Alan Wayne Partin

Professor

1987 …2019
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Research Output 1987 2019

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Article
2019
Open Access
Mesenchymal Stromal Cells
Prostatic Neoplasms
Bone Marrow
Safety
Neoplasms

Clinical Validation of IsoPSA™, a Single Parameter, Structure Based Assay for Improved Detection of High Grade Prostate Cancer

Stovsky, M., Klein, E. A., Chait, A., Manickam, K., Stephenson, A. J., Wagner, M., Dineen, M., Lotan, Y., Partin, A. W., Baniel, J., Kestranek, A., Gawande, P. & Boris Zaslavsky, Z., Jun 1 2019, In : The Journal of urology. 201, 6, p. 1115-1120 6 p.

Research output: Contribution to journalArticle

Prostate-Specific Antigen
Prostatic Neoplasms
Biopsy
Image-Guided Biopsy
Area Under Curve
Prostatectomy
Prostatic Neoplasms
Biopsy
Neoadjuvant Therapy
Demography
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
Neoplasm Metastasis
Survival
2018

Adjuvant radiation with androgen-deprivation therapy for men with lymph node metastases after radical prostatectomy: Identifying men who benefit

Gupta, M., Patel, H. D., Schwen, Z. R., Tran, P. T. & Partin, A. W., Jan 1 2018, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Prostatectomy
Androgens
Lymph Nodes
Radiation
Neoplasm Metastasis

A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10 ng/ml at Initial Biopsy

McKiernan, J., Donovan, M. J., Margolis, E., Partin, A. W., Carter, H. B., Brown, G., Torkler, P., Noerholm, M., Skog, J., Shore, N., Andriole, G., Thompson, I. & Carroll, P., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Exosomes
Prostate-Specific Antigen
Prostatic Neoplasms
Urine
Biopsy

Combining Prostate Health Index density, magnetic resonance imaging and prior negative biopsy status to improve the detection of clinically significant prostate cancer

Druskin, S. C., Tosoian, J. J., Young, A., Collica, S., Srivastava, A., Ghabili, K., Macura, K., Carter, H. B., Partin, A. W., Sokoll, L. J., Ross, A. E. & Pavlovich, C., Jan 1 2018, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Magnetic Resonance Imaging
Biopsy
Health
Carcinoid Tumor
Prostatic Neoplasms
2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid
human glutamate carboxypeptidase II

Initial Experience Performing In-office Ultrasound-guided Transperineal Prostate Biopsy Under Local Anesthesia Using the PrecisionPoint Transperineal Access System

Meyer, A. R., Joice, G. A., Schwen, Z. R., Partin, A. W., Allaf, M. E. & Gorin, M., Jan 1 2018, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Local Anesthesia
Prostate
Biopsy
Prostatic Neoplasms
Early Detection of Cancer

Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

Shrestha, E., White, J. R., Yu, S. H., Kulac, I., Ertunc, O., Demarzo, A. M., Yegnasubramanian, S., Mangold, L. A., Partin, A. W. & Sfanos, K., Jan 1 2018, In : Journal of Urology. 199, 1, p. 161-171 11 p.

Research output: Contribution to journalArticle

Microbiota
Prostatic Neoplasms
Urine
Biopsy
Prostate
Positron-Emission Tomography
Prostatic Neoplasms
Tomography
Surgical Pathology
Lymph Nodes

Subtyping the Risk of Intermediate Risk Prostate Cancer for Active Surveillance Based on Adverse Pathology at Radical Prostatectomy

Patel, H. D., Gupta, M., Tosoian, J. J., Carter, H. B., Partin, A. W. & Epstein, J. I., Jan 1 2018, (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Pathology
Prostate-Specific Antigen
Survival
2017

Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting

Lokhandwala, P., Riel, S. L., Haley, L., Lu, C., Chen, Y., Silberstein, J., Zhu, Y., Zheng, G., Lin, M-T., Gocke, C., Partin, A. W., Antonarakis, E., Luo, J. & Eshleman, J., Jan 1 2017, In : Journal of Molecular Diagnostics. 19, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Circulating Neoplastic Cells
Prostatic Neoplasms
Castration
Ligands

Association between combined TMPRSS2: ERG and PCA3 RNA urinary testing and detection of aggressive prostate cancer

EDRN-PCA3 Study Group, Aug 1 2017, In : JAMA oncology. 3, 8, p. 1085-1093 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
RNA
Biopsy
Prostate
Urine

Implementation of a Surgeon-Level Comparative Quality Performance Review to Improve Positive Surgical Margin Rates during Radical Prostatectomy

Matulewicz, R. S., Tosoian, J. J., Stimson, C. J., Ross, A. E., Chappidi, M., Lotan, T., Humphreys, E., Partin, A. W. & Schaeffer, E. M., May 1 2017, In : Journal of Urology. 197, 5, p. 1245-1250 6 p.

Research output: Contribution to journalArticle

Prostatectomy
Costs and Cost Analysis
Diagnosis-Related Groups
Prostate-Specific Antigen
Margins of Excision

Pathological analysis of the prostatic anterior fat pad at radical prostatectomy: insights from a prospective series

Ball, M. W., Harris, K. T., Schwen, Z. R., Mullins, J. K., Han, M., Walsh, P., Partin, A. W. & Epstein, J. I., Mar 1 2017, In : BJU International. 119, 3, p. 444-448 5 p.

Research output: Contribution to journalArticle

Prostatectomy
Adipose Tissue
Lymph Nodes
Recurrence
Proportional Hazards Models

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

Ross, A. E., Hughes, R. M., Glavaris, S., Ghabili, K., He, P., Anders, N., Harb, R., Tosoian, J. J., Marchionni, L., Schaeffer, E. M., Partin, A. W., Allaf, M. E., Bivalacqua, T., Chapman, C., O'Neal, T., Demarzo, A. M., Hurley, P., Rudek-Renaut, M. & Antonarakis, E., Jan 1 2017, In : Oncotarget. 8, 61, p. 104182-104192 11 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Pharmacokinetics
Observation
Neoplasms

Promoter methylation of MCAM, ERa and ERβ in serum of early stage prostate cancer patients

Brait Rodrigues De Oliveira, M., Banerjee, M., Maldonado, L., Ooki, A., Loyo, M., Guida, E., Izumchenko, E., Mangold, L., Humphreys, E., Rosenbaum, E., Partin, A. W., Sidransky, D. & Hoque, M., 2017, In : Oncotarget. 8, 9, p. 15431-15440 10 p.

Research output: Contribution to journalArticle

Methylation
Prostatic Neoplasms
Prostate-Specific Antigen
Serum
Sensitivity and Specificity

Prostate Health Index density improves detection of clinically significant prostate cancer

Tosoian, J. J., Druskin, S. C., Andreas, D., Mullane, P., Chappidi, M., Joo, S., Ghabili, K., Mamawala, M., Agostino, J., Carter, H. B., Partin, A. W., Sokoll, L. J. & Ross, A. E., 2017, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Health
Area Under Curve
Neoplasm Grading

Risk factors for metastatic prostate cancer: A sentinel event case series

Paller, C., Cole, A. P., Partin, A. W., Carducci, M. A. & Kanarek, N. F., Sep 15 2017, In : Prostate. 77, 13, p. 1366-1372 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Root Cause Analysis
Delayed Diagnosis
Delivery of Health Care
Health

The Impact of Downgrading from Biopsy Gleason 7 to Prostatectomy Gleason 6 on Biochemical Recurrence and Prostate Cancer Specific Mortality

Ham, W. S., Chalfin, H. J., Feng, Z., Trock, B., Epstein, J. I., Cheung, C., Humphreys, E., Partin, A. W. & Han, M., Apr 1 2017, In : Journal of Urology. 197, 4, p. 1060-1067 8 p.

Research output: Contribution to journalArticle

Neoplasm Grading
Prostatectomy
Prostatic Neoplasms
Biopsy
Recurrence

Use of the Prostate Health Index for detection of prostate cancer: results from a large academic practice

Tosoian, J. J., Druskin, S. C., Andreas, D., Mullane, P., Chappidi, M., Joo, S., Ghabili, K., Agostino, J., Macura, K., Carter, H. B., Schaeffer, E. M., Partin, A. W., Sokoll, L. J. & Ross, A. E., Jan 24 2017, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Health
Biopsy
Neoplasm Grading
2016

An Approach Using PSA Levels of 1.5 ng/mL as the Cutoff for Prostate Cancer Screening in Primary Care

Crawford, E. D., Rosenberg, M. T., Partin, A. W., Cooperberg, M. R., Maccini, M., Loeb, S., Pettaway, C. A., Shore, N. D., Arangua, P., Hoenemeyer, J., Leveridge, M., Leapman, M., Pinto, P., Thompson, I. M., Carroll, P., Eastham, J., Gomella, L. & Klein, E. A., Oct 1 2016, In : Urology. 96, p. 116-120 5 p.

Research output: Contribution to journalArticle

Prostate-Specific Antigen
Early Detection of Cancer
Prostatic Neoplasms
Primary Health Care

A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

Tosoian, J. J., Reyes, D. K., Gorin, M., Hortopan, S., Partin, A. W., Pienta, K., Ross, A. E. & Schaeffer, E. M., May 1 2016, In : Urology Case Reports. 6, p. 45-46 2 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Pubic Bone
Bone Marrow
Therapeutics

A novel urine exosome gene expression assay to predict high-grade prostate cancer at initial biopsy

McKiernan, J., Donovan, M. J., O'Neill, V., Bentink, S., Noerholm, M., Belzer, S., Skog, J., Kattan, M. W., Partin, A. W., Andriole, G., Brown, G., Wei, J. T., Thompson, I. M. & Carroll, P., Jul 1 2016, In : JAMA oncology. 2, 7, p. 882-889 8 p.

Research output: Contribution to journalArticle

Exosomes
Standard of Care
Prostatic Neoplasms
Prostate-Specific Antigen
Urine
Epigenomics
Prostatic Neoplasms
Biopsy
Prostate
Neoplasms

Clinical prospects of long noncoding RNAs as novel biomarkers and therapeutic targets in prostate cancer

Mouraviev, V., Lee, B., Patel, V., Albala, D., Johansen, T. E. B., Partin, A. W., Ross, A. & Perera, R. J., Mar 1 2016, In : Prostate Cancer and Prostatic Diseases. 19, 1, p. 14-20 7 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Prostatic Neoplasms
Biomarkers
Therapeutics
Neoplasms

Clinical validation of the 2005 isup gleason grading system in a cohort of intermediate and high risk men undergoing radical prostatectomy

Faraj, S. F., Bezerra, S. M., Yousefi, K., Fedor, H., Glavaris, S., Han, M., Partin, A. W., Humphreys, E., Tosoian, J., Johnson, M., Davicioni, E., Trock, B., Schaeffer, E. M., Ross, A. E. & Netto, G. J., Jan 5 2016, In : PLoS One. 11, 1, e0146189.

Research output: Contribution to journalArticle

Neoplasm Grading
Pathology
Prostatectomy
metastasis
Biomarkers
Prostate-Specific Antigen
Prostatectomy
Recurrence
Survival
Prostatic Neoplasms

From the Editors

Partin, A. W. & Wein, A., Jan 1 2016, In : Urology Case Reports. 4, p. 4 1 p.

Research output: Contribution to journalArticle

Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

Na, R., Zheng, S. L., Han, M., Yu, H., Jiang, D., Shah, S., Ewing, C. M., Zhang, L., Novakovic, K., Petkewicz, J., Gulukota, K., Helseth, D. L., Quinn, M., Humphries, E., Wiley, K. E., Isaacs, S. D., Wu, Y., Liu, X., Zhang, N., Wang, C. H. & 17 others, Khandekar, J., Hulick, P. J., Shevrin, D. H., Cooney, K. A., Shen, Z., Partin, A. W., Carter, H. B., Carducci, M. A., Eisenberger, M., Denmeade, S. R., McGuire, M., Walsh, P., Helfand, B. T., Brendler, C. B., Ding, Q., Xu, J. & Isaacs, W. B., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Germ-Line Mutation
Prostatic Neoplasms
Mutation
Mutation Rate
Lethal Genes
Neoplasm Grading
Prostatectomy
Recurrence
Kaplan-Meier Estimate
Margins of Excision

New Prostate Cancer Grading System Predicts Long-term Survival Following Surgery for Gleason Score 8-10 Prostate Cancer

Ham, W. S., Chalfin, H. J., Feng, Z., Trock, B., Epstein, J. I., Cheung, C., Humphreys, E., Partin, A. W. & Han, M., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Neoplasm Grading
Prostatic Neoplasms
Survival
Prostatectomy
Mortality

Patterns of Pelvic Lymph Node Dissection at the Time of Radical Prostatectomy for Low-risk Men

Chalfin, H. J., Feng, Z., Trock, B. & Partin, A. W., Oct 13 2016, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Prostatectomy
Lymph Node Excision
Neoplasm Metastasis
Lymph Nodes
Prostatic Neoplasms

Prediction of pathological stage based on clinical stage, serum prostate-specific antigen, and biopsy Gleason score: Partin Tables in the contemporary era

Tosoian, J. J., Chappidi, M., Feng, Z., Humphreys, E. B., Han, M., Pavlovich, C., Epstein, J. I., Partin, A. W. & Trock, B., 2016, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Nomograms
Neoplasm Grading
Prostate-Specific Antigen
Biopsy
Serum

Prostate Health Index improves multivariable risk prediction of aggressive prostate cancer

Loeb, S., Shin, S. S., Broyles, D. L., Wei, J. T., Sanda, M., Klee, G., Partin, A. W., Sokoll, L. J., Chan, D. W-Y., Bangma, C. H., van Schaik, R. H. N., Slawin, K. M., Marks, L. S. & Catalona, W. J., 2016, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Health
Biopsy
Prostate-Specific Antigen

Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies

Van Neste, L., Partin, A. W., Stewart, G. D., Epstein, J. I., Harrison, D. J. & Van Criekinge, W., Sep 1 2016, In : Prostate. 76, 12, p. 1078-1087 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Prostatic Neoplasms
Biopsy
Methylation
Neoplasms

Role of biobanking in urology: A review

Chalfin, H. J., Fabian, E., Mangold, L., Yeater, D. B., Pienta, K. & Partin, A. W., 2016, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Diagnostic Test Approval
Urology
Precision Medicine
Translational Medical Research
Ethics

SPINK1 Defines a Molecular Subtype of Prostate Cancer in Men with More Rapid Progression in an at Risk, Natural History Radical Prostatectomy Cohort

Johnson, M., Ross, A. E., Alshalalfa, M., Erho, N., Yousefi, K., Glavaris, S., Fedor, H., Han, M., Faraj, S. F., Bezerra, S. M., Netto, G., Partin, A. W., Trock, B., Davicioni, E. & Schaeffer, E. M., Nov 1 2016, In : Journal of Urology. 196, 5, p. 1436-1444 9 p.

Research output: Contribution to journalArticle

Prostatectomy
Natural History
Prostatic Neoplasms
Neoplasm Metastasis
Recurrence

Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men

Ross, A. E., Johnson, M., Yousefi, K., Davicioni, E., Netto, G. J., Marchionni, L., Fedor, H. L., Glavaris, S., Choeurng, V., Buerki, C., Erho, N., Lam, L. L., Humphreys, E. B., Faraj, S., Bezerra, S. M., Han, M., Partin, A. W., Trock, B. & Schaeffer, E. M., Jan 1 2016, In : European Urology. 69, 1, p. 157-165 9 p.

Research output: Contribution to journalArticle

Prostatectomy
Genomics
Natural History
Prostatic Neoplasms
Salvage Therapy

Urinary Biomarkers for Prostate Cancer

Tosoian, J. J., Ross, A. E., Sokoll, L. J., Partin, A. W. & Pavlovich, C., Feb 1 2016, In : Urologic Clinics of North America. 43, 1, p. 17-38 22 p.

Research output: Contribution to journalArticle

Serine Endopeptidases
Glutathione S-Transferase pi
Metabolomics
Trans-Activators
Microbiota
2015

18F-DCFBC PET/CT for PSMA-based detection and characterization of primary prostate cancer

Rowe, S., Gage, K. L., Faraj, S. F., Macura, K., Cornish, T. C., Gonzalez-Roibon, N., Guner, G., Munari, E., Partin, A. W., Pavlovich, C., Han, M., Carter, H. B., Bivalacqua, T., Blackford, A., Holt, D., Dannals, R. F., Netto, G. J., Lodge, M., Mease, R., Pomper, M. G. & 1 others, Cho, S. Y., Jul 1 2015, In : Journal of Nuclear Medicine. 56, 7, p. 1003-1010 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Prostate
Neoplasm Grading
Prostatic Hyperplasia
N-(N-((S)-1,3-Dicarboxypropyl)carbamoyl)-4-(18F)fluorobenzyl-L-cysteine

Evaluation of two mitochondrial DNA biomarkers for prostate cancer detection

Maragh, S., Veltri, R. W., Lund, S. P., Mangold, L., Isharwal, S., Christudass, C. S., Partin, A. W., Humphreys, E. B., Sorbara, L., Srivastava, S. & Wagner, P. D., Nov 24 2015, In : Cancer Biomarkers. 15, 6, p. 763-773 11 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Prostatic Neoplasms
Biomarkers
Tumor Biomarkers
Urine
Prostatectomy
Recurrence
Survival
Neoplasm Staging
Proportional Hazards Models
Prostatic Neoplasms
Biopsy
Research
Prostate-Specific Antigen
Disease Progression

Is clinical stage T2c prostate cancer an intermediate- or high-risk disease?

Klaassen, Z., Singh, A. A., Howard, L. E., Feng, Z., Trock, B., Terris, M. K., Aronson, W. J., Cooperberg, M. R., Amling, C. L., Kane, C. J., Partin, A. W., Han, M. & Freedland, S. J., May 1 2015, In : Cancer. 121, 9, p. 1414-1421 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Cancer Care Facilities
Recurrence
Prostate-Specific Antigen
Neoplasms

Prostate Health Index (PHI) Predicts High-stage Pathology in African American Men

Schwen, Z. R., Tosoian, J. J., Sokoll, L. J., Mangold, L., Humphreys, E., Schaeffer, E. M., Partin, A. W. & Ross, A. E., Sep 15 2015, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

African Americans
Prostate
Prostate-Specific Antigen
Pathology
Health

Risk Factors for Intraprostatic Incision into Malignant Glands at Radical Prostatectomy

Park, S. W., Readal, N., Jeong, B. C., Humphreys, E. B., Epstein, J. I., Partin, A. W. & Han, M., Aug 1 2015, In : European Urology. 68, 2, p. 311-316 6 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostate
Obesity
Confidence Intervals
Weights and Measures

Testosterone and prostate cancer: An evidence-based review of pathogenesis and oncologic risk

Michaud, J. E., Billups, K. L. & Partin, A. W., Dec 1 2015, In : Therapeutic Advances in Urology. 7, 6, p. 378-387 10 p.

Research output: Contribution to journalArticle

Testosterone
Prostatic Neoplasms
Hypogonadism
Androgens
Therapeutics

The prostate health index selectively identifies clinically significant prostate cancer

Loeb, S., Sanda, M. G., Broyles, D. L., Shin, S. S., Bangma, C. H., Wei, J. T., Partin, A. W., Klee, G. G., Slawin, K. M., Marks, L. S., Van Schaik, R. H. N., Chan, D. W-Y., Sokoll, L. J., Cruz, A. B., Mizrahi, I. A. & Catalona, W. J., Apr 1 2015, In : Journal of Urology. 193, 4, p. 1163-1169 7 p.

Research output: Contribution to journalArticle

Prostate-Specific Antigen
Prostate
Prostatic Neoplasms
Health
Area Under Curve