Alison Klein

Professor

19992019

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1999

Environmental covariates: Effects on the power of sib-pair linkage methods

Mandal, D. M., Sorant, A. J. M., Pugh, E., Marcus, S. E., Klein, A., Mathias, R., O'Neill, J., Temiyakarn, L. F., Wilson, A. F. & Bailey-Wilson, J. E., 1999, In : Genetic Epidemiology. 17, SUPPL. 1

Research output: Contribution to journalArticle

Possible linkage of alcoholism, monoamine oxidase activity and P300 amplitude to markers on chromosome 12q24

Juo, S. H. H., Pugh, E., Baffoe-Bonnie, A., Kingman, A., Sorant, A. J. M., Klein, A., O'Neill, J., Mathias, R., Wilson, A. F. & Bailey-Wilson, J. E., 1999, In : Genetic Epidemiology. 17, SUPPL. 1

Research output: Contribution to journalArticle

2001

Familial Pancreatic Cancer

Klein, A., Hruban, R. H., Brune, K. A., Petersen, G. M. & Goggins, M. S., Jul 2001, In : Cancer Journal. 7, 4, p. 266-273 8 p.

Research output: Contribution to journalArticle

Multilocus linkage analysis of the German asthma data

Zandi, P. P., Klein, A., Addington, A. M., Hetmanski, J. B., Roberts, L., Peila, R., Shrestha, S., Shaw, C. K., Heng Chew Kiat, C. K., Langefeld, C. D. & Beaty, T. L., 2001, In : Genetic Epidemiology. 21, SUPPL. 1

Research output: Contribution to journalArticle

Multipoint linkage analysis under heterogeneity: Incorporation of parametric and nonparametric approaches

Chiu, Y. F., Addington, A. M., Beaty, T. L., Klein, A. & Liang, K. Y., 2001, In : Genetic Epidemiology. 21, SUPPL. 1

Research output: Contribution to journalArticle

2002

Evidence for a major gene influencing risk of pancreatic cancer

Klein, A., Beaty, T. L., Bailey-Wilson, J. E., Brune, K. A., Hruban, R. H. & Petersen, G. M., Aug 2002, In : Genetic Epidemiology. 23, 2, p. 133-149 17 p.

Research output: Contribution to journalArticle

2003

Importance sampling method of correction for multiple testing in affected sib-pair linkage analysis.

Klein, A., Kovac, I., Sorant, A. J. M., Baffoe-Bonnie, A., Doan, B. Q., Ibay, G., Lockwood, E., Mandal, D., Santhosh, L., Weissbecker, K., Woo, J., Zambelli-Weiner, A., Zhang, J., Naiman, D. Q., Malley, J. & Bailey-Wilson, J. E., 2003, In : BMC Genetics. 4 Suppl 1, S73.

Research output: Contribution to journalArticle

2004

GeneLink: A database to facilitate genetic studies of complex traits

Gillanders, E. M., Masiello, A., Gildea, D., Umayam, L., Duggal, P., Jones, M. P., Klein, A., Freas-Lutz, D., Ibay, G., Trout, K., Wolfsberg, T. G., Trent, J. M., Bailey-Wilson, J. E. & Baxevanis, A. D., Oct 18 2004, In : BMC Genomics. 5, 81.

Research output: Contribution to journalArticle

Genetic research involving human biological materials: A need to tailor consent forms

Hull, S. C., Gooding, H., Klein, A., Warshauer-Baker, E., Metosky, S. & Wilfond, B. S., May 2004, In : IRB Ethics and Human Research. 26, 3, p. 1-7 7 p.

Research output: Contribution to journalArticle

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

Klein, A., Brune, K. A., Petersen, G. M., Goggins, M. S., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S. E. & Hruban, R. H., Apr 1 2004, In : Cancer Research. 64, 7, p. 2634-2638 5 p.

Research output: Contribution to journalArticle

2005

A genetic contribution to intraocular pressure: The Beaver Dam Eye Study

Duggal, P., Klein, A., Lee, K. E., Iyengar, S. K., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Feb 2005, In : Investigative Ophthalmology and Visual Science. 46, 2, p. 555-560 6 p.

Research output: Contribution to journalArticle

Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium

Duggal, P., Gillanders, E. M., Mathias, R., Ibay, G. P., Klein, A., Baffoe-Bonnie, A. B., Ou, L., Dusenberry, I. P., Tsai, Y. Y., Chines, P. S., Doan, B. Q. & Bailey-Wilson, J. E., Dec 30 2005, In : BMC Genetics. 6, SUPPL.1, S73.

Research output: Contribution to journalArticle

Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits

Klein, A., Tsai, Y. Y., Duggal, P., Gillanders, E. M., Barnhart, M., Mathias, R., Dusenberry, I. P., Turiff, A., Chines, P. S., Goldstein, J., Wojciechowski, R., Hening, W., Pugh, E. & Bailey-Wilson, J. E., Dec 30 2005, In : BMC Genetics. 6, SUPPL.1, S20.

Research output: Contribution to journalArticle

Overview of linkage analysis: application to pancreatic cancer.

Klein, A., 2005, In : Methods in molecular medicine. 103, p. 329-341 13 p.

Research output: Contribution to journalArticle

Polygenic effects and cigarette smoking account for a portion of the familial aggregation of nuclear sclerosis

Klein, A., Duggal, P., Lee, K. E., O'Neill, J. A., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Apr 15 2005, In : American Journal of Epidemiology. 161, 8, p. 707-713 7 p.

Research output: Contribution to journalArticle

Support for polygenic influences on ocular refractive error

Klein, A., Duggal, P., Lee, K. E., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Feb 2005, In : Investigative Ophthalmology and Visual Science. 46, 2, p. 442-446 5 p.

Research output: Contribution to journalArticle

Treatment of familial pancreatic cancer and its precursors

Hruban, R. H., Canto, M., Griffin, C., Kern, S. E., Klein, A., Laheru, D. & Yeo, C. J., Oct 2005, In : Current Treatment Options in Gastroenterology. 8, 5, p. 365-375 11 p.

Research output: Contribution to journalArticle

2006

DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease

Matsubayashi, H., Canto, M., Sato, N., Klein, A., Abe, T., Yamashita, K., Yeo, C. J., Kalloo, A. N., Hruban, R. H. & Goggins, M. S., Jan 15 2006, In : Cancer Research. 66, 2, p. 1208-1217 10 p.

Research output: Contribution to journalArticle

Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: Relationship to molecular mechanisms of gemcitabine resistance and survival

Sebastiani, V., Ricci, F., Rubio-Viquiera, B., Kulesza, P., Yeo, C. J., Hidalgo, M., Klein, A., Laheru, D. & Iacobuzio-Donahue, C. A., Apr 15 2006, In : Clinical Cancer Research. 12, 8, p. 2492-2497 6 p.

Research output: Contribution to journalArticle

Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer

Brune, K., Abe, T., Canto, M., O'Malley, L., Klein, A., Maitra, A., Volkan Adsay, N., Fishman, E. K., Cameron, J. L., Yeo, C. J., Kern, S. E., Goggins, M. S. & Hruban, R. H., Sep 2006, In : American Journal of Surgical Pathology. 30, 9, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

Pancreatic cancer genetic epidemiology consortium

Petersen, G. M., De Andrade, M., Goggins, M. S., Hruban, R. H., Bondy, M., Korczak, J. F., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., Seminara, D. & Klein, A., Apr 2006, In : Cancer Epidemiology Biomarkers and Prevention. 15, 4, p. 704-710 7 p.

Research output: Contribution to journalArticle

Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations

Hruban, R. H., Adsay, N. V., Albores-Saavedra, J., Anver, M. R., Biankin, A. V., Boivin, G. P., Furth, E. E., Furukawa, T., Klein, A., Klimstra, D. S., Kloppel, G., Lauwers, G. Y., Longnecker, D. S., Luttges, J., Maitra, A., Offerhaus, G. J. A., Pérez-Gallego, L., Redston, M. & Tuveson, D. A., Jan 1 2006, In : Cancer Research. 66, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

2007

Confirmation of linkage to ocular refraction on chromosome 22q and identification of a novel linkage region on 1q

Klein, A., Duggal, P., Lee, K. E., Klein, R., Bailey-Wilson, J. E. & Klein, B. E. K., Jan 2007, In : Archives of Ophthalmology. 125, 1, p. 80-85 6 p.

Research output: Contribution to journalArticle

Copy-number variants in patients with a strong family history of pancreatic cancer

Lucito, R., Suresh, S., Walter, K., Pandey, A., Lakshmi, B., Krasnitz, A., Sebat, J., Wigler, M., Klein, A., Brune, K., Palmisano, E., Maitra, A., Goggins, M. S. & Hruban, R. H., Oct 2007, In : Cancer Biology and Therapy. 6, 10, p. 1592-1599 8 p.

Research output: Contribution to journalArticle

Familial pancreatic cancer: from genes to improved patient care.

Hruban, R. H., Klein, A., Eshleman, J., Axilbund, J. E. & Goggins, M. S., Oct 2007, In : Expert Review of Gastroenterology and Hepatology. 1, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Identification of novel genetic loci for intraocular pressure: A genomewide scan of the beaver dam eye study

Duggal, P., Klein, A., Lee, K. E., Klein, R., Klein, B. E. K. & Bailey-Wilson, J. E., Jan 2007, In : Archives of Ophthalmology. 125, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

In reply [13]

Wang, W., Chen, S., Brune, K. A., Hruban, R. H., Parmigiani, G. & Klein, A., Nov 20 2007, In : Journal of Clinical Oncology. 25, 33, p. 5337-5338 2 p.

Research output: Contribution to journalArticle

Linkage analysis of chromosome 4 in families with familial pancreatic cancer

Klein, A., De Andrade, M., Hruban, R. H., Bondy, M., Schwartz, A. G., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., Goggins, M. S. & Petersen, G. M., Mar 2007, In : Cancer Biology and Therapy. 6, 3, p. 320-323 4 p.

Research output: Contribution to journalArticle

Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells

Salaria, S. N., Illei, P. B., Sharma, R., Walter, K. M., Klein, A., Eshleman, J., Maitra, A., Schulick, R., Winter, J., Ouellette, M. M., Goggins, M. S. & Hruban, R. H., Mar 2007, In : Cancer Biology and Therapy. 6, 3, p. 324-328 5 p.

Research output: Contribution to journalArticle

PancPRO: Risk assessment for individuals with a family history of pancreatic cancer

Wang, W., Chen, S., Brune, K. A., Hruban, R. H., Parmigiani, G. & Klein, A., Apr 10 2007, In : Journal of Clinical Oncology. 25, 11, p. 1417-1422 6 p.

Research output: Contribution to journalArticle

Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma

Infante, J. R., Matsubayashi, H., Sato, N., Tonascia, J. A., Klein, A., Riall, T. A., Yeo, C., Iacobuzio-Donahue, C. & Goggins, M. S., Jan 20 2007, In : Journal of Clinical Oncology. 25, 3, p. 319-325 7 p.

Research output: Contribution to journalArticle

The GLC1H glaucoma locus may reflect glaucoma with elevated intraocular pressure [4]

Duggal, P., Klein, A., Lee, K. E., Klein, R., Klein, B. E. K. & Bailey-Wilson, J. E., Dec 2007, In : Archives of Ophthalmology. 125, 12, p. 1716-1717 2 p.

Research output: Contribution to journalArticle

The prevalence of BRCA2 mutations in familial pancreatic cancer

Couch, F. J., Johnson, M. R., Rabe, K. G., Brune, K., De Andrade, M., Goggins, M. S., Rothenmund, H., Gallinger, S., Klein, A., Petersen, G. M. & Hruban, R. H., Feb 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 2, p. 342-346 5 p.

Research output: Contribution to journalArticle

Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer

Matsubayashi, H., Infante, J. R., Winter, J., Klein, A., Schulick, R., Hruban, R. H., Visvanathan, K. & Goggins, M. S., Oct 2007, In : Cancer Biology and Therapy. 6, 10, p. 1569-1575 7 p.

Research output: Contribution to journalArticle

2008

Allele-specific expression in the germline of patients with familial pancreatic cancer: An unbiased approach to cancer gene discovery

Aik, C. T., Fan, J. B., Karikari, C., Bibikova, M., Garcia, E. W., Zhou, L., Barker, D., Serre, D., Feldmann, G., Hruban, R. H., Klein, A., Goggins, M. S., Couch, F. J., Hudson, T. J., Winslow, R., Maitra, A. & Chakravarti, A., Jan 2008, In : Cancer Biology and Therapy. 7, 1, p. 137-146 10 p.

Research output: Contribution to journalArticle

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., Hong, S. M., Fu, B., Lin, M-T., Calhoun, E. S., Kamiyama, M., Walter, K., Nikolskaya, T., Nikolsky, Y., Hartigan, J., Smith, D. R. & 16 others, Hidalgo, M., Leach, S. D., Klein, A., Jaffee, E., Goggins, M. S., Maitra, A., Iacobuzio-Donahue, C., Eshleman, J., Kern, S. E., Hruban, R. H., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V. E. & Kinzler, K. W., Sep 26 2008, In : Science. 321, 5897, p. 1801-1806 6 p.

Research output: Contribution to journalArticle

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

Genetic and epigenetic alterations of familial pancreatic cancers

Brune, K., Hong, S. M., Li, A., Yachida, S., Abe, T., Griffith, M., Yang, D., Omura, N., Eshleman, J., Canto, M., Schulick, R., Klein, A., Hruban, R. H., Iacobuzio-Donohue, C. & Goggins, M. S., Dec 2008, In : Cancer Epidemiology Biomarkers and Prevention. 17, 12, p. 3536-3542 7 p.

Research output: Contribution to journalArticle

Incorporating tumor immunohistochemical markers in BRCA1 and BRCA2 carrier prediction

Tai, Y. C., Chen, S., Parmigiani, G. & Klein, A., Mar 20 2008, In : Breast Cancer Research. 10, 2, 401.

Research output: Contribution to journalArticle

Pancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study

De Gonzalez, A. B., Ji, E. Y., Lee, S. Y., Klein, A. & Sun, H. J., Feb 1 2008, In : Cancer Epidemiology Biomarkers and Prevention. 17, 2, p. 359-364 6 p.

Research output: Contribution to journalArticle

Prevalence of unsuspected pancreatic cysts on MDCT

Laffan, T. A., Horton, K. M., Klein, A., Berlanstein, B., Siegelman, S. S., Kawamoto, S., Johnson, P., Fishman, E. K. & Hruban, R. H., Sep 2008, In : American Journal of Roentgenology. 191, 3, p. 802-807 6 p.

Research output: Contribution to journalArticle

2009

Absence of deleterious palladin mutations in patients with familial pancreatic cancer

Klein, A., Borges, M., Griffith, M., Brune, K., Hong, S. M., Omura, N., Hruban, R. H. & Goggins, M. S., Apr 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 4, p. 1328-1330 3 p.

Research output: Contribution to journalArticle

Absence of germline BRCA1 mutations in familial pancreatic cancer patients

Axilbund, J. E., Argani, P., Kamiyama, M., Palmisano, E., Raben, M., Borges, M., Brune, K. A., Goggins, M. S., Hruban, R. H. & Klein, A., Jan 2009, In : Cancer Biology and Therapy. 8, 2, p. 131-135 5 p.

Research output: Contribution to journalArticle

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer

Lacobuzio-Donahue, C. A., Fu, B., Yachida, S., Luo, M., Abe, H., Henderson, C. M., Vilardell, F., Wang, Z., Keller, J. W., Banerjee, P., Herman, J. M., Cameron, J. L., Yeo, C. J., Halushka, M. K., Eshleman, J., Raben, M., Klein, A., Hruban, R. H., Hidalgo, M. & Laheru, D., Apr 10 2009, In : Journal of Clinical Oncology. 27, 11, p. 1806-1813 8 p.

Research output: Contribution to journalArticle

Elevated cancer mortality in the relatives of patients with pancreatic cancer

Wang, L., Brune, K. A., Visvanathan, K., Laheru, D., Herman, J., Wolfgang, C., Schulick, R., Cameron, J. L., Goggins, M. S., Hruban, R. H. & Klein, A., Nov 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 11, p. 2829-2834 6 p.

Research output: Contribution to journalArticle

EPHA2 is associated with age-related cortical cataract in mice and humans

Jun, G., Guo, H., Klein, B. E. K., Klein, R., Jie, J. W., Mitchell, P., Miao, H., Lee, K. E., Joshi, T., Buck, M., Chugha, P., Bardenstein, D., Klein, A., Bailey-Wilson, J. E., Gong, X., Spector, T. D., Andrew, T., Hammond, C. J., Elston, R. C., Iyengar, S. K. & 1 others, Wang, B., Jul 2009, In : PLoS Genetics. 5, 7, e1000584.

Research output: Contribution to journalArticle

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C. H., Palmisano, E., Brune, K., Jaffee, E., Iacobuzio-Donahue, C. A., Maitra, A., Parmigiani, G., Kern, S. E., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Eshleman, J., Goggins, M. S. & Klein, A., Apr 10 2009, In : Science. 324, 5924, p. 217 1 p.

Research output: Contribution to journalArticle

Familial pancreatic cancer

Shi, C., Hruban, R. H. & Klein, A., Mar 2009, In : Archives of Pathology and Laboratory Medicine. 133, 3, p. 365-374 10 p.

Research output: Contribution to journalArticle

Genetic mutations associated with Cigarette smoking in pancreatic cancer

Blackford, A., Parmigiani, G., Kensler, T. W., Wolfgang, C., Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Eshleman, J., Goggins, M. S., Jaffee, E., Iacobuzio-Donahue, C. A., Maitra, A., Klein, A., Cameron, J. L., Olino, K., Schulick, R., Winter, J., Vogelstein, B. & 3 others, Velculescu, V. E., Kinzler, K. W. & Hruban, R. H., Apr 15 2009, In : Cancer Research. 69, 8, p. 3681-3688 8 p.

Research output: Contribution to journalArticle

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

Amundadottir, L., Kraft, P., Stolzenberg-Solomon, R. Z., Fuchs, C. S., Petersen, G. M., Arslan, A. A., Bueno-De-Mesquita, H. B., Gross, M., Helzlsouer, K., Jacobs, E. J., LaCroix, A., Zheng, W., Albanes, D., Bamlet, W., Berg, C. D., Berrino, F., Bingham, S., Buring, J. E., Bracci, P. M., Canzian, F. & 51 others, Clavel-Chapelon, F., Clipp, S., Cotterchio, M., De Andrade, M., Duell, E. J., Fox, J. W., Gallinger, S., Gaziano, J. M., Giovannucci, E. L., Goggins, M. S., González, C. A., Hallmans, G., Hankinson, S. E., Hassan, M., Holly, E. A., Hunter, D. J., Hutchinson, A., Jackson, R., Jacobs, K. B., Jenab, M., Kaaks, R., Klein, A., Kooperberg, C., Kurtz, R. C., Li, D., Lynch, S. M., Mandelson, M., McWilliams, R. R., Mendelsohn, J. B., Michaud, D. S., Olson, S. H., Overvad, K., Patel, A. V., Peeters, P. H. M., Rajkovic, A., Riboli, E., Risch, H. A., Shu, X. O., Thomas, G., Tobias, G. S., Trichopoulos, D., Van Den Eeden, S. K., Virtamo, J., Wactawski-Wende, J., Wolpin, B. M., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Chanock, S. J., Hartge, P. & Hoover, R. N., Sep 2009, In : Nature Genetics. 41, 9, p. 986-990 5 p.

Research output: Contribution to journalArticle