Alban Latremoliere

Assistant Professor

20052019
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Research Output 2005 2019

2019

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury

Davies, A. J., Kim, H. W., Gonzalez-Cano, R., Choi, J., Back, S. K., Roh, S. E., Johnson, E., Gabriac, M., Kim, M. S., Lee, J., Lee, J. E., Kim, Y. S., Bae, Y. C., Kim, S. J., Lee, K. M., Na, H. S., Riva, P., Latremoliere, A., Rinaldi, S., Ugolini, S. & 2 others, Costigan, M. & Oh, S. B., Feb 7 2019, In : Cell. 176, 4, p. 716-728.e18

Research output: Contribution to journalArticle

Natural Killer Cells
Axons
Peripheral Nerve Injuries
Wounds and Injuries
Natural Killer Cell Receptors

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer (Nature, (2018), 563, 7732, (564-568), 10.1038/s41586-018-0701-2)

Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., Kreslavsky, T., Kogler, M., Hoffmann, D., Ticevic, M., da Luz Scheffer, D., Tortola, L., Cikes, D., Jais, A., Rangachari, M., Rao, S. & 21 others, Paolino, M., Novatchkova, M., Aichinger, M., Barrett, L., Latremoliere, A., Wirnsberger, G., Lametschwandtner, G., Busslinger, M., Zicha, S., Latini, A., Robson, S. C., Waisman, A., Andrews, N., Costigan, M., Channon, K. M., Weiss, G., Kozlov, A. V., Tebbe, M., Johnsson, K., Woolf, C. J. & Penninger, J. M., Aug 15 2019, In : Nature. 572, 7769, p. E18

Research output: Contribution to journalComment/debate

Open Access
Autoimmunity
Cell Proliferation
T-Lymphocytes
Neoplasms
2018

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

Cobos, E. J., Nickerson, C. A., Gao, F., Chandran, V., Bravo-Caparrós, I., González-Cano, R., Riva, P., Andrews, N. A., Latremoliere, A., Seehus, C. R., Perazzoli, G., Nieto, F. R., Joller, N., Painter, M. W., Ma, C. H. E., Omura, T., Chesler, E. J., Geschwind, D. H., Coppola, G., Rangachari, M. & 2 others, Woolf, C. J. & Costigan, M., Jan 30 2018, In : Cell Reports. 22, 5, p. 1301-1312 12 p.

Research output: Contribution to journalArticle

Hyperalgesia
Neuralgia
Neurons
Gene expression
Hypersensitivity

Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration

Latremoliere, A., Cheng, L., DeLisle, M., Wu, C., Chew, S., Hutchinson, E. B., Sheridan, A., Alexandre, C., Latremoliere, F., Sheu, S. H., Golidy, S., Omura, T., Huebner, E. A., Fan, Y., Whitman, M. C., Nguyen, E., Hermawan, C., Pierpaoli, C., Tischfield, M. A., Woolf, C. J. & 1 others, Engle, E. C., Aug 14 2018, In : Cell Reports. 24, 7, p. 1865-1879.e9

Research output: Contribution to journalArticle

Tubulin
Axons
Regeneration
Neurology
Nervous System

NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury

Inquimbert, P., Moll, M., Latremoliere, A., Tong, C. K., Whang, J., Sheehan, G. F., Smith, B. M., Korb, E., Athié, M. C. P., Babaniyi, O., Ghasemlou, N., Yanagawa, Y., Allis, C. D., Hof, P. R. & Scholz, J., May 29 2018, In : Cell Reports. 23, 9, p. 2678-2689 12 p.

Research output: Contribution to journalArticle

Posterior Horn Cells
Peripheral Nerve Injuries
N-Methyl-D-Aspartate Receptors
Neurons
Glutamate Receptors

Optical cuff for optogenetic control of the peripheral nervous system

Michoud, F., Sottas, L., Browne, L. E., Asboth, L., Latremoliere, A., Sakuma, M., Courtine, G., Woolf, C. J. & Lacour, S. P., Feb 1 2018, In : Journal of Neural Engineering. 15, 1, 015002.

Research output: Contribution to journalArticle

Optogenetics
Peripheral Nervous System
Neurology
Axons
Peripheral Nerves

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., Kreslavsky, T., Kogler, M., Hoffmann, D., Ticevic, M., da Luz Scheffer, D., Tortola, L., Cikes, D., Jais, A., Rangachari, M., Rao, S. & 21 others, Paolino, M., Novatchkova, M., Aichinger, M., Barrett, L., Latremoliere, A., Wirnsberger, G., Lametschwandtner, G., Busslinger, M., Zicha, S., Latini, A., Robson, S. C., Waisman, A., Andrews, N., Costigan, M., Channon, K. M., Weiss, G., Kozlov, A. V., Tebbe, M., Johnsson, K., Woolf, C. J. & Penninger, J. M., Nov 22 2018, In : Nature. 563, 7732, p. 564-568 5 p.

Research output: Contribution to journalLetter

Autoimmunity
T-Lymphocytes
sepiapterin reductase
Neoplasms
Enzymes

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections

Liu, Y., Latremoliere, A., Li, X., Zhang, Z., Chen, M., Wang, X., Fang, C., Zhu, J., Alexandre, C., Gao, Z., Chen, B., Ding, X., Zhou, J. Y., Zhang, Y., Chen, C., Wang, K. H., Woolf, C. J. & He, Z., Sep 27 2018, In : Nature. 561, 7724, p. 547-550 4 p.

Research output: Contribution to journalLetter

Touch
Neuralgia
Pyramidal Tracts
Neurons
Spinal Cord
2017

Arachidonic acid containing phosphatidylcholine increases due to microglial activation in ipsilateral spinal dorsal horn following spared sciatic nerve injury

Banno, T., Omura, T., Masaki, N., Arima, H., Xu, D., Okamoto, A., Costigan, M., Latremoliere, A., Matsuyama, Y. & Setou, M., May 1 2017, In : PLoS One. 12, 5, e0177595.

Research output: Contribution to journalArticle

Sciatic Nerve
Phosphatidylcholines
arachidonic acid
Arachidonic Acid
phosphatidylcholines

Combining Human and Rodent Genetics to Identify New Analgesics

Latremoliere, A. & Costigan, M., Jul 1 2017, (Accepted/In press) In : Neuroscience Bulletin. p. 1-13 13 p.

Research output: Contribution to journalArticle

sepiapterin reductase
Medical Genetics
Chronic Pain
GTP Cyclohydrolase
Analgesics

Decreased alertness due to sleep loss increases pain sensitivity in mice

Alexandre, C., Latremoliere, A., Ferreira, A., Miracca, G., Yamamoto, M., Scammell, T. E. & Woolf, C. J., Jun 1 2017, In : Nature Medicine. 23, 6, p. 768-774 7 p.

Research output: Contribution to journalArticle

Sleep
Pain
Wakefulness-Promoting Agents
Sleep Deprivation
Analgesics

Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses

Browne, L. E., Latremoliere, A., Lehnert, B. P., Grantham, A., Ward, C., Alexandre, C., Costigan, M., Michoud, F., Roberson, D. P., Ginty, D. D. & Woolf, C. J., Jul 5 2017, In : Cell Reports. 20, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

Nociceptors
Sensory Receptor Cells
Neurons
Optogenetics
Pain
2016

Corrections to "Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS"[Neuron 86, 1215-1227; June 3, 2015]

Omura, T., Omura, K., Tedeschi, A., Riva, P., Painter, M. W., Rojas, L., Martin, J., Lisi, V., Huebner, E. A., Latremoliere, A., Yin, Y., Barrett, L. B., Singh, B., Lee, S., Crisman, T., Gao, F., Li, S., Kapur, K., Geschwind, D. H., Kosik, K. S. & 6 others, Coppola, G., He, Z., Carmichael, S. T., Benowitz, L. I., Costigan, M. & Woolf, C. J., May 4 2016, In : Neuron. 90, 3, 1 p.

Research output: Contribution to journalComment/debate

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

Andrews, N. A., Latremoliere, A., Basbaum, A. I., Mogil, J. S., Porreca, F., Rice, A. S. C., Woolf, C. J., Currie, G. L., Dworkin, R. H., Eisenach, J. C., Evans, S., Gewandter, J. S., Gover, T. D., Handwerker, H., Huang, W., Iyengar, S., Jensen, M. P., Kennedy, J. D., Lee, N., Levine, J. & 14 others, Lidster, K., MacHin, I., McDermott, M. P., McMahon, S. B., Price, T. J., Ross, S. E., Scherrer, G., Seal, R. P., Sena, E. S., Silva, E., Stone, L., Svensson, C. I., Turk, D. C. & Whiteside, G., Apr 1 2016, In : Pain. 157, 4, p. 901-909 9 p.

Research output: Contribution to journalArticle

Safety
Pain
Research
Research Design
Public-Private Sector Partnerships

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

Kahle, K. T., Schmouth, J. F., Lavastre, V., Latremoliere, A., Zhang, J., Andrews, N., Omura, T., Laganière, J., Rochefort, D., Hince, P., Castonguay, G., Gaudet, R., Mapplebeck, J. C. S., Sotocinal, S. G., Duan, J., Ward, C., Khanna, A. R., Mogil, J. S., Dion, P. A., Woolf, C. J. & 2 others, Inquimbert, P. & Rouleau, G. A., Mar 29 2016, In : Science Signaling. 9, 421, ra32.

Research output: Contribution to journalArticle

Neuralgia
gamma-Aminobutyric Acid
Neurons
Phosphorylation
Phosphotransferases

Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure

Sakuma, M., Gorski, G., Sheu, S. H., Lee, S., Barrett, L. B., Singh, B., Omura, T., Latremoliere, A. & Woolf, C. J., Feb 1 2016, In : European Journal of Neuroscience. 43, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

Neuromuscular Junction
Denervation
Wounds and Injuries
Motor Endplate
Nerve Crush

La sépiaptérine réductase: Une nouvelle cible pour traiter les douleurs neuropathiques

Translated title of the contribution: Sepiapterin reductase as a novel target to treat neuropathic painLatremoliere, A., Feb 1 2016, In : Medecine/Sciences. 32, 2, p. 152-155 4 p.

Research output: Contribution to journalComment/debate

sepiapterin reductase
Alcohol Oxidoreductases
Enzyme Inhibitors
Analgesics
Animals

Spinal plasticity of the nociceptive system: The role of central sensitisation in chronic pain states

Latremoliere, A., Mar 5 2016, An Introduction to Pain and Nervous System Disorders. Wiley Blackwell, p. 35-87 53 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Central Nervous System Sensitization
Chronic Pain
Nociceptors
Nociceptive Pain
Pain
2015

Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms

Nawabi, H., Belin, S., Cartoni, R., Williams, P. R., Wang, C., Latremoliere, A., Wang, X., Zhu, J., Taub, D. G., Fu, X., Yu, B., Gu, X., Woolf, C. J., Liu, J. S., Gabel, C. V., Steen, J. A. & He, Z., Nov 18 2015, In : Neuron. 88, 4, p. 704-719 16 p.

Research output: Contribution to journalArticle

Growth Cones
Axons
Phosphotransferases
Microtubules
Regeneration

Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics

Belin, S., Nawabi, H., Wang, C., Tang, S., Latremoliere, A., Warren, P., Schorle, H., Uncu, C., Woolf, C. J., He, Z. & Steen, J. A., Jan 1 2015, In : Neuron. 86, 4, p. 1000-1014 15 p.

Research output: Contribution to journalArticle

Proteomics
Retinal Ganglion Cells
Wounds and Injuries
Down-Regulation
Optic Nerve Injuries

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

Latremoliere, A., Latini, A., Andrews, N., Cronin, S. J., Fujita, M., Gorska, K., Hovius, R., Romero, C., Chuaiphichai, S., Painter, M., Miracca, G., Babaniyi, O., Remor, A. P., Duong, K., Riva, P., Barrett, L. B., Ferreirós, N., Naylor, A., Penninger, J. M., Tegeder, I. & 6 others, Zhong, J., Blagg, J., Channon, K. M., Johnsson, K., Costigan, M. & Woolf, C. J., Jan 1 2015, In : Neuron. 86, 6, p. 1393-1406 14 p.

Research output: Contribution to journalArticle

sepiapterin reductase
Neuralgia
Sensory Receptor Cells
Hypersensitivity
Pain

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

Omura, T., Omura, K., Tedeschi, A., Riva, P., Painter, M. W., Rojas, L., Martin, J., Lisi, V., Huebner, E. A., Latremoliere, A., Yin, Y., Barrett, L. B., Singh, B., Lee, S., Crisman, T., Gao, F., Li, S., Kapur, K., Geschwind, D. H., Kosik, K. S. & 6 others, Coppola, G., He, Z., Carmichael, S. T., Benowitz, L. I., Costigan, M. & Woolf, C. J., Jun 3 2015, In : Neuron. 86, 5, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

Activins
Regeneration
Myelin Sheath
Axons
Neurons

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

Vicuña, L., Strochlic, D. E., Latremoliere, A., Bali, K. K., Simonetti, M., Husainie, D., Prokosch, S., Riva, P., Griffin, R. S., Njoo, C., Gehrig, S., Mall, M. A., Arnold, B., Devor, M., Woolf, C. J., Liberles, S. D., Costigan, M. & Kuner, R., May 1 2015, In : Nature Medicine. 21, 5, p. 518-523 6 p.

Research output: Contribution to journalArticle

Leukocyte Elastase
Serine Proteinase Inhibitors
T-cells
Neuralgia
Hyperalgesia
2014

Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration

Painter, M. W., Brosius Lutz, A., Cheng, Y. C., Latremoliere, A., Duong, K., Miller, C. M., Posada, S., Cobos, E. J., Zhang, A. X., Wagers, A. J., Havton, L. A., Barres, B., Omura, T. & Woolf, C. J., Jul 16 2014, In : Neuron. 83, 2, p. 331-343 13 p.

Research output: Contribution to journalArticle

Schwann Cells
Regeneration
Myelin Sheath
Wounds and Injuries
Transplants
2012

Analgesia by inhibiting tetrahydrobiopterin synthesis

Costigan, M., Latremoliere, A. & Woolf, C. J., Feb 1 2012, In : Current Opinion in Pharmacology. 12, 1, p. 92-99 8 p.

Research output: Contribution to journalReview article

sepiapterin reductase
GTP Cyclohydrolase
Analgesia
Sulfasalazine
Haplotypes
2011

Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice

Ma, C. H. E., Omura, T., Cobos, E. J., Latremoliere, A., Ghasemlou, N., Brenner, G. J., Van Veen, E., Barrett, L., Sawada, T., Gao, F., Coppola, G., Gertler, F., Costigan, M., Geschwind, D. & Woolf, C. J., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4332-4347 16 p.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
HSP27 Heat-Shock Proteins
Wounds and Injuries
Sciatic Nerve
Growth

GCH1, BH4 and pain

Latremoliere, A., Costigan, M. & Kirby, F. M., Jan 1 2011, In : Current Pharmaceutical Biotechnology. 12, 10, p. 1728-1741 14 p.

Research output: Contribution to journalArticle

GTP Cyclohydrolase
Pain
Chronic Pain
Haplotypes
Analgesics
Receptor, Serotonin, 5-HT1B
zolmitriptan
Neuralgia
N-Methyl-D-Aspartate Receptors
Constriction
2010

Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus infraorbital nerve-ligated rats - Behavioral, pharmacological and immunohistochemical investigations

Kayser, V., Viguier, F., Ioannidi, M., Bernard, J. F., Latremoliere, A., Michot, B., Vela, J. M., Buschmann, H., Hamon, M. & Bourgoin, S., Feb 1 2010, In : Neuropharmacology. 58, 2, p. 474-487 14 p.

Research output: Contribution to journalArticle

Tetrodotoxin
Neuralgia
Sciatic Nerve
Pharmacology
Hyperalgesia

Synaptic plasticity and central sensitization

Latremoliere, A. & Woolf, C. J., Aug 23 2010, In : Journal of Pain. 11, 8, p. 801-803 3 p.

Research output: Contribution to journalLetter

Central Nervous System Sensitization
Neuronal Plasticity
Synaptic Transmission
Synapses
2009

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

Latremoliere, A. & Woolf, C. J., Sep 1 2009, In : Journal of Pain. 10, 9, p. 895-926 32 p.

Research output: Contribution to journalReview article

Central Nervous System Sensitization
Neuronal Plasticity
Hypersensitivity
Pain
Nociceptors

T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity

Costigan, M., Moss, A., Latremoliere, A., Johnston, C., Verma-Gandhu, M., Herbert, T. A., Barrett, L., Brenner, G. J., Vardeh, D., Woolf, C. J. & Fitzgerald, M., Nov 18 2009, In : Journal of Neuroscience. 29, 46, p. 14415-14422 8 p.

Research output: Contribution to journalArticle

Neuralgia
Peripheral Nerve Injuries
Spinal Cord
Hypersensitivity
T-Lymphocytes
2008

Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats

Latremoliere, A., Mauborgne, A., Masson, J., Bourgoin, S., Kayser, V., Hamon, M. & Pohl, M., Aug 20 2008, In : Journal of Neuroscience. 28, 34, p. 8489-8501 13 p.

Research output: Contribution to journalArticle

Neuralgia
Constriction
Interleukin-6
Head
Cytokines
2007

Immunolabelling of the 5-HT3B receptor subunit in the central and peripheral nervous systems in rodents

Doucet, E., Latremoliere, A., Darmon, M., Hamon, M. & Emerit, M. B., Jul 1 2007, In : European Journal of Neuroscience. 26, 2, p. 355-366 12 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Peripheral Nervous System
Rodentia
Central Nervous System
Neurons

Lentiviral-mediated targeted NF-κB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat

Meunier, A., Latremoliere, A., Dominguez, E., Mauborgne, A., Philippe, S., Hamon, M., Mallet, J., Benoliel, J. J. & Pohl, M., Apr 1 2007, In : Molecular Therapy. 15, 4, p. 687-697 11 p.

Research output: Contribution to journalArticle

Neuralgia
Sciatic Nerve
Neuroglia
Spinal Cord
Wounds and Injuries
2005

Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons

Meunier, A., Latremoliere, A., Mauborgne, A., Bourgoin, S., Kayser, V., Cesselin, F., Hamon, M. & Pohl, M., Apr 1 2005, In : Molecular Therapy. 11, 4, p. 608-616 9 p.

Research output: Contribution to journalArticle

Trigeminal Ganglion
Enkephalins
Neuralgia
Neurons
Pain