Alison Klein

Professor

19992019
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Research Output 1999 2019

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Article
Article
Blood Group Antigens
Pancreatic Neoplasms
Genome-Wide Association Study
Genes
Telomerase

Absence of deleterious palladin mutations in patients with familial pancreatic cancer

Klein, A., Borges, M., Griffith, M., Brune, K., Hong, S. M., Omura, N., Hruban, R. H. & Goggins, M. S., Apr 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 4, p. 1328-1330 3 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genes
Germ-Line Mutation

Absence of germline BRCA1 mutations in familial pancreatic cancer patients

Axilbund, J. E., Argani, P., Kamiyama, M., Palmisano, E., Raben, M., Borges, M., Brune, K. A., Goggins, M. S., Hruban, R. H. & Klein, A., Jan 2009, In : Cancer Biology and Therapy. 8, 2, p. 131-135 5 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Pancreatic Neoplasms
BRCA1 Gene
Ovarian Neoplasms
Breast Neoplasms

A genetic contribution to intraocular pressure: The Beaver Dam Eye Study

Duggal, P., Klein, A., Lee, K. E., Iyengar, S. K., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Feb 2005, In : Investigative Ophthalmology and Visual Science. 46, 2, p. 555-560 6 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Rodentia
Genome
Multifactorial Inheritance
Genes

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Petersen, G. M., Amundadottir, L., Fuchs, C. S., Kraft, P., Stolzenberg-Solomon, R. Z., Jacobs, K. B., Arslan, A. A., Bueno-De-Mesquita, H. B., Gallinger, S., Gross, M., Helzlsouer, K., Holly, E. A., Jacobs, E. J., Klein, A., Lacroix, A., Li, D., Mandelson, M. T., Olson, S. H., Risch, H. A., Zheng, W. & 53 others, Albanes, D., Bamlet, W. R., Berg, C. D., Boutron-Ruault, M. C., Buring, J. E., Bracci, P. M., Canzian, F., Clipp, S., Cotterchio, M., De Andrade, M., Duell, E. J., Gaziano, J. M., Giovannucci, E. L., Goggins, M. S., Hallmans, G., Hankinson, S. E., Hassan, M., Howard, B., Hunter, D. J., Hutchinson, A., Jenab, M., Kaaks, R., Kooperberg, C., Krogh, V., Kurtz, R. C., Lynch, S. M., McWilliams, R. R., Mendelsohn, J. B., Michaud, D. S., Parikh, H., Patel, A. V., Peeters, P. H. M., Rajkovic, A., Riboli, E., Rodriguez, L., Seminara, D., Shu, X. O., Thomas, G., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Van Den Eeden, S. K., Virtamo, J., Wactawski-Wende, J., Wang, Z., Wolpin, B. M., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Fraumeni, J. F., Hoover, R. N., Hartge, P. & Chanock, S. J., Mar 2010, In : Nature Genetics. 42, 3, p. 224-228 5 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pancreatic Neoplasms
Single Nucleotide Polymorphism
Chromosomes
Alleles

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Walsh, N., Zhang, H., Hyland, P. L., Yang, Q., Mocci, E., Zhang, M., Childs, E. J., Collins, I., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P. M., Brennan, P., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goggins, M., Goodman, G. E., Goodman, P. J. & 78 others, Hung, R. J., Kooperberg, C., Kurtz, R. C., Malats, N., Lemarchand, L., Neale, R. E., Olson, S. H., Scelo, G., Shu, X. O., Van Den Eeden, S. K., Visvanathan, K., White, E., Zheng, W., Albanes, D., Andreotti, G., Babic, A., Bamlet, W. R., Berndt, S. I., Borgida, A., Boutron-Ruault, M. C., Brais, L., Bueno-De-Mesquita, B., Buring, J., Chaffee, K. G., Chanock, S., Cleary, S., Cotterchio, M., Foretova, L., Fuchs, C., M Gaziano, J. M., Giovannucci, E., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Helzlsouer, K. J., Herman, J., Holcatova, I., Holly, E. A., Hoover, R., Janout, V., Klein, E. A., Laheru, D., Lee, I. M., Lu, L., Mannisto, S., Milne, R. L., Oberg, A. L., Orlow, I., Patel, A. V., Peters, U., Porta, M., Real, F. X., Rothman, N., Sesso, H. D., Severi, G., Silverman, D., Strobel, O., Sund, M., Thornquist, M. D., Tobias, G. S., Wactawski-Wende, J., Wareham, N., Weiderpass, E., Wentzensen, N., Wheeler, W., Yu, H., Zeleniuch-Jacquotte, A., Kraft, P., Li, D., Jacobs, E. J., Petersen, G. M., Wolpin, B. M., Risch, H. A., Amundadottir, L. T., Yu, K., Klein, A. P. & Stolzenberg-Solomon, R. Z., Jun 1 2019, In : Journal of the National Cancer Institute. 111, 6, p. 557-567 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pancreatic Neoplasms
Genes
Single Nucleotide Polymorphism
Adenocarcinoma

A histomorphologic comparison of familial and sporadic pancreatic cancers

Singhi, A. D., Ishida, H., Ali, S. Z., Goggins, M. S., Canto, M., Wolfgang, C., Meriden, Z., Roberts, N., Klein, A. & Hruban, R. H., Jul 1 2015, In : Pancreatology. 15, 4, p. 387-391 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Dysplastic Nevus Syndrome
Peutz-Jeghers Syndrome
Neoplasms

Allele-specific expression in the germline of patients with familial pancreatic cancer: An unbiased approach to cancer gene discovery

Aik, C. T., Fan, J. B., Karikari, C., Bibikova, M., Garcia, E. W., Zhou, L., Barker, D., Serre, D., Feldmann, G., Hruban, R. H., Klein, A., Goggins, M. S., Couch, F. J., Hudson, T. J., Winslow, R., Maitra, A. & Chakravarti, A., Jan 2008, In : Cancer Biology and Therapy. 7, 1, p. 137-146 10 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Genetic Association Studies
Pancreatic Neoplasms
Alleles
Genes

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A. K., Jinawath, A., Yeo, C. J., Eshleman, J., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S., May 1 2017, In : Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

Research output: Contribution to journalArticle

Cadherins
Adenocarcinoma
Loss of Heterozygosity
Pancreatic Neoplasms
Carcinogenesis

Altered telomeres in tumors with ATRX and DAXX mutations

Heaphy, C. M., De Wilde, R. F., Jiao, Y., Klein, A. P., Edil, B. H., Shi, C., Bettegowda, C., Rodriguez, F. J., Eberhart, C. G., Hebbar, S., Offerhaus, G. J., McLendon, R., Rasheed, B. A., He, Y., Yan, H., Bigner, D. D., Oba-Shinjo, S. M., Marie, S. K. N., Riggins, G. J., Kinzler, K. W. & 5 others, Vogelstein, B., Hruban, R. H., Maitra, A., Papadopoulos, N. & Meeker, A. K., Jul 22 2011, In : Science. 333, 6041, p. 425 1 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
DNA Helicases
Neuroendocrine Carcinoma
Central Nervous System Neoplasms
Chromatin Assembly and Disassembly

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Cyst Fluid
Practice Management
Standard of Care

An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population

Klein, A., Lindström, S., Mendelsohn, J. B., Steplowski, E., Arslan, A. A., Bueno-de-Mesquita, H. B., Fuchs, C. S., Gallinger, S., Gross, M., Helzlsouer, K., Holly, E. A., Jacobs, E. J., LaCroix, A., Li, D., Mandelson, M. T., Olson, S. H., Petersen, G. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Zheng, W. & 42 others, Amundadottir, L., Albanes, D., Allen, N. E., Bamlet, W. R., Boutron-Ruault, M. C., Buring, J. E., Bracci, P. M., Canzian, F., Clipp, S., Cotterchio, M., Duell, E. J., Elena, J., Gaziano, J. M., Giovannucci, E. L., Goggins, M. S., Hallmans, G., Hassan, M., Hutchinson, A., Hunter, D. J., Kooperberg, C., Kurtz, R. C., Liu, S., Overvad, K., Palli, D., Patel, A. V., Rabe, K. G., Shu, X. O., Slimani, N., Tobias, G. S., Trichopoulos, D., Van Den Eeden, S. K., Vineis, P., Virtamo, J., Wactawski-Wende, J., Wolpin, B. M., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Chanock, S. J., Hoover, R. N., Hartge, P. & Kraft, P., Sep 13 2013, In : PLoS One. 8, 9, e72311.

Research output: Contribution to journalArticle

pancreatic neoplasms
Pancreatic Neoplasms
odds ratio
Odds Ratio
Population

Analysis of heritability and genetic architecture of pancreatic cancer: A PANC4 study

Chen, F., Childs, E. J., Mocci, E., Bracci, P., Gallinger, S., Li, D., Neale, R. E., Olson, S. H., Scelo, G., Bamlet, W. R., Blackford, A. L., Borges, M., Brennan, P., Chaffee, K. G., Duggal, P., Hassan, M. J., Holly, E. A., Hung, R. J., Goggins, M. G., Kurtz, R. C. & 6 others, Oberg, A. L., Orlow, I., Yu, H., Petersen, G. M., Risch, H. A. & Klein, A. P., Jan 1 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 7, p. 1238-1245 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genome-Wide Association Study
Genome
Neoplasm Genes
Linkage Disequilibrium

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

Sampson, J. N., Wheeler, W. A., Yeager, M., Panagiotou, O., Wang, Z., Berndt, S. I., Lan, Q., Abnet, C. C., Amundadottir, L. T., Figueroa, J. D., Landi, M. T., Mirabello, L., Savage, S. A., Taylor, P. R., De Vivo, I., McGlynn, K. A., Purdue, M. P., Rajaraman, P., Adami, H. O., Ahlbom, A. & 388 others, Albanes, D., Amary, M. F., An, S. J., Andersson, U., Andriole, G., Andrulis, I. L., Angelucci, E., Ansell, S. M., Arici, C., Armstrong, B. K., Arslan, A. A., Austin, M. A., Baris, D., Barkauskas, D. A., Bassig, B. A., Becker, N., Benavente, Y., Benhamou, S., Berg, C., Van Den Berg, D., Bernstein, L., Bertrand, K. A., Birmann, B. M., Black, A., Boeing, H., Boffetta, P., Boutron-Ruault, M. C., Bracci, P. M., Brinton, L., Brooks-Wilson, A. R., Bueno-De-Mesquita, H. B., Burdett, L., Buring, J., Butler, M. A., Cai, Q., Cancel-Tassin, G., Canzian, F., Carrato, A., Carreon, T., Carta, A., Chan, J. K. C., Chang, E. T., Chang, G. C., Chang, I. S., Chang, J., Chang-Claude, J., Chen, C. J., Chen, C. Y., Chen, C., Chen, C. H., Chen, C., Chen, H., Chen, K., Chen, K. Y., Chen, K. C., Chen, Y., Chen, Y. H., Chen, Y. S., Chen, Y. M., Chien, L. H., Chirlaque, M. D., Choi, J. E., Choi, Y. Y., Chow, W. H., Chung, C. C., Clavel, J., Clavel-Chapelon, F., Cocco, P., Colt, J. S., Comperat, E., Conde, L., Connors, J. M., Conti, D., Cortessis, V. K., Cotterchio, M., Cozen, W., Crouch, S., Crous-Bou, M., Cussenot, O., Davis, F. G., Ding, T., Diver, W. R., Dorronsoro, M., Dossus, L., Duell, E. J., Ennas, M. G., Erickson, R. L., Feychting, M., Flanagan, A. M., Foretova, L., Fraumeni, J. F., Freedman, N. D., Freeman, L. E. B., Fuchs, C., Gago-Dominguez, M., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., García-Closas, R., Gascoyne, R. D., Gastier-Foster, J., Gaudet, M. M., Gaziano, J. M., Giffen, C., Giles, G. G., Giovannucci, E., Glimelius, B., Goggins, M. S., Gokgoz, N., Goldstein, A. M., Gorlick, R., Gross, M., Grubb, R., Gu, J., Guan, P., Gunter, M., Guo, H., Habermann, T. M., Haiman, C. A., Halai, D., Hallmans, G., Hassan, M., Hattinger, C., He, Q., He, X., Helzlsouer, K., Henderson, B., Henriksson, R., Hjalgrim, H., Hoffman-Bolton, J., Hohensee, C., Holford, T. R., Holly, E. A., Hong, Y. C., Hoover, R. N., Horn-Ross, P. L., Hosain, G. M. M., Hosgood, H. D., Hsiao, C. F., Hu, N., Hu, W., Hu, Z., Huang, M. S., Huerta, J. M., Hung, J. Y., Hutchinson, A., Inskip, P. D., Jackson, R. D., Jacobs, E. J., Jenab, M., Jeon, H. S., Ji, B. T., Jin, G., Jin, L., Johansen, C., Johnson, A., Jung, Y. J., Kaaks, R., Kamineni, A., Kane, E., Kang, C. H., Karagas, M. R., Kelly, R. S., Khaw, K. T., Kim, C., Kim, H. N., Kim, J. H., Kim, J. S., Kim, Y. H., Kim, Y. T., Kim, Y. C., Kitahara, C. M., Klein, A., Klein, R. J., Kogevinas, M., Kohno, T., Kolonel, L. N., Kooperberg, C., Kricker, A., Krogh, V., Kunitoh, H., Kurtz, R. C., Kweon, S. S., La Croix, A., Lawrence, C., Lecanda, F., Lee, V. H. F., Li, D., Li, H., Li, J., Li, Y. J., Li, Y., Liao, L. M., Liebow, M., Lightfoot, T., Lim, W. Y., Lin, C. C., Lin, D., Lindstrom, S., Linet, M. S., Link, B. K., Liu, C., Liu, J., Liu, L., Ljungberg, B., Lloreta, J., Di Lollo, S., Lu, D., Lund, E., Malats, N., Mannisto, S., Marchand, L. L., Marina, N., Masala, G., Mastrangelo, G., Matsuo, K., Maynadie, M., McKay, J., McKean-Cowdin, R., Melbye, M., Melin, B. S., Michaud, D. S., Mitsudomi, T., Monnereau, A., Montalvan, R., Moore, L. E., Mortensen, L. M., Nieters, A., North, K. E., Novak, A. J., Oberg, A. L., Offit, K., Oh, I. J., Olson, S. H., Palli, D., Pao, W., Park, I. K., Park, J. Y., Park, K. H., Patiño-Garcia, A., Pavanello, S., Peeters, P. H. M., Perng, R. P., Peters, U., Petersen, G. M., Picci, P., Pike, M. C., Porru, S., Prescott, J., Prokunina-Olsson, L., Qian, B., Qiao, Y. L., Rais, M., Riboli, E., Riby, J., Risch, H. A., Rizzato, C., Rodabough, R., Roman, E., Roupret, M., Ruder, A. M., De Sanjose, S., Scelo, G., Schned, A., Schumacher, F., Schwartz, K., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H. D., Setiawan, V. W., Severi, G., Severson, R. K., Shanafelt, T. D., Shen, H., Shen, W., Shin, M. H., Shiraishi, K., Shu, X. O., Siddiq, A., Sierrasesúmaga, L., Sihoe, A. D. L., Skibola, C. F., Smith, A., Smith, M. T., Southey, M. C., Spinelli, J. J., Staines, A., Stampfer, M., Stern, M. C., Stevens, V. L., Stolzenberg-Solomon, R. S., Su, J., Su, W. C., Sund, M., Sung, J. S., Sung, S. W., Tan, W., Tang, W., Tardón, A., Thomas, D., Thompson, C. A., Tinker, L. F., Tirabosco, R., Tjønneland, A., Travis, R. C., Trichopoulos, D., Tsai, F. Y., Tsai, Y. H., Tucker, M., Turner, J., Vajdic, C. M., Vermeulen, R. C. H., Villano, D. J., Vineis, P., Virtamo, J., Visvanathan, K., Wactawski-Wende, J., Wang, C., Wang, C. L., Wang, J. C., Wang, J., Wei, F., Weiderpass, E., Weiner, G. J., Weinstein, S., Wentzensen, N., White, E., Witzig, T. E., Wolpin, B. M., Wong, M. P., Wu, C., Wu, G., Wu, J., Wu, T., Wu, W., Wu, X., Wu, Y. L., Wunder, J. S., Xiang, Y. B., Xu, J., Xu, P., Yang, P. C., Yang, T. Y., Ye, Y., Yin, Z., Yokota, J., Yoon, H. I., Yu, C. J., Yu, H., Yu, K., Yuan, J. M., Zelenetz, A., Zeleniuch-Jacquotte, A., Zhang, X. C., Zhang, Y., Zhao, X., Zhao, Z., Zheng, H., Zheng, T., Zheng, W., Zhou, B., Zhu, M., Zucca, M., Boca, S. M., Cerhan, J. R., Ferri, G. M., Hartge, P., Hsiung, C. A., Magnani, C., Miligi, L., Morton, L. M., Smedby, K. E., Teras, L. R., Vijai, J., Wang, S. S., Brennan, P., Caporaso, N. E., Hunter, D. J., Kraft, P., Rothman, N., Silverman, D. T., Slager, S. L., Chanock, S. J. & Chatterjee, N., 2016, In : Journal of the National Cancer Institute. 107, 12, djv279.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Smoking
Neoplasms
Lung Neoplasms
Confidence Intervals

Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: A tool for pharmacogenetic studies

Ghosh, S., Hossain, M. Z., Borges, M., Goggins, M. S., Ingersoll, R. G., Eshleman, J., Klein, A. & Kern, S. E., Apr 5 2012, In : PLoS One. 7, 4, e34426.

Research output: Contribution to journalArticle

thymidylate synthase
pharmacogenomics
Thymidylate Synthase
Minisatellite Repeats
minisatellite repeats

A New Fast Phasing Method Based On Haplotype Subtraction

Mocci, E., Debeljak, M., Klein, A. & Eshleman, J., May 1 2019, In : Journal of Molecular Diagnostics. 21, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

Haplotypes
Alleles
Genotype
Genome
Homozygote

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

Alzheimer’s Disease Neuroimaging Initiative, Aug 1 2019, In : PLoS genetics. 15, 8, p. e1008344

Research output: Contribution to journalArticle

Open Access
pancreatic neoplasms
Neoplasm Genes
adenocarcinoma
Pancreatic Neoplasms
sensitivity analysis

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European–American population

Vergara, C., Bomotti, S. M., Valencia, C., Klein, B. E. K., Lee, K. E., Klein, R., Klein, A. & Duggal, P., Jan 1 2018, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

Exome
Confidence Intervals
Hyperopia
Refractive Errors
Vision Disorders

Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

Telomeres Mendelian Randomization Collaboration, 2017, In : JAMA oncology. 3, 5, p. 636-651 16 p.

Research output: Contribution to journalArticle

Telomere
Random Allocation
Odds Ratio
Confidence Intervals
Neoplasms

Association of common susceptibility variants of pancreatic cancer in higher-risk patients: A PACGENE study

Childs, E. J., Chaffee, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Cote, M. L., Bondy, M. L., Hruban, R. H., Chanock, S. J., Hoover, R. N., Fuchs, C. S., Rider, D. N., Amundadottir, L. T., Stolzenberg-Solomon, R., Wolpin, B. M., Risch, H. A., Goggins, M. S., Petersen, G. M. & Klein, A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Ovarian Neoplasms
Single Nucleotide Polymorphism
BRCA2 Gene
Breast Neoplasms

Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy

Taube, J. M., Klein, A., Brahmer, J., Xu, H., Pan, X., Kim, J. H., Chen, L., Pardoll, A. M., Topalian, S. & Anders, R. A., Oct 1 2014, In : Clinical Cancer Research. 20, 19, p. 5064-5074 11 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Ligands
Neoplasms
Renal Cell Carcinoma
Programmed Cell Death 1 Ligand 2 Protein

ATM mutations in patients with hereditary pancreatic cancer

Roberts, N., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., Axilbund, J., Schulick, R., Ali, S. Z., Eshleman, J., Velculescu, V. E., Goggins, M. S., Vogelstein, B., Papadopoulos, N., Hruban, R. H., Kinzler, K. W. & 1 others, Klein, A., Jan 2012, In : Cancer Discovery. 2, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Pancreatic Neoplasms
Mutation
Genes
Adenocarcinoma

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: A PACGENE study

Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. S., Hruban, R. H., Cote, M. L., McWilliams, R. R., Roberts, N., Cannon-Albright, L. A., Li, D., Moyes, K., Wenstrup, R. J., Hartman, A. R., Seminara, D., Klein, A. & Petersen, G. M., Jul 2 2015, In : Genetics in Medicine. 17, 7, p. 569-577 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genetic Testing
Genes
Viverridae

Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors

Yachida, S., White, C. M., Naito, Y., Zhong, Y., Brosnan, J. A., Macgregor-Das, A. M., Morgan, R. A., Saunders, T., Laheru, D., Herman, J. M., Hruban, R. H., Klein, A., Jones, S., Velculescu, V. E., Wolfgang, C. & Iacobuzio-Donahue, C. A., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6339-6347 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survivors
Genes
Carcinoma
Survival
Tumor-Infiltrating Lymphocytes
Melanoma
Neoplasms
Melanocytes
Nevus

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M. T., Allen, P. J., Schattner, M., Brand, R. E., Singhi, A. D., Petersen, G. M., Hong, S. M., Kim, S. C., Falconi, M., Doglioni, C., Weiss, M. J., Ahuja, N., He, J. & 20 others, Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. S., Hruban, R. H., Wolfgang, C., Klein, A., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & O'Broin-Lennon, A. M., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Biomarkers
Biopsy
DNA

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Childs, E. J., Mocci, E., Campa, D., Bracci, P. M., Gallinger, S., Goggins, M. S., Li, D., Neale, R. E., Olson, S. H., Scelo, G., Amundadottir, L. T., Bamlet, W. R., Bijlsma, M. F., Blackford, A., Borges, M., Brennan, P., Brenner, H., Bueno-De-Mesquita, H. B., Canzian, F., Capurso, G. & 42 others, Cavestro, G. M., Chaffee, K. G., Chanock, S. J., Cleary, S. P., Cotterchio, M., Foretova, L., Fuchs, C., Funel, N., Gazouli, M., Hassan, M., Herman, J. M., Holcatova, I., Holly, E. A., Hoover, R. N., Hung, R. J., Janout, V., Key, T. J., Kupcinskas, J., Kurtz, R. C., Landi, S., Lu, L., Malecka-Panas, E., Mambrini, A., Mohelnikova-Duchonova, B., Neoptolemos, J. P., Oberg, A. L., Orlow, I., Pasquali, C., Pezzilli, R., Rizzato, C., Saldia, A., Scarpa, A., Stolzenberg-Solomon, R. Z., Strobel, O., Tavano, F., Vashist, Y. K., Vodicka, P., Wolpin, B. M., Yu, H., Petersen, G. M., Risch, H. A. & Klein, A., Aug 30 2015, In : Nature Genetics. 47, 8, p. 911-916 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Odds Ratio
Confidence Intervals
Penetrance
DNA Mismatch Repair

Confirmation of linkage to ocular refraction on chromosome 22q and identification of a novel linkage region on 1q

Klein, A., Duggal, P., Lee, K. E., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Jan 2007, In : Archives of Ophthalmology. 125, 1, p. 80-85 6 p.

Research output: Contribution to journalArticle

Ocular Refraction
Myopia
Rodentia
Chromosomes
Sclerosis

Copy-number variants in patients with a strong family history of pancreatic cancer

Lucito, R., Suresh, S., Walter, K., Pandey, A., Lakshmi, B., Krasnitz, A., Sebat, J., Wigler, M., Klein, A., Brune, K., Palmisano, E., Maitra, A., Goggins, M. S. & Hruban, R. H., Oct 2007, In : Cancer Biology and Therapy. 6, 10, p. 1592-1599 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Germ Cells
Genes
Chromosomes, Human, Pair 19
Inborn Genetic Diseases

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., Hong, S. M., Fu, B., Lin, M-T., Calhoun, E. S., Kamiyama, M., Walter, K., Nikolskaya, T., Nikolsky, Y., Hartigan, J., Smith, D. R. & 16 others, Hidalgo, M., Leach, S. D., Klein, A., Jaffee, E., Goggins, M. S., Maitra, A., Iacobuzio-Donahue, C., Eshleman, J., Kern, S. E., Hruban, R. H., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V. E. & Kinzler, K. W., Sep 26 2008, In : Science. 321, 5897, p. 1801-1806 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Gene Expression Profiling
Oligonucleotide Array Sequence Analysis
Point Mutation

Current gene discovery strategies for ocular conditions

Duggal, P., Ibay, G. & Klein, A., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7761-7770 10 p.

Research output: Contribution to journalArticle

Genetic Linkage
Eye Diseases
Genetic Association Studies
Genomics

Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance

Abe, T., Blackford, A. L., Tamura, K., Ford, M., McCormick, P., Chuidian, M., Almario, J. A., Borges, M., O'Broin-Lennon, A. M., Shin, E., Klein, A., Hruban, R. H., Canto, M. & Goggins, M. S., May 1 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 13, p. 1070-1080 11 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Pancreatic Neoplasms
Neoplasm Genes
Mutation
Incidence

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Cho, C., Macgregor-Das, A., Siddiqui, A., Witmer, P. D., Tamura, K., Song, T. J., Almario, J. A. N., Brant, A., Borges, M., Ford, M., Barkley, T., He, J., Weiss, M. J., Wolfgang, C., Roberts, N., Hruban, R. H. & 2 others, Klein, A. & Goggins, M. S., Oct 20 2017, In : Journal of Clinical Oncology. 35, 30, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Adenocarcinoma
Pancreatic Neoplasms
Neoplasm Genes
Neoplasms

Detectable clonal mosaicism and its relationship to aging and cancer

Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M. J., Cullen, M., Epstein, C. G., Burdett, L., Dean, M. C., Chatterjee, N., Sampson, J., Chung, C. C., Kovaks, J., Gapstur, S. M., Stevens, V. L. & 169 others, Teras, L. T., Gaudet, M. M., Albanes, D., Weinstein, S. J., Virtamo, J., Taylor, P. R., Freedman, N. D., Abnet, C. C., Goldstein, A. M., Hu, N., Yu, K., Yuan, J. M., Liao, L., Ding, T., Qiao, Y. L., Gao, Y. T., Koh, W. P., Xiang, Y. B., Tang, Z. Z., Fan, J. H., Aldrich, M. C., Amos, C., Blot, W. J., Bock, C. H., Gillanders, E. M., Harris, C. C., Haiman, C. A., Henderson, B. E., Kolonel, L. N., Le Marchand, L., McNeill, L. H., Rybicki, B. A., Schwartz, A. G., Signorello, L. B., Spitz, M. R., Wiencke, J. K., Wrensch, M., Wu, X., Zanetti, K. A., Ziegler, R. G., Figueroa, J. D., Garcia-Closas, M., Malats, N., Marenne, G., Prokunina-Olsson, L., Baris, D., Schwenn, M., Johnson, A., Landi, M. T., Goldin, L., Consonni, D., Bertazzi, P. A., Rotunno, M., Rajaraman, P., Andersson, U., Freeman, L. E. B., Berg, C. D., Buring, J. E., Butler, M. A., Carreon, T., Feychting, M., Ahlbom, A., Gaziano, J. M., Giles, G. G., Hallmans, G., Hankinson, S. E., Hartge, P., Henriksson, R., Inskip, P. D., Johansen, C., Landgren, A., McKean-Cowdin, R., Michaud, D. S., Melin, B. S., Peters, U., Ruder, A. M., Sesso, H. D., Severi, G., Shu, X. O., Visvanathan, K., White, E., Wolk, A., Zeleniuch-Jacquotte, A., Zheng, W., Silverman, D. T., Kogevinas, M., Gonzalez, J. R., Villa, O., Li, D., Duell, E. J., Risch, H. A., Olson, S. H., Kooperberg, C., Wolpin, B. M., Jiao, L., Hassan, M., Wheeler, W., Arslan, A. A., Bueno-De-Mesquita, H. B., Fuchs, C. S., Gallinger, S., Gross, M. D., Holly, E. A., Klein, A., Lacroix, A., Mandelson, M. T., Petersen, G., Boutron-Ruault, M. C., Bracci, P. M., Canzian, F., Chang, K., Cotterchio, M., Giovannucci, E. L., Goggins, M. S., Bolton, J. A. H., Jenab, M., Khaw, K. T., Krogh, V., Kurtz, R. C., McWilliams, R. R., Mendelsohn, J. B., Rabe, K. G., Riboli, E., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Elena, J. W., Yu, H., Amundadottir, L., Stolzenberg-Solomon, R. Z., Kraft, P., Schumacher, F., Stram, D., Savage, S. A., Mirabello, L., Andrulis, I. L., Wunder, J. S., García, A. P., Sierrasesà maga, L., Barkauskas, D. A., Gorlick, R. G., Purdue, M., Chow, W. H., Moore, L. E., Schwartz, K. L., Davis, F. G., Hsing, A. W., Berndt, S. I., Black, A., Wentzensen, N., Brinton, L. A., Lissowska, J., Peplonska, B., McGlynn, K. A., Cook, M. B., Graubard, B. I., Kratz, C. P., Greene, M. H., Erickson, R. L., Hunter, D. J., Thomas, G., Hoover, R. N., Real, F. X., Fraumeni, J. F., Caporaso, N. E., Tucker, M., Rothman, N., Pérez-Jurado, L. A. & Chanock, S. J., Jun 2012, In : Nature Genetics. 44, 6, p. 651-658 8 p.

Research output: Contribution to journalArticle

Mosaicism
Neoplasms
Odds Ratio
DNA
Cheek

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas

Determinants and prognostic value of quality of life in patients with pancreatic ductal adenocarcinoma

Deng, Y., Tu, H., Pierzynski, J. A., Miller, E. D., Gu, X., Huang, M., Chang, D. W., Ye, Y., Hildebrandt, M. A. T., Klein, A., Zhao, R., Lippman, S. M. & Wu, X., Mar 1 2018, In : European Journal of Cancer. 92, p. 20-32 13 p.

Research output: Contribution to journalArticle

Value of Life
Adenocarcinoma
Quality of Life
Hispanic Americans
Pancreatic Neoplasms

DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease

Matsubayashi, H., Canto, M., Sato, N., Klein, A., Abe, T., Yamashita, K., Yeo, C. J., Kalloo, A. N., Hruban, R. H. & Goggins, M. S., Jan 15 2006, In : Cancer Research. 66, 2, p. 1208-1217 10 p.

Research output: Contribution to journalArticle

Pancreatic Juice
Pancreatic Diseases
DNA Methylation
Methylation
Pancreatic Neoplasms

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer

Lacobuzio-Donahue, C. A., Fu, B., Yachida, S., Luo, M., Abe, H., Henderson, C. M., Vilardell, F., Wang, Z., Keller, J. W., Banerjee, P., Herman, J. M., Cameron, J. L., Yeo, C. J., Halushka, M. K., Eshleman, J., Raben, M., Klein, A., Hruban, R. H., Hidalgo, M. & Laheru, D., Apr 10 2009, In : Journal of Clinical Oncology. 27, 11, p. 1806-1813 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Carcinoma
Autopsy
Genes
p53 Genes

Elevated cancer mortality in the relatives of patients with pancreatic cancer

Wang, L., Brune, K. A., Visvanathan, K., Laheru, D., Herman, J., Wolfgang, C., Schulick, R., Cameron, J. L., Goggins, M. S., Hruban, R. H. & Klein, A., Nov 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 11, p. 2829-2834 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mortality
Neoplasms
Registries
Spouses

Environmental covariates: Effects on the power of sib-pair linkage methods

Mandal, D. M., Sorant, A. J. M., Pugh, E., Marcus, S. E., Klein, A., Mathias, R., O'Neill, J., Temiyakarn, L. F., Wilson, A. F. & Bailey-Wilson, J. E., 1999, In : Genetic Epidemiology. 17, SUPPL. 1

Research output: Contribution to journalArticle

EPHA2 is associated with age-related cortical cataract in mice and humans

Jun, G., Guo, H., Klein, B. E. K., Klein, R., Jie, J. W., Mitchell, P., Miao, H., Lee, K. E., Joshi, T., Buck, M., Chugha, P., Bardenstein, D., Klein, A., Bailey-Wilson, J. E., Gong, X., Spector, T. D., Andrew, T., Hammond, C. J., Elston, R. C., Iyengar, S. K. & 1 others, Wang, B., Jul 2009, In : PLoS Genetics. 5, 7, e1000584.

Research output: Contribution to journalArticle

cataract
Cataract
mice
protein
blindness

Erratum: Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk (PLoS ONE (2015) 10:3 (e0117574) DOI:10.1371/journal.pone.0117574)

Arem, H., Yu, K., Xiong, X., Moy, K., Freedman, N. D., Mayne, S. T., Albanes, D., Amundadottir, L. T., Arslan, A. A., Austin, M., Bamlet, W. R., Beane-Freeman, L., Bracci, P., Canzian, F., Chanock, S. J., Cotterchio, M., Duell, E. J., Gallinger, S., Giles, G. G., Goggins, M. & 35 others, Goodman, P. J., Hartge, P., Hassan, M., Helzlsouer, K., Henderson, B., Holly, E. A., Hoover, R., Jacobs, E. J., Kamineni, A., Klein, A., Klein, E., Kolonel, L. N., Li, D., Malats, N., Männistö, S., McCullough, M. L., Olson, S. H., Orlow, I., Peters, U., Petersen, G. M., Porta, M., Severi, G., Shu, X. O., Van Den Eeden, S., Visvanathan, K., White, E., Yu, H., Zeleniuch-Jacquotte, A., Zheng, W., Tobias, G. S., Maeder, D., Brotzman, M., Risch, H., Sampson, J. N. & Stolzenberg-Solomon, R. Z., Jun 3 2015, In : PLoS One. 10, 6, e0129983.

Research output: Contribution to journalArticle

Erratum: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma (Nature (2012) 486 (266-270) DOI: 10.1038/nature11114)

Pérez-Mancera, P. A., Rust, A. G., Van Der Weyden, L., Kristiansen, G., Li, A., Sarver, A. L., Silverstein, K. A. T., Grützmann, R., Aust, D., Rümmele, P., Knösel, T., Herd, C., Stemple, D. L., Kettleborough, R., Brosnan, J. A., Li, A., Morgan, R., Knight, S., Yu, J., Stegeman, S. & 17 others, Collier, L. S., Ten Hoeve, J. J., De Ridder, J., Klein, A., Goggins, M. S., Hruban, R. H., Chang, D. K., Biankin, A. V., Grimmond, S. M., Initiative, A. P. C. G., Wessels, L. F. A., Wood, S. A., Iacobuzio-Donahue, C. A., Pilarsky, C., Largaespada, D. A., Adams, D. J. & Tuveson, D. A., Feb 21 2013, In : Nature. 494, 7437, p. 390 1 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Deubiquitinating Enzymes

Evidence for a major gene influencing risk of pancreatic cancer

Klein, A., Beaty, T. L., Bailey-Wilson, J. E., Brune, K. A., Hruban, R. H. & Petersen, G. M., Aug 2002, In : Genetic Epidemiology. 23, 2, p. 133-149 17 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genes
Age of Onset
Smoking
Dysplastic Nevus Syndrome

Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure

Chen, F., Klein, A., Klein, B. E. K., Lee, K. E., Truitt, B., Klein, R., Iyengar, S. K. & Duggal, P., 2015, In : Investigative Ophthalmology and Visual Science. 56, 1, p. 544-551 8 p.

Research output: Contribution to journalArticle

Exome
Intraocular Pressure
Genes
Caveolins
Genome-Wide Association Study

Exome Array Analysis of Nuclear Lens Opacity

Loomis, S. J., Klein, A., Lee, K. E., Chen, F., Bomotti, S., Truitt, B., Iyengar, S. K., Klein, R., Klein, B. E. K. & Duggal, P., Nov 29 2017, (Accepted/In press) In : Ophthalmic Epidemiology. p. 1-5 5 p.

Research output: Contribution to journalArticle

Exome
Cataract
Sclerosis
Genes
Gene Frequency

Exome-Wide Association Study of Pancreatic Cancer Risk

Grant, R. C., Denroche, R. E., Borgida, A., Virtanen, C., Cook, N., Smith, A. L., Connor, A. A., Wilson, J. M., Peterson, G., Roberts, N., Klein, A., Grimmond, S. M., Biankin, A., Cleary, S., Moore, M., Lemire, M., Zogopoulos, G., Stein, L. & Gallinger, S., Feb 1 2018, In : Gastroenterology. 154, 3, p. 719-722.e3

Research output: Contribution to journalArticle

Exome
Pancreatic Neoplasms
Genes
Genetic Heterogeneity
Neoplasm Genes

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C. H., Palmisano, E., Brune, K., Jaffee, E., Iacobuzio-Donahue, C. A., Maitra, A., Parmigiani, G., Kern, S. E., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Eshleman, J., Goggins, M. S. & Klein, A., Apr 10 2009, In : Science. 324, 5924, p. 217 1 p.

Research output: Contribution to journalArticle

Tumor Suppressor Proteins
identification method
Germ-Line Mutation
Terminator Codon
Sequence Deletion

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

Serous Cystadenocarcinoma
Neoplasms
Proteins
Carcinoma, Ductal, Breast
Human Chromosomes

Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies

Bai, H., Gayyed, M. F., Lam-Himlin, D. M., Klein, A., Nayar, S. K., Xu, Y., Khan, M., Argani, P., Pan, D. & Anders, R. A., Sep 2012, In : Human Pathology. 43, 9, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Liver
Hepatocellular Carcinoma
Neoplasms
Proteins