Alena Savonenko

Associate Professor

1990 …2019
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Research Output 1990 2019

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1. Information role of fibrinogen content in functioning of fibrinolysis and haemostasis

Andreenko, G. V., Podorolskaja, L. V., Nikolskaja, K. A., Savonenko, A. & Serebrjakova, T. N., 1996, In : Fibrinolysis. 10, SUPPL. 1, p. 1 1 p.

Research output: Contribution to journalArticle

Fibrinolysis
Hemostatics
Hemostasis
Fibrinogen
Pathology

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice

Andreasson, K. I., Savonenko, A., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A., Kaufmann, W. E., Worley, P. F., Isakson, P. & Markowska, A. L., Oct 15 2001, In : Journal of Neuroscience. 21, 20, p. 8198-8209 12 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Transgenic Mice
Apoptosis
Neurons
Non-Steroidal Anti-Inflammatory Agents

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

Savonenko, A., Melnikova, T., Laird, F. M., Stewart, K. A., Price, D. L. & Wong, P. C., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5585-5590 6 p.

Research output: Contribution to journalArticle

Neuregulin-1
Schizophrenia
Phenotype
Amyloid beta-Protein Precursor
Spine

Alzheimer's therapeutics: Translation of preclinical science to clinical drug development

Savonenko, A., Melnikova, T., Hiatt, A., Li, T., Worley, P. F., Troncoso, J. C., Wong, P. C. & Price, D. L., Jan 2012, In : Neuropsychopharmacology. 37, 1, p. 261-277 17 p.

Research output: Contribution to journalArticle

Clinical Trials
Pharmaceutical Preparations
Amyloid Precursor Protein Secretases
Translational Medical Research
Neurobiology

A mouse model of blast injury to brain: Initial pathological, neuropathological, and behavioral characterization

Koliatsos, V. E., Cernak, I., Xu, L., Song, Y., Savonenko, A., Crain, B. J., Eberhart, C. G., Frangakis, C., Melnikova, T., Kim, H. & Lee, D., May 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 5, p. 399-416 18 p.

Research output: Contribution to journalArticle

Blast Injuries
Torso
Veterans
Wounds and Injuries
Brain

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

Liu, Y., Yoo, M. J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E. & Lee, M. K., Dec 17 2008, In : Journal of Neuroscience. 28, 51, p. 13805-13814 10 p.

Research output: Contribution to journalArticle

Amyloid
Transgenic Mice
Alzheimer Disease
Pathology
Prosencephalon

Amyloid precursor protein increases cortical neuron size in transgenic mice

Oh, E., Savonenko, A., King, J. F., Fangmark Tucker, S. M., Rudow, G. L., Xu, G., Borchelt, D. R. & Troncoso, J. C., Aug 2009, In : Neurobiology of Aging. 30, 8, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transgenic Mice
Neurons
Alzheimer Disease
Transgenes
Freezing
Learning
Avoidance Learning
Problem-Based Learning
Conflict (Psychology)

Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation

Zhang, W., Chuang, Y. A., Na, Y., Ye, Z., Yang, L., Lin, R., Zhou, J., Wu, J., Qiu, J., Savonenko, A., Leahy, D. J., Huganir, R., Linden, D. J. & Worley, P. F., Jul 11 2019, In : Molecular cell. 75, 1, p. 13-25.e5

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Retroelements
Hippocampus
Learning

Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment

Barrett, F., Workman, C. I., Sair, H., Savonenko, A., Kraut, M. A., Sodums, D. J., Joo, J. H., Nassery, N., Marano, C. M., Munro, C., Brandt, J., Zhou, Y., Wong, D. F. & Smith, G., 2017, (Accepted/In press) In : Human Brain Mapping.

Research output: Contribution to journalArticle

Denervation
Serotonin
Alzheimer Disease
Parietal Lobe
Brain

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H-K. & Wong, P. C., Dec 14 2005, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Amyloidosis
Neurons
Alzheimer Disease

Cannabinoid CB2 receptors in a mouse model of Aβ amyloidosis: Immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation

Savonenko, A., Melnikova, T., Wang, Y., Ravert, H., Gao, Y., Koppel, J., Lee, D., Pletnikova, O., Cho, E., Sayyida, N., Hiatt, A., Troncoso, J. C., Davies, P., Dannals, R. F., Pomper, M. G. & Horti, A., Jun 18 2015, In : PLoS One. 10, 6, e0129618.

Research output: Contribution to journalArticle

cannabinoids
amyloidosis
Cannabinoid Receptors
Cannabinoids
Biomarkers

Change in behavior with the development of long-term sensitization of a defensive reflex in the edible snail

Beregovoi, N. A., Gainutdinov, K. L., Safronova, O. G. & Savonenko, A., Jul 1991, In : Neuroscience and Behavioral Physiology. 21, 4, p. 321-323 3 p.

Research output: Contribution to journalArticle

Helix (Snails)
Electroshock
Animal Behavior
Exploratory Behavior
Snails

Chapter 5.5 Transgenic mouse models of Alzheimer's disease and episodic-like memory

Borchelt, D. R. & Savonenko, A., 2008, In : Handbook of Behavioral Neuroscience. 18, p. 553-573 21 p.

Research output: Contribution to journalArticle

Episodic Memory
Transgenic Mice
Alzheimer Disease
Amyloid Plaques
Memory Disorders
Adenosine Triphosphatases
Rats
Ethanol
Erythrocytes
Health

Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory

Savonenko, A., Werka, T., Nikolaev, E., Zieliñski, K. & Kaczmarek, L., Jul 2003, In : Learning and Memory. 10, 4, p. 293-303 11 p.

Research output: Contribution to journalArticle

Long-Term Memory
N-Methyl-D-Aspartate Receptors
Fear
Avoidance Learning
Problem-Based Learning

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern

Melnikova, T., Savonenko, A., Wang, Q., Liang, X., Hand, T., Wu, L., Kaufmann, W. E., Vehmas, A. & Andreasson, K. I., 2006, In : Neuroscience. 141, 3, p. 1149-1162 14 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Amyloid
Alzheimer Disease
Presenilin-1
Amyloid beta-Protein Precursor

Cytochemical characteristics of the brain of alcohol-nonpreferring wistar rats with different learning abilities

Sergutina, A. V., Savonenko, A., Gershtein, L. M. & Nikol'skaya, K. A., Feb 1999, In : Bulletin of Experimental Biology and Medicine. 127, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Aminopeptidases
Aptitude
Glucosephosphate Dehydrogenase
Wistar Rats
Rats

Defensive conditioning-related functional heterogeneity among nuclei of the rat amygdala revealed by c-Fos mapping

Savonenko, A., Filipkowski, R. K., Werka, T., Zielinski, K. & Kaczmarek, L., Oct 1999, In : Neuroscience. 94, 3, p. 723-733 11 p.

Research output: Contribution to journalArticle

Amygdala
Grooming
Prosencephalon
Statistical Factor Analysis
Fear

Defensive conditioning-related increase in AP-1 transcription factor in the rat cortex

Lukasiuk, K., Savonenko, A., Nikolaev, E., Rydz, M. & Kaczmarek, L., Apr 6 1999, In : Molecular Brain Research. 67, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Electrophoretic Mobility Shift Assay
Proto-Oncogene Proteins c-fos
Brain
Visual Cortex

Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats

Markowska, A. L. & Savonenko, A., Dec 15 2002, In : Journal of Neuroscience. 22, 24, p. 10985-10995 11 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Cognition
Estrogens
Scopolamine Hydrobromide
Ovariectomy

Effects of conditioned and predictive stimuli on the fly-away escape response in a two-way shuttle box

Savonenko, A. & Zielinski, K., 1998, In : Acta Neurobiologiae Experimentalis. 58, 4, p. 321 1 p.

Research output: Contribution to journalArticle

Escape Reaction
Operant Conditioning
Diptera

Enhanced polyubiquitination of shank3 and NMDA receptor in a mouse model of autism

Bangash, M. A., Park, J. M., Melnikova, T., Wang, D., Jeon, S. K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H. E., Kee, S. E., Tu, J. C., Hu, J. H., Petralia, R. S., Linden, D. J., Powell, C. M., Savonenko, A. & 2 others, Xiao, B. & Worley, P. F., May 27 2011, In : Cell. 145, 5, p. 758-772 15 p.

Research output: Contribution to journalArticle

Autistic Disorder
N-Methyl-D-Aspartate Receptors
Synapses
Proteasome Endopeptidase Complex
Assays

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

Schilling, G., Savonenko, A., Coonfield, M. L., Morton, J. L., Vorovich, E., Gale, A., Neslon, C., Chan, N., Eaton, M., Fromholt, D., Ross, C. A. & Borchelt, D. R., May 2004, In : Experimental Neurology. 187, 1, p. 137-149 13 p.

Research output: Contribution to journalArticle

coenzyme Q10
Celecoxib
Huntington Disease
Transgenic Mice
Pharmacology

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R. & Savonenko, A., May 25 2005, In : Journal of Neuroscience. 25, 21, p. 5217-5224 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid Plaques
Transgenic Mice
Water
Genotype

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Savonenko, A., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P. F., Price, D. L., Tang, F., Markowska, A. L. & Borchelt, D. R., Apr 2005, In : Neurobiology of Disease. 18, 3, p. 602-617 16 p.

Research output: Contribution to journalArticle

Episodic Memory
Memory Disorders
Amyloid
Transgenic Mice
Neurotransmitter Agents

Erratum: Retraction notice to: Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

Bangash, M. A., Park, J. M., Melnikova, T., Wang, D., Jeon, S. K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H. E., Kee, S. E., Tu, J. C., Hu, J. H., Petralia, R. S., Linden, D. J., Powell, C. M., Savonenko, A. & 2 others, Xiao, B. & Worley, P. F., Jan 7 2013, In : Cell. 152, 1-2, p. 367 1 p.

Research output: Contribution to journalArticle

Autistic Disorder
N-Methyl-D-Aspartate Receptors
Apolipoproteins E
bexarotene

Escape from shock versus escape from shock accompanied by a visual stimulus in rats

Zieliński, K. & Savonenko, A., 2000, In : Acta Neurobiologiae Experimentalis. 60, 4, p. 457-465 9 p.

Research output: Contribution to journalArticle

Darkness
Shock
Cues
Foot

How do rats cope with the two-way escape problem in a homogenous shuttle box?

Savonenko, A., Brush, F. R. & Zieliński, K., 1999, In : Acta Neurobiologiae Experimentalis. 59, 2, p. 145-157 13 p.

Research output: Contribution to journalArticle

Diptera
Shock
Open Access
Hydroxyurea
Down Syndrome
Episodic Memory
Nootropic Agents
Unfolded Protein Response

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

Savonenko, A., Munoz, P., Melnikova, T., Wang, Q., Liang, X., Breyer, R. M., Montine, T. J., Kirkwood, A. & Andreasson, K., May 2009, In : Experimental Neurology. 217, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Sensory Gating
Cyclooxygenase 2
Dinoprostone
Cognition
Neurological Models

Increased estrogen receptor β expression correlates with decreased spine formation in the rat hippocampus

Szymczak, S., Kalita, K., Jaworski, J., Mioduszewska, B., Savonenko, A., Markowska, A., Merchenthaler, I. & Kaczmarek, L., 2006, In : Hippocampus. 16, 5, p. 453-463 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Synapses
Hippocampus
Spine
Kainic Acid
Down Syndrome
Pyramidal Cells
Messenger RNA
Learning
Neurons

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice

Tabatadze, N., Savonenko, A., Song, H., Bandaru, V. V. R., Chu, M. & Haughey, N., Oct 2010, In : Journal of Neuroscience Research. 88, 13, p. 2940-2951 12 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Sphingolipids
Ceramides
Brain
N-Methyl-D-Aspartate Receptors

Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

Modi, H. R., Wang, Q., Sahithi, G. D., Sherman, D., Greenwald, E., Savonenko, A., Geocadin, R. & Thakor, N. V., Sep 1 2017, In : PLoS One. 12, 9, e0182707.

Research output: Contribution to journalArticle

coma
cardiac arrest
Coma
Arousal
Heart Arrest

Izmenenie povedeniia pri vyrabotke dolgovremennoǐ sensitizatsii oboronitel'nogo refleksa u vinogradnoǐ ulitki.

Translated title of the contribution: Behavioral changes during the acquisition of long-term sensitization of the defensive reflex in the edible snailBeregovoǐ, N. A., Gaǐnutdinov, K. L., Safronova, O. G. & Savonenko, A., May 1990, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 40, 3, p. 594-596 3 p.

Research output: Contribution to journalArticle

Long-Term Memory
Snails
Reflex

Kharakteristika Na, K-ATFazy éritrotsitov krys s raznym otnosheniem k étanolu v norme i posle khronicheskoǐ alkogolizatsii.

Translated title of the contribution: The normal characteristics of erythrocyte Na, K-ATPase in rats with different behaviors to ethanol and after chronic alcoholizationSavonenko, A. & Prokop'eva, V. D., Jun 1993, In : Byulleten Eksperimentalnoi Biologii i Meditsiny. 115, 6, p. 631-632 2 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Rats
Ethanol
Erythrocytes
Magnesium Chloride

Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest

Schreckinger, M., Geocadin, R., Savonenko, A., Yamashita, S., Melnikova, T., Thakor, N. V. & Hanley, D. F., Oct 2007, In : Resuscitation. 75, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

Heart Arrest
Wounds and Injuries
Startle Reflex
Reflex
Ischemia

Modeling an anti-amyloid combination therapy for Alzheimer's disease

Chow, V. W., Savonenko, A., Melnikova, T., Kim, H., Price, D. L., Li, T. & Wong, P. C., 2010, In : Science Translational Medicine. 2, 13

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Amyloid
Alzheimer Disease
Serum Amyloid A Protein
Enzymes

Molecular imaging of serotonin degeneration in mild cognitive impairment

Smith, G., Barrett, F., Joo, J. H., Nassery, N., Savonenko, A., Sodums, D. J., Marano, C. M., Munro, C., Brandt, J., Kraut, M. A., Zhou, Y., Wong, D. F. & Workman, C. I., Sep 1 2017, In : Neurobiology of Disease. 105, p. 33-41 9 p.

Research output: Contribution to journalArticle

Molecular Imaging
Serotonin Plasma Membrane Transport Proteins
Serotonin
Cerebrovascular Circulation
Regional Blood Flow

Morfokhimicheskie osobennosti neǐronov sensomotornoǐ kory i neostriatuma krys s razlichnoǐ stepen'iu predpochteniia alkogolia.

Translated title of the contribution: The morphochemical characteristics of the neurons of the sensorimotor cortex and neostriatum in rats with differing degrees of alcohol preferenceGershteǐn, L. M., Nikol'skaia, K. A. & Savonenko, A., Mar 1995, In : Fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 81, 3, p. 90-96 7 p.

Research output: Contribution to journalArticle

Neostriatum
Alcohols
Neurons
Albumins
Cytoplasm

Morphochemical features of sensorimotor cortex and neostriatum neurons in rats with different levels of alcohol preference

Gershtein, L. M., Nikol'skaya, K. A. & Savonenko, A., 1997, In : Neuroscience and Behavioral Physiology. 27, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

Neostriatum
Alcohols
Cell Size
Neurons
Ethanol

Morphometry of the human substantia nigra in ageing and Parkinson's disease

Rudow, G., O'Brien, R., Savonenko, A., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Marsh, L., Dawson, T. M., Crain, B. J., West, M. J. & Troncoso, J. C., Apr 2008, In : Acta Neuropathologica. 115, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

Substantia Nigra
Parkinson Disease
Neurons
Tyrosine 3-Monooxygenase
Hypertrophy

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Savonenko, A., Xu, G. M., Price, D. L., Borchelt, D. R. & Markowska, A. L., Apr 2003, In : Neurobiology of Disease. 12, 3, p. 194-211 18 p.

Research output: Contribution to journalArticle

Transgenic Mice
Amyloid beta-Protein Precursor
Amyloid Plaques
Alzheimer Disease
Amyloid

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

Schilling, G., Savonenko, A., Klevytska, A., Morton, J. L., Tucker, S. M., Poirier, M., Gale, A., Chan, N., Gonzales, V., Slunt, H. H., Coonfield, M. L., Jenkins, N. A., Copeland, N. G., Ross, C. A. & Borchelt, D. R., Aug 1 2004, In : Human Molecular Genetics. 13, 15, p. 1599-1610 12 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Huntington Disease
Transgenic Mice
Glutamine
Phenotype

Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease

Klevytska, A. M., Tebbenkamp, A. T. N., Savonenko, A. & Borchelt, D. R., Apr 2010, In : Journal of Neuropathology and Experimental Neurology. 69, 4, p. 396-404 9 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Huntington Disease
Life Expectancy
Histones
Acetylation

Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G. & Borchelt, D. R., Dec 2005, In : PLoS Medicine. 2, 12, p. 1318-1333 16 p., e355.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Pathology

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

Horti, A., Naik, R., Foss, C., Minn, I., Misheneva, V., Du, Y., Wang, Y., Mathews, W. B., Wu, Y., Hall, A., LaCourse, C., Ahn, H. H., Nam, H., Lesniak, W., Valentine, H., Pletnikova, O., Troncoso, J. C., Smith, M. D., Calabresi, P., Savonenko, A. & 3 others, Dannals, R. F., Pletnikov, M. & Pomper, M. G., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Microglia
Alzheimer Disease
Demyelinating Diseases
Cognition
Task Performance and Analysis
Aptitude
Water
Short-Term Memory