Alison Klein

Professor

19992019
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Research Output 1999 2019

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Article
2009

Serum fatty acid synthase as a marker of pancreatic neoplasia

Walter, K., Hong, S. M., Nyhan, S., Canto, M., Fedarko, N. S., Klein, A., Griffith, M., Omura, N., Medghalchi, S., Kuhajda, F. & Goggins, M. S., Sep 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 9, p. 2380-2385 6 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Serum
Neoplasms
Adenocarcinoma
Chronic Pancreatitis

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

Blackford, A., Serrano, O. K., Wolfgang, C., Parmigiani, G., Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Eshleman, J., Goggins, M. S., Jaffee, E., Iacobuzio-Donahue, C. A., Maitra, A., Cameron, J. L., Olino, K., Schulick, R., Winter, J., Herman, J. M., Laheru, D. & 5 others, Klein, A., Vogelstein, B., Kinzler, K. W., Velculescu, V. E. & Hruban, R. H., Jul 15 2009, In : Clinical Cancer Research. 15, 14, p. 4674-4679 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Adenocarcinoma
Gene Silencing
Mutation
2008

Allele-specific expression in the germline of patients with familial pancreatic cancer: An unbiased approach to cancer gene discovery

Aik, C. T., Fan, J. B., Karikari, C., Bibikova, M., Garcia, E. W., Zhou, L., Barker, D., Serre, D., Feldmann, G., Hruban, R. H., Klein, A., Goggins, M. S., Couch, F. J., Hudson, T. J., Winslow, R., Maitra, A. & Chakravarti, A., Jan 2008, In : Cancer Biology and Therapy. 7, 1, p. 137-146 10 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Genetic Association Studies
Pancreatic Neoplasms
Alleles
Genes

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., Hong, S. M., Fu, B., Lin, M-T., Calhoun, E. S., Kamiyama, M., Walter, K., Nikolskaya, T., Nikolsky, Y., Hartigan, J., Smith, D. R. & 16 others, Hidalgo, M., Leach, S. D., Klein, A., Jaffee, E., Goggins, M. S., Maitra, A., Iacobuzio-Donahue, C., Eshleman, J., Kern, S. E., Hruban, R. H., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V. E. & Kinzler, K. W., Sep 26 2008, In : Science. 321, 5897, p. 1801-1806 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Gene Expression Profiling
Oligonucleotide Array Sequence Analysis
Point Mutation

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

Serous Cystadenocarcinoma
Neoplasms
Proteins
Carcinoma, Ductal, Breast
Human Chromosomes

Genetic and epigenetic alterations of familial pancreatic cancers

Brune, K., Hong, S. M., Li, A., Yachida, S., Abe, T., Griffith, M., Yang, D., Omura, N., Eshleman, J., Canto, M., Schulick, R., Klein, A., Hruban, R. H., Iacobuzio-Donohue, C. & Goggins, M. S., Dec 2008, In : Cancer Epidemiology Biomarkers and Prevention. 17, 12, p. 3536-3542 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epigenomics
Adenocarcinoma
Methylation
Mutation

Incorporating tumor immunohistochemical markers in BRCA1 and BRCA2 carrier prediction

Tai, Y. C., Chen, S., Parmigiani, G. & Klein, A., Mar 20 2008, In : Breast Cancer Research. 10, 2, 401.

Research output: Contribution to journalArticle

BRCA2 Protein
BRCA1 Protein
Predictive Value of Tests
Genetic Predisposition to Disease
Heterozygote

Pancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study

De Gonzalez, A. B., Ji, E. Y., Lee, S. Y., Klein, A. & Sun, H. J., Feb 1 2008, In : Cancer Epidemiology Biomarkers and Prevention. 17, 2, p. 359-364 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Insulin Resistance
Neoplasms
Aspartate Aminotransferases
Alanine Transaminase

Prevalence of unsuspected pancreatic cysts on MDCT

Laffan, T. A., Horton, K. M., Klein, A., Berlanstein, B., Siegelman, S. S., Kawamoto, S., Johnson, P., Fishman, E. K. & Hruban, R. H., Sep 2008, In : American Journal of Roentgenology. 191, 3, p. 802-807 6 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Pancreas
Outpatients
Pancreatic Diseases
2007

Confirmation of linkage to ocular refraction on chromosome 22q and identification of a novel linkage region on 1q

Klein, A., Duggal, P., Lee, K. E., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Jan 2007, In : Archives of Ophthalmology. 125, 1, p. 80-85 6 p.

Research output: Contribution to journalArticle

Ocular Refraction
Myopia
Rodentia
Chromosomes
Sclerosis

Copy-number variants in patients with a strong family history of pancreatic cancer

Lucito, R., Suresh, S., Walter, K., Pandey, A., Lakshmi, B., Krasnitz, A., Sebat, J., Wigler, M., Klein, A., Brune, K., Palmisano, E., Maitra, A., Goggins, M. S. & Hruban, R. H., Oct 2007, In : Cancer Biology and Therapy. 6, 10, p. 1592-1599 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Germ Cells
Genes
Chromosomes, Human, Pair 19
Inborn Genetic Diseases

Familial pancreatic cancer: from genes to improved patient care.

Hruban, R. H., Klein, A., Eshleman, J., Axilbund, J. E. & Goggins, M. S., Oct 2007, In : Expert Review of Gastroenterology and Hepatology. 1, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Pancreatic Neoplasms
Patient Care
Mutation
Germ-Line Mutation

Identification of novel genetic loci for intraocular pressure: A genomewide scan of the beaver dam eye study

Duggal, P., Klein, A., Lee, K. E., Klein, R., Klein, B. E. K. & Bailey-Wilson, J. E., Jan 2007, In : Archives of Ophthalmology. 125, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

Genetic Loci
Intraocular Pressure
Rodentia
Internal-External Control
Blood Pressure

In reply [13]

Wang, W., Chen, S., Brune, K. A., Hruban, R. H., Parmigiani, G. & Klein, A., Nov 20 2007, In : Journal of Clinical Oncology. 25, 33, p. 5337-5338 2 p.

Research output: Contribution to journalArticle

Linkage analysis of chromosome 4 in families with familial pancreatic cancer

Klein, A., De Andrade, M., Hruban, R. H., Bondy, M., Schwartz, A. G., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., Goggins, M. S. & Petersen, G. M., Mar 2007, In : Cancer Biology and Therapy. 6, 3, p. 320-323 4 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 4
Pancreatic Neoplasms
Cluster Analysis
Adenocarcinoma
Chromosomes

Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells

Salaria, S. N., Illei, P. B., Sharma, R., Walter, K. M., Klein, A., Eshleman, J., Maitra, A., Schulick, R., Winter, J., Ouellette, M. M., Goggins, M. S. & Hruban, R. H., Mar 2007, In : Cancer Biology and Therapy. 6, 3, p. 324-328 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Adenocarcinoma
Stromal Cells
Cell Line

PancPRO: Risk assessment for individuals with a family history of pancreatic cancer

Wang, W., Chen, S., Brune, K. A., Hruban, R. H., Parmigiani, G. & Klein, A., Apr 10 2007, In : Journal of Clinical Oncology. 25, 11, p. 1417-1422 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Genes
Registries
Aptitude
ROC Curve

Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma

Infante, J. R., Matsubayashi, H., Sato, N., Tonascia, J. A., Klein, A., Riall, T. A., Yeo, C., Iacobuzio-Donahue, C. & Goggins, M. S., Jan 20 2007, In : Journal of Clinical Oncology. 25, 3, p. 319-325 7 p.

Research output: Contribution to journalArticle

Cysteine
Adenocarcinoma
Fibroblasts
Proteins
Pancreatic Neoplasms

The GLC1H glaucoma locus may reflect glaucoma with elevated intraocular pressure [4]

Duggal, P., Klein, A., Lee, K. E., Klein, R., Klein, B. E. K. & Bailey-Wilson, J. E., Dec 2007, In : Archives of Ophthalmology. 125, 12, p. 1716-1717 2 p.

Research output: Contribution to journalArticle

Eye Proteins
Transcription Factor TFIIIA
Lod Score
Genetic Linkage
Cytoskeletal Proteins

The prevalence of BRCA2 mutations in familial pancreatic cancer

Couch, F. J., Johnson, M. R., Rabe, K. G., Brune, K., De Andrade, M., Goggins, M. S., Rothenmund, H., Gallinger, S., Klein, A., Petersen, G. M. & Hruban, R. H., Feb 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 2, p. 342-346 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Ovarian Neoplasms
BRCA2 Gene
Breast Neoplasms

Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer

Matsubayashi, H., Infante, J. R., Winter, J., Klein, A., Schulick, R., Hruban, R. H., Visvanathan, K. & Goggins, M. S., Oct 2007, In : Cancer Biology and Therapy. 6, 10, p. 1569-1575 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Survival
Kaplan-Meier Estimate
Proportional Hazards Models
2006

DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease

Matsubayashi, H., Canto, M., Sato, N., Klein, A., Abe, T., Yamashita, K., Yeo, C. J., Kalloo, A. N., Hruban, R. H. & Goggins, M. S., Jan 15 2006, In : Cancer Research. 66, 2, p. 1208-1217 10 p.

Research output: Contribution to journalArticle

Pancreatic Juice
Pancreatic Diseases
DNA Methylation
Methylation
Pancreatic Neoplasms

Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: Relationship to molecular mechanisms of gemcitabine resistance and survival

Sebastiani, V., Ricci, F., Rubio-Viquiera, B., Kulesza, P., Yeo, C. J., Hidalgo, M., Klein, A., Laheru, D. & Iacobuzio-Donahue, C. A., Apr 15 2006, In : Clinical Cancer Research. 12, 8, p. 2492-2497 6 p.

Research output: Contribution to journalArticle

gemcitabine
Deoxycytidine Kinase
Pancreatic Neoplasms
Survival
Lymphocytes

Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer

Brune, K., Abe, T., Canto, M., O'Malley, L., Klein, A., Maitra, A., Volkan Adsay, N., Fishman, E. K., Cameron, J. L., Yeo, C. J., Kern, S. E., Goggins, M. S. & Hruban, R. H., Sep 2006, In : American Journal of Surgical Pathology. 30, 9, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Atrophy
Pancreas
Neoplasms
Tomography

Pancreatic cancer genetic epidemiology consortium

Petersen, G. M., De Andrade, M., Goggins, M. S., Hruban, R. H., Bondy, M., Korczak, J. F., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., Seminara, D. & Klein, A., Apr 2006, In : Cancer Epidemiology Biomarkers and Prevention. 15, 4, p. 704-710 7 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Pancreatic Neoplasms
Epidemiology
Referral and Consultation
Genetic Research

Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations

Hruban, R. H., Adsay, N. V., Albores-Saavedra, J., Anver, M. R., Biankin, A. V., Boivin, G. P., Furth, E. E., Furukawa, T., Klein, A., Klimstra, D. S., Kloppel, G., Lauwers, G. Y., Longnecker, D. S., Luttges, J., Maitra, A., Offerhaus, G. J. A., Pérez-Gallego, L., Redston, M. & Tuveson, D. A., Jan 1 2006, In : Cancer Research. 66, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Consensus
Pathology
Terminology
Neoplasms
2005

A genetic contribution to intraocular pressure: The Beaver Dam Eye Study

Duggal, P., Klein, A., Lee, K. E., Iyengar, S. K., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Feb 2005, In : Investigative Ophthalmology and Visual Science. 46, 2, p. 555-560 6 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Rodentia
Genome
Multifactorial Inheritance
Genes

Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium

Duggal, P., Gillanders, E. M., Mathias, R., Ibay, G. P., Klein, A., Baffoe-Bonnie, A. B., Ou, L., Dusenberry, I. P., Tsai, Y. Y., Chines, P. S., Doan, B. Q. & Bailey-Wilson, J. E., Dec 30 2005, In : BMC Genetics. 6, SUPPL.1, S73.

Research output: Contribution to journalArticle

Linkage Disequilibrium
Single Nucleotide Polymorphism
Alcoholism
Education

Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits

Klein, A., Tsai, Y. Y., Duggal, P., Gillanders, E. M., Barnhart, M., Mathias, R., Dusenberry, I. P., Turiff, A., Chines, P. S., Goldstein, J., Wojciechowski, R., Hening, W., Pugh, E. & Bailey-Wilson, J. E., Dec 30 2005, In : BMC Genetics. 6, SUPPL.1, S20.

Research output: Contribution to journalArticle

Linkage Disequilibrium
Single Nucleotide Polymorphism
Alcoholism
Aptitude
Microsatellite Repeats

Overview of linkage analysis: application to pancreatic cancer.

Klein, A., 2005, In : Methods in molecular medicine. 103, p. 329-341 13 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genes
Genetic Loci
Neoplasm Genes
Research Personnel

Polygenic effects and cigarette smoking account for a portion of the familial aggregation of nuclear sclerosis

Klein, A., Duggal, P., Lee, K. E., O'Neill, J. A., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Apr 15 2005, In : American Journal of Epidemiology. 161, 8, p. 707-713 7 p.

Research output: Contribution to journalArticle

Sclerosis
Smoking
Cataract
Blindness
Pedigree

Support for polygenic influences on ocular refractive error

Klein, A., Duggal, P., Lee, K. E., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Feb 2005, In : Investigative Ophthalmology and Visual Science. 46, 2, p. 442-446 5 p.

Research output: Contribution to journalArticle

Refractive Errors
Myopia
Sex Education
Ocular Refraction
Hyperopia

Treatment of familial pancreatic cancer and its precursors

Hruban, R. H., Canto, M., Griffin, C., Kern, S. E., Klein, A., Laheru, D. & Yeo, C. J., Oct 2005, In : Current Treatment Options in Gastroenterology. 8, 5, p. 365-375 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Therapeutics
Pancreas
p16 Genes
Diet Therapy
2004

GeneLink: A database to facilitate genetic studies of complex traits

Gillanders, E. M., Masiello, A., Gildea, D., Umayam, L., Duggal, P., Jones, M. P., Klein, A., Freas-Lutz, D., Ibay, G., Trout, K., Wolfsberg, T. G., Trent, J. M., Bailey-Wilson, J. E. & Baxevanis, A. D., Oct 18 2004, In : BMC Genomics. 5, 81.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Genetic Linkage
Chromosome Mapping
Information Storage and Retrieval
Pedigree

Genetic research involving human biological materials: A need to tailor consent forms

Hull, S. C., Gooding, H., Klein, A., Warshauer-Baker, E., Metosky, S. & Wilfond, B. S., May 2004, In : IRB Ethics and Human Research. 26, 3, p. 1-7 7 p.

Research output: Contribution to journalArticle

Consent Forms
genetic research
Genetic Research
Ownership
Confidentiality

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

Klein, A., Brune, K. A., Petersen, G. M., Goggins, M. S., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S. E. & Hruban, R. H., Apr 1 2004, In : Cancer Research. 64, 7, p. 2634-2638 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Confidence Intervals
2003

Importance sampling method of correction for multiple testing in affected sib-pair linkage analysis.

Klein, A., Kovac, I., Sorant, A. J. M., Baffoe-Bonnie, A., Doan, B. Q., Ibay, G., Lockwood, E., Mandal, D., Santhosh, L., Weissbecker, K., Woo, J., Zambelli-Weiner, A., Zhang, J., Naiman, D. Q., Malley, J. & Bailey-Wilson, J. E., 2003, In : BMC Genetics. 4 Suppl 1, S73.

Research output: Contribution to journalArticle

Education
Datasets
2002

Evidence for a major gene influencing risk of pancreatic cancer

Klein, A., Beaty, T. L., Bailey-Wilson, J. E., Brune, K. A., Hruban, R. H. & Petersen, G. M., Aug 2002, In : Genetic Epidemiology. 23, 2, p. 133-149 17 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genes
Age of Onset
Smoking
Dysplastic Nevus Syndrome
2001

Familial Pancreatic Cancer

Klein, A., Hruban, R. H., Brune, K. A., Petersen, G. M. & Goggins, M. S., Jul 2001, In : Cancer Journal. 7, 4, p. 266-273 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Dysplastic Nevus Syndrome
Peutz-Jeghers Syndrome
Hereditary Nonpolyposis Colorectal Neoplasms
Germ-Line Mutation

Multilocus linkage analysis of the German asthma data

Zandi, P. P., Klein, A., Addington, A. M., Hetmanski, J. B., Roberts, L., Peila, R., Shrestha, S., Shaw, C. K., Heng Chew Kiat, C. K., Langefeld, C. D. & Beaty, T. L., 2001, In : Genetic Epidemiology. 21, SUPPL. 1

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 2
Asthma
Logistic Models
Regression Analysis
Chromosomes, Human, Pair 15

Multipoint linkage analysis under heterogeneity: Incorporation of parametric and nonparametric approaches

Chiu, Y. F., Addington, A. M., Beaty, T. L., Klein, A. & Liang, K. Y., 2001, In : Genetic Epidemiology. 21, SUPPL. 1

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 6
Information Dissemination
Genetic Models
Asthma
Genome
1999

Environmental covariates: Effects on the power of sib-pair linkage methods

Mandal, D. M., Sorant, A. J. M., Pugh, E., Marcus, S. E., Klein, A., Mathias, R., O'Neill, J., Temiyakarn, L. F., Wilson, A. F. & Bailey-Wilson, J. E., 1999, In : Genetic Epidemiology. 17, SUPPL. 1

Research output: Contribution to journalArticle

Possible linkage of alcoholism, monoamine oxidase activity and P300 amplitude to markers on chromosome 12q24

Juo, S. H. H., Pugh, E., Baffoe-Bonnie, A., Kingman, A., Sorant, A. J. M., Klein, A., O'Neill, J., Mathias, R., Wilson, A. F. & Bailey-Wilson, J. E., 1999, In : Genetic Epidemiology. 17, SUPPL. 1

Research output: Contribution to journalArticle

Monoamine Oxidase
Genetic Markers
Alcoholism
Alleles