Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Pharmacology Medicine & Life Sciences
Modulators Chemical Compounds
Fear Medicine & Life Sciences
Allosteric Site Medicine & Life Sciences
Glutamic Acid Medicine & Life Sciences
Metabotropic Glutamate 5 Receptor Medicine & Life Sciences
Anxiety Medicine & Life Sciences
Pregnanolone Medicine & Life Sciences

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Research Output 2004 2013

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement

Gregory, K. J. , Herman, E. J. , Ramsey, A. J. , Hammond, A. S. , Byun, N. E. , Stauffer, S. R. , Manka, J. T. , Jadhav, S. , Bridges, T. M. , Weaver, C. D. , Niswender, C. M. , Steckler, T. , Drinkenburg, W. H. , Ahnaou, A. , Lavreysen, H. , Macdonald, G. J. , Bartolomé, J. M. , Mackie, C. , Hrupka, B. J. , Caron, M. G. & 4 others Daigle, T. L., Lindsley, C. W., Conn, P. J. & Jones, C. K. Nov 2013 In : Journal of Pharmacology and Experimental Therapeutics. 347, 2, p. 438-457 20 p.

Research output: Research - peer-reviewArticle

Metabotropic Glutamate 5 Receptor
N-Methylaspartate
Schizophrenia
piperazine
2-(4-(2-(benzyloxy)acetyl)piperazin-1-yl)benzonitrile

Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology

Hammond, A. S., Rodriguez, A. L., Townsend, S. D., Niswender, C. M., Gregory, K. J., Lindsley, C. W. & Conn, P. J. Oct 20 2010 In : ACS Chemical Neuroscience. 1, 10, p. 702-716 15 p.

Research output: Research - peer-reviewArticle

Allosteric Site
Pharmacology
Ligands
Modulators
Chemical activation

Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273

Engers, D. W., Rodriguez, A. L., Williams, R., Hammond, A. S., Venable, D., Oluwatola, O., Sulikowski, G. A., Conn, P. J. & Lindsley, C. W. Apr 17 2009 In : ChemMedChem. 4, 4, p. 505-511 7 p.

Research output: Research - peer-reviewArticle

Oxadiazoles
Modulators
Glutamic Acid
Modulation
S-(4-fluorophenyl)-(3-(3-(4-fluorophenyl)-(1,2,4)-oxadiazol-5-yl)piperidin-1-yl)methanone

Sex differences in hormonal modulation of anxiety measured with light-enhanced startle: Possible role for arginine vasopressin in the male

Toufexis, D., Davis, C., Hammond, A. & Davis, M. Sep 28 2005 In : Journal of Neuroscience. 25, 39, p. 9010-9016 7 p.

Research output: Research - peer-reviewArticle

Arginine Vasopressin
Sex Characteristics
Anxiety
Light
Fear

Progesterone attenuates corticotropin-releasing factor-enhanced but not fear-potentiated startle via the activity of its neuroactive metabolite, allopregnanolone

Toufexis, D. J., Davis, C., Hammond, A. & Davis, M. Nov 10 2004 In : Journal of Neuroscience. 24, 45, p. 10280-10287 8 p.

Research output: Research - peer-reviewArticle

Pregnanolone
Corticotropin-Releasing Hormone
Fear
Progesterone
Intraventricular Infusions