Research Output 1983 2017

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2017

Antecedent Nippostrongylus infection alters the lung immune response to Plasmodium berghei

Craig, J. M. & Scott, A. L. Aug 1 2017 In : Parasite Immunology. 39, 8, e12441

Research output: Research - peer-reviewArticle

Nippostrongylus
Plasmodium berghei
Lung
Infection
Malaria

Immune-mediated inflammation in the pathogenesis of emphysema: insights from mouse models

Craig, J. M., Scott, A. L. & Mitzner, W. Feb 6 2017 (Accepted/In press) In : Cell and Tissue Research. p. 1-15 15 p.

Research output: Research - peer-reviewArticle

Emphysema
Inflammation
Macrophage Activation
Smoke
Tobacco Products

MTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

Hallowell, R. W., Collins, S. L., Craig, J. M., Zhang, Y., Oh, M., Illei, P. B., Chan-Li, Y., Vigeland, C. L., Mitzner, W., Scott, A. L., Powell, J. D. & Horton, M. R. Jan 27 2017 In : Nature Communications. 8, 14208

Research output: Research - peer-reviewArticle

Thermogenesis
Helminths
Macrophages
Infection
macrophages

Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages

Chatterjee, S., Talaat, K. R., van Seventer, E. E., Feng, C. G., Scott, A. L., Jedlicka, A., Dziedzic, A. & Nutman, T. B. Jun 1 2017 In : PLoS ONE. 12, 6, e0179701

Research output: Research - peer-reviewArticle

Mycobacterium
interleukin-4
interleukin-10
macrophages
loci

The innate immune response to lower respiratory tract E. Coli infection and the role of the CCL2-CCR2 axis in neonatal mice

McGrath-Morrow, S. A., Ndeh, R., Collaco, J. M., Poupore, A. K., Dikeman, D., Zhong, Q., Singer, B. D., D'Alessio, F. & Scott, A. Sep 1 2017 In : Cytokine. 97, p. 108-116 9 p.

Research output: Research - peer-reviewArticle

Escherichia coli Infections
Innate Immunity
Respiratory System
Newborn Infant
Escherichia coli

Whole blood cytokine response to local traffic-related particulate matter in peruvian children with and without asthma

Negherbon, J. P., Romero, K., Williams, D. A. L., Guerrero-Preston, R. E., Hartung, T., Scott, A. L., Breysse, P. N., Checkley, W. & Hansel, N. N. Mar 30 2017 In : Frontiers in Pharmacology. 8, MAR, 157

Research output: Research - peer-reviewArticle

Particulate Matter
Asthma
Cytokines
Interleukin-8
Endotoxins
2016

CD36 mediates H2O2-induced calcium influx in lung microvascular endothelial cells

Suresh, K., Servinsky, L., Reyes, J., Undem, C., Zaldumbide, J., Rentsendorj, O., Modekurty, S., Dodd-o, J. M., Scott, A., Pearse, D. B. & Shimoda, L. A. Dec 2 2016 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 1, p. L143-L153

Research output: Research - peer-reviewArticle

Endothelial Cells
Calcium
Lung
TRPV Cation Channels
Cell Membrane

Diagnosis of Strongyloides stercoralis: Detection of parasite-derived DNA in urine

Lodh, N., Caro, R., Sofer, S., Scott, A., Krolewiecki, A. & Shiff, C. Nov 1 2016 In : Acta Tropica. 163, p. 9-13 5 p.

Research output: Research - peer-reviewArticle

Strongyloides stercoralis
Parasites
Urine
DNA
Infection

Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes

Lagassé, H. A. D., Anidi, I. U., Craig, J. M., Limjunyawong, N., Poupore, A. K., Mitzner, W. & Scott, A. L. May 1 2016 In : Journal of Leukocyte Biology. 99, 5, p. 659-671 13 p.

Research output: Research - peer-reviewArticle

Lung Injury
Malaria
Monocytes
Erythrocytes
Lung
2015

Experimental progressive emphysema in BALB/cJ mice as a model for chronic alveolar destruction in humans

Limjunyawong, N., Craig, J. M., Daniel Lagassé, H. A., Scott, A. L. & Mitzner, W. Sep 1 2015 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 7, p. L662-L676

Research output: Research - peer-reviewArticle

Emphysema
Pancreatic Elastase
Lung
Inbred C57BL Mouse
Chronic Obstructive Pulmonary Disease
Regulatory T-Lymphocytes
Messenger RNA
Lung
Acute Lung Injury
Adoptive Transfer
2014

Helminths in the lungs

Craig, J. M. & Scott, A. L. 2014 In : Parasite Immunology. 36, 9, p. 463-474 12 p.

Research output: Research - peer-reviewArticle

Helminths
Lung
Parasites
Immune System
Immunity

Immune Responses in Macaques to a Prototype Recombinant Adenovirus Live Oral Human Papillomavirus 16 Vaccine

Berg, M. G., Adams, R. J., Gambhira, R., Siracusa, M. C., Scott, A. L., Roden, R. B. S. & Ketner, G. 2014 In : Clinical and Vaccine Immunology. 21, 9, p. 1224-1231 8 p.

Research output: Research - peer-reviewArticle

Papillomavirus Vaccines
Human papillomavirus 16
Macaca
Adenoviridae
Immunization

Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia

Mharakurwa, S., Daniels, R., Scott, A., Wirth, D. F., Thuma, P. & Volkman, S. K. Mar 12 2014 In : Malaria Journal. 13, 1, 89

Research output: Research - peer-reviewArticle

Zambia
Plasmodium falciparum
Malaria
Population
Parasites
2013

CD36 and Fyn Kinase Mediate Malaria-Induced Lung Endothelial Barrier Dysfunction in Mice Infected with Plasmodium berghei

Anidi, I. U., Servinsky, L. E., Rentsendorj, O., Stephens, R. S., Scott, A. L. & Pearse, D. B. Aug 15 2013 In : PLoS One. 8, 8, e71010

Research output: Research - peer-reviewArticle

Plasmodium berghei
malaria
phosphotransferases (kinases)
lungs
mice
Pancreatic Elastase
Emphysema
Elastin
Laboratory Animals
Inbred C57BL Mouse

Selection for chloroquine-sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia

Mharakurwa, S., Sialumano, M., Liu, K., Scott, A. & Thuma, P. Dec 19 2013 In : Malaria Journal. 12, 1, 453

Research output: Research - peer-reviewArticle

Zambia
Anopheles
Chloroquine
Plasmodium falciparum
Malaria

Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites

Tse, S. W., Cockburn, I. A., Zhang, H., Scott, A. L. & Zavala, F. Jul 2013 In : Genes and Immunity. 14, 5, p. 302-309 8 p.

Research output: Research - peer-reviewArticle

Sporozoites
Malaria
Immunization
T-Lymphocytes
Liver
2012

Challenges and prospects for malaria elimination in the Southern Africa region

Moss, W. J., Norris, D. E., Mharakurwa, S., Scott, A., Mulenga, M., Mason, P. R., Chipeta, J. & Thuma, P. E. Mar 2012 In : Acta Tropica. 121, 3, p. 207-211 5 p.

Research output: Research - peer-reviewArticle

Southern Africa
Malaria
Research
Capacity Building
Genetic Vectors

Filarial and Wolbachia genomics

Scott, A. L., Ghedin, E., Nutman, T. B., McReynolds, L. A., Poole, C. B., Slatko, B. E. & Foster, J. M. Feb 2012 In : Parasite Immunology. 34, 2-3, p. 121-129 9 p.

Research output: Research - peer-reviewArticle

Wolbachia
Genomics
Parasites
Genome
Helminth Genome
2010

Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons

Park, K. & Scott, A. L. Dec 2010 In : Journal of Leukocyte Biology. 88, 6, p. 1081-1087 7 p.

Research output: Research - peer-reviewArticle

Interferon Type I
Dendritic Cells
Macrophages
cholesterol 25-hydroxylase
Enzymes
2009

The alternatively activated human-redux

Scott, A. L. Jun 5 2009 In : Journal of Infectious Diseases. 199, 12, p. 1723-1725 3 p.

Research output: Research - peer-reviewArticle

The genome of Brugia malayi - All worms are not created equal

Scott, A. L. & Ghedin, E. Mar 2009 In : Parasitology International. 58, 1, p. 6-11 6 p.

Research output: Research - peer-reviewArticle

Brugia malayi
Genome
Brugia
Parasites
Ocular Onchocerciasis
2008

17β-estradiol alters the activity of conventional and IFN-producing killer dendritic cells

Siracusa, M. C., Overstreet, M. G., Housseau, F., Scott, A. L. & Klein, S. L. Feb 1 2008 In : Journal of Immunology. 180, 3, p. 1423-1431 9 p.

Research output: Research - peer-reviewArticle

Dendritic Cells
Estradiol
Interleukin-12
Innate Immunity
Bone Marrow

Dynamics of lung macrophage activation in response to helminth infection

Siracusa, M. C., Reece, J. J., Urban, J. F. & Scott, A. L. Dec 1 2008 In : Journal of Leukocyte Biology. 84, 6, p. 1422-1433 12 p.

Research output: Research - peer-reviewArticle

Macrophage Activation
Helminths
Macrophages
Lung
Infection

Hookworm-induced persistent changes to the immunological environment of the lung

Reece, J. J., Siracusa, M. C., Southard, T. L., Brayton, C. F., Urban, J. F. & Scott, A. L. Aug 2008 In : Infection and Immunity. 76, 8, p. 3511-3524 14 p.

Research output: Research - peer-reviewArticle

Ancylostomatoidea
Lung
Allergens
Parasites
Infection
2007

Draft genome of the filarial nematode parasite Brugia malayi

Ghedin, E. , Wang, S. , Spiro, D. , Caler, E. , Zhao, Q. , Crabtree, J. , Allen, J. E. , Delcher, A. L. , Guiliano, D. B. , Miranda-Saavedra, D. , Angiuoli, S. V. , Creasy, T. , Amedeo, P. , Haas, B. , El-Sayed, N. M. , Wortman, J. R. , Feldblyum, T. , Tallon, L. , Schatz, M. , Shumway, M. & 51 others Koo, H., Salzberg, S. L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G. J., Carlow, C. K. S., Crawford, M. J., Daub, J., Dimmic, M. W., Estes, C. F., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, M., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B. W., Li, W., Lindblom, T. H., Lustigman, S., Ma, D., Maina, C. V., Martin, D. M. A., McCarter, J. P., McReynolds, L., Mitreva, M., Nutman, T. B., Parkinson, J., Peregrín-Alvarez, J. M., Poole, C., Ren, Q., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T. R., Ware, J., Wei, A. D., Weil, G., Williams, D. J., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M. L. & Scott, A. L. Sep 21 2007 In : Science. 317, 5845, p. 1756-1760 5 p.

Research output: Research - peer-reviewArticle

Brugia malayi
Parasites
Genome
Ocular Onchocerciasis
Elephantiasis

Proinflammatory cytokine gene expression by murine macrophages in response to Brugia malayi Wolbachia surface protein

Porksakorn, C., Nuchprayoon, S., Park, K. & Scott, A. L. 2007 In : Mediators of Inflammation. 2007, 84318

Research output: Research - peer-reviewArticle

Brugia malayi
Wolbachia
Membrane Proteins
Macrophages
Cytokines
2006

Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-β-dependent mechanism

Kato, A., Truong-Tran, A. Q., Scott, A. L., Matsumoto, K. & Schleimer, R. P. Nov 15 2006 In : Journal of Immunology. 177, 10, p. 7164-7172 9 p.

Research output: Research - peer-reviewArticle

B-Cell Activating Factor
Epithelial Cells
Ligands
B-Lymphocytes
Proteins

Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria

Ockenhouse, C. F., Hu, W. C., Kester, K. E., Cummings, J. F., Stewart, A., Heppner, D. G., Jedlicka, A. E., Scott, A. L., Wolfe, N. D., Vahey, M. & Burke, D. S. Oct 2006 In : Infection and Immunity. 74, 10, p. 5561-5573 13 p.

Research output: Research - peer-reviewArticle

Malaria
Blood Cells
Gene Expression
Infection
Apoptosis

Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages

Reece, J. J., Siracusa, M. C. & Scott, A. L. Sep 2006 In : Infection and Immunity. 74, 9, p. 4970-4981 12 p.

Research output: Research - peer-reviewArticle

Helminths
Alveolar Macrophages
Innate Immunity
Lung
Infection

Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection

Cernetich, A., Garver, L. S., Jedlicka, A. E., Klein, P. W., Kumar, N., Scott, A. L. & Klein, S. L. Jun 2006 In : Infection and Immunity. 74, 6, p. 3190-3203 14 p.

Research output: Research - peer-reviewArticle

Sex Characteristics
Malaria
Interferon-gamma
Steroids
Infection

The expanding realm of heterologous immunity: Friend or foe?

Page, K. R., Scott, A. L. & Manabe, Y. C. Feb 2006 In : Cellular Microbiology. 8, 2, p. 185-196 12 p.

Research output: Research - peer-reviewArticle

Heterologous Immunity
Infection
T-cells
T-Lymphocytes
Heterophile Antigens
2005
Restriction Fragment Length Polymorphisms
Parasites
Polymerase Chain Reaction
Brugia pahangi
Brugia malayi

Erratum: Multiple-laboratory comparison of microarray platforms (Nature Methods (2005) vol.2 (345-349))

Irizarry, R. A. , Warren, D. , Spencer, F. , Kim, I. F. , Biswal, S. , Frank, B. C. , Gabrielson, E. , Garcia, J. G. N. , Geoghegan, J. , Germino, G. , Griffin, C. , Hilmer, S. C. , Hoffman, E. , Jedlicka, A. E. , Kawasaki, E. , Martínez-Murillo, F. , Morsberger, L. , Lee, H. , Petersen, D. , Quackenbush, J. & 5 others Scott, A., Wilson, M., Yang, Y., Ye, S. Q. & Yu, W. Jun 2005 In : Nature Methods. 2, 6, p. 477 1 p.

Research output: Research - peer-reviewArticle

Genetic predisposition to latex allergy: Role of interleukin 13 and interleukin 18

Brown, R. H., Hamilton, R. G., Mintz, M., Jedlicka, A. E., Scott, A. L. & Kleeberger, S. R. 2005 In : Anesthesiology. 102, 3, p. 496-502 7 p.

Research output: Research - peer-reviewArticle

Latex Hypersensitivity
Interleukin-18
Interleukin-13
Latex
Genetic Predisposition to Disease

Global gene expression analysis of Anopheles gambiae responses to microbial challenge

Aguilar, R., Jedlicka, A. E., Mintz, M., Mahairaki, V., Scott, A. L. & Dimopoulos, G. Jul 2005 In : Insect Biochemistry and Molecular Biology. 35, 7, p. 709-719 11 p.

Research output: Research - peer-reviewArticle

Anopheles gambiae
gene expression
genes
proteins
Gene Expression

Lymphatic filariasis in Ghana: Establishing the potential for an urban cycle of transmission

Gbakima, A. A., Appawu, M. A., Dadzie, S., Karikari, C., Sackey, S. O., Baffoe-Wilmot, A., Gyapong, J. & Scott, A. L. Apr 2005 In : Tropical Medicine and International Health. 10, 4, p. 387-392 6 p.

Research output: Research - peer-reviewArticle

Filarial Elephantiasis
Ghana
Wuchereria bancrofti
Culicidae
Disease Vectors
Ascaris suum
Spermatozoa
Proteins
Protein Domains
Ascaris

MSP domain proteins

Tarr, D. E. K. & Scott, A. L. May 2005 In : Trends in Parasitology. 21, 5, p. 224-231 8 p.

Research output: Research - peer-reviewArticle

Spermatozoa
Proteins
Protein Domains
Actins
Protein Interaction Domains and Motifs

Multiple-laboratory comparison of microarray platforms

Irizarry, R. A. , Warren, D. , Spencer, F. , Kim, I. F. , Biswal, S. , Frank, B. C. , Gabrielson, E. , Garcia, J. G. N. , Geoghegan, J. , Germino, G. , Griffin, C. , Hilmer, S. C. , Hoffman, E. , Jedlicka, A. E. , Kawasaki, E. , Martínez-Murillo, F. , Morsberger, L. , Lee, H. , Petersen, D. , Quackenbush, J. & 5 others Scott, A., Wilson, M., Yang, Y., Ye, S. Q. & Yu, W. May 2005 In : Nature Methods. 2, 5, p. 345-349 5 p.

Research output: Research - peer-reviewArticle

RNA
Baltimore
Meta-Analysis
Research Personnel
Technology

Mycobacterium-induced potentiation of type 1 immune responses and protection against malaria are host specific

Page, K. R., Jedlicka, A. E., Fakheri, B., Noland, G. S., Kesavan, A. K., Scott, A. L., Kumar, N. & Manabe, Y. C. Dec 2005 In : Infection and Immunity. 73, 12, p. 8369-8380 12 p.

Research output: Research - peer-reviewArticle

Plasmodium yoelii
Mycobacterium
Malaria
Mycobacterium tuberculosis
Inbred C57BL Mouse
2004

Differential expression of immunoregulatory genes in male and female Norway rats following infection with Seoul virus

Klein, S. L., Cernetich, A., Hilmer, S., Hoffman, E. P., Scott, A. L. & Glass, G. E. Sep 2004 In : Journal of Medical Virology. 74, 1, p. 180-190 11 p.

Research output: Research - peer-reviewArticle

Seoul virus
Viruses
Gene Expression
Infection
Genes

MSP domain proteins show enhanced expression in male germ line cells

Tarr, D. E. K. & Scott, A. L. Sep 2004 In : Molecular and Biochemical Parasitology. 137, 1, p. 87-98 12 p.

Research output: Research - peer-reviewArticle

Germ Cells
Spermatozoa
Proteins
Protein Domains
Testis
2003

Thioredoxin from Brugia malayi: Defining a 16-kilodalton class of thioredoxins from nematodes

Kunchithapautham, K., Padmavathi, B., Narayanan, R. B., Kaliraj, P. & Scott, A. L. Jul 1 2003 In : Infection and Immunity. 71, 7, p. 4119-4126 8 p.

Research output: Research - peer-reviewArticle

Brugia malayi
Thioredoxins
Proteins
Mammals
Reactive Oxygen Species
2002

Development of antigen detection ELISA for the diagnosis of brugian and bancroftian filariasis using antibodies to recombinant filarial antigens Bm-SXP-1 and Wb-SXP-1

Lalitha, P., Eswaran, D., Gnanasekar, M., Rao, K. V. N., Narayanan, R. B., Scott, A., Nutman, T. & Kaliraj, P. 2002 In : Microbiology and Immunology. 46, 5, p. 327-332 6 p.

Research output: Research - peer-reviewArticle

Filariasis
Enzyme-Linked Immunosorbent Assay
Antigens
Antibodies
Infection

Erratum: Development of antigen detection ELISA for the diagnosis of brugian and bancroftian filariasis using antibodies to recombinant filarial antigens Bm-SXP-1 and Wb-SXP-1 (Microbiology and Immunology (2002) 46:5 (327-332))

Lalitha, P., Eswaran, D., Gnanasekar, M., Rao, K. V. N., Narayanan, R. B., Scott, A., Nutman, T. & Kaliraj, P. 2002 In : Microbiology and Immunology. 46, 9, p. 645 1 p.

Research output: Research - peer-reviewArticle

Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity, and crystal structure

Zang, X., Taylor, P., Wang, J. M., Meyer, D. J., Scott, A. L., Walkinshaw, M. D. & Maizels, R. M. Nov 15 2002 In : Journal of Biological Chemistry. 277, 46, p. 44261-44267 7 p.

Research output: Research - peer-reviewArticle

Macrophage Migration-Inhibitory Factors
Cloning
Genes
Crystal structure
Cytokines

Molecular characterization of a calcium binding translationally controlled tumor protein homologue from the filarial parasites Brugia malayi and Wuchereria bancrofti

Gnanasekar, M., Rao, K. V. N., Chen, L., Narayanan, R. B., Geetha, M., Scott, A. L., Ramaswamy, K. & Kaliraj, P. Apr 30 2002 In : Molecular and Biochemical Parasitology. 121, 1, p. 107-118 12 p.

Research output: Research - peer-reviewArticle

Brugia malayi
Wuchereria bancrofti
Parasites
Calcium
translationally-controlled 1 tumor protein

Neonatal sex steroids affect responses to Seoul virus infection in male but not female Norway rats

Klein, S. L., Marson, A. L., Scott, A. L., Ketner, G. & Glass, G. E. 2002 In : Brain, Behavior, and Immunity. 16, 6, p. 736-746 11 p.

Research output: Research - peer-reviewArticle

Seoul virus
Virus Diseases
Steroids
Testosterone
Viruses