Alena Savonenko

Associate Professor

1990 …2019

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1990

Izmenenie povedeniia pri vyrabotke dolgovremennoǐ sensitizatsii oboronitel'nogo refleksa u vinogradnoǐ ulitki.

Translated title of the contribution: Behavioral changes during the acquisition of long-term sensitization of the defensive reflex in the edible snailBeregovoǐ, N. A., Gaǐnutdinov, K. L., Safronova, O. G. & Savonenko, A. V., May 1 1990, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 40, 3, p. 594-596 3 p.

Research output: Contribution to journalArticle

1991

Change in behavior with the development of long-term sensitization of a defensive reflex in the edible snail

Beregovoi, N. A., Gainutdinov, K. L., Safronova, O. G. & Savonenko, A. V., Jul 1 1991, In : Neuroscience and Behavioral Physiology. 21, 4, p. 321-323 3 p.

Research output: Contribution to journalArticle

Kharakteristika Na, K-ATFazy éritrotsitov krys s raznym otnosheniem k étanolu v norme i posle khronicheskoǐ alkogolizatsii.

Translated title of the contribution: The normal characteristics of erythrocyte Na, K-ATPase in rats with different behaviors to ethanol and after chronic alcoholizationSavonenko, A. V. & Prokop'eva, V. D., Jun 1 1993, In : Byulleten Eksperimentalnoi Biologii i Meditsiny. 115, 6, p. 631-632 2 p.

Research output: Contribution to journalArticle

1995

Morfokhimicheskie osobennosti neǐronov sensomotornoǐ kory i neostriatuma krys s razlichnoǐ stepen'iu predpochteniia alkogolia.

Translated title of the contribution: The morphochemical characteristics of the neurons of the sensorimotor cortex and neostriatum in rats with differing degrees of alcohol preferenceGershteǐn, L. M., Nikol'skaia, K. A. & Savonenko, A. V., Mar 1 1995, In : Fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 81, 3, p. 90-96 7 p.

Research output: Contribution to journalArticle

Psikhofiziologicheskie markery predraspolozhennosti k razvitiiu alkogol'noǐ zavisimosti u krys.

Translated title of the contribution: The psychophysiological markers of a predisposition to the development of alcohol dependence in ratsSavonenko, A. V., Adrianov, O. S., Nikol'skaia, K. A., Osipov, A. I. & Eshchenko, O. V., Mar 1 1995, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 45, 2, p. 416-419 4 p.

Research output: Contribution to journalArticle

1996

1. Information role of fibrinogen content in functioning of fibrinolysis and haemostasis

Andreenko, G. V., Podorolskaja, L. V., Nikolskaja, K. A., Savonenko, A. V. & Serebrjakova, T. N., Jan 1 1996, In : Fibrinolysis. 10, SUPPL. 1, 1 p.

Research output: Contribution to journalArticle

The sensitivity of cognitive processes to the inhomogeneity of natural magnetic fields

Nikolskaya, K., Shtemler, V., Yeschenko, O., Savonenko, A., Osipov, A. & Nickolsky, S., Dec 1 1996, In : Electromagnetic Biology and Medicine. 15, 3, p. 163-174 12 p.

Research output: Contribution to journalArticle

The sensitivity of cognitive processes to the inhomogeneity of natural magnetic fields

Nikolskaya, K., Shtemler, V., Yeschenko, O., Savonenko, A., Osipov, A. & Nickolsky, S., Jan 1 1996, In : Electro- and Magnetobiology. 15, 3, p. 163-174 12 p.

Research output: Contribution to journalArticle

Weak magnetic fields and cognitive activity

Nikol'skaya, K. A., Shtemler, V. M., Savonenko, A. V., Osipov, A. I. & Nikol'skii, S. V., Dec 1 1996, In : Biofizika. 41, 4, 1 p.

Research output: Contribution to journalArticle

1997

Morphochemical features of sensorimotor cortex and neostriatum neurons in rats with different levels of alcohol preference

Gershtein, L. M., Nikol'skaya, K. A. & Savonenko, A. V., Jan 1 1997, In : Neuroscience and Behavioral Physiology. 27, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

1998

Analysis of individual variability in complex task acquisition as a method to differentiate stages of learning

Savonenko, A., Danilets, A. & Zielinski, K., Dec 1 1998, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 48, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

Zavisimost' obucheniia reaktsii aktivnogo izbeganiia ot preodoleniia problemnoi situatsii v chelnochnoi kamere.

Translated title of the contribution: The dependence of learning an active avoidance reaction on overcoming a problem-solving situation in a shuttle boxSavonenko, A. V. & Zieliński, K., Mar 1998, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 48, 2, p. 229-239 11 p.

Research output: Contribution to journalArticle

1999

Cytochemical characteristics of the brain of alcohol-nonpreferring wistar rats with different learning abilities

Sergutina, A. V., Savonenko, A. V., Gershtein, L. M. & Nikol'skaya, K. A., Feb 1999, In : Bulletin of Experimental Biology and Medicine. 127, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Defensive conditioning-related functional heterogeneity among nuclei of the rat amygdala revealed by c-Fos mapping

Savonenko, A., Filipkowski, R. K., Werka, T., Zielinski, K. & Kaczmarek, L., Oct 1 1999, In : Neuroscience. 94, 3, p. 723-733 11 p.

Research output: Contribution to journalArticle

Defensive conditioning-related increase in AP-1 transcription factor in the rat cortex

Lukasiuk, K., Savonenko, A., Nikolaev, E., Rydz, M. & Kaczmarek, L., Apr 6 1999, In : Molecular Brain Research. 67, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

How do rats cope with the two-way escape problem in a homogenous shuttle box?

Savonenko, A. V., Brush, F. R. & Zieliński, K., Jul 5 1999, In : Acta Neurobiologiae Experimentalis. 59, 2, p. 145-157 13 p.

Research output: Contribution to journalArticle

Studies of individual differences as a method for discriminating the stages of acquisition of a conditioned reflex

Savonenko, A. V., Danilets, A. V. & Zelin'ski, K., May 1 1999, In : Neuroscience and Behavioral Physiology. 29, 3, p. 295-303 9 p.

Research output: Contribution to journalArticle

Tsitokhimicheskie osobennosti mozga otvergaiushchikh alkogol' krys Vistar, kotorye razlichaiutsia po sposobnosti k obucheniiu.

Translated title of the contribution: Cytochemical brain characteristics of rejecting alcohol Wistar rats with various learning abilitySergutina, A. V., Savonenko, A. V., Gershtein, L. M. & Nikol'skaia, K. A., Feb 1 1999, In : Biulleten' eksperimental'noi biologii i meditsiny. 127, 2, p. 180-182 3 p.

Research output: Contribution to journalArticle

2000

Escape from shock versus escape from shock accompanied by a visual stimulus in rats

Zieliński, K. & Savonenko, A. V., Dec 20 2000, In : Acta Neurobiologiae Experimentalis. 60, 4, p. 457-465 9 p.

Research output: Contribution to journalArticle

Zapazdyvatel'noe tormozhenie reaktsii aktivnogo izbeganiia i mezhsignal'nye reaktsii v chelnochnoi kamere u krys.

Translated title of the contribution: Delay inhibition of the active avoidance reflex and intertrial responses in rats in the shuttle boxZieliński, K., Nikolaev, E. & Savonenko, A., Dec 2000, In : Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 86, 12, p. 1644-1655 12 p.

Research output: Contribution to journalArticle

2001

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice

Andreasson, K. I., Savonenko, A., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A., Kaufmann, W. E., Worley, P. F., Isakson, P. & Markowska, A. L., Oct 15 2001, In : Journal of Neuroscience. 21, 20, p. 8198-8209 12 p.

Research output: Contribution to journalArticle

2002

Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats

Markowska, A. L. & Savonenko, A. V., Dec 15 2002, In : Journal of Neuroscience. 22, 24, p. 10985-10995 11 p.

Research output: Contribution to journalArticle

Retardation of cognitive aging by life-long diet restriction: Implications for genetic variance

Markowska, A. L. & Savonenko, A., Jan 26 2002, In : Neurobiology of Aging. 23, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

2003

Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory

Savonenko, A., Werka, T., Nikolaev, E., Zieliñski, K. & Kaczmarek, L., Jul 1 2003, In : Learning and Memory. 10, 4, p. 293-303 11 p.

Research output: Contribution to journalArticle

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Savonenko, A. V., Xu, G. M., Price, D. L., Borchelt, D. R. & Markowska, A. L., Apr 2003, In : Neurobiology of Disease. 12, 3, p. 194-211 18 p.

Research output: Contribution to journalArticle

The cognitive effects of ovariectomy and estrogen replacement are modulated by aging

Savonenko, A. V. & Markowska, A. L., Jul 4 2003, In : Neuroscience. 119, 3, p. 821-830 10 p.

Research output: Contribution to journalArticle

2004

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

Schilling, G., Savonenko, A. V., Coonfield, M. L., Morton, J. L., Vorovich, E., Gale, A., Neslon, C., Chan, N., Eaton, M., Fromholt, D., Ross, C. A. & Borchelt, D. R., May 1 2004, In : Experimental Neurology. 187, 1, p. 137-149 13 p.

Research output: Contribution to journalArticle

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

Schilling, G., Savonenko, A. V., Klevytska, A., Morton, J. L., Tucker, S. M., Poirier, M., Gale, A., Chan, N., Gonzales, V., Slunt, H. H., Coonfield, M. L., Jenkins, N. A., Copeland, N. G., Ross, C. A. & Borchelt, D. R., Aug 1 2004, In : Human molecular genetics. 13, 15, p. 1599-1610 12 p.

Research output: Contribution to journalArticle

2005

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H. K. & Wong, P. C., Dec 14 2005, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R. & Savonenko, A. V., May 25 2005, In : Journal of Neuroscience. 25, 21, p. 5217-5224 8 p.

Research output: Contribution to journalArticle

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Savonenko, A., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P. F., Price, D. L., Tang, F., Markowska, A. L. & Borchelt, D. R., Apr 2005, In : Neurobiology of Disease. 18, 3, p. 602-617 16 p.

Research output: Contribution to journalArticle

Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A. V., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G. & Borchelt, D. R., Dec 1 2005, In : PLoS medicine. 2, 12, p. 1318-1333 16 p., e355.

Research output: Contribution to journalArticle

2006

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern

Melnikova, T., Savonenko, A., Wang, Q., Liang, X., Hand, T., Wu, L., Kaufmann, W. E., Vehmas, A. & Andreasson, K. I., Aug 1 2006, In : Neuroscience. 141, 3, p. 1149-1162 14 p.

Research output: Contribution to journalArticle

Increased estrogen receptor β expression correlates with decreased spine formation in the rat hippocampus

Szymczak, S., Kalita, K., Jaworski, J., Mioduszewska, B., Savonenko, A., Markowska, A., Merchenthaler, I. & Kaczmarek, L., Nov 14 2006, In : Hippocampus. 16, 5, p. 453-463 11 p.

Research output: Contribution to journalArticle

2007

Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest

Schreckinger, M., Geocadin, R. G., Savonenko, A., Yamashita, S., Melnikova, T., Thakor, N. V. & Hanley, D. F., Oct 1 2007, In : Resuscitation. 75, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

2008

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K. A., Price, D. L. & Wong, P. C., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5585-5590 6 p.

Research output: Contribution to journalArticle

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

Liu, Y., Yoo, M. J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E. & Lee, M. K., Dec 17 2008, In : Journal of Neuroscience. 28, 51, p. 13805-13814 10 p.

Research output: Contribution to journalArticle

Morphometry of the human substantia nigra in ageing and Parkinson's disease

Rudow, G., O'Brien, R., Savonenko, A. V., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Marsh, L., Dawson, T. M., Crain, B. J., West, M. J. & Troncoso, J. C., Apr 1 2008, In : Acta neuropathologica. 115, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

2009

Amyloid precursor protein increases cortical neuron size in transgenic mice

Oh, E. S., Savonenko, A. V., King, J. F., Fangmark Tucker, S. M., Rudow, G. L., Xu, G., Borchelt, D. R. & Troncoso, J. C., Aug 1 2009, In : Neurobiology of Aging. 30, 8, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

Savonenko, A., Munoz, P., Melnikova, T., Wang, Q., Liang, X., Breyer, R. M., Montine, T. J., Kirkwood, A. & Andreasson, K., May 1 2009, In : Experimental Neurology. 217, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

2010

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice

Tabatadze, N., Savonenko, A., Song, H., Bandaru, V. V. R., Chu, M. & Haughey, N. J., Oct 1 2010, In : Journal of neuroscience research. 88, 13, p. 2940-2951 12 p.

Research output: Contribution to journalArticle

Modeling an anti-amyloid combination therapy for Alzheimer's disease

Chow, V. W., Savonenko, A. V., Melnikova, T., Kim, H., Price, D. L., Li, T. & Wong, P. C., Jun 7 2010, In : Science translational medicine. 2, 13, p. 13ra1

Research output: Contribution to journalArticle

Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease

Klevytska, A. M., Tebbenkamp, A. T. N., Savonenko, A. V. & Borchelt, D. R., Apr 1 2010, In : Journal of neuropathology and experimental neurology. 69, 4, p. 396-404 9 p.

Research output: Contribution to journalArticle

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

Horti, A. G., Gao, Y., Ravert, H. T., Finley, P., Valentine, H., Wong, D. F., Endres, C. J., Savonenko, A. V. & Dannals, R. F., Jul 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 5202-5207 6 p.

Research output: Contribution to journalArticle

2011

A mouse model of blast injury to brain: Initial pathological, neuropathological, and behavioral characterization

Koliatsos, V. E., Cernak, I., Xu, L., Song, Y., Savonenko, A., Crain, B. J., Eberhart, C. G., Frangakis, C. E., Melnikova, T., Kim, H. & Lee, D., May 1 2011, In : Journal of neuropathology and experimental neurology. 70, 5, p. 399-416 18 p.

Research output: Contribution to journalArticle

Enhanced polyubiquitination of shank3 and NMDA receptor in a mouse model of autism

Bangash, M. A., Park, J. M., Melnikova, T., Wang, D., Jeon, S. K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H. E., Kee, S. E., Tu, J. C., Hu, J. H., Petralia, R. S., Linden, D. J., Powell, C. M., Savonenko, A. & 2 others, Xiao, B. & Worley, P. F., May 27 2011, In : Cell. 145, 5, p. 758-772 15 p.

Research output: Contribution to journalArticle

2013

Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis

Melnikova, T., Fromholt, S., Kim, H. S., Lee, D., Xu, G., Price, A., Moore, B. D., Golde, T. E., Felsenstein, K. M., Savonenko, A. & Borchelt, D. R., Feb 27 2013, In : Journal of Neuroscience. 33, 9, p. 3765-3779 15 p.

Research output: Contribution to journalArticle