Alena Savonenko

Associate Professor

1990 …2019
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Research Output 1990 2019

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Article
2019

Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation

Zhang, W., Chuang, Y. A., Na, Y., Ye, Z., Yang, L., Lin, R., Zhou, J., Wu, J., Qiu, J., Savonenko, A., Leahy, D. J., Huganir, R., Linden, D. J. & Worley, P. F., Jul 11 2019, In : Molecular cell. 75, 1, p. 13-25.e5

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Retroelements
Hippocampus
Learning
Open Access
Hydroxyurea
Down Syndrome
Episodic Memory
Nootropic Agents
Unfolded Protein Response

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

Horti, A., Naik, R., Foss, C., Minn, I., Misheneva, V., Du, Y., Wang, Y., Mathews, W. B., Wu, Y., Hall, A., LaCourse, C., Ahn, H. H., Nam, H., Lesniak, W., Valentine, H., Pletnikova, O., Troncoso, J. C., Smith, M. D., Calabresi, P., Savonenko, A. & 3 others, Dannals, R. F., Pletnikov, M. & Pomper, M. G., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Microglia
Alzheimer Disease
Demyelinating Diseases

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A., Benneyworth, M. A., Lesné, S. E., Liao, D., Araque, A. & Lee, M. K., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

Memory Disorders
Transgenic Mice
Lewy Body Disease
Parkinson Disease
Dementia
2017

Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment

Barrett, F., Workman, C. I., Sair, H., Savonenko, A., Kraut, M. A., Sodums, D. J., Joo, J. H., Nassery, N., Marano, C. M., Munro, C., Brandt, J., Zhou, Y., Wong, D. F. & Smith, G., 2017, (Accepted/In press) In : Human Brain Mapping.

Research output: Contribution to journalArticle

Denervation
Serotonin
Alzheimer Disease
Parietal Lobe
Brain
Down Syndrome
Pyramidal Cells
Messenger RNA
Learning
Neurons

Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

Modi, H. R., Wang, Q., Sahithi, G. D., Sherman, D., Greenwald, E., Savonenko, A., Geocadin, R. & Thakor, N. V., Sep 1 2017, In : PLoS One. 12, 9, e0182707.

Research output: Contribution to journalArticle

coma
cardiac arrest
Coma
Arousal
Heart Arrest

Molecular imaging of serotonin degeneration in mild cognitive impairment

Smith, G., Barrett, F., Joo, J. H., Nassery, N., Savonenko, A., Sodums, D. J., Marano, C. M., Munro, C., Brandt, J., Kraut, M. A., Zhou, Y., Wong, D. F. & Workman, C. I., Sep 1 2017, In : Neurobiology of Disease. 105, p. 33-41 9 p.

Research output: Contribution to journalArticle

Molecular Imaging
Serotonin Plasma Membrane Transport Proteins
Serotonin
Cerebrovascular Circulation
Regional Blood Flow
2016

Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa: APPsi transgenic model of Alzheimer's disease

Melnikova, T., Park, D. M., Becker, L., Lee, D., Cho, E., Sayyida, N., Tian, J., Bandeen Roche, K. J., Borchelt, D. R. & Savonenko, A., Dec 1 2016, In : Neurobiology of Disease. 96, p. 171-185 15 p.

Research output: Contribution to journalArticle

Trans-Activators
Dentate Gyrus
Tetracycline
Amyloid beta-Protein Precursor
Sex Characteristics
2015

Cannabinoid CB2 receptors in a mouse model of Aβ amyloidosis: Immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation

Savonenko, A., Melnikova, T., Wang, Y., Ravert, H., Gao, Y., Koppel, J., Lee, D., Pletnikova, O., Cho, E., Sayyida, N., Hiatt, A., Troncoso, J. C., Davies, P., Dannals, R. F., Pomper, M. G. & Horti, A., Jun 18 2015, In : PLoS One. 10, 6, e0129618.

Research output: Contribution to journalArticle

cannabinoids
amyloidosis
Cannabinoid Receptors
Cannabinoids
Biomarkers
2013

Erratum: Retraction notice to: Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

Bangash, M. A., Park, J. M., Melnikova, T., Wang, D., Jeon, S. K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H. E., Kee, S. E., Tu, J. C., Hu, J. H., Petralia, R. S., Linden, D. J., Powell, C. M., Savonenko, A. & 2 others, Xiao, B. & Worley, P. F., Jan 7 2013, In : Cell. 152, 1-2, p. 367 1 p.

Research output: Contribution to journalArticle

Autistic Disorder
N-Methyl-D-Aspartate Receptors
Apolipoproteins E
bexarotene

Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis

Melnikova, T., Fromholt, S., Kim, H., Lee, D., Xu, G., Price, A., Moore, B. D., Golde, T. E., Felsenstein, K. M., Savonenko, A. & Borchelt, D. R., Feb 27 2013, In : Journal of Neuroscience. 33, 9, p. 3765-3779 15 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Phenotype
Long-Term Memory
Short-Term Memory

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

Laclair, K. D., Manaye, K. F., Lee, D. L., Allard, J. S., Savonenko, A., Troncoso, J. C. & Wong, P. C., 2013, In : Molecular Neurodegeneration. 8, 1, 18.

Research output: Contribution to journalArticle

Apolipoproteins E
Retinoid X Receptors
Alzheimer Disease
Brain
Amyloidosis
2012

Alzheimer's therapeutics: Translation of preclinical science to clinical drug development

Savonenko, A., Melnikova, T., Hiatt, A., Li, T., Worley, P. F., Troncoso, J. C., Wong, P. C. & Price, D. L., Jan 2012, In : Neuropsychopharmacology. 37, 1, p. 261-277 17 p.

Research output: Contribution to journalArticle

Clinical Trials
Pharmaceutical Preparations
Amyloid Precursor Protein Secretases
Translational Medical Research
Neurobiology
2011

A mouse model of blast injury to brain: Initial pathological, neuropathological, and behavioral characterization

Koliatsos, V. E., Cernak, I., Xu, L., Song, Y., Savonenko, A., Crain, B. J., Eberhart, C. G., Frangakis, C., Melnikova, T., Kim, H. & Lee, D., May 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 5, p. 399-416 18 p.

Research output: Contribution to journalArticle

Blast Injuries
Torso
Veterans
Wounds and Injuries
Brain

Enhanced polyubiquitination of shank3 and NMDA receptor in a mouse model of autism

Bangash, M. A., Park, J. M., Melnikova, T., Wang, D., Jeon, S. K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H. E., Kee, S. E., Tu, J. C., Hu, J. H., Petralia, R. S., Linden, D. J., Powell, C. M., Savonenko, A. & 2 others, Xiao, B. & Worley, P. F., May 27 2011, In : Cell. 145, 5, p. 758-772 15 p.

Research output: Contribution to journalArticle

Autistic Disorder
N-Methyl-D-Aspartate Receptors
Synapses
Proteasome Endopeptidase Complex
Assays
2010

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice

Tabatadze, N., Savonenko, A., Song, H., Bandaru, V. V. R., Chu, M. & Haughey, N., Oct 2010, In : Journal of Neuroscience Research. 88, 13, p. 2940-2951 12 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Sphingolipids
Ceramides
Brain
N-Methyl-D-Aspartate Receptors

Modeling an anti-amyloid combination therapy for Alzheimer's disease

Chow, V. W., Savonenko, A., Melnikova, T., Kim, H., Price, D. L., Li, T. & Wong, P. C., 2010, In : Science Translational Medicine. 2, 13

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Amyloid
Alzheimer Disease
Serum Amyloid A Protein
Enzymes

Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease

Klevytska, A. M., Tebbenkamp, A. T. N., Savonenko, A. & Borchelt, D. R., Apr 2010, In : Journal of Neuropathology and Experimental Neurology. 69, 4, p. 396-404 9 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Huntington Disease
Life Expectancy
Histones
Acetylation

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

Horti, A., Gao, Y., Ravert, H. T., Finley, P., Valentine, H., Wong, D. F., Endres, C. J., Savonenko, A. & Dannals, R. F., Jul 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 5202-5207 6 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Positron emission tomography
Cannabinoids
Positron-Emission Tomography
Brain
2009

Amyloid precursor protein increases cortical neuron size in transgenic mice

Oh, E., Savonenko, A., King, J. F., Fangmark Tucker, S. M., Rudow, G. L., Xu, G., Borchelt, D. R. & Troncoso, J. C., Aug 2009, In : Neurobiology of Aging. 30, 8, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transgenic Mice
Neurons
Alzheimer Disease
Transgenes

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

Savonenko, A., Munoz, P., Melnikova, T., Wang, Q., Liang, X., Breyer, R. M., Montine, T. J., Kirkwood, A. & Andreasson, K., May 2009, In : Experimental Neurology. 217, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Sensory Gating
Cyclooxygenase 2
Dinoprostone
Cognition
Neurological Models
2008

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

Savonenko, A., Melnikova, T., Laird, F. M., Stewart, K. A., Price, D. L. & Wong, P. C., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5585-5590 6 p.

Research output: Contribution to journalArticle

Neuregulin-1
Schizophrenia
Phenotype
Amyloid beta-Protein Precursor
Spine

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

Liu, Y., Yoo, M. J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E. & Lee, M. K., Dec 17 2008, In : Journal of Neuroscience. 28, 51, p. 13805-13814 10 p.

Research output: Contribution to journalArticle

Amyloid
Transgenic Mice
Alzheimer Disease
Pathology
Prosencephalon

Chapter 5.5 Transgenic mouse models of Alzheimer's disease and episodic-like memory

Borchelt, D. R. & Savonenko, A., 2008, In : Handbook of Behavioral Neuroscience. 18, p. 553-573 21 p.

Research output: Contribution to journalArticle

Episodic Memory
Transgenic Mice
Alzheimer Disease
Amyloid Plaques
Memory Disorders

Morphometry of the human substantia nigra in ageing and Parkinson's disease

Rudow, G., O'Brien, R., Savonenko, A., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Marsh, L., Dawson, T. M., Crain, B. J., West, M. J. & Troncoso, J. C., Apr 2008, In : Acta Neuropathologica. 115, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

Substantia Nigra
Parkinson Disease
Neurons
Tyrosine 3-Monooxygenase
Hypertrophy
2007

Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest

Schreckinger, M., Geocadin, R., Savonenko, A., Yamashita, S., Melnikova, T., Thakor, N. V. & Hanley, D. F., Oct 2007, In : Resuscitation. 75, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

Heart Arrest
Wounds and Injuries
Startle Reflex
Reflex
Ischemia
2006

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern

Melnikova, T., Savonenko, A., Wang, Q., Liang, X., Hand, T., Wu, L., Kaufmann, W. E., Vehmas, A. & Andreasson, K. I., 2006, In : Neuroscience. 141, 3, p. 1149-1162 14 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Amyloid
Alzheimer Disease
Presenilin-1
Amyloid beta-Protein Precursor

Increased estrogen receptor β expression correlates with decreased spine formation in the rat hippocampus

Szymczak, S., Kalita, K., Jaworski, J., Mioduszewska, B., Savonenko, A., Markowska, A., Merchenthaler, I. & Kaczmarek, L., 2006, In : Hippocampus. 16, 5, p. 453-463 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Synapses
Hippocampus
Spine
Kainic Acid
2005

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H-K. & Wong, P. C., Dec 14 2005, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Amyloidosis
Neurons
Alzheimer Disease

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R. & Savonenko, A., May 25 2005, In : Journal of Neuroscience. 25, 21, p. 5217-5224 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid Plaques
Transgenic Mice
Water
Genotype

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Savonenko, A., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P. F., Price, D. L., Tang, F., Markowska, A. L. & Borchelt, D. R., Apr 2005, In : Neurobiology of Disease. 18, 3, p. 602-617 16 p.

Research output: Contribution to journalArticle

Episodic Memory
Memory Disorders
Amyloid
Transgenic Mice
Neurotransmitter Agents

Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G. & Borchelt, D. R., Dec 2005, In : PLoS Medicine. 2, 12, p. 1318-1333 16 p., e355.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Pathology

Role of Alzheimer's disease models in designing and testing experimental therapeutics

Savonenko, A., Laird, F. M., Troncoso, J. C., Wong, P. C. & Price, D. L., 2005, In : Drug Discovery Today: Disease Models. 2, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Alzheimer Disease
Investigational Therapies
Memory Disorders
Amyloid
2004

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

Schilling, G., Savonenko, A., Coonfield, M. L., Morton, J. L., Vorovich, E., Gale, A., Neslon, C., Chan, N., Eaton, M., Fromholt, D., Ross, C. A. & Borchelt, D. R., May 2004, In : Experimental Neurology. 187, 1, p. 137-149 13 p.

Research output: Contribution to journalArticle

coenzyme Q10
Celecoxib
Huntington Disease
Transgenic Mice
Pharmacology

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

Schilling, G., Savonenko, A., Klevytska, A., Morton, J. L., Tucker, S. M., Poirier, M., Gale, A., Chan, N., Gonzales, V., Slunt, H. H., Coonfield, M. L., Jenkins, N. A., Copeland, N. G., Ross, C. A. & Borchelt, D. R., Aug 1 2004, In : Human Molecular Genetics. 13, 15, p. 1599-1610 12 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Huntington Disease
Transgenic Mice
Glutamine
Phenotype
2003

Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory

Savonenko, A., Werka, T., Nikolaev, E., Zieliñski, K. & Kaczmarek, L., Jul 2003, In : Learning and Memory. 10, 4, p. 293-303 11 p.

Research output: Contribution to journalArticle

Long-Term Memory
N-Methyl-D-Aspartate Receptors
Fear
Avoidance Learning
Problem-Based Learning

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Savonenko, A., Xu, G. M., Price, D. L., Borchelt, D. R. & Markowska, A. L., Apr 2003, In : Neurobiology of Disease. 12, 3, p. 194-211 18 p.

Research output: Contribution to journalArticle

Transgenic Mice
Amyloid beta-Protein Precursor
Amyloid Plaques
Alzheimer Disease
Amyloid

The cognitive effects of ovariectomy and estrogen replacement are modulated by aging

Savonenko, A. & Markowska, A. L., Jul 4 2003, In : Neuroscience. 119, 3, p. 821-830 10 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Ovariectomy
Estrogens
Scopolamine Hydrobromide
Periodicity
2002

Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats

Markowska, A. L. & Savonenko, A., Dec 15 2002, In : Journal of Neuroscience. 22, 24, p. 10985-10995 11 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Cognition
Estrogens
Scopolamine Hydrobromide
Ovariectomy
Cognition
Task Performance and Analysis
Aptitude
Water
Short-Term Memory

Retardation of cognitive aging by life-long diet restriction: Implications for genetic variance

Markowska, A. L. & Savonenko, A., 2002, In : Neurobiology of Aging. 23, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

Inbred F344 Rats
Diet
Inbred BN Rats
Norway
Cognition

Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.

Jankowsky, J. L., Savonenko, A., Schilling, G., Wang, J., Xu, G. & Borchelt, D. R., Sep 2002, In : Current Neurology and Neuroscience Reports. 2, 5, p. 457-464 8 p.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Transgenic Mice
Trinucleotide Repeats
Prions
Amyotrophic Lateral Sclerosis
2001

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice

Andreasson, K. I., Savonenko, A., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A., Kaufmann, W. E., Worley, P. F., Isakson, P. & Markowska, A. L., Oct 15 2001, In : Journal of Neuroscience. 21, 20, p. 8198-8209 12 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Transgenic Mice
Apoptosis
Neurons
Non-Steroidal Anti-Inflammatory Agents
2000

Escape from shock versus escape from shock accompanied by a visual stimulus in rats

Zieliński, K. & Savonenko, A., 2000, In : Acta Neurobiologiae Experimentalis. 60, 4, p. 457-465 9 p.

Research output: Contribution to journalArticle

Darkness
Shock
Cues
Foot

Zapazdyvatel'noe tormozhenie reaktsii aktivnogo izbeganiia i mezhsignal'nye reaktsii v chelnochnoi kamere u krys.

Translated title of the contribution: Delay inhibition of the active avoidance reflex and intertrial responses in rats in the shuttle boxZieliński, K., Nikolaev, E. & Savonenko, A., Dec 2000, In : Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 86, 12, p. 1644-1655 12 p.

Research output: Contribution to journalArticle

Reflex
Safety
Inhibition (Psychology)
Conditioning (Psychology)
1999

Cytochemical characteristics of the brain of alcohol-nonpreferring wistar rats with different learning abilities

Sergutina, A. V., Savonenko, A., Gershtein, L. M. & Nikol'skaya, K. A., Feb 1999, In : Bulletin of Experimental Biology and Medicine. 127, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Aminopeptidases
Aptitude
Glucosephosphate Dehydrogenase
Wistar Rats
Rats

Defensive conditioning-related functional heterogeneity among nuclei of the rat amygdala revealed by c-Fos mapping

Savonenko, A., Filipkowski, R. K., Werka, T., Zielinski, K. & Kaczmarek, L., Oct 1999, In : Neuroscience. 94, 3, p. 723-733 11 p.

Research output: Contribution to journalArticle

Amygdala
Grooming
Prosencephalon
Statistical Factor Analysis
Fear

Defensive conditioning-related increase in AP-1 transcription factor in the rat cortex

Lukasiuk, K., Savonenko, A., Nikolaev, E., Rydz, M. & Kaczmarek, L., Apr 6 1999, In : Molecular Brain Research. 67, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Electrophoretic Mobility Shift Assay
Proto-Oncogene Proteins c-fos
Brain
Visual Cortex