Alexis Hammond


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Modulators Chemical Compounds
Metabotropic Glutamate 5 Receptor Medicine & Life Sciences
Allosteric Site Medicine & Life Sciences
Fear Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Pregnanolone Medicine & Life Sciences
Oxadiazoles Medicine & Life Sciences
Arginine Vasopressin Medicine & Life Sciences

Research Output 2004 2013

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement

Gregory, K. J. , Herman, E. J. , Ramsey, A. J. , Hammond, A. S. , Byun, N. E. , Stauffer, S. R. , Manka, J. T. , Jadhav, S. , Bridges, T. M. , Weaver, C. D. , Niswender, C. M. , Steckler, T. , Drinkenburg, W. H. , Ahnaou, A. , Lavreysen, H. , Macdonald, G. J. , Bartolomé, J. M. , Mackie, C. , Hrupka, B. J. , Caron, M. G. & 4 others Daigle, T. L., Lindsley, C. W., Conn, P. J. & Jones, C. K., Nov 2013, In : Journal of Pharmacology and Experimental Therapeutics. 347, 2, p. 438-457 20 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
Startle Reflex
Allosteric Site

Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology

Hammond, A. S., Rodriguez, A. L., Townsend, S. D., Niswender, C. M., Gregory, K. J., Lindsley, C. W. & Conn, P. J., Oct 20 2010, In : ACS Chemical Neuroscience. 1, 10, p. 702-716 15 p.

Research output: Contribution to journalArticle

Allosteric Site
Chemical activation

Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273

Engers, D. W., Rodriguez, A. L., Williams, R., Hammond, A. S., Venable, D., Oluwatola, O., Sulikowski, G. A., Conn, P. J. & Lindsley, C. W., Apr 17 2009, In : ChemMedChem. 4, 4, p. 505-511 7 p.

Research output: Contribution to journalArticle

Glutamic Acid

Sex differences in hormonal modulation of anxiety measured with light-enhanced startle: Possible role for arginine vasopressin in the male

Toufexis, D., Davis, C., Hammond, A. & Davis, M., Sep 28 2005, In : Journal of Neuroscience. 25, 39, p. 9010-9016 7 p.

Research output: Contribution to journalArticle

Arginine Vasopressin
Sex Characteristics

Progesterone attenuates corticotropin-releasing factor-enhanced but not fear-potentiated startle via the activity of its neuroactive metabolite, allopregnanolone

Toufexis, D. J., Davis, C., Hammond, A. & Davis, M., Nov 10 2004, In : Journal of Neuroscience. 24, 45, p. 10280-10287 8 p.

Research output: Contribution to journalArticle

Corticotropin-Releasing Hormone
Intraventricular Infusions