Alison Klein

Professor

19992019
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Research Output 1999 2019

2019

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Walsh, N., Zhang, H., Hyland, P. L., Yang, Q., Mocci, E., Zhang, M., Childs, E. J., Collins, I., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P. M., Brennan, P., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goggins, M., Goodman, G. E., Goodman, P. J. & 78 others, Hung, R. J., Kooperberg, C., Kurtz, R. C., Malats, N., Lemarchand, L., Neale, R. E., Olson, S. H., Scelo, G., Shu, X. O., Van Den Eeden, S. K., Visvanathan, K., White, E., Zheng, W., Albanes, D., Andreotti, G., Babic, A., Bamlet, W. R., Berndt, S. I., Borgida, A., Boutron-Ruault, M. C., Brais, L., Bueno-De-Mesquita, B., Buring, J., Chaffee, K. G., Chanock, S., Cleary, S., Cotterchio, M., Foretova, L., Fuchs, C., M Gaziano, J. M., Giovannucci, E., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Helzlsouer, K. J., Herman, J., Holcatova, I., Holly, E. A., Hoover, R., Janout, V., Klein, E. A., Laheru, D., Lee, I. M., Lu, L., Mannisto, S., Milne, R. L., Oberg, A. L., Orlow, I., Patel, A. V., Peters, U., Porta, M., Real, F. X., Rothman, N., Sesso, H. D., Severi, G., Silverman, D., Strobel, O., Sund, M., Thornquist, M. D., Tobias, G. S., Wactawski-Wende, J., Wareham, N., Weiderpass, E., Wentzensen, N., Wheeler, W., Yu, H., Zeleniuch-Jacquotte, A., Kraft, P., Li, D., Jacobs, E. J., Petersen, G. M., Wolpin, B. M., Risch, H. A., Amundadottir, L. T., Yu, K., Klein, A. P. & Stolzenberg-Solomon, R. Z., Jun 1 2019, In : Journal of the National Cancer Institute. 111, 6, p. 557-567 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pancreatic Neoplasms
Genes
Single Nucleotide Polymorphism
Adenocarcinoma

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Cyst Fluid
Practice Management
Standard of Care

Analysis of heritability and genetic architecture of pancreatic cancer: A PANC4 study

Chen, F., Childs, E. J., Mocci, E., Bracci, P., Gallinger, S., Li, D., Neale, R. E., Olson, S. H., Scelo, G., Bamlet, W. R., Blackford, A. L., Borges, M., Brennan, P., Chaffee, K. G., Duggal, P., Hassan, M. J., Holly, E. A., Hung, R. J., Goggins, M. G., Kurtz, R. C. & 6 others, Oberg, A. L., Orlow, I., Yu, H., Petersen, G. M., Risch, H. A. & Klein, A. P., Jan 1 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 7, p. 1238-1245 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Genome-Wide Association Study
Genome
Neoplasm Genes
Linkage Disequilibrium

A New Fast Phasing Method Based On Haplotype Subtraction

Mocci, E., Debeljak, M., Klein, A. & Eshleman, J., May 1 2019, In : Journal of Molecular Diagnostics. 21, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

Haplotypes
Alleles
Genotype
Genome
Homozygote

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

Alzheimer’s Disease Neuroimaging Initiative, Aug 1 2019, In : PLoS genetics. 15, 8, p. e1008344

Research output: Contribution to journalArticle

Open Access
pancreatic neoplasms
Neoplasm Genes
adenocarcinoma
Pancreatic Neoplasms
sensitivity analysis

Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance

Abe, T., Blackford, A. L., Tamura, K., Ford, M., McCormick, P., Chuidian, M., Almario, J. A., Borges, M., O'Broin-Lennon, A. M., Shin, E., Klein, A., Hruban, R. H., Canto, M. & Goggins, M. S., May 1 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 13, p. 1070-1080 11 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Pancreatic Neoplasms
Neoplasm Genes
Mutation
Incidence

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

Hutchings, D., Jiang, Z., Skaro, M., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Zheng, L., Klimstra, D. S., Brand, R. E., Singhi, A. D., Goggins, M. S., Klein, A., Roberts, N. & Hruban, R. H., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Pancreatic Neoplasms
Colloids
Adenocarcinoma
Carcinoma

Management of patients with increased risk for familial pancreatic cancer: Updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium

Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E., Fockens, P., Gress, T. M., Van Hooft, J. E., Hruban, R. H., Kastrinos, F., Klein, A., Lennon, A. M., Lucas, A., Park, W., Rustgi, A. & 6 others, Simeone, D., Stoffel, E., Vasen, H. F. A., Cahen, D. L., Canto, M. I. & Bruno, M., Jan 1 2019, (Accepted/In press) In : Gut. 319352.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Consensus
Germ-Line Mutation
Cost-Benefit Analysis

Pancreatic cancer: a growing burden

Klein, A. P., Dec 2019, In : The Lancet Gastroenterology and Hepatology. 4, 12, p. 895-896 2 p.

Research output: Contribution to journalComment/debate

Open Access
Pancreatic Neoplasms

Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

Skaro, M., Nanda, N., Gauthier, C., Felsenstein, M., Jiang, Z., Qiu, M., Shindo, K., Yu, J., Hutchings, D., Javed, A. A., Beckman, R., He, J., Wolfgang, C., Thompson, E., Hruban, R. H., Klein, A., Goggins, M. S., Wood, L. D. & Roberts, N., May 1 2019, In : Gastroenterology. 156, 6, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasms
Pancreatic Neoplasms
Mutation
Confidence Intervals

Screening for Pancreatic Cancer - Is There Hope?

O'Broin-Lennon, A. M., Hruban, R. H. & Klein, A., Oct 1 2019, In : JAMA internal medicine. 179, 10, p. 1313-1315 3 p.

Research output: Contribution to journalEditorial

Pancreatic Neoplasms
Pancreatic Neoplasms
Pancreatectomy
Length of Stay
Adenocarcinoma
Mortality
2018

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European–American population

Vergara, C., Bomotti, S. M., Valencia, C., Klein, B. E. K., Lee, K. E., Klein, R., Klein, A. & Duggal, P., Jan 1 2018, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

Exome
Confidence Intervals
Hyperopia
Refractive Errors
Vision Disorders

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas

Determinants and prognostic value of quality of life in patients with pancreatic ductal adenocarcinoma

Deng, Y., Tu, H., Pierzynski, J. A., Miller, E. D., Gu, X., Huang, M., Chang, D. W., Ye, Y., Hildebrandt, M. A. T., Klein, A., Zhao, R., Lippman, S. M. & Wu, X., Mar 1 2018, In : European Journal of Cancer. 92, p. 20-32 13 p.

Research output: Contribution to journalArticle

Value of Life
Adenocarcinoma
Quality of Life
Hispanic Americans
Pancreatic Neoplasms

Exome-Wide Association Study of Pancreatic Cancer Risk

Grant, R. C., Denroche, R. E., Borgida, A., Virtanen, C., Cook, N., Smith, A. L., Connor, A. A., Wilson, J. M., Peterson, G., Roberts, N., Klein, A., Grimmond, S. M., Biankin, A., Cleary, S., Moore, M., Lemire, M., Zogopoulos, G., Stein, L. & Gallinger, S., Feb 1 2018, In : Gastroenterology. 154, 3, p. 719-722.e3

Research output: Contribution to journalArticle

Exome
Pancreatic Neoplasms
Genes
Genetic Heterogeneity
Neoplasm Genes

Familial pancreatic cancer

Roberts, N. & Klein, A., Apr 11 2018, Pancreatic Cancer. Springer New York, p. 553-572 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
Mutation
Penetrance
Germ-Line Mutation
Early Detection of Cancer

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Klein, A., Wolpin, B. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Mocci, E., Zhang, M., Canzian, F., Childs, E. J., Hoskins, J. W., Jermusyk, A., Zhong, J., Chen, F., Albanes, D., Andreotti, G., Arslan, A. A., Babic, A., Bamlet, W. R., Beane-Freeman, L., Berndt, S. I., Blackford, A. & 103 others, Borges, M., Borgida, A., Bracci, P. M., Brais, L., Brennan, P., Brenner, H., Bueno-De-Mesquita, B., Buring, J., Campa, D., Capurso, G., Cavestro, G. M., Chaffee, K. G., Chung, C. C., Cleary, S., Cotterchio, M., Dijk, F., Duell, E. J., Foretova, L., Fuchs, C., Funel, N., Gallinger, S., Gaziano, J. M. M., Gazouli, M., Giles, G. G., Giovannucci, E., Goggins, M. S., Goodman, G. E., Goodman, P. J., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Hegyi, P., Helzlsouer, K. J., Herman, J., Holcatova, I., Holly, E. A., Hoover, R., Hung, R. J., Jacobs, E. J., Jamroziak, K., Janout, V., Kaaks, R., Khaw, K. T., Klein, E. A., Kogevinas, M., Kooperberg, C., Kulke, M. H., Kupcinskas, J., Kurtz, R. J., Laheru, D., Landi, S., Lawlor, R. T., Lee, I. M., Lemarchand, L., Lu, L., Malats, N., Mambrini, A., Mannisto, S., Milne, R. L., Mohelníková-Duchoňová, B., Neale, R. E., Neoptolemos, J. P., Oberg, A. L., Olson, S. H., Orlow, I., Pasquali, C., Patel, A. V., Peters, U., Pezzilli, R., Porta, M., Real, F. X., Rothman, N., Scelo, G., Sesso, H. D., Severi, G., Shu, X. O., Silverman, D., Smith, J. P., Soucek, P., Sund, M., Talar-Wojnarowska, R., Tavano, F., Thornquist, M. D., Tobias, G. S., Van Den Eeden, S. K., Vashist, Y., Visvanathan, K., Vodicka, P., Wactawski-Wende, J., Wang, Z., Wentzensen, N., White, E., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Zheng, W., Kraft, P., Li, D., Chanock, S., Obazee, O., Petersen, G. M. & Amundadottir, L. T., Dec 1 2018, In : Nature Communications. 9, 1, 556.

Research output: Contribution to journalArticle

genome
loci
Pancreatic Neoplasms
Meta-Analysis
Genes

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C., Hruban, R. H., Ishii, M., Klein, A., Reh, D. D., Rooper, L., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K. & 5 others, Agrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In : Nature Communications. 9, 1, 5410.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
deletion
Dystrophin
Genes
genes

Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers

Schunke, K. J., Rosati, L. M., Zahurak, M., Herman, J. M., Narang, A., Usach, I., Klein, A., Yeo, C. J., Korman, L. T., Hruban, R. H., Cameron, J. L., Laheru, D. & Abrams, R. A., Jan 1 2018, (Accepted/In press) In : Advances in Radiation Oncology.

Research output: Contribution to journalArticle

Mitomycin
Pancreatic Neoplasms
Fluorouracil
Prospective Studies
Survival

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., MacGregor-Das, A., Borges, M., Wolfgang, C., Weiss, M. J., He, J., Canto, M., Petersen, G. M., Gallinger, S., Syngal, S., Brand, R. E., Rustgi, A., Olson, S. H., Stoffel, E., Cote, M. L. & 13 others, Zogopoulos, G., Potash, J. B., Goes, F. S., McCombie, R. W., Zandi, P. P., Pirooznia, M., Kramer, M., Parla, J., Eshleman, J., Roberts, N., Hruban, R. H., Klein, A. & Goggins, M. S., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4767-4772 6 p.

Research output: Contribution to journalArticle

Carboxypeptidases A
Pancreatic Neoplasms
Endoplasmic Reticulum Stress
Mutation
Enzymes

Refraction and change in refraction over a 20-year period in the beaver dam eye study

Bomotti, S., Lau, B. M., Klein, B. E. K., Lee, K. E., Klein, R., Duggal, P. & Klein, A., Sep 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4518-4524 7 p.

Research output: Contribution to journalArticle

Cohort Effect
Rodentia
Confidence Intervals
Cataract
Sclerosis

Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance

Canto, M., Almario, J. A., Schulick, R. D., Yeo, C. J., Klein, A., Blackford, A., Shin, E., Sanyal, A., Yenokyan, G., O'Broin-Lennon, A. M., Kamel, I. R., Fishman, E. K., Wolfgang, C., Weiss, M. J., Hruban, R. H. & Goggins, M. S., Sep 1 2018, In : Gastroenterology. 155, 3, p. 740-751.e2

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Cysts
Endosonography
Pancreatic Ducts
2017

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A. K., Jinawath, A., Yeo, C. J., Eshleman, J., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S., May 1 2017, In : Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

Research output: Contribution to journalArticle

Cadherins
Adenocarcinoma
Loss of Heterozygosity
Pancreatic Neoplasms
Carcinogenesis

Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

Telomeres Mendelian Randomization Collaboration, 2017, In : JAMA oncology. 3, 5, p. 636-651 16 p.

Research output: Contribution to journalArticle

Telomere
Random Allocation
Odds Ratio
Confidence Intervals
Neoplasms

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M. T., Allen, P. J., Schattner, M., Brand, R. E., Singhi, A. D., Petersen, G. M., Hong, S. M., Kim, S. C., Falconi, M., Doglioni, C., Weiss, M. J., Ahuja, N., He, J. & 20 others, Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. S., Hruban, R. H., Wolfgang, C., Klein, A., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & O'Broin-Lennon, A. M., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Biomarkers
Biopsy
DNA

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Cho, C., Macgregor-Das, A., Siddiqui, A., Witmer, P. D., Tamura, K., Song, T. J., Almario, J. A. N., Brant, A., Borges, M., Ford, M., Barkley, T., He, J., Weiss, M. J., Wolfgang, C., Roberts, N., Hruban, R. H. & 2 others, Klein, A. & Goggins, M. S., Oct 20 2017, In : Journal of Clinical Oncology. 35, 30, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Adenocarcinoma
Pancreatic Neoplasms
Neoplasm Genes
Neoplasms

Exome Array Analysis of Nuclear Lens Opacity

Loomis, S. J., Klein, A., Lee, K. E., Chen, F., Bomotti, S., Truitt, B., Iyengar, S. K., Klein, R., Klein, B. E. K. & Duggal, P., Nov 29 2017, (Accepted/In press) In : Ophthalmic Epidemiology. p. 1-5 5 p.

Research output: Contribution to journalArticle

Exome
Cataract
Sclerosis
Genes
Gene Frequency

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Fang, J., Jia, J., Makowski, M., Xu, M., Wang, Z., Zhang, T., Hoskins, J. W., Choi, J., Han, Y., Zhang, M., Thomas, J., Kovacs, M., Collins, I., Dzyadyk, M., Thompson, A., O'Neill, M., Das, S., Lan, Q., Koster, R., Stolzenberg-Solomon, R. S. & 215 others, Kraft, P., Wolpin, B. M., Jansen, P. W. T. C., Olson, S., McGlynn, K. A., Kanetsky, P. A., Chatterjee, N., Barrett, J. H., Dunning, A. M., Taylor, J. C., Newton-Bishop, J. A., Timothy Bishop, D., Andresson, T., Petersen, G. M., Amos, C. I., Iles, M. M., Nathanson, K. L., Landi, M. T., Vermeulen, M., Brown, K. M., Amundadottir, L. T., Canzian, F., Kooperberg, C., Arslan, A. A., Bracci, P. M., Buring, J., Duell, E. J., Gallinger, S., Jacobs, E. J., Kamineni, A., Van Den Eeden, S., Klein, A., Kolonel, L. N., Li, D., Olson, S. H., Risch, H. A., Sesso, H. D., Visvanathan, K., Zheng, W., Albanes, D., Austin, M. A., Boutron-Ruault, M. C., Bueno-De-Mesquita, H. B., Cotterchio, M., Gaziano, J. M., Giovannucci, E. L., Goggins, M. S., Gross, M., Hassan, M., Helzlsouer, K. J., Holly, E. A., Hunter, D. J., Jenab, M., Kaaks, R., Key, T. J., Khaw, K. T., Krogh, V., Kurtz, R. C., LaCroix, A., Le Marchand, L., Mannisto, S., Patel, A. V., Peeters, P. H. M., Riboli, E., Shu, X. O., Sund, M., Thornquist, M., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Wactawski-Wende, J., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Hoover, R., Hartge, P., Fuchs, C., Chanock, S. J., Stevens, V., Albanes, D., Caporaso, N. E., Brennan, P., McKay, J., Wu, X., Hung, R. J., McLaughlin, J. R., Bickeboller, H., Risch, A., Wichmann, E., Houlston, R. S., Mann, G., Hopper, J., Aitken, J., Armstrong, B., Giles, G., Holland, E., Kefford, R., Cust, A., Jenkins, M., Schmid, H., Puig, S., Aguilera, P., Badenas, C., Barreiro, A., Carrera, C., Gabriel, D., Xavier, P. G., Iglesias-Garcia, P., Malvehy, J., Mila, M., Pigem, R., Potrony, M., Puig Butille, J. A., Tell-Marti, G., Hayward, N. K., Martin, N. G., Montgomery, G., Duffy, D. L., Whiteman, D. C., MacGregor, S., Calista, D., Landi, G., Minghetti, P., Arcangeli, F., Bertazzi, P. A., Ghiorzo, P., Bianchi-Scarra, G., Pastorino, L., Bruno, W., Andreotti, V., Queirolo, P., Spagnolo, F., MacKie, R., Lang, J., Gruis, N., Van Nieuwpoort, F. A., Out, C., Bergman, W., Kukutsch, N., Bavinck, J. N. B., Bakker, B., Van Der Stoep, N., Ter Huurne, J., Van Der Rhee, H., Bekkenk, M., Snels, D., Van Praag, M., Brochez, L., Gerritsen, R., Crijns, M., Vasen, H., Janssen, B., Ingvar, C., Olsson, H., Jönsson, G., Borg, Å., Harbst, K., Nielsen, K., Zander, A. S., Molven, A., Helsing, P., Andresen, P. A., Rootwelt, H., Akslen, L. A., Paillerets, B. B. D., Demenais, F., Avril, M. F., Chaudru, V., Jeannin, P., Lesueur, F., Maubec, E., Mohamdi, H., Bossard, M., Vaysse, A., Boitier, F., Caron, O., Caux, F., Dalle, S., Dereure, O., Leroux, D., Martin, L., Mateus, C., Robert, C., Stoppa-Lyonnet, D., Thomas, L., Wierzbicka, E., Elder, D. E., Ming, M., Mitra, N., Debniak, T., Lubinski, J., Hocevar, M., Novakovic, S., Peric, B., Skerl, P., Hansson, J., Höiom, V., Friedman, E., Azizi, E., Baron-Epel, O., Scope, A., Pavlotsky, F., Cohen-Manheim, I., Laitman, Y., Harland, M., Randerson-Moor, J., Laye, J., Davies, J., Nsengimana, J., O'Shea, S., Chan, M., Gascoyne, J., Tucker, M. A., Goldstein, A. M. & Yang, X. R., Jan 1 2017, In : Nature Communications. 8, 15034.

Research output: Contribution to journalArticle

Zinc Fingers
loci
Zinc
zinc
cancer

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection

Debeljak, M., Mocci, E., Morrison, M. C., Pallavajjalla, A., Beierl, K., Amiel, M., Noë, M., Wood, L. D., Lin, M-T., Gocke, C., Klein, A., Fuchs, E. J., Jones, R. J. & Eshleman, J., May 1 2017, In : Journal of Molecular Diagnostics. 19, 3, p. 427-436 10 p.

Research output: Contribution to journalArticle

Chimerism
Haplotypes
Leukemia
Recurrence
Bone Marrow Transplantation

Impact of sixteen established pancreatic cancer susceptibility loci in American Jews

Streicher, S. A., Klein, A., Olson, S. H., Amundadottir, L. T., DeWan, A. T., Zhao, H. & Risch, H. A., Oct 1 2017, In : Cancer Epidemiology Biomarkers and Prevention. 26, 10, p. 1540-1548 9 p.

Research output: Contribution to journalArticle

Jews
Pancreatic Neoplasms
Genetic Research
Molecular Epidemiology
Principal Component Analysis

Inherited pancreatic cancer

Chen, F., Roberts, N. & Klein, A., Dec 1 2017, In : Chinese Clinical Oncology. 6, 6, 58.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Penetrance
Neoplasm Genes
Ovarian Neoplasms
Cluster Analysis

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Tamura, K., Almario, J. A. N., Brant, A., Borges, M., Siddiqui, A., Datta, L., Wolfgang, C., Hruban, R. H., Klein, A. & Goggins, M. S., Feb 7 2017, In : Oncotarget. 8, 31, p. 50824-50831 8 p.

Research output: Contribution to journalArticle

Lipase
Pancreatic Neoplasms
Pancreatitis
Esters
Alleles

Quantifying the genetic correlation between multiple cancer types

Lindström, S., Finucane, H., Bulik-Sullivan, B., Schumacher, F. R., Amos, C. I., Hung, R. J., Rand, K., Gruber, S. B., Conti, D., Permuth, J. B., Lin, H. Y., Goode, E. L., Sellers, T. A., Amundadottir, L. T., Stolzenberg-Solomon, R., Klein, A., Petersen, G., Risch, H., Wolpin, B., Hsu, L. & 11 others, Huyghe, J. R., Chang-Claude, J., Chan, A., Berndt, S., Eeles, R., Easton, D., Haiman, C. A., Hunter, D. J., Neale, B., Price, A. L. & Kraft, P., Sep 1 2017, In : Cancer Epidemiology Biomarkers and Prevention. 26, 9, p. 1427-1435 9 p.

Research output: Contribution to journalArticle

Neoplasms
Colorectal Neoplasms
Lung Neoplasms
Breast Neoplasms
Genome-Wide Association Study
2016

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

Sampson, J. N., Wheeler, W. A., Yeager, M., Panagiotou, O., Wang, Z., Berndt, S. I., Lan, Q., Abnet, C. C., Amundadottir, L. T., Figueroa, J. D., Landi, M. T., Mirabello, L., Savage, S. A., Taylor, P. R., De Vivo, I., McGlynn, K. A., Purdue, M. P., Rajaraman, P., Adami, H. O., Ahlbom, A. & 388 others, Albanes, D., Amary, M. F., An, S. J., Andersson, U., Andriole, G., Andrulis, I. L., Angelucci, E., Ansell, S. M., Arici, C., Armstrong, B. K., Arslan, A. A., Austin, M. A., Baris, D., Barkauskas, D. A., Bassig, B. A., Becker, N., Benavente, Y., Benhamou, S., Berg, C., Van Den Berg, D., Bernstein, L., Bertrand, K. A., Birmann, B. M., Black, A., Boeing, H., Boffetta, P., Boutron-Ruault, M. C., Bracci, P. M., Brinton, L., Brooks-Wilson, A. R., Bueno-De-Mesquita, H. B., Burdett, L., Buring, J., Butler, M. A., Cai, Q., Cancel-Tassin, G., Canzian, F., Carrato, A., Carreon, T., Carta, A., Chan, J. K. C., Chang, E. T., Chang, G. C., Chang, I. S., Chang, J., Chang-Claude, J., Chen, C. J., Chen, C. Y., Chen, C., Chen, C. H., Chen, C., Chen, H., Chen, K., Chen, K. Y., Chen, K. C., Chen, Y., Chen, Y. H., Chen, Y. S., Chen, Y. M., Chien, L. H., Chirlaque, M. D., Choi, J. E., Choi, Y. Y., Chow, W. H., Chung, C. C., Clavel, J., Clavel-Chapelon, F., Cocco, P., Colt, J. S., Comperat, E., Conde, L., Connors, J. M., Conti, D., Cortessis, V. K., Cotterchio, M., Cozen, W., Crouch, S., Crous-Bou, M., Cussenot, O., Davis, F. G., Ding, T., Diver, W. R., Dorronsoro, M., Dossus, L., Duell, E. J., Ennas, M. G., Erickson, R. L., Feychting, M., Flanagan, A. M., Foretova, L., Fraumeni, J. F., Freedman, N. D., Freeman, L. E. B., Fuchs, C., Gago-Dominguez, M., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., García-Closas, R., Gascoyne, R. D., Gastier-Foster, J., Gaudet, M. M., Gaziano, J. M., Giffen, C., Giles, G. G., Giovannucci, E., Glimelius, B., Goggins, M. S., Gokgoz, N., Goldstein, A. M., Gorlick, R., Gross, M., Grubb, R., Gu, J., Guan, P., Gunter, M., Guo, H., Habermann, T. M., Haiman, C. A., Halai, D., Hallmans, G., Hassan, M., Hattinger, C., He, Q., He, X., Helzlsouer, K., Henderson, B., Henriksson, R., Hjalgrim, H., Hoffman-Bolton, J., Hohensee, C., Holford, T. R., Holly, E. A., Hong, Y. C., Hoover, R. N., Horn-Ross, P. L., Hosain, G. M. M., Hosgood, H. D., Hsiao, C. F., Hu, N., Hu, W., Hu, Z., Huang, M. S., Huerta, J. M., Hung, J. Y., Hutchinson, A., Inskip, P. D., Jackson, R. D., Jacobs, E. J., Jenab, M., Jeon, H. S., Ji, B. T., Jin, G., Jin, L., Johansen, C., Johnson, A., Jung, Y. J., Kaaks, R., Kamineni, A., Kane, E., Kang, C. H., Karagas, M. R., Kelly, R. S., Khaw, K. T., Kim, C., Kim, H. N., Kim, J. H., Kim, J. S., Kim, Y. H., Kim, Y. T., Kim, Y. C., Kitahara, C. M., Klein, A., Klein, R. J., Kogevinas, M., Kohno, T., Kolonel, L. N., Kooperberg, C., Kricker, A., Krogh, V., Kunitoh, H., Kurtz, R. C., Kweon, S. S., La Croix, A., Lawrence, C., Lecanda, F., Lee, V. H. F., Li, D., Li, H., Li, J., Li, Y. J., Li, Y., Liao, L. M., Liebow, M., Lightfoot, T., Lim, W. Y., Lin, C. C., Lin, D., Lindstrom, S., Linet, M. S., Link, B. K., Liu, C., Liu, J., Liu, L., Ljungberg, B., Lloreta, J., Di Lollo, S., Lu, D., Lund, E., Malats, N., Mannisto, S., Marchand, L. L., Marina, N., Masala, G., Mastrangelo, G., Matsuo, K., Maynadie, M., McKay, J., McKean-Cowdin, R., Melbye, M., Melin, B. S., Michaud, D. S., Mitsudomi, T., Monnereau, A., Montalvan, R., Moore, L. E., Mortensen, L. M., Nieters, A., North, K. E., Novak, A. J., Oberg, A. L., Offit, K., Oh, I. J., Olson, S. H., Palli, D., Pao, W., Park, I. K., Park, J. Y., Park, K. H., Patiño-Garcia, A., Pavanello, S., Peeters, P. H. M., Perng, R. P., Peters, U., Petersen, G. M., Picci, P., Pike, M. C., Porru, S., Prescott, J., Prokunina-Olsson, L., Qian, B., Qiao, Y. L., Rais, M., Riboli, E., Riby, J., Risch, H. A., Rizzato, C., Rodabough, R., Roman, E., Roupret, M., Ruder, A. M., De Sanjose, S., Scelo, G., Schned, A., Schumacher, F., Schwartz, K., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H. D., Setiawan, V. W., Severi, G., Severson, R. K., Shanafelt, T. D., Shen, H., Shen, W., Shin, M. H., Shiraishi, K., Shu, X. O., Siddiq, A., Sierrasesúmaga, L., Sihoe, A. D. L., Skibola, C. F., Smith, A., Smith, M. T., Southey, M. C., Spinelli, J. J., Staines, A., Stampfer, M., Stern, M. C., Stevens, V. L., Stolzenberg-Solomon, R. S., Su, J., Su, W. C., Sund, M., Sung, J. S., Sung, S. W., Tan, W., Tang, W., Tardón, A., Thomas, D., Thompson, C. A., Tinker, L. F., Tirabosco, R., Tjønneland, A., Travis, R. C., Trichopoulos, D., Tsai, F. Y., Tsai, Y. H., Tucker, M., Turner, J., Vajdic, C. M., Vermeulen, R. C. H., Villano, D. J., Vineis, P., Virtamo, J., Visvanathan, K., Wactawski-Wende, J., Wang, C., Wang, C. L., Wang, J. C., Wang, J., Wei, F., Weiderpass, E., Weiner, G. J., Weinstein, S., Wentzensen, N., White, E., Witzig, T. E., Wolpin, B. M., Wong, M. P., Wu, C., Wu, G., Wu, J., Wu, T., Wu, W., Wu, X., Wu, Y. L., Wunder, J. S., Xiang, Y. B., Xu, J., Xu, P., Yang, P. C., Yang, T. Y., Ye, Y., Yin, Z., Yokota, J., Yoon, H. I., Yu, C. J., Yu, H., Yu, K., Yuan, J. M., Zelenetz, A., Zeleniuch-Jacquotte, A., Zhang, X. C., Zhang, Y., Zhao, X., Zhao, Z., Zheng, H., Zheng, T., Zheng, W., Zhou, B., Zhu, M., Zucca, M., Boca, S. M., Cerhan, J. R., Ferri, G. M., Hartge, P., Hsiung, C. A., Magnani, C., Miligi, L., Morton, L. M., Smedby, K. E., Teras, L. R., Vijai, J., Wang, S. S., Brennan, P., Caporaso, N. E., Hunter, D. J., Kraft, P., Rothman, N., Silverman, D. T., Slager, S. L., Chanock, S. J. & Chatterjee, N., 2016, In : Journal of the National Cancer Institute. 107, 12, djv279.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Smoking
Neoplasms
Lung Neoplasms
Confidence Intervals

Association of common susceptibility variants of pancreatic cancer in higher-risk patients: A PACGENE study

Childs, E. J., Chaffee, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Cote, M. L., Bondy, M. L., Hruban, R. H., Chanock, S. J., Hoover, R. N., Fuchs, C. S., Rider, D. N., Amundadottir, L. T., Stolzenberg-Solomon, R., Wolpin, B. M., Risch, H. A., Goggins, M. S., Petersen, G. M. & Klein, A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Ovarian Neoplasms
Single Nucleotide Polymorphism
BRCA2 Gene
Breast Neoplasms

Erratum: Using quantitative seroproteomics to identify antibody biomarkers in pancreatic cancer (Cancer Immunology Research (2016) 4 (225-233))

Jhaveri, D. T., Kim, M. S., Thompson, E. D., Huang, L., Sharma, R. & Klein, A. P., May 1 2016, In : Cancer immunology research. 4, 5, p. 472 1 p.

Research output: Contribution to journalComment/debate

Allergy and Immunology
Pancreatic Neoplasms
Biomarkers
Antibodies
Research

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

MacHiela, M. J., Zhou, W., Karlins, E., Sampson, J. N., Freedman, N. D., Yang, Q., Hicks, B., Dagnall, C., Hautman, C., Jacobs, K. B., Abnet, C. C., Aldrich, M. C., Amos, C., Amundadottir, L. T., Arslan, A. A., Beane-Freeman, L. E., Berndt, S. I., Black, A., Blot, W. J., Bock, C. H. & 156 others, Bracci, P. M., Brinton, L. A., Bueno-De-Mesquita, H. B., Burdett, L., Buring, J. E., Butler, M. A., Canzian, F., Carreón, T., Chaffee, K. G., Chang, I. S., Chatterjee, N., Chen, C., Chen, C., Chen, K., Chung, C. C., Cook, L. S., Crous Bou, M., Cullen, M., Davis, F. G., De Vivo, I., Ding, T., Doherty, J., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Friedenreich, C. M., Fuchs, C. S., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., Gaudet, M. M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Haiman, C. A., Hallmans, G., Hankinson, S. E., Harris, C. C., Henriksson, R., Holly, E. A., Hong, Y. C., Hoover, R. N., Hsiung, C. A., Hu, N., Hu, W., Hunter, D. J., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, A., Klein, R., Koh, W. P., Kolonel, L. N., Kooperberg, C., Kraft, P., Krogh, V., Kurtz, R. C., Lacroix, A., Lan, Q., Landi, M. T., Marchand, L. L., Li, D., Liang, X., Liao, L. M., Lin, D., Liu, J., Lissowska, J., Lu, L., Magliocco, A. M., Malats, N., Matsuo, K., McNeill, L. H., McWilliams, R. R., Melin, B. S., Mirabello, L., Moore, L., Olson, S. H., Orlow, I., Park, J. Y., Patinõ-Garcia, A., Peplonska, B., Peters, U., Petersen, G. M., Pooler, L., Prescott, J., Prokunina-Olsson, L., Purdue, M. P., Qiao, Y. L., Rajaraman, P., Real, F. X., Riboli, E., Risch, H. A., Rodriguez-Santiago, B., Ruder, A. M., Savage, S. A., Schumacher, F., Schwartz, A. G., Schwartz, K. L., Seow, A., Wendy Setiawan, V., Severi, G., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Van Den Berg, D., Visvanathan, K., Wacholder, S., Wang, J. C., Wang, Z., Wentzensen, N., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wong, M. P., Wu, C., Wu, T., Wu, X., Wu, Y. L., Wunder, J. S., Xia, L., Yang, H. P., Yang, P. C., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Ziegler, R. G., Perez-Jurado, L. A., Caporaso, N. E., Rothman, N., Tucker, M., Dean, M. C., Yeager, M. & Chanock, S. J., Jun 13 2016, In : Nature Communications. 7, 11843.

Research output: Contribution to journalArticle

Mosaicism
chromosomes
X Chromosome
Chromosomes
Sex Chromosomes

Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression

Hoskins, J. W., Ibrahim, A., Emmanuel, M. A., Manmiller, S. M., Wu, Y., O'Neill, M., Jia, J., Collins, I., Zhang, M., Thomas, J. V., Rost, L. M., Das, S., Parikh, H., Haake, J. M., Matters, G. L., Kurtz, R. C., Bamlet, W. R., Klein, A., Stolzenberg-Solomon, R., Wolpin, B. M. & 7 others, Yarden, R., Wang, Z., Smith, J., Olson, S. H., Andresson, T., Petersen, G. M. & Amundadottir, L. T., 2016, In : Human Molecular Genetics. 25, 21, p. 4726-4738 13 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Alleles
TCF Transcription Factors
Nuclear RNA
Exosome Multienzyme Ribonuclease Complex

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report

Miller, M. S., Allen, P., Brentnall, T. A., Goggins, M. S., Hruban, R. H., Petersen, G. M., Rao, C. V., Whitcomb, D. C., Brand, R. E., Chari, S. T., Klein, A., Lubman, D. M., Rhim, A. D., Simeone, D. M., Wolpin, B. M., Umar, A., Srivastava, S., Steele, V. E. & Rinaudo, J. A. S., Sep 1 2016, In : Pancreas. 45, 8, p. 1080-1091 12 p.

Research output: Contribution to journalArticle

Chemoprevention
Pancreatic Neoplasms
Education
National Cancer Institute (U.S.)
Population

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

Zhang, M., Wang, Z., Obazee, O., Jia, J., Childs, E. J., Hoskins, J., Figlioli, G., Mocci, E., Collins, I., Chung, C. C., Hautman, C., Arslan, A. A., Beane-Freeman, L., Bracci, P. M., Buring, J., Duell, E. J., Gallinger, S., Giles, G. G., Goodman, G. E., Goodman, P. J. & 103 others, Kamineni, A., Kolonel, L. N., Kulke, M. H., Malats, N., Olson, S. H., Sesso, H. D., Visvanathan, K., White, E., Zheng, W., Abnet, C. C., Albanes, D., Andreotti, G., Brais, L., Bas Bueno-de-Mesquita, H., Basso, D., Berndt, S. I., Boutron-Ruault, M. C., Bijlsma, M. F., Brenner, H., Burdette, L., Campa, D., Caporaso, N. E., Capurso, G., Cavestro, G. M., Cotterchio, M., Costello, E., Elena, J., Boggi, U., Michael Gaziano, J., Gazouli, M., Giovannucci, E. L., Goggins, M. S., Gross, M., Haiman, C. A., Hassan, M., Helzlsouer, K. J., Hu, N., Hunter, D. J., Iskierka-Jazdzewska, E., Jenab, M., Kaaks, R., Key, T. J., Khaw, K. T., Klein, E. A., Kogevinas, M., Krogh, V., Kupcinskas, J., Kurtz, R. C., Landi, M. T., Landi, S., Marchand, L. L., Mambrini, A., Mannisto, S., Milne, R. L., Neale, R. E., Oberg, A. L., Panico, S., Patel, A. V., Peeters, P. H. M., Peters, U., Pezzilli, R., Porta, M., Purdue, M., Ramón Quiros, J., Riboli, E., Rothman, N., Scarpa, A., Scelo, G., Shu, X. O., Silverman, D. T., Soucek, P., Strobel, O., Sund, M., Malecka-Panas, E., Taylor, P. R., Tavano, F., Travis, R. C., Thornquist, M., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Vashist, Y., Vodicka, P., Wactawski-Wende, J., Wentzensen, N., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Kooperberg, C., Risch, H. A., Jacobs, E. J., Li, D., Fuchs, C., Hoover, R., Hartge, P., Chanock, S. J., Petersen, G. M., Stolzenberg-Solomon, R. S., Wolpin, B. M., Kraft, P., Klein, A., Canzian, F. & Amundadottir, L. T., 2016, In : Oncotarget. 7, 41, p. 66328-66343 16 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Chromosomes
Genome-Wide Association Study
Odds Ratio
Single Nucleotide Polymorphism

Using quantitative seroproteomics to identify antibody biomarkers in pancreatic cancer

Jhaveri, D. T., Kim, M. S., Thompson, E., Huang, L., Sharma, R., Klein, A., Zheng, L., Le, D., Laheru, D., Pandey, A., Jaffee, E. & Anders, R. A., Mar 1 2016, In : Cancer immunology research. 4, 3, p. 225-233 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Biomarkers
Immunoprecipitation
Antibodies
Cancer Vaccines

Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalent

Chen, F., Duggal, P., Klein, B. E. K., Lee, K. E., Truitt, B., Klein, R., Iyengar, S. K. & Klein, A., Jul 14 2016, In : Molecular Vision. 22, p. 783-796 14 p.

Research output: Contribution to journalArticle

Myopia
Genes
Gene Frequency
Hyperopia
Refractive Errors

Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer

Roberts, N., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., Stoffel, E., Syngal, S., Zogopoulos, G., Ali, S. Z., Axilbund, J., Chaffee, K. G., Chen, Y. C., Cote, M. L., Childs, E. J., Douville, C. & 25 others, Goes, F. S., Herman, J. M., Iacobuzio-Donahue, C., Kramer, M., Makohon-Moore, A., McCombie, R. W., McMahon, K. W., Niknafs, N., Parla, J., Pirooznia, M., Potash, J. B., Rhim, A. D., Smith, A. L., Wang, Y., Wolfgang, C., Wood, L. D., Zandi, P. P., Goggins, M. S., Karchin, R., Eshleman, J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Hruban, R. H. & Klein, A., Feb 1 2016, In : Cancer Discovery. 6, 2, p. 166-175 10 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Genome
Exome
Inborn Genetic Diseases

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

MGS (Molecular Genetics of Schizophrenia) GWAS Consortium, GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium), The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium, PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium, PanScan Consortium & The GAME-ON/ELLIPSE Consortium, Dec 1 2016, In : PLoS Genetics. 12, 12, e1006493.

Research output: Contribution to journalArticle

Genome-Wide Association Study
genome
single nucleotide polymorphism
Single Nucleotide Polymorphism
polymorphism
2015

A histomorphologic comparison of familial and sporadic pancreatic cancers

Singhi, A. D., Ishida, H., Ali, S. Z., Goggins, M. S., Canto, M., Wolfgang, C., Meriden, Z., Roberts, N., Klein, A. & Hruban, R. H., Jul 1 2015, In : Pancreatology. 15, 4, p. 387-391 5 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreas
Dysplastic Nevus Syndrome
Peutz-Jeghers Syndrome
Neoplasms

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: A PACGENE study

Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. S., Hruban, R. H., Cote, M. L., McWilliams, R. R., Roberts, N., Cannon-Albright, L. A., Li, D., Moyes, K., Wenstrup, R. J., Hartman, A. R., Seminara, D., Klein, A. & Petersen, G. M., Jul 2 2015, In : Genetics in Medicine. 17, 7, p. 569-577 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genetic Testing
Genes
Viverridae

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Childs, E. J., Mocci, E., Campa, D., Bracci, P. M., Gallinger, S., Goggins, M. S., Li, D., Neale, R. E., Olson, S. H., Scelo, G., Amundadottir, L. T., Bamlet, W. R., Bijlsma, M. F., Blackford, A., Borges, M., Brennan, P., Brenner, H., Bueno-De-Mesquita, H. B., Canzian, F., Capurso, G. & 42 others, Cavestro, G. M., Chaffee, K. G., Chanock, S. J., Cleary, S. P., Cotterchio, M., Foretova, L., Fuchs, C., Funel, N., Gazouli, M., Hassan, M., Herman, J. M., Holcatova, I., Holly, E. A., Hoover, R. N., Hung, R. J., Janout, V., Key, T. J., Kupcinskas, J., Kurtz, R. C., Landi, S., Lu, L., Malecka-Panas, E., Mambrini, A., Mohelnikova-Duchonova, B., Neoptolemos, J. P., Oberg, A. L., Orlow, I., Pasquali, C., Pezzilli, R., Rizzato, C., Saldia, A., Scarpa, A., Stolzenberg-Solomon, R. Z., Strobel, O., Tavano, F., Vashist, Y. K., Vodicka, P., Wolpin, B. M., Yu, H., Petersen, G. M., Risch, H. A. & Klein, A., Aug 30 2015, In : Nature Genetics. 47, 8, p. 911-916 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Odds Ratio
Confidence Intervals
Penetrance
DNA Mismatch Repair

Erratum: Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk (PLoS ONE (2015) 10:3 (e0117574) DOI:10.1371/journal.pone.0117574)

Arem, H., Yu, K., Xiong, X., Moy, K., Freedman, N. D., Mayne, S. T., Albanes, D., Amundadottir, L. T., Arslan, A. A., Austin, M., Bamlet, W. R., Beane-Freeman, L., Bracci, P., Canzian, F., Chanock, S. J., Cotterchio, M., Duell, E. J., Gallinger, S., Giles, G. G., Goggins, M. & 35 others, Goodman, P. J., Hartge, P., Hassan, M., Helzlsouer, K., Henderson, B., Holly, E. A., Hoover, R., Jacobs, E. J., Kamineni, A., Klein, A., Klein, E., Kolonel, L. N., Li, D., Malats, N., Männistö, S., McCullough, M. L., Olson, S. H., Orlow, I., Peters, U., Petersen, G. M., Porta, M., Severi, G., Shu, X. O., Van Den Eeden, S., Visvanathan, K., White, E., Yu, H., Zeleniuch-Jacquotte, A., Zheng, W., Tobias, G. S., Maeder, D., Brotzman, M., Risch, H., Sampson, J. N. & Stolzenberg-Solomon, R. Z., Jun 3 2015, In : PLoS One. 10, 6, e0129983.

Research output: Contribution to journalArticle

Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure

Chen, F., Klein, A., Klein, B. E. K., Lee, K. E., Truitt, B., Klein, R., Iyengar, S. K. & Duggal, P., 2015, In : Investigative Ophthalmology and Visual Science. 56, 1, p. 544-551 8 p.

Research output: Contribution to journalArticle

Exome
Intraocular Pressure
Genes
Caveolins
Genome-Wide Association Study