Alison Klein

Research output

Research output per year 1999 2007 2009 2011 2012 2015 2016 2017 2018 2019 2020 2021 2022 2023 2023

• 167 Article
• 21 Review article
• 5 Comment/debate
• 3 Chapter
• 5 More
  • 3 Letter
  • 1 Editorial
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2023

  Does acute pancreatitis herald pancreatic ductal adenocarcinoma? A multicenter electronic health research network study

  Singh, R. R., Klein, A. P., Sharma, N. R. & O'Reilly, E. M., Feb 2023, In: Cancer medicine. 12, 3, p. 2505-2513 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatitis 100%
  • Adenocarcinoma 80%
  • Pancreas 70%
  • Health 50%
  • Early Diagnosis 11%

• Epidemiology of Pancreatic Cancer

  Mocci, E. & Klein, A. P., Jan 1 2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition. wiley, p. 899-904 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Erratum to: Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings (Diabetes 2023; 72: 433–448)

  Mastracci, T. L., Apte, M., Amundadottir, L. T., Alvarsson, A., Artandi, S., Bellin, M. D., Bernal-Mizrachi, E., Caicedo, A., Campbell-Thompson, M., Cruz-Monserrate, Z., Ouaamari, A. E., Gaulton, K. J., Geisz, A., Goodarzi, M. O., Hara, M., Hull-Meichle, R. L., Kleger, A., Klein, A. P., Kopp, J. L., Kulkarni, R. N., & 14 othersMuzumdar, M. D., Naren, A. P., Oakes, S. A., Olesen, S. S., Phelps, E. A., Powers, A. C., Stabler, C. L., Tirkes, T., Whitcomb, D. C., Yadav, D., Yong, J., Zaghloul, N. A., Pandol, S. J. & Sander, M., Aug 2023, In: Diabetes. 72, 8, p. 1173 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Molecular Medicine 100%
  • Pancreatic Diseases 90%
  • Los Angeles 83%
  • Gastroenterology 78%
  • Pediatrics 44%

• Familial Pancreatic Cancer

  Klein, A. P., Jan 1 2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition. wiley, p. 951-956 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

  King, S. D., Veliginti, S., Brouwers, M. C. G. J., Ren, Z., Zheng, W., Setiawan, V. W., Wilkens, L. R., Shu, X. O., Arslan, A. A., Beane Freeman, L. E., Bracci, P. M., Canzian, F., Du, M., Gallinger, S. J., Giles, G. G., Goodman, P. J., Haiman, C. A., Kogevinas, M., Kooperberg, C., LeMarchand, L., & 57 othersNeale, R. E., Visvanathan, K., White, E., Albanes, D., Andreotti, G., Babie, A., Berndt, S. I., Brais, L. K., Brennan, P., Buring, J. E., Rabe, K. G., Bamlet, W. R., Chanock, S. J., Fuchs, C. S., Gaziano, J. M., Giovannucci, E. L., Hackert, T., Hassan, M. M., Katzke, V., Kurtz, R. C., Lee, I. M., Malats, N., Murphy, N., Oberg, A. L., Orlow, I., Porta, M., Real, F. X., Rothman, N., Sesso, H. D., Silverman, D. T., Thompson, I. M., Wactawski-Wende, J., Wang, X., Wentzensen, N., Yu, H., Zeleniuch-Jacquotte, A., Yu, K., Wolpin, B. M., Duell, E. J., Li, D., Hung, R. J., Perdomo, S., McCullough, M. L., Freedman, N. D., Patel, A. V., Peters, U., Riboli, E., Sund, M., Tjønneland, A., Zhong, J., Van Den Eeden, S. K., Kraft, P., Risch, H. A., Amundadottir, L. T., Klein, A. P., Stolzenberg-Solomon, R. Z. & Antwi, S. O., Sep 1 2023, In: Cancer Epidemiology Biomarkers and Prevention. 32, 9, p. 1265-1269 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-alcoholic Fatty Liver Disease 100%
  • Genetic Predisposition to Disease 94%
  • Random Allocation 91%
  • Pancreatic Neoplasms 88%
  • Confidence Intervals 39%

• Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions

  Colon Cancer Family Registry Study (CCFR), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Endometrial Cancer Association Consortium (ECAC), International Lung Cancer Consortium (ILCCO), Ovarian Cancer Association Consortium (OCAC), Pancreatic Cancer Cohort Consortium (PanScan), Pancreatic Cancer Case-Control Consortium (PanC4), The PRACTICAL Consortium, Breast Cancer Association Consortium (BCAC) & Colorectal Transdisciplinary Study (CORECT), Jun 1 2023, In: Journal of the National Cancer Institute. 115, 6, p. 712-732 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Genome 100%
  • Neoplasms 47%
  • Genome-Wide Association Study 29%
  • Transcriptome 12%
  • Kidney Neoplasms 7%

• Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings

  Mastracci, T. L., Apte, M., Amundadottir, L. T., Alvarsson, A., Artandi, S., Bellin, M. D., Bernal-Mizrachi, E., Caicedo, A., Campbell-Thompson, M., Cruz-Monserrate, Z., Ouaamari, A. E., Gaulton, K. J., Geisz, A., Goodarzi, M. O., Hara, M., Hull-Meichle, R. L., Kleger, A., Klein, A. P., Kopp, J. L., Kulkarni, R. N., & 14 othersMuzumdar, M. D., Naren, A. P., Oakes, S. A., Olesen, S. S., Phelps, E. A., Powers, A. C., Stabler, C. L., Tirkes, T., Whitcomb, D. C., Yadav, D., Yong, J., Zaghloul, N. A., Pandol, S. J. & Sander, M., Apr 2023, In: Diabetes. 72, 4, p. 433-448 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Diseases 100%
  • Pancreas 66%
  • Education 48%
  • Exocrine Pancreas 34%
  • Metabolic Diseases 27%

• Rare variant analyses across multiethnic cohorts identify novel genes for refractive error

  Consortium for Refractive Error and Myopia (CREAM), Dec 2023, In: Communications biology. 6, 1, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Refractive Errors 100%
  • Error 63%
  • risk factors 41%
  • heritability 37%
  • Genes 34%

• Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype

  Kim, J., Yuan, C., Amundadottir, L. T., Wolpin, B. M., Klein, A. P., Risch, H. A. & Kraft, P., Sep 1 2023, In: Cancer Epidemiology Biomarkers and Prevention. 32, 9, p. 1242-1248 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lewis Blood Group Antigens 100%
  • Blood Group Antigens 70%
  • Pancreatic Neoplasms 61%
  • Alleles 47%
  • Genotype 46%

• Screening for pancreatic cancer has the potential to save lives, but is it practical?

  Mazer, B. L., Lee, J. W., Roberts, N. J., Chu, L. C., Lennon, A. M., Klein, A. P., Eshleman, J. R., Fishman, E. K., Canto, M. I., Goggins, M. G. & Hruban, R. H., 2023, In: Expert Review of Gastroenterology and Hepatology. 17, 6, p. 555-574 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • Pancreatic Neoplasms 100%
  • Circulating Tumor DNA 37%
  • Artificial Intelligence 34%
  • Pancreatic Diseases 34%
  • Exosomes 31%

• Somatic loss of ATM is a late event in pancreatic tumorigenesis

  Paranal, R. M., Jiang, Z., Hutchings, D., Kryklyva, V., Gauthier, C., Fujikura, K., Nanda, N., Huang, B., Skaro, M., Wolfgang, C. L., He, J., Klimstra, D. S., Brand, R. E., Singhi, A. D., DeMarzo, A., Zheng, L., Goggins, M., Brosens, L. A. A., Hruban, R. H., Klein, A. P., & 3 othersLotan, T., Wood, L. D. & Roberts, N. J., Aug 2023, In: Journal of Pathology. 260, 4, p. 455-464 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Carcinogenesis 100%
  • Adenocarcinoma 68%
  • Mucinous Adenocarcinoma 55%
  • Pancreatic Neoplasms 41%
  • Carcinoma in Situ 24%

• The association between genetically elevated polyunsaturated fatty acids and risk of cancer

  MMAC, ECAC, ILCCO, The PRACTICAL Consortium, PanScan, PANC4, Fatty Acids in Cancer Mendelian Randomization Collaboration, ACCC, CCFR-CORECT-GECCO, EPITHYR & InterLymph, May 2023, In: EBioMedicine. 91, 104510.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyunsaturated Fatty Acid 100%
  • Unsaturated Fatty Acids 90%
  • Fatty Acid Desaturases 36%
  • Random Allocation 30%
  • Esophageal Squamous Cell Carcinoma 27%
• 2022

  Association analyses of rare variants identify two genes associated with refractive error

  Patasova, K., Haarman, A. E. G., Musolf, A. M., Mahroo, O. A., Rahi, J. S., Falchi, M., Verhoeven, V. J. M., Bailey-Wilson, J. E., Klaver, C. C. W., Duggal, P., Klein, A., Guggenheim, J. A., Hammond, C. J. & Hysi, P. G., Sep 2022, In: PloS one. 17, 9 September, e0272379.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Refractive Errors 100%
  • Genes 34%
  • Genome-Wide Association Study 25%
  • Gene Frequency 23%
  • Retina 21%

• Endoplasmic stress-inducing variants in carboxyl ester lipase and pancreatic cancer risk

  Kawamoto, M., Yoshida, T., Tamura, K., Dbouk, M., Canto, M. I., Burkhart, R., He, J., Roberts, N. J., Klein, A. P. & Goggins, M., Nov 2022, In: Pancreatology. 22, 7, p. 959-964 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress 100%
  • Lipase 99%
  • Esters 91%
  • Pancreatic Neoplasms 84%
  • Mason-Type Diabetes 27%

• Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer: A case-control study and meta-analysis

  Kawamoto, M., Kohi, S., Abe, T., Dbouk, M., Macgregor-Das, A., Koi, C., Song, K. B., Borges, M., Sugimine, R., Laheru, D., Hruban, R. H., Roberts, N., Klein, A. P. & Goggins, M., Apr 1 2022, In: International Journal of Cancer. 150, 7, p. 1123-1133 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress 100%
  • Pancreatic Neoplasms 84%
  • Case-Control Studies 72%
  • Meta-Analysis 66%
  • Odds Ratio 41%

• Familial pancreatic cancer: who should be considered for genetic testing?

  Kartal, K., Guan, Z., Tang, R., Griffin, M., Wang, Y., Braun, D., Klein, A. P. & Hughes, K. S., Apr 2022, In: Irish journal of medical science. 191, 2, p. 641-650 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Testing 100%
  • Pancreatic Neoplasms 91%
  • Dysplastic Nevus Syndrome 26%
  • Hereditary Nonpolyposis Colorectal Neoplasms 23%
  • Hereditary Breast and Ovarian Cancer Syndrome 14%

• Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance

  Kimura, H., Paranal, R. M., Nanda, N., Wood, L. D., Eshleman, J. R., Hruban, R. H., Goggins, M. G., Klein, A. P., Brand, R., Cote, M. L., Du, M., Gallinger, S., Goggins, M., Kurtz, R. C., Petersen, G. M., Rustgi, A. K., Schwartz, A. G., Stoffel, E. M., Syngal, S., Zogopoulos, G., & 1 othersRoberts, N. J., Jan 2022, In: eLife. 11, e71137.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alleles 100%
  • Adenocarcinoma 89%
  • Pancreatic Neoplasms 21%
  • Uncertainty 20%
  • Counseling 19%

• Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings

  Mastracci, T. L., Apte, M., Amundadottir, L. T., Alvarsson, A., Artandi, S., Bellin, M. D., Bernal-Mizrachi, E., Caicedo, A., Campbell-Thompson, M., Cruz-Monserrate, Z., El Ouaamari, A., Gaulton, K. J., Geisz, A., Goodarzi, M. O., Hara, M., Hull-Meichle, R. L., Kleger, A., Klein, A. P., Kopp, J. L., Kulkarni, R. N., & 14 othersMuzumdar, M. D., Naren, A. P., Oakes, S. A., Olesen, S. S., Phelps, E. A., Powers, A. C., Stabler, C. L., Tirkes, T., Whitcomb, D. C., Yadav, D., Yong, J., Zaghloul, N. A., Sander, M. & Pandol, S. J., Oct 1 2022, In: Pancreas. 51, 9, p. 1061-1073 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Diseases 100%
  • Pancreas 66%
  • Education 48%
  • Exocrine Pancreas 34%
  • National Institutes of Health (U.S.) 26%

• Pancreatic Adenocarcinoma: Trends in Epidemiology, Risk Factors, and Outcomes

  Afghani, E. & Klein, A. P., Oct 2022, In: Hematology/Oncology Clinics of North America. 36, 5, p. 879-895 17 p.

  Research output: Contribution to journal › Review article › peer-review

• Risk of Pancreatic Cancer in the Long-Term Prospective Follow-Up of Familial Pancreatic Cancer Kindreds

  Porter, N., Laheru, D., Lau, B., He, J., Zheng, L., Narang, A., Roberts, N. J., Canto, M. I., Lennon, A. M., Goggins, M. G., Hruban, R. H. & Klein, A. P., Dec 1 2022, In: Journal of the National Cancer Institute. 114, 12, p. 1681-1688 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Confidence Intervals 22%
  • Incidence 14%
  • Age of Onset 7%
  • Sample Size 6%

• The age-dependent association of risk factors with pancreatic cancer

  PanScan/PanC4 I-III Consortium, Jul 2022, In: Annals of Oncology. 33, 7, p. 693-701 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • SEER Program 55%
  • Genome-Wide Association Study 41%
  • Confidence Intervals 23%
  • Blood Group Antigens 14%

• The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival

  Dbouk, M., Katona, B. W., Brand, R. E., Chak, A., Syngal, S., Farrell, J. J., Kastrinos, F., Stoffel, E. M., Blackford, A. L., Rustgi, A. K., Dudley, B., Lee, L. S., Chhoda, A., Kwon, R., Ginsberg, G. G., Klein, A. P., Kamel, I., Hruban, R. H., He, J., Shin, E. J., & 3 othersLennon, A. M., Canto, M. I. & Goggins, M., Jun 1 2022, In: Journal of Clinical Oncology. 4, JCO.22.00298.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Early Detection of Cancer 100%
  • Pancreatic Neoplasms 99%
  • Adenocarcinoma 82%
  • Survival 58%
  • Pancreas 20%
• 2021

  A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer

  PanScan Consortium & PanC4 Consortium, Oct 7 2021, In: American journal of human genetics. 108, 10, p. 1852-1865 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chymotrypsin 100%
  • Pancreatic Neoplasms 71%
  • Exons 63%
  • Chymotrypsinogen 51%
  • Genome-Wide Association Study 31%

• A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

  PanGenEU Investigators & SBC/EPICURO Investigators, Dec 2021, In: Genome Medicine. 13, 1, 15.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Genetic Predisposition to Disease 97%
  • Pancreatic Neoplasms 90%
  • Computer Simulation 45%
  • Spatial Analysis 41%

• A pooled genome-wide association study identifies pancreatic cancer susceptibility loci on chromosome 19p12 and 19p13.3 in the full-Jewish population

  Streicher, S. A., Klein, A. P., Olson, S. H., Kurtz, R. C., Amundadottir, L. T., DeWan, A. T., Zhao, H. & Risch, H. A., Feb 2021, In: Human genetics. 140, 2, p. 309-319 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Jews 100%
  • Genome-Wide Association Study 74%
  • Pancreatic Neoplasms 67%
  • Chromosomes 56%
  • Single Nucleotide Polymorphism 44%
  1 Scopus citations

• A risk prediction tool for individuals with a family history of breast, ovarian, or pancreatic cancer: BRCAPANCPRO

  Blackford, A. L., Childs, E. J., Porter, N., Petersen, G. M., Rabe, K. G., Gallinger, S., Borgida, A., Syngal, S., Cote, M. L., Schwartz, A. G., Goggins, M. G., Hruban, R. H., Parmigiani, G. & Klein, A. P., Dec 7 2021, In: British journal of cancer. 125, 12, p. 1712-1717 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Ovarian Neoplasms 96%
  • Breast Neoplasms 67%
  • Health Services Needs and Demand 14%
  • Pedigree 14%

• Challenges of the current precision medicine approach for pancreatic cancer: A single institution experience between 2013 and 2017

  Ding, D., Javed, A. A., Cunningham, D., Teinor, J., Wright, M., Javed, Z. N., Wilt, C., Parish, L., Hodgin, M., Ryan, A., Judkins, C., McIntyre, K., Klein, R., Azad, N., Lee, V., Donehower, R., De Jesus-Acosta, A., Murphy, A., Le, D. T., Shin, E. J., & 30 othersLennon, A. M., Khashab, M., Singh, V., Klein, A. P., Roberts, N. J., Hacker-Prietz, A., Manos, L., Walsh, C., Groshek, L., Brown, C., Yuan, C., Blair, A. B., Groot, V., Gemenetzis, G., Yu, J., Weiss, M. J., Burkhart, R. A., Burns, W. R., He, J., Cameron, J. L., Narang, A., Zaheer, A., Fishman, E. K., Thompson, E. D., Anders, R., Hruban, R. H., Jaffee, E., Wolfgang, C. L., Zheng, L. & Laheru, D. A., Jan 28 2021, In: Cancer Letters. 497, p. 221-228 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Precision Medicine 100%
  • Pancreatic Neoplasms 87%
  • Adenocarcinoma 36%
  • High-Throughput Nucleotide Sequencing 33%
  • Clinical Decision-Making 12%
  2 Scopus citations

• Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer

  Zhou, C., Porter, N., Borges, M., Gauthier, C., Ferguson, L., Huang, B., Nanda, N., He, J., Laheru, D., Hruban, R. H., Goggins, M., Klein, A. P. & Roberts, N. J., Aug 2021, In: Pancreatology. 21, 5, p. 938-941 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Methylation 95%
  • BRCA2 Gene 37%
  • BRCA1 Gene 36%
  • Gene Silencing 28%

• Germline sequence analysis of RABL3 in a large series of pancreatic ductal adenocarcinoma patients reveals no evidence of deleterious variants

  the Familial Pancreatic Cancer Genome Sequencing Project, Aug 2021, In: Genes Chromosomes and Cancer. 60, 8, p. 559-564 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sequence Analysis 100%
  • Pancreatic Neoplasms 84%
  • Adenocarcinoma 84%
  • Neoplasm Genes 77%
  • Neoplasms 23%

• Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: A pathway analysis of genome-wide association studies

  Julián-Serrano, S., Yuan, F., Wheeler, W., Benyamin, B., Machiela, M. J., Arslan, A. A., Beane-Freeman, L. E., Bracci, P. M., Duell, E. J., Du, M., Gallinger, S., Giles, G. G., Goodman, P. J., Kooperberg, C., Marchand, L. L., Neale, R. E., Shu, X. O., Van Den Eeden, S. K., Visvanathan, K., Zheng, W., & 59 othersAlbanes, D., Andreotti, G., Ardanaz, E., Babic, A., Berndt, S. I., Brais, L. K., Brennan, P., Bueno-De-Mesquita, B., Buring, J. E., Chanock, S. J., Childs, E. J., Chung, C. C., Fabiánová, E., Foretová, L., Fuchs, C. S., Gaziano, J. M., Gentiluomo, M., Giovannucci, E. L., Goggins, M. G., Hackert, T., Hartge, P., Hassan, M. M., Holcátová, I., Holly, E. A., Hung, R. I., Janout, V., Kurtz, R. C., Lee, I. M., Malats, N., McKean, D., Milne, R. L., Newton, C. C., Oberg, A. L., Perdomo, S., Peters, U., Porta, M., Rothman, N., Schulze, M. B., Sesso, H. D., Silverman, D. T., Thompson, I. M., Wactawski-Wende, J., Weiderpass, E., Wenstzensen, N., White, E., Wilkens, L. R., Yu, H., Zeleniuch-Jacquotte, A., Zhong, J., Kraft, P., Li, D., Campbell, P. T., Petersen, G. M., Wolpin, B. M., Risch, H. A., Amundadottir, L. T., Klein, A. P., Yu, K. & Stolzenberg-Solomon, R. Z., Oct 1 2021, In: American Journal of Clinical Nutrition. 114, 4, p. 1408-1417 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepcidins 100%
  • Genome-Wide Association Study 78%
  • Iron 62%
  • Adenocarcinoma 58%
  • Transferrin Receptors 52%

• Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals

  Endometrial Cancer Association Consortium (ECAC), Esophageal Cancer GWAS Consortium, Glioma International Case Control Consortium (GICC), Head-Neck Cancer GWAS Consortium, International Lung Cancer Consortium (ILCCO), Melanoma GWAS Consortium, Ovarian Cancer Association Consortium (OCAC), Pancreatic Cancer Case-Control Consortium (PanC4), Pancreatic Cancer Cohort Consortium (PanScan), PRACTICAL Consortium, CRUK, BPC3, CAPS, PEGASUS, Renal Cancer GWAS Consortium, Breast Cancer Association Consortium (BCAC), Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR) & Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Jul 8 2021, In: Human Genetics and Genomics Advances. 2, 3, 100041.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasms 100%
  • Estrogen Receptors 62%
  • Prostatic Neoplasms 52%
  • Genome-Wide Association Study 46%
  • Pancreatic Neoplasms 41%

• Novel models of genetic education and testing for pancreatic cancer interception: Preliminary results from the GENERATE study

  Furniss, C. S., Yurgelun, M. B., Ukaegbu, C., Constantinou, P. E., Lafferty, C. C., Talcove-Berko, E. R., Schwartz, A. N., Stopfer, J. E., Underhill-Blazey, M., Kenner, B., Nelson, S. H., Okumura, S., Law, S., Zhou, A. Y., Coffin, T. B., Rodriguez, N. J., Uno, H., Ocean, A. J., McAllister, F., Lowy, A. M., & 8 othersLippman, S. M., Klein, A. P., Madlensky, L., Petersen, G. M., Garber, J. E., Goggins, M. G., Maitra, A. & Syngal, S., Nov 2021, In: Cancer Prevention Research. 14, 11, p. 1021-1032 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Testing 100%
  • Pancreatic Neoplasms 91%
  • Risk Assessment 80%
  • Adenocarcinoma 75%
  • Education 60%

• Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors

  Klein, A. P., Jul 2021, In: Nature Reviews Gastroenterology and Hepatology. 18, 7, p. 493-502 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Pancreatic Neoplasms 100%
  • Life Style 86%
  • Epidemiology 83%
  • Hereditary pancreatitis 24%
  • Neoplasm Genes 16%

• Pancreatic cancer pathology viewed in the light of evolution

  Noë, M., Hong, S. M., Wood, L. D., Thompson, E. D., Roberts, N. J., Goggins, M. G., Klein, A. P., Eshleman, J. R., Kern, S. E. & Hruban, R. H., Sep 2021, In: Cancer and Metastasis Reviews. 40, 3, p. 661-674 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Pathology 66%
  • Adenocarcinoma 41%

• Risk of Pancreatic Cancer among Individuals with Pathogenic Variants in the ATM Gene

  Hsu, F. C., Roberts, N. J., Childs, E., Porter, N., Rabe, K. G., Borgida, A., Ukaegbu, C., Goggins, M. G., Hruban, R. H., Zogopoulos, G., Syngal, S., Gallinger, S., Petersen, G. M. & Klein, A. P., Nov 2021, In: JAMA Oncology. 7, 11, p. 1664-1668 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Genes 42%
  • Penetrance 18%
  • Multicenter Studies 14%
  • Cohort Studies 11%

• Smoking modifies pancreatic cancer risk loci on 2q21.3

  Mocci, E., Kundu, P., Wheeler, W., Arslan, A. A., Beane-Freeman, L. E., Bracci, P. M., Brennan, P., Canzian, F., Du, M., Gallinger, S., Giles, G. G., Goodman, P. J., Kooperberg, C., Le Marchand, L., Neale, R. E., Shu, X. O., Visvanathan, K., White, E., Zheng, W., Albanes, D., & 57 othersAndreotti, G., Babic, A., Bamlet, W. R., Berndt, S. I., Blackford, A. L., Bueno-De-Mesquita, B., Buring, J. E., Campa, D., Chanock, S. J., Childs, E. J., Duell, E. J., Fuchs, C. S., Gaziano, J. M., Giovannucci, E. L., Goggins, M. G., Hartge, P., Hassan, M. M., Holly, E. A., Hoover, R. N., Hung, R. J., Kurtz, R. C., Lee, I. M., Malats, N., Milne, R. L., Ng, K., Oberg, A. L., Panico, S., Peters, U., Porta, M., Rabe, K. G., Riboli, E., Rothman, N., Scelo, G., Sesso, H. D., Silverman, D. T., Stevens, V. L., Strobel, O., Thompson, I. M., Tjonneland, A., Trichopoulou, A., van Den Eeden, S. K., Wactawski-Wende, J., Wentzensen, N., Wilkens, L. R., Yu, H., Yuan, F., Zeleniuch-Jacquotte, A., Amundadottir, L. T., Li, D., Jacobs, E. J., Petersen, G. M., Wolpin, B. M., Risch, H. A., Kraft, P., Chatterjee, N., Klein, A. P. & Stolzenberg-Solomon, R., Jun 1 2021, In: Cancer Research. 81, 11, p. 3134-3143 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Quantitative Trait Loci 99%
  • Single Nucleotide Polymorphism 88%
  • Cyclin T 87%
  • Smoking 76%

• The Role of Inherited Pathogenic CDKN2A Variants in Susceptibility to Pancreatic Cancer

  Kimura, H., Klein, A. P., Hruban, R. H. & Roberts, N. J., Sep 1 2021, In: Pancreas. 50, 8, p. 1123-1130 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Adenocarcinoma 41%
  • p16 Genes 36%
  • Neoplasm Genes 28%
  • Melanoma 21%

• Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer

  Corlin, L., Ruan, M., Tsilidis, K. K., Bouras, E., Yu, Y. H., Stolzenberg-Solomon, R., Klein, A. P., Risch, H. A., Amos, C. I., Sakoda, L. C., Vodička, P., Rish, P. K., Beck, J., Platz, E. A. & Michaud, D. S., Jun 1 2021, In: JNCI Cancer Spectrum. 5, 3, pkab037.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mendelian Randomization Analysis 100%
  • Periodontal Diseases 66%
  • Colorectal Neoplasms 49%
  • Lung Neoplasms 49%
  • Pancreatic Neoplasms 45%
• 2020

  Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

  Glioma International Case-Control Study (GICC), International Lung Cancer Consortium (ILCCO), Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium, International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph), Ovarian Cancer Association Consortium (OCAC), Oral Cancer GWAS, Pancreatic Cancer Case-Control Consortium (PanC4), Pancreatic Cancer Cohort Consortium (PanScan), Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL), Renal Cancer GWAS, Testicular Cancer Consortium (TECAC), Breast Cancer Association Consortium (BCAC), Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON), Colon Cancer Family Registry (CCFR), Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT), Endometrial Cancer Association Consortium (ECAC), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) & Melanoma Genetics Consortium (GenoMEL), Dec 1 2020, In: Nature communications. 11, 1, 3353.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Size Effect 100%
  • cancer 82%
  • genome 57%
  • predictions 47%
  • Genome-Wide Association Study 46%
  9 Scopus citations

• Associations between genetically predicted blood protein biomarkers and pancreatic cancer risk

  Zhu, J., Shu, X., Guo, X., Liu, D., Bao, J., Milne, R. L., Giles, G. G., Wu, C., Du, M., White, E., Risch, H. A., Malats, N., Duell, E. J., Goodman, P. J., Li, D., Bracci, P., Katzke, V., Neale, R. E., Gallinger, S., van Den Eeden, S. K., & 17 othersArslan, A. A., Canzian, F., Kooperberg, C., Beane Freeman, L. E., Scelo, G., Visvanathan, K., Haiman, C. A., Le Marchand, L., Yu, H., Petersen, G. M., Stolzenberg-Solomon, R., Klein, A. P., Cai, Q., Long, J., Shu, X. O., Zheng, W. & Wu, L., Jul 2020, In: Cancer Epidemiology Biomarkers and Prevention. 29, 7, p. 1501-1508 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Blood Proteins 93%
  • Adenocarcinoma 82%
  • Biomarkers 68%
  • Proteins 35%
  4 Scopus citations

• A transcriptome-wide association study identifies novel candidate susceptibility genes for pancreatic cancer

  Zhong, J., Jermusyk, A., Wu, L., Hoskins, J. W., Collins, I., Mocci, E., Zhang, M., Song, L., Chung, C. C., Zhang, T., Xiao, W., Albanes, D., Andreotti, G., Arslan, A. A., Babic, A., Bamlet, W. R., Beane-Freeman, L., Berndt, S., Borgida, A., Bracci, P. M., & 75 othersBrais, L., Brennan, P., Bueno-De-Mesquita, B., Buring, J., Canzian, F., Childs, E. J., Cotterchio, M., Du, M., Duell, E. J., Fuchs, C., Gallinger, S., Michael Gaziano, J., Giles, G. G., Giovannucci, E., Goggins, M., Goodman, G. E., Goodman, P. J., Haiman, C., Hartge, P., Hasan, M., Helzlsouer, K. J., Holly, E. A., Klein, E. A., Kogevinas, M., Kurtz, R. J., LeMarchand, L., Malats, N., Männistö, S., Milne, R., Neale, R. E., Ng, K., Obazee, O., Oberg, A. L., Orlow, I., Patel, A. V., Peters, U., Porta, M., Rothman, N., Scelo, G., Sesso, H. D., Severi, G., Sieri, S., Silverman, D., Sund, M., Tjønneland, A., Thornquist, M. D., Tobias, G. S., Trichopoulou, A., van Den Eeden, S. K., Visvanathan, K., Wactawski-Wende, J., Wentzensen, N., White, E., Yu, H., Yuan, C., Zeleniuch-Jacquotte, A., Hoover, R., Brown, K., Kooperberg, C., Risch, H. A., Jacobs, E. J., Li, D., Yu, K., Shu, X. O., Chanock, S. J., Wolpin, B. M., Stolzenberg-Solomon, R. Z., Chatterjee, N., Klein, A. P., Smith, J. P., Kraft, P., Shi, J., Petersen, G. M., Zheng, W. & Amundadottir, L. T., Oct 1 2020, In: Journal of the National Cancer Institute. 112, 10, p. 1003-1012 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Transcriptome 97%
  • Genes 42%
  • Genotype 37%
  • Genome-Wide Association Study 36%
  9 Scopus citations

• Bayesian copy number detection and association in large-scale studies

  Cristiano, S., McKean, D., Carey, J., Bracci, P., Brennan, P., Chou, M., Du, M., Gallinger, S., Goggins, M. G., Hassan, M. M., Hung, R. J., Kurtz, R. C., Li, D., Lu, L., Neale, R., Olson, S., Petersen, G., Rabe, K. G., Fu, J., Risch, H., & 4 othersRosner, G. L., Ruczinski, I., Klein, A. P. & Scharpf, R. B., Sep 7 2020, In: BMC cancer. 20, 1, 856.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Pancreatic Neoplasms 90%
  • Oncogenes 45%
  • Uncertainty 43%
  • Noise 43%

• Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing

  Macgregor-Das, A., Yu, J., Tamura, K., Abe, T., Suenaga, M., Shindo, K., Borges, M., Koi, C., Kohi, S., Sadakari, Y., Dal Molin, M., Almario, J. A., Ford, M., Chuidian, M., Burkhart, R., He, J., Hruban, R. H., Eshleman, J. R., Klein, A. P., Wolfgang, C. L., & 2 othersCanto, M. I. & Goggins, M., Jun 2020, In: Journal of Molecular Diagnostics. 22, 6, p. 748-756 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circulating Tumor DNA 100%
  • High-Throughput Nucleotide Sequencing 66%
  • Pancreatic Neoplasms 65%
  • Mutation 38%
  • DNA 27%
  2 Scopus citations

• Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

  Lennon, A. M., Buchanan, A. H., Kinde, I., Warren, A., Honushefsky, A., Cohain, A. T., Ledbetter, D. H., Sanfilippo, F., Sheridan, K., Rosica, D., Adonizio, C. S., Hwang, H. J., Lahouel, K., Cohen, J. D., Douville, C., Pate, A. A., Hagmann, L. N., Rolston, D. D., Malani, N., Zhou, S., & 20 othersBettegowda, C., Diehl, D. L., Urban, B., Still, C. D., Kann, L., Woods, J. I., Salvati, Z. M., Vadakara, J., Leeming, R., Bhattacharya, P., Walter, C., Parker, A., Lengauer, C., Klein, A., Tomasetti, C., Fishman, E. K., Hruban, R. H., Kinzler, K. W., Vogelstein, B. & Papadopoulos, N., Jul 3 2020, In: Science. 369, 6499, eabb9601.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Positron Emission Tomography Computed Tomography 100%
  • Hematologic Tests 31%
  • Neoplasms 29%
  • Blood Safety 21%
  • Standard of Care 14%
  66 Scopus citations

• Genetic and circulating biomarker data improve risk prediction for pancreatic cancer in the general population

  Kim, J., Yuan, C., Babic, A., Bao, Y., Clish, C. B., Pollak, M. N., Amundadottir, L. T., Klein, A. P., Stolzenberg-Solomon, R. Z., Pandharipande, P. V., Brais, L. K., Welch, M. W., Ng, K., Giovannucci, E. L., Sesso, H. D., Manson, J. A. E., Stampfer, M. J., Fuchs, C. S., Wolpin, B. M. & Kraft, P., May 2020, In: Cancer Epidemiology Biomarkers and Prevention. 29, 5, p. 999-1008 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms 100%
  • Biomarkers 68%
  • Population 41%
  • Genetic Polymorphisms 12%
  • ROC Curve 9%
  3 Scopus citations

• Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer

  Abe, T., Koi, C., Kohi, S., Song, K. B., Tamura, K., Macgregor-Das, A., Kitaoka, N., Chuidian, M., Ford, M., Dbouk, M., Borges, M., He, J., Burkhart, R., Wolfgang, C. L., Klein, A. P., Eshleman, J. R., Hruban, R. H., Canto, M. I. & Goggins, M., May 2020, In: Clinical Gastroenterology and Hepatology. 18, 5, p. 1161-1169.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Biomarkers 100%
  • Pancreatic Neoplasms 97%
  • Single Nucleotide Polymorphism 68%
  • Antigens 65%
  • Carbohydrates 59%
  8 Scopus citations

• Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk

  Yuan, F., Hung, R. J., Walsh, N., Zhang, H., Platz, E. A., Wheeler, W., Song, L., Arslan, A. A., Beane Freeman, L. E., Bracci, P., Canzian, F., Du, M., Gallinger, S., Giles, G. G., Goodman, P. J., Kooperberg, C., Le Marchand, L., Neale, R. E., Rosendahl, J., Scelo, G., & 55 othersShu, X. O., Visvanathan, K., White, E., Zheng, W., Albanes, D., Amiano, P., Andreotti, G., Babic, A., Bamlet, W. R., Berndt, S. I., Brennan, P., Bueno-De-Mesquita, B., Buring, J. E., Campbell, P. T., Chanock, S. J., Fuchs, C. S., Michael Gaziano, J., Goggins, M. G., Hackert, T., Hartge, P., Hassan, M. M., Holly, E. A., Hoover, R. N., Katzke, V., Kirsten, H., Kurtz, R. C., Lee, I. M., Malats, N., Milne, R. L., Murphy, N., Ng, K., Oberg, A. L., Porta, M., Rabe, K. G., Real, F. X., Rothman, N., Sesso, H. D., Silverman, D. T., Thompson, I. M., Wactawski-Wende, J., Wang, X., Wentzensen, N., Wilkens, L. R., Yu, H., Zeleniuch-Jacquotte, A., Shi, J., Duell, E. J., Amundadottir, L. T., Li, D., Petersen, G. M., Wolpin, B. M., Risch, H. A., Yu, K., Klein, A. P. & Stolzenberg-Solomon, R., Sep 15 2020, In: Cancer Research. 80, 18, p. 4004-4013 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intestinal Diseases 100%
  • Genome-Wide Association Study 82%
  • Genetic Predisposition to Disease 80%
  • Adenocarcinoma 61%
  • Ulcerative Colitis 38%
  1 Scopus citations

• Genome-wide gene⇓diabetes and gene⇓obesity interaction scan in 8,255 cases and 11,900 controls from panscan and PanC4 consortia

  Tang, H., Jiang, L., Stolzenberg-Solomon, R. Z., Arslan, A. A., Beane Freeman, L. E., Bracci, P. M., Brennan, P., Canzian, F., Du, M., Gallinger, S., Giles, G. G., Goodman, P. J., Kooperberg, C., Le Marchand, L., Neale, R. E., Shu, X. O., Visvanathan, K., White, E., Zheng, W., Albanes, D., & 51 othersAndreotti, G., Babic, A., Bamlet, W. R., Berndt, S. I., Blackford, A., Bueno-De-Mesquita, B., Buring, J. E., Campa, D., Chanock, S. J., Childs, E., Duell, E. J., Fuchs, C., Michael Gaziano, J., Goggins, M., Hartge, P., Hassam, M. H., Holly, E. A., Hoover, R. N., Hung, R. J., Kurtz, R. C., Lee, I. M., Malats, N., Milne, R. L., Ng, K., Oberg, A. L., Orlow, I., Peters, U., Porta, M., Rabe, K. G., Rothman, N., Scelo, G., Sesso, H. D., Silverman, D. T., Thompson, I. M., Tjønneland, A., Trichopoulou, A., Wactawski-Wende, J., Wentzensen, N., Wilkens, L. R., Yu, H., Zeleniuch-Jacquotte, A., Amundadottir, L. T., Jacobs, E. J., Petersen, G. M., Wolpin, B. M., Risch, H. A., Chatterjee, N., Klein, A. P., Li, D., Kraft, P. & Wei, P., Sep 2020, In: Cancer Epidemiology Biomarkers and Prevention. 29, 9, p. 1784-1791 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Neoplasms 100%
  • Genome-Wide Association Study 73%
  • Genome 71%
  • Single Nucleotide Polymorphism 59%
  • Obesity 49%
  2 Scopus citations

• Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium

  Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E. K., Fockens, P., Gress, T. M., Van Hooft, J. E., Hruban, R. H., Kastrinos, F., Klein, A., Lennon, A. M., Lucas, A., Park, W., Rustgi, A., & 6 othersSimeone, D., Stoffel, E., Vasen, H. F. A., Cahen, D. L., Canto, M. I. & Bruno, M., Jan 1 2020, In: Gut. 69, 1, p. 7-17 11 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Consensus 100%
  • Early Detection of Cancer 99%
  • Pancreatic Neoplasms 99%
  • Germ-Line Mutation 39%
  • Hereditary pancreatitis 28%
  60 Scopus citations

• Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk

  Ghoneim, D. H., Zhu, J., Zheng, W., Long, J., Murff, H. J., Ye, F., Setiawan, V. W., Wilkens, L. R., Khankari, N. K., Haycock, P., Antwi, S. O., Yang, Y., Arslan, A. A., Freeman, L. E. B., Bracci, P. M., Canzian, F., Du, M., Gallinger, S., Giles, G. G., Goodman, P. J., & 57 othersKooperberg, C., Marchand, L. L., Neale, R. E., Scelo, G., Visvanathan, K., White, E., Albane, D., Amiano, P., Andreott, G., Babic, A., Bamlet, W. R., Berndt, S. I., Brais, L. K., Brennan, P., Bueno-De-Mesquita, B., Buring, J. E., Campbell, P. T., Rabe, K. G., Chanock, S. J., Duggal, P., Fuchs, C. S., Gaziano, J. M., Goggins, M. G., Hackert, T., Hassan, M. M., Helzlsouer, K. J., Holly, E. A., Hoover, R. N., Katske, V., Kurtz, R. C., Lee, I. M., Malats, N., Milne, R. L., Murphy, N., Oberg, A. L., Porta, M., Rothman, N., Sesso, H. D., Silverman, D. T., Ian, T., Wactawski-Wende, J., Wang, X., Wentzensen, N., Yu, H., Zeleniuch-Jacquotte, A., Yu, K., Wolpin, B. M., Jacobs, E. J., Duell, E. J., Risch, H. A., Petersen, G. M., Amundadottir, L. T., Kraft, P., Klein, A. P., Stolzenberg-Solomon, R. Z., Shu, X. O. & Wu, L., Dec 2020, In: Cancer Epidemiology Biomarkers and Prevention. 29, 12, p. 2735-2739 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mendelian Randomization Analysis 100%
  • Unsaturated Fatty Acids 66%
  • Pancreatic Neoplasms 58%
  • Odds Ratio 22%
  • Confidence Intervals 15%