Alan Keith Meeker

Associate Professor

1984 …2019
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Research Output 1984 2019

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Article
2019
Translational Medical Research
Biomarkers
Prostatic Neoplasms
Telomere
Tissue

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

Bell, W. R., Meeker, A. K., Rizzo, A., Rajpara, S., Rosenthal, I. M., Flores Bellver, M., Aparicio Domingo, S., Zhong, X., Barber, J. R., Joshu, C. E., Canto-Soler, M. V., Eberhart, C. G. & Heaphy, C. M., Jan 1 2019, In : Brain Pathology. 29, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Telomere
Phenotype
DNA
Retina

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N., London, N., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access
Deceleration
Cell Division
Incidence
Neoplasms
Stem Cells

High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer

Gorbounov, M., Carleton, N. M., Asch-Kendrick, R. J., Xian, L., Rooper, L., Chia, L., Cimino-Mathews, A., Cope, L., Meeker, A., Stearns, V., Veltri, R. W., Bae, Y. K. & Resar, L. M. S., Jan 1 2019, (Accepted/In press) In : Breast Cancer Research and Treatment.

Research output: Contribution to journalArticle

High Mobility Group Proteins
Estrogen Receptors
Breast Neoplasms
Gene Expression
Neoplasms

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Núñez, F. J., Mendez, F. M., Kadiyala, P., Alghamri, M. S., Savelieff, M. G., Garcia-Fabiani, M. B., Haase, S., Koschmann, C., Calinescu, A. A., Kamran, N., Saxena, M., Patel, R., Carney, S., Guo, M. Z., Edwards, M., Ljungman, M., Qin, T., Sartor, M. A., Tagett, R., Venneti, S. & 15 others, Brosnan-Cashman, J., Meeker, A. K., Gorbunova, V., Zhao, L., Kremer, D. M., Zhang, L., Lyssiotis, C. A., Jones, L., Herting, C. J., Ross, J. L., Hambardzumyan, D., Hervey-Jumper, S., Figueroa, M. E., Lowenstein, P. R. & Castro, M. G., Feb 13 2019, In : Science translational medicine. 11, 479, eaaq1427.

Research output: Contribution to journalArticle

alpha-Thalassemia
X-Linked Genes
Epigenomics
Glioma
DNA Damage

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

Amano, H., Chaudhury, A., Rodriguez-Aguayo, C., Lu, L., Akhanov, V., Catic, A., Popov, Y. V., Verdin, E., Johnson, H., Stossi, F., Sinclair, D. A., Nakamaru-Ogiso, E., Lopez-Berestein, G., Chang, J. T., Neilson, J. R., Meeker, A. K., Finegold, M., Baur, J. A. & Sahin, E., Jun 4 2019, In : Cell Metabolism. 29, 6, p. 1274-1290.e9

Research output: Contribution to journalArticle

Sirtuins
Telomere
Telomere Shortening
NAD
DNA Damage
2018
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Nutrition Surveys
Telomere
Leukocytes
Cross-Sectional Studies

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Brosnan-Cashman, J. A., Yuan, M., Graham, M. K., Rizzo, A. J., Myers, K. M., Davis, C., Zhang, R., Esopi, D. M., Raabe, E., Eberhart, C. G., Heaphy, C. M. & Meeker, A. K., Sep 1 2018, In : PLoS One. 13, 9, e0204159.

Research output: Contribution to journalArticle

Telomere Homeostasis
telomeres
Glioma
Cells
cell lines

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer

Haffner, M. C., Guner, G., Taheri, D., Netto, G. J., Palsgrove, D. N., Zheng, Q., Guedes, L. B., Kim, K., Tsai, H., Esopi, D. M., Lotan, T., Sharma, R., Meeker, A. K., Chinnaiyan, A. M., Nelson, W. G., Yegnasubramanian, S., Luo, J., Mehra, R., Antonarakis, E., Drake, C. G. & 1 others, Demarzo, A. M., Jun 1 2018, In : American Journal of Pathology. 188, 6, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Ligands
Programmed Cell Death 1 Receptor
Adenocarcinoma
Small Cell Carcinoma

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C., Hruban, R. H., Ishii, M., Klein, A., Reh, D. D., Rooper, L., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K. & 5 others, Agrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In : Nature Communications. 9, 1, 5410.

Research output: Contribution to journalArticle

Olfactory Esthesioneuroblastoma
deletion
Dystrophin
Genes
genes

Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer

Boudadi, K., Suzman, D. L., Anagnostou, V., Fu, W., Luber, B., Wang, H., Niknafs, N., White, J. R., Silberstein, J. L., Sullivan, R., Dowling, D., Harb, R., Nirschl, T. R., Veeneman, B. A., Tomlins, S. A., Wang, Y., Jendrisak, A., Graf, R. P., Dittamore, R., Carducci, M. A. & 8 others, Eisenberger, M., Haffner, M. C., Meeker, A. K., Eshleman, J., Luo, J., Velculescu, V. E., Drake, C. G. & Antonarakis, E., Jun 19 2018, In : Oncotarget. 9, 47, p. 28561-28571 11 p.

Research output: Contribution to journalArticle

DNA Repair
Disease-Free Survival
Prostatic Neoplasms
Survival
Circulating Neoplastic Cells

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

Baena-Del Valle, J. A., Zheng, Q., Esopi, D. M., Rubenstein, M., Hubbard, G. K., Moncaliano, M. C., Hruszkewycz, A., Vaghasia, A., Yegnasubramanian, S., Wheelan, S., Meeker, A. K., Heaphy, C. M., Graham, M. K. & Demarzo, A. M., Jan 1 2018, In : Journal of Pathology. 244, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Telomerase
Telomere
Cell Line
telomerase RNA

PD-L1 expression in medulloblastoma: An evaluation by subgroup

Martin, A., Nirschl, C. J., Polanczyk, M. J., Bell, W. R., Nirschl, T. R., Harris-Bookman, S., Phallen, J., Hicks, J., Martinez, D., Ogurtsova, A., Xu, H., Sullivan, L. M., Meeker, A. K., Raabe, E., Cohen, K. J., Eberhart, C. G., Burger, P. C., Santi, M., Taube, J. M., Pardoll, A. M. & 2 others, Drake, C. G. & Lim, M., Apr 10 2018, In : Oncotarget. 9, 27, p. 19177-19191 15 p.

Research output: Contribution to journalArticle

Medulloblastoma
Interferon-gamma
Biomarkers
Cell Line
Tumor Microenvironment

Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations

Weber, K. A., Heaphy, C. M., Joshu, C. E., Lu, J., Rohrmann, S., Bienstock, J. L., Agurs-Collins, T., Meeker, A. K. & Platz, E. A., Aug 1 2018, In : Cancer Causes and Control. 29, 8, p. 759-767 9 p.

Research output: Contribution to journalArticle

Telomere
Fetal Blood
Leukocytes
Mothers
Newborn Infant

TERT promoter mutations in solitary fibrous tumour

Demicco, E. G., Wani, K., Ingram, D., Wagner, M., Maki, R. G., Rizzo, A., Meeker, A. K., Lazar, A. J. & Wang, W. L., Jan 1 2018, (Accepted/In press) In : Histopathology.

Research output: Contribution to journalArticle

Solitary Fibrous Tumors
Mutation
Neoplasm Metastasis
Neoplasms

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

Diplas, B. H., He, X., Brosnan-Cashman, J. A., Liu, H., Chen, L. H., Wang, Z., Moure, C. J., Killela, P. J., Loriaux, D. B., Lipp, E. S., Greer, P. K., Yang, R., Rizzo, A. J., Rodriguez, F. J., Friedman, A. H., Friedman, H. S., Wang, S., He, Y., McLendon, R. E., Bigner, D. D. & 4 others, Jiao, Y., Waitkus, M. S., Meeker, A. K. & Yan, H., Dec 1 2018, In : Nature Communications. 9, 1, 2087.

Research output: Contribution to journalArticle

telomeres
Isocitrate Dehydrogenase
dehydrogenases
Glioblastoma
Telomere Homeostasis
Tumor Microenvironment
Macrophages
Neoplasms
Ovarian epithelial cancer
Recurrence

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Krueger, T. E., Thorek, D. L. J., Meeker, A. K., Isaacs, J. T. & Brennen, W., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
Mesenchymal Stromal Cells
Prostatic Neoplasms
Neoplasms
2017
Glioblastoma
Cytomegalovirus
Glioma
In Situ Hybridization
Real-Time Polymerase Chain Reaction

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A. K., Jinawath, A., Yeo, C. J., Eshleman, J., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S., May 1 2017, In : Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

Research output: Contribution to journalArticle

Cadherins
Adenocarcinoma
Loss of Heterozygosity
Pancreatic Neoplasms
Carcinogenesis

Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Mar 15 2017, In : Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Neuroendocrine Tumors
Survival
Neoplasm Metastasis
Recurrence

Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., Demarzo, A. M., Meeker, A. K. & Platz, E. A., Jan 1 2017, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Telomere
Stromal Cells
Prostate
Prostatic Neoplasms
Smoking

Differential long-term stability of microRNAs and RNU6B snRNA in 12-20 year old archived formalin-fixed paraffin-embedded specimens

Peskoe, S. B., Barber, J. R., Zheng, Q., Meeker, A. K., Demarzo, A. M., Platz, E. A. & Lupold, S., Jan 6 2017, In : BMC Cancer. 17, 1, 32.

Research output: Contribution to journalArticle

Small Nuclear RNA
MicroRNAs
Paraffin
Formaldehyde
RNA

Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH

Sharifi-Sanjani, M., Meeker, A. K. & Mourkioti, F., Sep 1 2017, In : Nature Protocols. 12, 9, p. 1855-1870 16 p.

Research output: Contribution to journalArticle

Telomere
Fluorescence In Situ Hybridization
Fluorescence
Tissue
Nucleic Acid Probes

Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm with Features Distinct from Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Boyer, D. F., McKelvie, P. A., De Leval, L., Edlefsen, K. L., Ko, Y. H., Aberman, Z. A., Kovach, A. E., Masih, A., Nishino, H. T., Weiss, L. M., Meeker, A. K., Nardi, V., Palisoc, M., Shao, L., Pittaluga, S., Ferry, J. A., Harris, N. L. & Sohani, A. R., 2017, In : American Journal of Surgical Pathology. 41, 3, p. 299-312 14 p.

Research output: Contribution to journalArticle

Satellite Viruses
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Fibrin
Human Herpesvirus 4

Immune-checkpoint status in penile squamous cell carcinoma: a North American cohort

Cocks, M., Taheri, D., Ball, M. W., Bezerra, S. M., Del Carmen Rodriguez, M., Ricardo, B. F. P., Bivalacqua, T., Sharma, R. B., Meeker, A. K., Chaux, A., Burnett, A. & Netto, G. J., Jan 1 2017, In : Human Pathology. 59, p. 55-61 7 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Neoplasms
Stromal Cells
Penile Neoplasms
Surgical Pathology

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate

Brennen, W., Zhang, B., Kulac, I., Kisteman, L. N., Antony, L., Wang, H., Meeker, A. K., Demarzo, A. M., Garraway, I. P., Denmeade, S. R. & Isaacs, J. T., 2017, In : Oncotarget. 8, 29, p. 46710-46727 18 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Prostate
Prostatic Neoplasms
Chondrogenesis
Adipogenesis

PD-L1 expression and the immune microenvironment in primary invasive lobular carcinomas of the breast

Thompson, E., Taube, J. M., Asch-Kendrick, R. J., Ogurtsova, A., Xu, H., Sharma, R., Meeker, A. K., Argani, P., Emens, L. A. & Cimino-Mathews, A. M., Nov 1 2017, In : Modern Pathology. 30, 11, p. 1551-1560 10 p.

Research output: Contribution to journalArticle

Lobular Carcinoma
Tumor-Infiltrating Lymphocytes
Breast
Breast Neoplasms
Ductal Carcinoma

Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment

Muroyama, Y., Nirschl, T. R., Kochel, C. M., Lopez-Bujanda, Z., Theodros, D., Mao, W., Carrera-Haro, M. A., Ghasemzadeh, A., Marciscano, A. E., Velarde, E., Tam, A. J., Thoburn, C. J., Uddin, M., Meeker, A. K., Anders, R. A., Pardoll, A. M. & Drake, C. G., Nov 1 2017, In : Cancer immunology research. 5, 11, p. 992-1004 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Regulatory T-Lymphocytes
Radiotherapy
Tumor-Infiltrating Lymphocytes
Neoplasms

Th17 immune microenvironment in Epstein-Barr virus-negative Hodgkin lymphoma: Implications for immunotherapy

Duffield, A. S., Ascierto, M. L., Anders, R. A., Taube, J. M., Meeker, A. K., Chen, S., McMiller, T. L., Phillips, N. A., Xu, H., Ogurtsova, A., Berger, A. E., Pardoll, D. M., Topalian, S. L. & Ambinder, R. F., Jul 25 2017, In : Blood Advances. 1, 17, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

Open Access
Human Herpesvirus 4
Hodgkin Disease
Immunotherapy
Interleukin-23
Interleukin-17
2016

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

Hackeng, W. M., Brosens, L. A. A., Poruk, K. E., Noë, M., Hosoda, W., Poling, J. S., Rizzo, A., Campbell-Thompson, M., Atkinson, M. A., Konukiewitz, B., Klöppel, G., Heaphy, C. M., Meeker, A. K. & Wood, L. D., Oct 1 2016, In : Human Pathology. 56, p. 93-100 8 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Neuroendocrine Tumors
Telomere
Carcinogenesis
Fluorescence In Situ Hybridization

Analysis of potential response predictors to capecitabine/temozolomide in metastatic pancreatic neuroendocrine tumors

Cives, M., Ghayouri, M., Morse, B., Brelsford, M., Black, M., Rizzo, A., Meeker, A. K. & Strosberg, J., 2016, In : Endocrine-Related Cancer. 23, 9, p. 759-767 9 p.

Research output: Contribution to journalArticle

temozolomide
Neuroendocrine Tumors
Telomere Homeostasis
Methyltransferases
DNA

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

Koschmann, C., Calinescu, A. A., Nunez, F. J., Mackay, A., Fazal-Salom, J., Thomas, D., Mendez, F., Kamran, N., Dzaman, M., Mulpuri, L., Krasinkiewicz, J., Doherty, R., Lemons, R., Brosnan-Cashman, J. A., Li, Y., Roh, S., Zhao, L., Appelman, H., Ferguson, D., Gorbunova, V. & 4 others, Meeker, A. K., Jones, C., Lowenstein, P. R. & Castro, M. G., Mar 2 2016, In : Science Translational Medicine. 8, 328, 328ra28.

Research output: Contribution to journalArticle

DNA End-Joining Repair
Glioblastoma
Glioma
Histone Chaperones
Mutation

Development and application of a novel model system to study "active" and "passive" tumor targeting

Mukherjee, A., Kumar, B., Hatano, K., Russell, L. M., Trock, B., Searson, P. C., Meeker, A. K., Pomper, M. G. & Lupold, S., Oct 1 2016, In : Molecular Cancer Therapeutics. 15, 10, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

Neoplasms
Half-Life
human glutamate carboxypeptidase II
Antibodies
Heterografts

High-resolution telomere fluorescence in situ hybridization reveals intriguing anomalies in germ cell tumors

Shekhani, M. T., Barber, J. R., Bezerra, S. M., Heaphy, C. M., Gonzalez Roibon, N. D., Taheri, D., Reis, L. O., Guner, G., Joshu, C. E., Netto, G. J. & Meeker, A. K., Aug 1 2016, In : Human Pathology. 54, p. 106-112 7 p.

Research output: Contribution to journalArticle

Germ Cell and Embryonal Neoplasms
Telomere
Fluorescence In Situ Hybridization
Telomere Homeostasis
Germ Cells

Inactivating ARID1A tumor suppressor enhances TERT transcription and maintains telomere length in cancer cells

Suryo Rahmanto, Y., Jung, J. G., Wu, R. C., Kobayashi, Y., Heaphy, C. M., Meeker, A. K., Wang, T-L. & Shih, I. M., 2016, In : Journal of Biological Chemistry. 291, 18, p. 9690-9699 10 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Transcription
Reverse Transcription
Tumors

Influence of in Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?

Weber, K. A., Heaphy, C. M., Rohrmann, S., Gonzalez, B., Bienstock, J. L., Agurs-Collins, T., Platz, E. A. & Meeker, A. K., 2016, In : Prostate Cancer. 2016, 3691650.

Research output: Contribution to journalArticle

Telomere
Fetal Blood
Prostatic Neoplasms
Leukocytes
Mothers

Low p16INK4a Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone

Graham, M. K., Principessa, L., Antony, L., Meeker, A. K. & Isaacs, J. T., 2016, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Telomerase
Prostate
Epithelial Cells
Cell Aging
Cyclin-Dependent Kinase Inhibitor p16

MUC1-ARF - A novel MUC1 protein that resides in the nucleus and is expressed by alternate reading frame translation of MUC1 mRNA

Chalick, M., Jacobi, O., Pichinuk, E., Garbar, C., Bensussan, A., Meeker, A. K., Ziv, R., Zehavi, T., Smorodinsky, N. I., Hilkens, J., Hanisch, F. G., Rubinstein, D. B. & Wreschner, D. H., Oct 1 2016, In : PLoS One. 11, 10, e0165031.

Research output: Contribution to journalArticle

Reading Frames
Protein Biosynthesis
translation (genetics)
Messenger RNA
Proteins

PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas

Cimino-Mathews, A. M., Thompson, E., Taube, J. M., Ye, X., Lu, Y., Meeker, A. K., Xu, H., Sharma, R., Lecksell, K., Cornish, T. C., Cuka, N., Argani, P. & Emens, L. A., Jan 1 2016, In : Human Pathology. 47, 1, p. 52-63 12 p.

Research output: Contribution to journalArticle

CD80 Antigens
Tumor Microenvironment
Breast Neoplasms
Ligands
Tumor-Infiltrating Lymphocytes

The immune microenvironment of breast ductal carcinoma in situ

Thompson, E., Taube, J. M., Elwood, H., Sharma, R., Meeker, A. K., Warzecha, H. N., Argani, P., Cimino-Mathews, A. M. & Emens, L. A., Mar 1 2016, In : Modern Pathology. 29, 3, p. 249-258 10 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Tumor-Infiltrating Lymphocytes
Ligands
Breast Neoplasms
Epidermal Growth Factor
Tumor-Infiltrating Lymphocytes
Cisplatin
Urinary Bladder
Carcinoma
Drug Therapy
2015

Assessment of tumoral PD-L1 expression and intratumoral CD8+ T cells in urothelial carcinoma

Faraj, S. F., Munari, E., Guner, G., Taube, J. M., Anders, R. A., Hicks, J., Meeker, A. K., Schoenberg, M., Bivalacqua, T., Drake, C. & Netto, G. J., Mar 1 2015, In : Urology. 85, 3

Research output: Contribution to journalArticle

Ligands
Carcinoma
T-Lymphocytes
Cystectomy
Neoplasms

Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer

Julin, B., Shui, I., Heaphy, C. M., Joshu, C. E., Meeker, A. K., Giovannucci, E., De Vivo, I. & Platz, E. A., Feb 17 2015, In : British Journal of Cancer. 112, 4, p. 769-776 8 p.

Research output: Contribution to journalArticle

Telomere
Prostatic Neoplasms
Leukocytes
Odds Ratio
Confidence Intervals

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Block, K. I., Gyllenhaal, C., Lowe, L., Amedei, A., Ruhul Amin, A. R. M., Amin, A., Aquilano, K., Arbiser, J., Arreola, A., Arzumanyan, A., Salman Ashraf, S., Azmi, A. S., Benencia, F., Bhakta, D., Bilsland, A., Bishayee, A., Blain, S. W., Block, P. B., Boosani, C. S., Carey, T. E. & 160 others, Carnero, A., Carotenuto, M., Casey, S. C., Chakrabarti, M., Chaturvedi, R., Chen, G. Z., Chen, H., Chen, S., Chen, Y. C., Choi, B. K., Ciriolo, M. R., Coley, H. M., Collins, A. R., Connell, M., Crawford, S., Curran, C. S., Dabrosin, C., Damia, G., Dasgupta, S., DeBerardinis, R. J., Decker, W. K., Dhawan, P., Diehl, A. M. E., Dong, J. T., Dou, Q. P., Drewa, J. E., Elkord, E., El-Rayes, B., Feitelson, M. A., Felsheru, D. W., Ferguson, L. R., Fimognari, C., Firestone, G. L., Frezza, C., Fujii, H., Fuster, M. M., Generali, D., Georgakilas, A. G., Gieseler, F., Gilbertson, M., Green, M. F., Grue, B., Guhal, G., Halicka, D., Helferich, W. G., Heneberg, P., Hentosh, P., Hirschey, M. D., Hofseth, L. J., Holcombe, R. F., Honoki, K., Hsu, H. Y., Huang, G. S., Jensen, L. D., Jiang, W. G., Jones, L. W., Karpowicz, P. A., Keith, W. N., Kerkar, S. P., Khan, G. N., Khatami, M., Ko, Y. H., Kucuk, O., Kulathinal, R. J., Kumar, N. B., Kwon, B. S., Leb, A., Leab, M. A., Lee, H. Y., Lichtor, T., Lin, L. T., Locasale, J. W., Lokeshwar, B. L., Longo, V. D., Lyssiotis, C. A., MacKenzie, K. L., Malhotra, M., Marino, M., Martinez-Chantar, M. L., Matheu, A., Maxwellx, C., McDonnell, E., Meeker, A. K., Mehrmohamadi, M., Mehta, K., Michelotti, G. A., Mohammad, R. M., Mohammed, S. I., Morre, D. J., Muqbil, I., Muralidharcq, V., Murphy, M. P., Nagaraju, G. P., Nahta, R., Niccolai, E., Nowsheen, S., Panis, C., Pantano, F., Parslow, V. R., Pawelec, G., Pedersen, P. L., Poore, B., Poudyal, D., Prakash, S., Prince, M., Raffaghello, L., Rathmell, J. C., Rathmell, W. K., Ray, S. K., Reichrath, J., Rezazadeh, S., Ribatti, D., Ricciardiello, L., Robeydf, R. B., Rodierdh, F., Rupasinghe, H. P. V., Russo, G. L., Ryan, E. P., Samadi, A. K., Sanchez-Garcia, I., Sanders, A. J., Santini, D., Sarkar, M., Sasada, T., Saxena, N. K., Shackelford, R. E., Shantha Kumara, H. M. C., Sharma, D., Shin, D. M., Sidransky, D., Siegelin, M. D., Signori, E., Singh, N., Sivanand, S., Sliva, D., Smythe, C., Spagnuolo, C., Stafforini, D. M., Stagg, J., Subbarayan, P. R., Sundin, T., Talib, W. H., Thompson, S. K., Tran, P. T., Ungefroren, H., Vander Heiden, M. G., Venkateswaran, V., Vinay, D. S., Vlachostergios, P. J., Wang, Z., Wellen, K. E., Whelan, R. L., Yang, E. S., Yang, H., Yang, X., Yaswen, P., Yedjou, C., Yin, X., Zhu, J. & Zollo, M., 2015, In : Seminars in Cancer Biology. 35, p. S276-S304

Research output: Contribution to journalArticle

Tumor Microenvironment
Recurrence
Neoplasms
Genetic Heterogeneity
Poisons

Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: Implications for PD-1 pathway blockade

Taube, J. M., Young, G. D., McMiller, T. L., Chen, S., Salas, J. T., Pritchard, T. S., Xu, H., Meeker, A. K., Fan, J., Cheadle, C., Berger, A. E., Pardoll, A. M. & Topalian, S., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 3969-3976 8 p.

Research output: Contribution to journalArticle

Regulator Genes
Melanoma
Antigen Presentation
Immunosuppression
Interleukin-10

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

Cochran, R. L., Cidado, J., Kim, M., Zabransky, D. J., Croessmann, S., Chu, D., Wong, H. Y., Beaver, J., Cravero, K., Erlanger, B., Parsons, H., Heaphy, C. M., Meeker, A. K., Lauring, J. & Park, B. H., 2015, In : Oncotarget. 6, 28, p. 25240-25251 12 p.

Research output: Contribution to journalArticle

Alleles
Phenotype
Mutation
Gene Targeting
Penetrance

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

Ferguson, L. R., Chen, H., Collins, A. R., Connell, M., Damia, G., Dasgupta, S., Malhotra, M., Meeker, A. K., Amedei, A., Amin, A., Ashraf, S. S., Aquilano, K., Azmi, A. S., Bhakta, D., Bilsland, A., Boosani, C. S., Chen, S., Ciriolo, M. R., Fujii, H., Guha, G. & 15 others, Halicka, D., Helferich, W. G., Keith, W. N., Mohammed, S. I., Niccolai, E., Yang, X., Honoki, K., Parslow, V. R., Prakash, S., Rezazadeh, S., Shackelford, R. E., Sidransky, D., Tran, P. T., Yang, E. S. & Maxwell, C. A., 2015, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalArticle

Genomic Instability
Diet
Neoplasms
DNA Damage
Centrosome

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

Bodelon, C., Heaphy, C. M., Meeker, A. K., Geller, B., Vacek, P. M., Weaver, D. L., Chicoine, R. E., Shepherd, J. A., Mahmoudzadeh, A. P., Patel, D. A., Brinton, L. A., Sherman, M. E. & Gierach, G. L., Oct 30 2015, (Accepted/In press) In : BMC Cancer.

Research output: Contribution to journalArticle

Image-Guided Biopsy
Telomere
Breast
Leukocytes
Biopsy

Paucity of PD-L1 expression in prostate cancer: Innate and adaptive immune resistance

Martin, A., Nirschl, T. R., Nirschl, C. J., Francica, B. J., Kochel, C. M., Van Bokhoven, A., Meeker, A. K., Lucia, M. S., Anders, R. A., Demarzo, A. M. & Drake, C. G., Dec 1 2015, In : Prostate Cancer and Prostatic Diseases. 18, 4, p. 325-332 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Ligands
Phosphoric Monoester Hydrolases
Cell Line
Prostate