Alena Savonenko

Associate Professor

1990 …2019

Research output per year

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Research Output

Article

1. Information role of fibrinogen content in functioning of fibrinolysis and haemostasis

Andreenko, G. V., Podorolskaja, L. V., Nikolskaja, K. A., Savonenko, A. & Serebrjakova, T. N., 1996, In : Fibrinolysis. 10, SUPPL. 1, p. 1 1 p.

Research output: Contribution to journalArticle

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice

Andreasson, K. I., Savonenko, A., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A., Kaufmann, W. E., Worley, P. F., Isakson, P. & Markowska, A. L., Oct 15 2001, In : Journal of Neuroscience. 21, 20, p. 8198-8209 12 p.

Research output: Contribution to journalArticle

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

Savonenko, A., Melnikova, T., Laird, F. M., Stewart, K. A., Price, D. L. & Wong, P. C., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5585-5590 6 p.

Research output: Contribution to journalArticle

Alzheimer's therapeutics: Translation of preclinical science to clinical drug development

Savonenko, A., Melnikova, T., Hiatt, A., Li, T., Worley, P. F., Troncoso, J. C., Wong, P. C. & Price, D. L., Jan 2012, In : Neuropsychopharmacology. 37, 1, p. 261-277 17 p.

Research output: Contribution to journalArticle

A mouse model of blast injury to brain: Initial pathological, neuropathological, and behavioral characterization

Koliatsos, V. E., Cernak, I., Xu, L., Song, Y., Savonenko, A., Crain, B. J., Eberhart, C. G., Frangakis, C. E., Melnikova, T., Kim, H. & Lee, D., May 1 2011, In : Journal of neuropathology and experimental neurology. 70, 5, p. 399-416 18 p.

Research output: Contribution to journalArticle

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

Liu, Y., Yoo, M. J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E. & Lee, M. K., Dec 17 2008, In : Journal of Neuroscience. 28, 51, p. 13805-13814 10 p.

Research output: Contribution to journalArticle

Amyloid precursor protein increases cortical neuron size in transgenic mice

Oh, E., Savonenko, A., King, J. F., Fangmark Tucker, S. M., Rudow, G. L., Xu, G., Borchelt, D. R. & Troncoso, J. C., Aug 2009, In : Neurobiology of Aging. 30, 8, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Analysis of individual variability in complex task acquisition as a method to differentiate stages of learning

Savonenko, A., Danilets, A. & Zielinski, K., Dec 1 1998, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 48, 2, p. 240-250 11 p.

Research output: Contribution to journalArticle

Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation

Zhang, W., Chuang, Y. A., Na, Y., Ye, Z., Yang, L., Lin, R., Zhou, J., Wu, J., Qiu, J., Savonenko, A., Leahy, D. J., Huganir, R., Linden, D. J. & Worley, P. F., Jul 11 2019, In : Molecular cell. 75, 1, p. 13-25.e5

Research output: Contribution to journalArticle

Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment

Barrett, F., Workman, C. I., Sair, H., Savonenko, A., Kraut, M. A., Sodums, D. J., Joo, J. H., Nassery, N., Marano, C. M., Munro, C., Brandt, J., Zhou, Y., Wong, D. F. & Smith, G., 2017, (Accepted/In press) In : Human Brain Mapping.

Research output: Contribution to journalArticle

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H. K. & Wong, P. C., Dec 14 2005, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

Cannabinoid CB2 receptors in a mouse model of Aβ amyloidosis: Immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation

Savonenko, A. V., Melnikova, T., Wang, Y., Ravert, H., Gao, Y., Koppel, J., Lee, D., Pletnikova, O., Cho, E., Sayyida, N., Hiatt, A., Troncoso, J., Davies, P., Dannals, R. F., Pomper, M. G. & Horti, A. G., Jun 18 2015, In : PloS one. 10, 6, e0129618.

Research output: Contribution to journalArticle

Change in behavior with the development of long-term sensitization of a defensive reflex in the edible snail

Beregovoi, N. A., Gainutdinov, K. L., Safronova, O. G. & Savonenko, A. V., Jul 1 1991, In : Neuroscience and Behavioral Physiology. 21, 4, p. 321-323 3 p.

Research output: Contribution to journalArticle

Chapter 5.5 Transgenic mouse models of Alzheimer's disease and episodic-like memory

Borchelt, D. R. & Savonenko, A., 2008, In : Handbook of Behavioral Neuroscience. 18, p. 553-573 21 p.

Research output: Contribution to journalArticle

Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory

Savonenko, A., Werka, T., Nikolaev, E., Zieliñski, K. & Kaczmarek, L., Jul 1 2003, In : Learning and Memory. 10, 4, p. 293-303 11 p.

Research output: Contribution to journalArticle

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern

Melnikova, T., Savonenko, A., Wang, Q., Liang, X., Hand, T., Wu, L., Kaufmann, W. E., Vehmas, A. & Andreasson, K. I., 2006, In : Neuroscience. 141, 3, p. 1149-1162 14 p.

Research output: Contribution to journalArticle

Cytochemical characteristics of the brain of alcohol-nonpreferring wistar rats with different learning abilities

Sergutina, A. V., Savonenko, A., Gershtein, L. M. & Nikol'skaya, K. A., Feb 1999, In : Bulletin of Experimental Biology and Medicine. 127, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Defensive conditioning-related functional heterogeneity among nuclei of the rat amygdala revealed by c-Fos mapping

Savonenko, A., Filipkowski, R. K., Werka, T., Zielinski, K. & Kaczmarek, L., Oct 1999, In : Neuroscience. 94, 3, p. 723-733 11 p.

Research output: Contribution to journalArticle

Defensive conditioning-related increase in AP-1 transcription factor in the rat cortex

Lukasiuk, K., Savonenko, A., Nikolaev, E., Rydz, M. & Kaczmarek, L., Apr 6 1999, In : Molecular Brain Research. 67, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats

Markowska, A. L. & Savonenko, A., Dec 15 2002, In : Journal of Neuroscience. 22, 24, p. 10985-10995 11 p.

Research output: Contribution to journalArticle

Effects of conditioned and predictive stimuli on the fly-away escape response in a two-way shuttle box

Savonenko, A. & Zielinski, K., 1998, In : Acta Neurobiologiae Experimentalis. 58, 4, p. 321 1 p.

Research output: Contribution to journalArticle

Enhanced polyubiquitination of shank3 and NMDA receptor in a mouse model of autism

Bangash, M. A., Park, J. M., Melnikova, T., Wang, D., Jeon, S. K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H. E., Kee, S. E., Tu, J. C., Hu, J. H., Petralia, R. S., Linden, D. J., Powell, C. M., Savonenko, A. & 2 others, Xiao, B. & Worley, P. F., May 27 2011, In : Cell. 145, 5, p. 758-772 15 p.

Research output: Contribution to journalArticle

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

Schilling, G., Savonenko, A., Coonfield, M. L., Morton, J. L., Vorovich, E., Gale, A., Neslon, C., Chan, N., Eaton, M., Fromholt, D., Ross, C. A. & Borchelt, D. R., May 2004, In : Experimental Neurology. 187, 1, p. 137-149 13 p.

Research output: Contribution to journalArticle

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R. & Savonenko, A., May 25 2005, In : Journal of Neuroscience. 25, 21, p. 5217-5224 8 p.

Research output: Contribution to journalArticle

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Savonenko, A., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P. F., Price, D. L., Tang, F., Markowska, A. L. & Borchelt, D. R., Apr 2005, In : Neurobiology of Disease. 18, 3, p. 602-617 16 p.

Research output: Contribution to journalArticle

Escape from shock versus escape from shock accompanied by a visual stimulus in rats

Zieliński, K. & Savonenko, A. V., Dec 20 2000, In : Acta Neurobiologiae Experimentalis. 60, 4, p. 457-465 9 p.

Research output: Contribution to journalArticle

How do rats cope with the two-way escape problem in a homogenous shuttle box?

Savonenko, A. V., Brush, F. R. & Zieliński, K., Jul 5 1999, In : Acta Neurobiologiae Experimentalis. 59, 2, p. 145-157 13 p.

Research output: Contribution to journalArticle

Open Access

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

Savonenko, A., Munoz, P., Melnikova, T., Wang, Q., Liang, X., Breyer, R. M., Montine, T. J., Kirkwood, A. & Andreasson, K., May 1 2009, In : Experimental Neurology. 217, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Increased estrogen receptor β expression correlates with decreased spine formation in the rat hippocampus

Szymczak, S., Kalita, K., Jaworski, J., Mioduszewska, B., Savonenko, A., Markowska, A., Merchenthaler, I. & Kaczmarek, L., Nov 14 2006, In : Hippocampus. 16, 5, p. 453-463 11 p.

Research output: Contribution to journalArticle

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice

Tabatadze, N., Savonenko, A., Song, H., Bandaru, V. V. R., Chu, M. & Haughey, N., Oct 2010, In : Journal of Neuroscience Research. 88, 13, p. 2940-2951 12 p.

Research output: Contribution to journalArticle

Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

Modi, H. R., Wang, Q., Sahithi, G. D., Sherman, D., Greenwald, E., Savonenko, A., Geocadin, R. & Thakor, N. V., Sep 1 2017, In : PLoS One. 12, 9, e0182707.

Research output: Contribution to journalArticle

Izmenenie povedeniia pri vyrabotke dolgovremennoǐ sensitizatsii oboronitel'nogo refleksa u vinogradnoǐ ulitki.

Translated title of the contribution: Behavioral changes during the acquisition of long-term sensitization of the defensive reflex in the edible snailBeregovoǐ, N. A., Gaǐnutdinov, K. L., Safronova, O. G. & Savonenko, A., May 1990, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 40, 3, p. 594-596 3 p.

Research output: Contribution to journalArticle

Kharakteristika Na, K-ATFazy éritrotsitov krys s raznym otnosheniem k étanolu v norme i posle khronicheskoǐ alkogolizatsii.

Translated title of the contribution: The normal characteristics of erythrocyte Na, K-ATPase in rats with different behaviors to ethanol and after chronic alcoholizationSavonenko, A. & Prokop'eva, V. D., Jun 1993, In : Byulleten Eksperimentalnoi Biologii i Meditsiny. 115, 6, p. 631-632 2 p.

Research output: Contribution to journalArticle

Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest

Schreckinger, M., Geocadin, R., Savonenko, A., Yamashita, S., Melnikova, T., Thakor, N. V. & Hanley, D. F., Oct 2007, In : Resuscitation. 75, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

Modeling an anti-amyloid combination therapy for Alzheimer's disease

Chow, V. W., Savonenko, A., Melnikova, T., Kim, H., Price, D. L., Li, T. & Wong, P. C., 2010, In : Science Translational Medicine. 2, 13

Research output: Contribution to journalArticle

Molecular imaging of serotonin degeneration in mild cognitive impairment

Smith, G., Barrett, F., Joo, J. H., Nassery, N., Savonenko, A., Sodums, D. J., Marano, C. M., Munro, C., Brandt, J., Kraut, M. A., Zhou, Y., Wong, D. F. & Workman, C. I., Sep 1 2017, In : Neurobiology of Disease. 105, p. 33-41 9 p.

Research output: Contribution to journalArticle

Morfokhimicheskie osobennosti neǐronov sensomotornoǐ kory i neostriatuma krys s razlichnoǐ stepen'iu predpochteniia alkogolia.

Translated title of the contribution: The morphochemical characteristics of the neurons of the sensorimotor cortex and neostriatum in rats with differing degrees of alcohol preferenceGershteǐn, L. M., Nikol'skaia, K. A. & Savonenko, A., Mar 1995, In : Fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 81, 3, p. 90-96 7 p.

Research output: Contribution to journalArticle

Morphochemical features of sensorimotor cortex and neostriatum neurons in rats with different levels of alcohol preference

Gershtein, L. M., Nikol'skaya, K. A. & Savonenko, A., 1997, In : Neuroscience and Behavioral Physiology. 27, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

Morphometry of the human substantia nigra in ageing and Parkinson's disease

Rudow, G., O'Brien, R., Savonenko, A., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Marsh, L., Dawson, T. M., Crain, B. J., West, M. J. & Troncoso, J. C., Apr 2008, In : Acta Neuropathologica. 115, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Savonenko, A. V., Xu, G. M., Price, D. L., Borchelt, D. R. & Markowska, A. L., Apr 2003, In : Neurobiology of Disease. 12, 3, p. 194-211 18 p.

Research output: Contribution to journalArticle

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

Schilling, G., Savonenko, A., Klevytska, A., Morton, J. L., Tucker, S. M., Poirier, M., Gale, A., Chan, N., Gonzales, V., Slunt, H. H., Coonfield, M. L., Jenkins, N. A., Copeland, N. G., Ross, C. A. & Borchelt, D. R., Aug 1 2004, In : Human Molecular Genetics. 13, 15, p. 1599-1610 12 p.

Research output: Contribution to journalArticle

Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease

Klevytska, A. M., Tebbenkamp, A. T. N., Savonenko, A. & Borchelt, D. R., Apr 2010, In : Journal of Neuropathology and Experimental Neurology. 69, 4, p. 396-404 9 p.

Research output: Contribution to journalArticle

Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G. & Borchelt, D. R., Dec 2005, In : PLoS Medicine. 2, 12, p. 1318-1333 16 p., e355.

Research output: Contribution to journalArticle

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

Horti, A., Naik, R., Foss, C., Minn, I., Misheneva, V., Du, Y., Wang, Y., Mathews, W. B., Wu, Y., Hall, A., LaCourse, C., Ahn, H. H., Nam, H., Lesniak, W., Valentine, H., Pletnikova, O., Troncoso, J. C., Smith, M. D., Calabresi, P., Savonenko, A. & 3 others, Dannals, R. F., Pletnikov, M. & Pomper, M. G., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1686-1691 6 p.

Research output: Contribution to journalArticle

Psikhofiziologicheskie markery predraspolozhennosti k razvitiiu alkogol'noǐ zavisimosti u krys.

Translated title of the contribution: The psychophysiological markers of a predisposition to the development of alcohol dependence in ratsSavonenko, A. V., Adrianov, O. S., Nikol'skaia, K. A., Osipov, A. I. & Eshchenko, O. V., Mar 1 1995, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 45, 2, p. 416-419 4 p.

Research output: Contribution to journalArticle

Retardation of cognitive aging by life-long diet restriction: Implications for genetic variance

Markowska, A. L. & Savonenko, A., Jan 26 2002, In : Neurobiology of Aging. 23, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle