Alena Savonenko

Associate Professor

1990 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1990 2019

1990

Izmenenie povedeniia pri vyrabotke dolgovremennoǐ sensitizatsii oboronitel'nogo refleksa u vinogradnoǐ ulitki.

Translated title of the contribution: Behavioral changes during the acquisition of long-term sensitization of the defensive reflex in the edible snailBeregovoǐ, N. A., Gaǐnutdinov, K. L., Safronova, O. G. & Savonenko, A., May 1990, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 40, 3, p. 594-596 3 p.

Research output: Contribution to journalArticle

Long-Term Memory
Snails
Reflex
1991

Change in behavior with the development of long-term sensitization of a defensive reflex in the edible snail

Beregovoi, N. A., Gainutdinov, K. L., Safronova, O. G. & Savonenko, A., Jul 1991, In : Neuroscience and Behavioral Physiology. 21, 4, p. 321-323 3 p.

Research output: Contribution to journalArticle

Helix (Snails)
Electroshock
Animal Behavior
Exploratory Behavior
Snails
1993
Adenosine Triphosphatases
Rats
Ethanol
Erythrocytes
Health

Kharakteristika Na, K-ATFazy éritrotsitov krys s raznym otnosheniem k étanolu v norme i posle khronicheskoǐ alkogolizatsii.

Translated title of the contribution: The normal characteristics of erythrocyte Na, K-ATPase in rats with different behaviors to ethanol and after chronic alcoholizationSavonenko, A. & Prokop'eva, V. D., Jun 1993, In : Byulleten Eksperimentalnoi Biologii i Meditsiny. 115, 6, p. 631-632 2 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Rats
Ethanol
Erythrocytes
Magnesium Chloride
1995

Morfokhimicheskie osobennosti neǐronov sensomotornoǐ kory i neostriatuma krys s razlichnoǐ stepen'iu predpochteniia alkogolia.

Translated title of the contribution: The morphochemical characteristics of the neurons of the sensorimotor cortex and neostriatum in rats with differing degrees of alcohol preferenceGershteǐn, L. M., Nikol'skaia, K. A. & Savonenko, A., Mar 1995, In : Fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 81, 3, p. 90-96 7 p.

Research output: Contribution to journalArticle

Neostriatum
Alcohols
Neurons
Albumins
Cytoplasm

Psikhofiziologicheskie markery predraspolozhennosti k razvitiiu alkogol'noǐ zavisimosti u krys.

Translated title of the contribution: The psychophysiological markers of a predisposition to the development of alcohol dependence in ratsSavonenko, A., Adrianov, O. S., Nikol'skaia, K. A., Osipov, A. I. & Eshchenko, O. V., Mar 1995, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 45, 2, p. 416-419 4 p.

Research output: Contribution to journalArticle

Psychophysiology
Classical Conditioning
Disease Susceptibility
Feeding Behavior
Alcoholism
1996

1. Information role of fibrinogen content in functioning of fibrinolysis and haemostasis

Andreenko, G. V., Podorolskaja, L. V., Nikolskaja, K. A., Savonenko, A. & Serebrjakova, T. N., 1996, In : Fibrinolysis. 10, SUPPL. 1, p. 1 1 p.

Research output: Contribution to journalArticle

Fibrinolysis
Hemostatics
Hemostasis
Fibrinogen
Pathology

Slabye magnitnye polia i poznavatel'naia deiatel'nost'.

Translated title of the contribution: Weak magnetic fields and cognitive activityNikol'skaia, K. A., Shtemler, A. V., Savonenko, A., Osipov, A. I. & Nikol'skii, S. V., Jul 1996, In : Biofizika. 41, 4, p. 887-893 7 p.

Research output: Contribution to journalArticle

Magnetic Fields
Nootropic Agents
Cognition
Wistar Rats
Depression

The sensitivity of cognitive processes to the inhomogeneity of natural magnetic fields

Nikolskaya, K., Shtemler, V., Yeschenko, O., Savonenko, A., Osipov, A. & Nickolsky, S., 1996, In : Electromagnetic Biology and Medicine. 15, 3, p. 163-174 12 p.

Research output: Contribution to journalArticle

Magnetic Fields
magnetic fields
cognition
mental depression
Magnets

The sensitivity of cognitive processes to the inhomogeneity of natural magnetic fields

Nikolskaya, K., Shtemler, V., Yeschenko, O., Savonenko, A., Osipov, A. & Nickolsky, S., 1996, In : Electro- and Magnetobiology. 15, 3, p. 163-174 12 p.

Research output: Contribution to journalArticle

Magnetic Fields
magnetic fields
cognition
mental depression
Magnets
1997

Morphochemical features of sensorimotor cortex and neostriatum neurons in rats with different levels of alcohol preference

Gershtein, L. M., Nikol'skaya, K. A. & Savonenko, A., 1997, In : Neuroscience and Behavioral Physiology. 27, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

Neostriatum
Alcohols
Cell Size
Neurons
Ethanol
1998
Freezing
Learning
Avoidance Learning
Problem-Based Learning
Conflict (Psychology)

Effects of conditioned and predictive stimuli on the fly-away escape response in a two-way shuttle box

Savonenko, A. & Zielinski, K., 1998, In : Acta Neurobiologiae Experimentalis. 58, 4, p. 321 1 p.

Research output: Contribution to journalArticle

Escape Reaction
Operant Conditioning
Diptera

Zavisimost' obucheniia reaktsii aktivnogo izbeganiia ot preodoleniia problemnoi situatsii v chelnochnoi kamere.

Translated title of the contribution: The dependence of learning an active avoidance reaction on overcoming a problem-solving situation in a shuttle boxSavonenko, A. V. & Zieliński, K., Mar 1998, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 48, 2, p. 229-239 11 p.

Research output: Contribution to journalArticle

Avoidance Learning
Problem-Based Learning
Learning
Freezing
Shock
1999

Cytochemical characteristics of the brain of alcohol-nonpreferring wistar rats with different learning abilities

Sergutina, A. V., Savonenko, A., Gershtein, L. M. & Nikol'skaya, K. A., Feb 1999, In : Bulletin of Experimental Biology and Medicine. 127, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Aminopeptidases
Aptitude
Glucosephosphate Dehydrogenase
Wistar Rats
Rats

Defensive conditioning-related functional heterogeneity among nuclei of the rat amygdala revealed by c-Fos mapping

Savonenko, A., Filipkowski, R. K., Werka, T., Zielinski, K. & Kaczmarek, L., Oct 1999, In : Neuroscience. 94, 3, p. 723-733 11 p.

Research output: Contribution to journalArticle

Amygdala
Grooming
Prosencephalon
Statistical Factor Analysis
Fear

Defensive conditioning-related increase in AP-1 transcription factor in the rat cortex

Lukasiuk, K., Savonenko, A., Nikolaev, E., Rydz, M. & Kaczmarek, L., Apr 6 1999, In : Molecular Brain Research. 67, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Electrophoretic Mobility Shift Assay
Proto-Oncogene Proteins c-fos
Brain
Visual Cortex

How do rats cope with the two-way escape problem in a homogenous shuttle box?

Savonenko, A., Brush, F. R. & Zieliński, K., 1999, In : Acta Neurobiologiae Experimentalis. 59, 2, p. 145-157 13 p.

Research output: Contribution to journalArticle

Diptera
Shock

Studies of individual differences as a method for discriminating the stages of acquisition of a conditioned reflex

Savonenko, A., Danilets, A. V. & Zelin'ski, K., May 1999, In : Neuroscience and Behavioral Physiology. 29, 3, p. 295-303 9 p.

Research output: Contribution to journalArticle

Classical Conditioning
Individuality
Learning
Freezing
Animal Behavior

Tsitokhimicheskie osobennosti mozga otvergaiushchikh alkogol' krys Vistar, kotorye razlichaiutsia po sposobnosti k obucheniiu.

Translated title of the contribution: Cytochemical brain characteristics of rejecting alcohol Wistar rats with various learning abilitySergutina, A. V., Savonenko, A., Gershtein, L. M. & Nikol'skaia, K. A., Feb 1999, In : Byulleten Eksperimentalnoi Biologii i Meditsiny. 127, 2, p. 180-182 3 p.

Research output: Contribution to journalArticle

Operant Conditioning
Glutamate Dehydrogenase
Histocytochemistry
Aminopeptidases
Aptitude
2000

Escape from shock versus escape from shock accompanied by a visual stimulus in rats

Zieliński, K. & Savonenko, A., 2000, In : Acta Neurobiologiae Experimentalis. 60, 4, p. 457-465 9 p.

Research output: Contribution to journalArticle

Darkness
Shock
Cues
Foot

Zapazdyvatel'noe tormozhenie reaktsii aktivnogo izbeganiia i mezhsignal'nye reaktsii v chelnochnoi kamere u krys.

Translated title of the contribution: Delay inhibition of the active avoidance reflex and intertrial responses in rats in the shuttle boxZieliński, K., Nikolaev, E. & Savonenko, A., Dec 2000, In : Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. 86, 12, p. 1644-1655 12 p.

Research output: Contribution to journalArticle

Reflex
Safety
Inhibition (Psychology)
Conditioning (Psychology)
2001

Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice

Andreasson, K. I., Savonenko, A., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A., Kaufmann, W. E., Worley, P. F., Isakson, P. & Markowska, A. L., Oct 15 2001, In : Journal of Neuroscience. 21, 20, p. 8198-8209 12 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Transgenic Mice
Apoptosis
Neurons
Non-Steroidal Anti-Inflammatory Agents
2002

Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats

Markowska, A. L. & Savonenko, A., Dec 15 2002, In : Journal of Neuroscience. 22, 24, p. 10985-10995 11 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Cognition
Estrogens
Scopolamine Hydrobromide
Ovariectomy
Cognition
Task Performance and Analysis
Aptitude
Water
Short-Term Memory

Retardation of cognitive aging by life-long diet restriction: Implications for genetic variance

Markowska, A. L. & Savonenko, A., 2002, In : Neurobiology of Aging. 23, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

Inbred F344 Rats
Diet
Inbred BN Rats
Norway
Cognition

Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.

Jankowsky, J. L., Savonenko, A., Schilling, G., Wang, J., Xu, G. & Borchelt, D. R., Sep 2002, In : Current Neurology and Neuroscience Reports. 2, 5, p. 457-464 8 p.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Transgenic Mice
Trinucleotide Repeats
Prions
Amyotrophic Lateral Sclerosis
2003

Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory

Savonenko, A., Werka, T., Nikolaev, E., Zieliñski, K. & Kaczmarek, L., Jul 2003, In : Learning and Memory. 10, 4, p. 293-303 11 p.

Research output: Contribution to journalArticle

Long-Term Memory
N-Methyl-D-Aspartate Receptors
Fear
Avoidance Learning
Problem-Based Learning

Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

Savonenko, A., Xu, G. M., Price, D. L., Borchelt, D. R. & Markowska, A. L., Apr 2003, In : Neurobiology of Disease. 12, 3, p. 194-211 18 p.

Research output: Contribution to journalArticle

Transgenic Mice
Amyloid beta-Protein Precursor
Amyloid Plaques
Alzheimer Disease
Amyloid

The cognitive effects of ovariectomy and estrogen replacement are modulated by aging

Savonenko, A. & Markowska, A. L., Jul 4 2003, In : Neuroscience. 119, 3, p. 821-830 10 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Ovariectomy
Estrogens
Scopolamine Hydrobromide
Periodicity
2004

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

Schilling, G., Savonenko, A., Coonfield, M. L., Morton, J. L., Vorovich, E., Gale, A., Neslon, C., Chan, N., Eaton, M., Fromholt, D., Ross, C. A. & Borchelt, D. R., May 2004, In : Experimental Neurology. 187, 1, p. 137-149 13 p.

Research output: Contribution to journalArticle

coenzyme Q10
Celecoxib
Huntington Disease
Transgenic Mice
Pharmacology

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

Schilling, G., Savonenko, A., Klevytska, A., Morton, J. L., Tucker, S. M., Poirier, M., Gale, A., Chan, N., Gonzales, V., Slunt, H. H., Coonfield, M. L., Jenkins, N. A., Copeland, N. G., Ross, C. A. & Borchelt, D. R., Aug 1 2004, In : Human Molecular Genetics. 13, 15, p. 1599-1610 12 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Huntington Disease
Transgenic Mice
Glutamine
Phenotype
2005

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H-K. & Wong, P. C., Dec 14 2005, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Amyloidosis
Neurons
Alzheimer Disease

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R. & Savonenko, A., May 25 2005, In : Journal of Neuroscience. 25, 21, p. 5217-5224 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid Plaques
Transgenic Mice
Water
Genotype

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Savonenko, A., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P. F., Price, D. L., Tang, F., Markowska, A. L. & Borchelt, D. R., Apr 2005, In : Neurobiology of Disease. 18, 3, p. 602-617 16 p.

Research output: Contribution to journalArticle

Episodic Memory
Memory Disorders
Amyloid
Transgenic Mice
Neurotransmitter Agents

Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G. & Borchelt, D. R., Dec 2005, In : PLoS Medicine. 2, 12, p. 1318-1333 16 p., e355.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Pathology

Role of Alzheimer's disease models in designing and testing experimental therapeutics

Savonenko, A., Laird, F. M., Troncoso, J. C., Wong, P. C. & Price, D. L., 2005, In : Drug Discovery Today: Disease Models. 2, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Alzheimer Disease
Investigational Therapies
Memory Disorders
Amyloid
2006

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern

Melnikova, T., Savonenko, A., Wang, Q., Liang, X., Hand, T., Wu, L., Kaufmann, W. E., Vehmas, A. & Andreasson, K. I., 2006, In : Neuroscience. 141, 3, p. 1149-1162 14 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Amyloid
Alzheimer Disease
Presenilin-1
Amyloid beta-Protein Precursor

Increased estrogen receptor β expression correlates with decreased spine formation in the rat hippocampus

Szymczak, S., Kalita, K., Jaworski, J., Mioduszewska, B., Savonenko, A., Markowska, A., Merchenthaler, I. & Kaczmarek, L., 2006, In : Hippocampus. 16, 5, p. 453-463 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Synapses
Hippocampus
Spine
Kainic Acid
2007

Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest

Schreckinger, M., Geocadin, R., Savonenko, A., Yamashita, S., Melnikova, T., Thakor, N. V. & Hanley, D. F., Oct 2007, In : Resuscitation. 75, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

Heart Arrest
Wounds and Injuries
Startle Reflex
Reflex
Ischemia

β-secretase: Physiological role and target validation

Laird, F. M., Farah, M. H., Lee, H-K., Savonenko, A., Price, D. L. & Wong, P. C., 2007, Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. Springer US, p. 59-76 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid Precursor Protein Secretases
Amyloid
Cognition
Therapeutics
Validation Studies
2008

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

Savonenko, A., Melnikova, T., Laird, F. M., Stewart, K. A., Price, D. L. & Wong, P. C., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5585-5590 6 p.

Research output: Contribution to journalArticle

Neuregulin-1
Schizophrenia
Phenotype
Amyloid beta-Protein Precursor
Spine

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

Liu, Y., Yoo, M. J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E. & Lee, M. K., Dec 17 2008, In : Journal of Neuroscience. 28, 51, p. 13805-13814 10 p.

Research output: Contribution to journalArticle

Amyloid
Transgenic Mice
Alzheimer Disease
Pathology
Prosencephalon

Chapter 5.5 Transgenic mouse models of Alzheimer's disease and episodic-like memory

Borchelt, D. R. & Savonenko, A., 2008, In : Handbook of Behavioral Neuroscience. 18, p. 553-573 21 p.

Research output: Contribution to journalArticle

Episodic Memory
Transgenic Mice
Alzheimer Disease
Amyloid Plaques
Memory Disorders

Morphometry of the human substantia nigra in ageing and Parkinson's disease

Rudow, G., O'Brien, R., Savonenko, A., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Marsh, L., Dawson, T. M., Crain, B. J., West, M. J. & Troncoso, J. C., Apr 2008, In : Acta Neuropathologica. 115, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

Substantia Nigra
Parkinson Disease
Neurons
Tyrosine 3-Monooxygenase
Hypertrophy
2009

Amyloid precursor protein increases cortical neuron size in transgenic mice

Oh, E., Savonenko, A., King, J. F., Fangmark Tucker, S. M., Rudow, G. L., Xu, G., Borchelt, D. R. & Troncoso, J. C., Aug 2009, In : Neurobiology of Aging. 30, 8, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transgenic Mice
Neurons
Alzheimer Disease
Transgenes

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

Savonenko, A., Munoz, P., Melnikova, T., Wang, Q., Liang, X., Breyer, R. M., Montine, T. J., Kirkwood, A. & Andreasson, K., May 2009, In : Experimental Neurology. 217, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

Sensory Gating
Cyclooxygenase 2
Dinoprostone
Cognition
Neurological Models
2010

Aging of the Brain and Alzheimer's Disease

Price, D. L., Savonenko, A., Albert, M., Troncoso, J. C. & Wong, P. C., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 187-195 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain Diseases
Alzheimer Disease
Amyloid Precursor Protein Secretases
Peptides
Amyloid

Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics

Price, D. L., Savonenko, A., Li, T., Lee, M. K. & Wong, P. C., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 231-258 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid Precursor Protein Secretases
Alzheimer Disease
Theoretical Models
Proteins
Therapeutics

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice

Tabatadze, N., Savonenko, A., Song, H., Bandaru, V. V. R., Chu, M. & Haughey, N., Oct 2010, In : Journal of Neuroscience Research. 88, 13, p. 2940-2951 12 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Sphingolipids
Ceramides
Brain
N-Methyl-D-Aspartate Receptors