic Antibodies
Immunosuppression
Autoantibodies
Phenotype
Neoplasms
Set theory
Incidence

Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program

Ogdie, A., Sparks, J. A., Angeles-Han, S. T., Bush, K., Castelino, F. V., Golding, A., Jiang, Y., Kahlenberg, J. M., Kim, A. H. J., Lee, Y. C., Machireddy, K., Ombrello, M. J., Shah, A., Wallace, Z. S., Nigrovic, P. A. & Makris, U. E., Jan 1 2018, (Accepted/In press) In : Arthritis Care and Research.

Research output: Contribution to journalArticle

Mentors
Rheumatology
Research Personnel
Research
Focus Groups

Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans

Gourh, P., Remmers, E. F., Boyden, S. E., Alexander, T., Morgan, N., Shah, A., Mayes, M. D., Doumatey, A., Bentley, A. R., Shriner, D., Domsic, R. T., Medsger, T. A., Steen, V. D., Ramos, P. S., Silver, R. M., Korman, B., Varga, J., Schiopu, E., Khanna, D., Hsu, V. & 22 others, Gordon, J. K., Saketkoo, L. A., Gladue, H., Kron, B., Criswell, L. A., Derk, C. T., Bridges, S. L., Shanmugam, V. K., Kolstad, K. D., Chung, L., Jan, R., Bernstein, E. J., Goldberg, A., Trojanowski, M., Kafaja, S., Maksimowicz-McKinnon, K. M., Mullikin, J. C., Adeyemo, A., Rotimi, C., Boin, F., Kastner, D. L. & Wigley, F., Oct 1 2018, In : Arthritis and Rheumatology. 70, 10, p. 1654-1660 7 p.

Research output: Contribution to journalArticle

Exome
Gene Regulatory Networks
African Americans
Systemic Scleroderma
Genes
Immunotherapy
Arthritis
Immunosuppression
Neoplasms
Phenotype

Impact of Radiation Therapy on Scleroderma and Cancer Outcomes in Scleroderma Patients With Breast Cancer

Shah, D. J., Hirpara, R., Poelman, C. L., Woods, A., Hummers, L., Wigley, F., Wright, J., Parekh, A., Steen, V. D., Domsic, R. T. & Shah, A., Oct 1 2018, In : Arthritis Care and Research. 70, 10, p. 1517-1524 8 p.

Research output: Contribution to journalArticle

Radiotherapy
Breast Neoplasms
Neoplasms
Systemic Scleroderma
Erythema

Right ventricular myofilament functional differences in humans with systemic sclerosis-associated versus idiopathic pulmonary arterial hypertension

Hsu, S., Kokkonen-Simon, K. M., Kirk, J. A., Kolb, T. M., Damico, R. L., Mathai, S., Mukherjee, M., Shah, A., Wigley, F., Margulies, K. B., Hassoun, P. M., Halushka, M. K., Tedford, R. J. & Kass, D. A., Jan 1 2018, In : Circulation. 137, 22, p. 2360-2370 11 p.

Research output: Contribution to journalArticle

Myofibrils
Systemic Scleroderma
Pulmonary Hypertension
Muscle Cells
Calcium

Vascular complications in systemic sclerosis: a prospective cohort study

Mecoli, C., Shah, A., Boin, F., Wigley, F. & Hummers, L., May 26 2018, (Accepted/In press) In : Clinical Rheumatology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Blood Vessels
Pulmonary Hypertension
Cohort Studies
Prospective Studies
2017

Association of Fibrosing Myopathy in Systemic Sclerosis and Higher Mortality

Paik, J., Wigley, F., Shah, A., Corse, A. M., Casciola Rosen, L. A., Hummers, L. & Mammen, A. L., Nov 1 2017, In : Arthritis Care and Research. 69, 11, p. 1764-1770 7 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Muscular Diseases
Muscles
Myositis
Mortality

Brief Report: Anti–RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma

Shah, A., Xu, G., Rosen, A., Hummers, L., Wigley, F., Elledge, S. J. & Casciola Rosen, L. A., Jun 1 2017, In : Arthritis and Rheumatology. 69, 6, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

Antibodies
Autoantibodies
Neoplasms
Cytidine Triphosphate
Odds Ratio

Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database

Morgan, N., Shah, A., Mayes, M. D., Domsic, R. T., Medsger, T. A., Steen, V. D., Varga, J., Carns, M., Ramos, P. S., Silver, R. M., Schiopu, E., Khanna, DI., Hsu, V., Gordon, J. K., Gladue, H., Saketkoo, L. A., Criswell, L. A., Derk, C. T., Trojanowski, M. A., Shanmugam, V. K. & 9 others, Chung, L., Valenzuela, A., Jan, R., Goldberg, A., Remmers, E. F., Kastner, D. L., Wigley, F., Gourh, P. & Boin, F., Dec 1 2017, In : Medicine (United States). 96, 51, e8980.

Research output: Contribution to journalArticle

Systemic Scleroderma
African Americans
Cohort Studies
Genome
Databases
Myositis
Rheumatic Diseases
Autoantibodies
Dermatomyositis
Breast Neoplasms
Preexisting Condition Coverage
Vasculitis
Autoimmune Diseases
Arthritis
Myalgia
Raynaud Disease
Botulinum Toxins
Controlled Clinical Trials
Hand
Placebos

Two Cases of Sinusitis Induced by Immune Checkpoint Inhibition

Dein, E., Sharfman, W., Kim, J., Gellad, F., Shah, A. A., Bingham, C. O. & Cappelli, L. C., Jun 13 2017, (Accepted/In press) In : Journal of Immunotherapy.

Research output: Contribution to journalArticle

Sinusitis
CTLA-4 Antigen
Melanoma
Cell Death
Monoclonal Antibodies
2016
Gangrene
Interferons
Antibodies
Proteins
Case-Control Studies

Cancer and autoimmunity: Harnessing longitudinal cohorts to probe the link

Egiziano, G., Bernatsky, S. & Shah, A., 2016, (Accepted/In press) In : Best Practice and Research: Clinical Rheumatology.

Research output: Contribution to journalArticle

Autoimmunity
Rheumatic Diseases
Neoplasms
Knowledge Bases
Rare Diseases

Exhaled nitric oxide in pulmonary arterial hypertension associated with systemic sclerosis

Cao, Z., Mathai, S., Hummers, L., Shah, A., Wigley, F., Lechtzin, N., Hassoun, P. M. & Girgis, R. E., Dec 1 2016, In : Pulmonary Circulation. 6, 4, p. 545-550 6 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pulmonary Hypertension
Nitric Oxide
Healthy Volunteers
Lung

Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: A case control study in Caucasian patients

Wu, M., Assassi, S., Salazar, G. A., Pedroza, C., Gorlova, O. Y., Chen, W. V., Charles, J., Taing, M. L., Liao, K., Wigley, F., Hummers, L., Shah, A., Hinchcliff, M., Khanna, D., Schiopu, E., Phillips, K., Furst, D. E., Steen, V., Baron, M., Hudson, M. & 17 others, Zhou, X., Pope, J., Jones, N., Docherty, P., Khalidi, N. A., Robinson, D., Simms, R. W., Silver, R. M., Frech, T. M., Fessler, B. J., Fritzler, M. J., Molitor, J. A., Segal, B. M., Movahedian, M., Martín, J., Varga, J. & Mayes, M. D., Jan 20 2016, In : Arthritis Research and Therapy. 18, 1, 20.

Research output: Contribution to journalArticle

Idiopathic Interstitial Pneumonias
Genetic Loci
Systemic Scleroderma
Genetic Predisposition to Disease
Case-Control Studies
Sjogren's Syndrome
Arthritis
T-cells
Cells
Programmed Cell Death 1 Receptor

Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension

Hsu, S., Houston, B. A., Tampakakis, E., Bacher, A. C., Rhodes, P. S., Mathai, S., Damico, R. L., Kolb, T. M., Hummers, L., Shah, A., McMahan, Z., Corona Villalobos, C., Zimmerman, S., Wigley, F., Hassoun, P. M., Kass, D. A. & Tedford, R. J., May 12 2016, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Ergometry
Right Ventricular Function
Systemic Scleroderma
Recycling

Symptomatic and Electrodiagnostic Features of Peripheral Neuropathy in Scleroderma

Paik, J., Mammen, A. L., Wigley, F., Shah, A., Hummers, L. & Polydefkis, M. J., Aug 1 2016, In : Arthritis Care and Research. 68, 8, p. 1150-1157 8 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Neural Conduction
Limited Scleroderma
Diabetes Mellitus
Skin

Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer

Xu, G. J., Shah, A., Li, M. Z., Xu, Q., Rosen, A., Casciola Rosen, L. A. & Elledge, S. J., Nov 22 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 47, p. E7526-E7534

Research output: Contribution to journalArticle

Autoantigens
Spliceosomes
Autoantibodies
Autoimmune Diseases
Epitopes

The recurrence of digital ulcers in patients with systemic sclerosis after discontinuation of oral treprostinil

Shah, A., Schiopu, E., Chatterjee, S., Csuka, M. E., Frech, T., Goldberg, A., Spiera, R., Peng, S. L., McBride, R. J., Cleveland, J. M. & Steen, V., Sep 1 2016, In : Journal of Rheumatology. 43, 9, p. 1665-1671 7 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Ulcer
Recurrence
Pharmaceutical Preparations
treprostinil

Thrombotic complications after radial arterial line placement in systemic sclerosis: A case series

Paik, J., Hirpara, R., Heller, J. A., Hummers, L., Wigley, F. & Shah, A., 2016, (Accepted/In press) In : Seminars in Arthritis and Rheumatism.

Research output: Contribution to journalArticle

Vascular Access Devices
Systemic Scleroderma
Amputation
Intensive Care Units
Hand

Unique Abnormalities in Right Ventricular Longitudinal Strain in Systemic Sclerosis Patients

Mukherjee, M., Chung, S. E., Ton, V. K., Tedford, R. J., Hummers, L., Wigley, F., Abraham, T. P. & Shah, A., Jun 1 2016, In : Circulation: Cardiovascular Imaging. 9, 6, e003792.

Research output: Contribution to journalArticle

Systemic Scleroderma
Heart Ventricles
Sclerosis
Reference Values
2015

Barriers to and facilitators of a career as a physician-scientist among rheumatologists in the US

Ogdie, A., Shah, A., Makris, U. E., Jiang, Y., Nelson, A. E., Kim, A. H. J., Angeles-Han, S. T., Castelino, F. V., Golding, A., Muscal, E., Kahlenberg, J. M. & Barg, F. K., Sep 1 2015, In : Arthritis Care and Research. 67, 9, p. 1191-1201 11 p.

Research output: Contribution to journalArticle

Rheumatology
Physicians
Research
Research Personnel
Mentors
RNA Polymerase III
Neoplasms
Autoantibodies
Mutation
Early Detection of Cancer

Cardiac metabolomics and autopsy in a patient with early diffuse systemic sclerosis presenting with dyspnea: A case report

Frech, T. M., Revelo, M. P., Ryan, J. J., Shah, A., Gordon, J., Domsic, R., Hant, F., Assassi, S., Shanmugam, V. K., Hinchcliff, M., Steen, V., Khanna, D., Bernstein, E. J., Cox, J., Luem, N. & Drakos, S., Jun 10 2015, In : Journal of Medical Case Reports. 9, 1, 136.

Research output: Contribution to journalArticle

Diffuse Scleroderma
Metabolomics
Dyspnea
Autopsy
Respiratory Function Tests
Autoantibodies
RNA Polymerase III
Neoplasms
Age of Onset
Type I DNA Topoisomerase

Intravenous immunoglobulin may be an effective therapy for refractory, active diffuse cutaneous systemic sclerosis

Poelman, C. L., Hummers, L., Wigley, F., Anderson, C., Boin, F. & Shah, A., Feb 1 2015, In : Journal of Rheumatology. 42, 2, p. 236-242 7 p.

Research output: Contribution to journalArticle

Diffuse Scleroderma
Intravenous Immunoglobulins
Mycophenolic Acid
Relaxin
Skin

Molecular subsetting of interferon pathways in Sjögren's syndrome

Hall, J. C., Baer, A., Shah, A., Criswell, L. A., Shiboski, C. H., Rosen, A. & Casciola Rosen, L. A., Sep 1 2015, In : Arthritis and Rheumatology. 67, 9, p. 2437-2446 10 p.

Research output: Contribution to journalArticle

Interferons
Salivary Glands
Lip
Interferon-gamma
Lacrimal Apparatus

Patient perspectives in OMERACT provide an anchor for future metric development and improved approaches to healthcare delivery in connective tissue disease related interstitial lung disease (CTD-ILD)

Mittoo, S., Frankel, S., Lesage, D., Strand, V., Shah, A., Christopher-Stine, L., Danoff, S., Hummers, L., Swigris, J. J., Huscher, D., Christensen, A. M., Cenac, S. L., Erbil, J. K., Ferguson, S., Garcia-Valladares, I., Grewal, H. K., Orbai, A-M., Smith, K., Tran, M., Bingham, C. & 3 others, Castelino, F. V., Fischer, A. & Saketkoo, L. A., Sep 1 2015, In : Current Respiratory Medicine Reviews. 11, 2, p. 175-183 9 p.

Research output: Contribution to journalArticle

Connective Tissue Diseases
Interstitial Lung Diseases
Delivery of Health Care
Focus Groups
Dyspnea
Raynaud Disease
Antibodies
Body Temperature Regulation
Autoantibodies
Serum

Review: Cancer-induced autoimmunity in the rheumatic diseases

Shah, A., Casciola Rosen, L. A. & Rosen, A., Feb 1 2015, In : Arthritis and Rheumatology. 67, 2, p. 317-326 10 p.

Research output: Contribution to journalArticle

Dermatomyositis
Systemic Scleroderma
Rheumatic Diseases
Autoimmunity
Autoimmune Diseases

Spectrum of Muscle Histopathologic Findings in Forty-Two Scleroderma Patients with Weakness

Paik, J., Wigley, F., Lloyd, T., Corse, A. M., Casciola Rosen, L. A., Shah, A., Boin, F., Hummers, L. & Mammen, A. L., Oct 1 2015, In : Arthritis Care and Research. 67, 10, p. 1416-1425 10 p.

Research output: Contribution to journalArticle

Muscular Diseases
Fibrosis
Myositis
Denervation
Muscles
2014

Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma

Moinzadeh, P., Fonseca, C., Hellmich, M., Shah, A., Chighizola, C., Denton, C. P. & Ong, V. H., Feb 14 2014, In : Arthritis Research and Therapy. 16, 1, R53.

Research output: Contribution to journalArticle

RNA Polymerase III
Autoantibodies
Neoplasms
Antibodies
Systemic Scleroderma