Alan Meeker

Research output

Research output per year 1984 2004 2009 2011 2013 2014 2015 2016 2017 2018 2019 2021 2022 2024

• 170 Article
• 11 Review article
• 4 Comment/debate
• 3 Letter
• 3 More
  • 2 Chapter
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2024

  Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

  Ertunc, O., Smearman, E., Zheng, Q., Hicks, J. L., Brosnan-Cashman, J. A., Jones, T., Gomes-Alexandre, C., Trabzonlu, L., Meeker, A. K., De Marzo, A. M. & Heaphy, C. M., Feb 2024, In: Prostate. 84, 2, p. 148-157 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere 100%
  • Prostate 75%
  • In Situ Hybridization 36%
  • Formaldehyde 9%
  • Paraffin 9%

• DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks

  Pinto, L. M., Pailas, A., Bondarchenko, M., Sharma, A. B., Neumann, K., Rizzo, A. J., Jeanty, C., Nicot, N., Racca, C., Graham, M. K., Naughton, C., Liu, Y., Chen, C. L., Meakin, P. J., Gilbert, N., Britton, S., Meeker, A. K., Heaphy, C. M., Larminat, F. & Van Dyck, E., Feb 9 2024, In: Nucleic acids research. 52, 3, p. 1136-1155 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • R-Loop Structures 100%
  • Double-Stranded DNA Breaks 71%
  • Centromere 56%
  • Chromatin 54%
  • Genomic Instability 51%
• 2023

  Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer

  Mori, J. O., Elhussin, I., Brennen, W. N., Graham, M. K., Lotan, T. L., Yates, C. C., De Marzo, A. M., Denmeade, S. R., Yegnasubramanian, S., Nelson, W. G., Denis, G. V., Platz, E. A., Meeker, A. K. & Heaphy, C. M., 2023, (Accepted/In press) In: Nature Reviews Urology.

  Research output: Contribution to journal › Review article › peer-review

  • Cellular Senescence 100%
  • Prostatic Neoplasms 72%
  • Fibroblasts 67%
  • Tumor Microenvironment 47%
  • Growth 22%
• 2022

  Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma

  Argani, P., Tickoo, S. K., Matoso, A., Pratilas, C. A., Mehra, R., Tretiakova, M., Sibony, M., Meeker, A. K., Lin, M. T., Reuter, V. E., Epstein, J. I., Gagan, J. & Palsgrove, D. N., Jul 1 2022, In: American Journal of Surgical Pathology. 46, 7, p. 988-999 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Wilms Tumor 100%
  • Adenoma 77%
  • Mutation 33%
  • Microdissection 9%
  • Pediatrics 9%

• ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors

  Pladevall-Morera, D., Castejón-Griñán, M., Aguilera, P., Gaardahl, K., Ingham, A., Brosnan-Cashman, J. A., Meeker, A. K. & Lopez-Contreras, A. J., Apr 1 2022, In: Cancers. 14, 7, 1790.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • PDGF receptor tyrosine kinase 100%
  • Glioma 55%
  • Temozolomide 24%
  • Glioblastoma 19%
  • Astrocytoma 11%

• ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

  Qin, T., Mullan, B., Ravindran, R., Messinger, D., Siada, R., Cummings, J. R., Harris, M., Muruganand, A., Pyaram, K., Miklja, Z., Reiber, M., Garcia, T., Tran, D., Danussi, C., Brosnan-Cashman, J., Pratt, D., Zhao, X., Rehemtulla, A., Sartor, M. A., Venneti, S., & 7 othersMeeker, A. K., Huse, J. T., Morgan, M. A., Lowenstein, P. R., Castro, M. G., Yadav, V. N. & Koschmann, C., Jan 11 2022, In: Cell Reports. 38, 2, 110216.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phase Transition 100%
  • Radio 80%
  • Glioblastoma 78%
  • Glioma 73%
  • Cell Cycle 62%

• Erratum: Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization (Clin Cancer Res (2017) 23 (3150–3157) DOI: 10.1158/1078-0432.CCR-16-1490)

  Holdhoff, M., Guner, G., Rodriguez, F. J., Hicks, J. L., Zheng, Q., Forman, M. S., Ye, X., Grossman, S. A., Meeker, A. K., Heaphy, C. M., Eberhart, C. G., De Marzo, A. M. & Boger, R., Apr 15 2022, In: Clinical Cancer Research. 28, 8, p. 1737 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Cytomegalovirus 100%
  • Glioblastoma 99%
  • Glioma 92%
  • In Situ Hybridization 91%
  • Emotions 79%

• LY6S, a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated wit Inflammation and Viral Resistance

  Shmerling, M., Chalik, M., Smorodinsky, N. I., Meeker, A., Roy, S., Sagi-Assif, O., Meshel, T., Danilevsky, A., Shomron, N., Levinger, S., Nishry, B., Baruchi, D., Shargorodsky, A., Ziv, R., Sarusi-Portuguez, A., Lahav, M., Ehrlich, M., Braschi, B., Bruford, E., Witz, I. P., & 1 othersWreschner, D. H., Apr 1 2022, In: ImmunoHorizons. 6, 4, p. 253-272 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Wit and Humor 100%
  • Spleen 59%
  • Inflammation 44%
  • Genes 30%
  • Multigene Family 27%

• Re: Oncogenic Gene Fusions in Nonneoplastic Precursors as Evidence That Bacterial Infection Can Initiate Prostate Cancer

  Shrestha, E., Coulter, J. B., Guzman, W., Ozbek, B., Hess, M. M., Mummert, L., Ernst, S. E., Maynard, J. P., Meeker, A. K., Heaphy, C. M., Haffner, M. C., De Marzo, A. M. & Sfanos, K. S., May 1 2022, In: Journal of Urology. 207, 5, p. 1147 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• The prostate tissue-based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy

  Heaphy, C. M., Joshu, C. E., Barber, J. R., Davis, C., Lu, J., Zarinshenas, R., Giovannucci, E., Mucci, L. A., Stampfer, M. J., Han, M., De Marzo, A. M., Lotan, T. L., Platz, E. A. & Meeker, A. K., Sep 2022, In: Journal of Pathology: Clinical Research. 8, 5, p. 481-491 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere 100%
  • Prostatectomy 93%
  • Prostate 75%
  • Prostatic Neoplasms 72%
  • Biomarkers 59%

• Therapeutic Vulnerability to ATR Inhibition in Concurrent NF1 and ATRX-Deficient/ALT-Positive High-Grade Solid Tumors

  Yuan, M., Eberhart, C. G., Pratilas, C. A., Blakeley, J. O., Davis, C., Stojanova, M., Reilly, K., Meeker, A. K., Heaphy, C. M. & Rodriguez, F. J., Jun 1 2022, In: Cancers. 14, 12, 3015.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere Homeostasis 100%
  • Neurofibromatosis 1 82%
  • Cell Line 27%
  • Temozolomide 25%
  • Neoplasms 21%
• 2021

  Correction: Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors (Oncogene, (2020), 39, 45, (6935-6949), 10.1038/s41388-020-01479-6)

  Zhu, Y., Dalrymple, S. L., Coleman, I., Zheng, S. L., Xu, J., Hooper, J. E., Antonarakis, E. S., De Marzo, A. M., Meeker, A. K., Nelson, P. S., Isaacs, W. B., Denmeade, S. R., Luo, J., Brennen, W. N. & Isaacs, J. T., Jun 3 2021, In: Oncogene. 40, 22, p. 3914-3916 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Androgen Receptors 100%
  • Oncogenes 88%
  • Prostatic Neoplasms 73%

• Correction to: Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors (Oncogene, (2020), 39, 45, (6935-6949), 10.1038/s41388-020-01479-6)

  Zhu, Y., Dalrymple, S. L., Coleman, I., Zheng, S. L., Xu, J., Hooper, J. E., Antonarakis, E. S., De Marzo, A. M., Meeker, A. K., Nelson, P. S., Isaacs, W. B., Denmeade, S. R., Luo, J., Brennen, W. N. & Isaacs, J. T., Mar 18 2021, In: Oncogene. 40, 11, p. 2148 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • RNA-Seq 100%
  • Androgen Receptors 92%
  • Oncogenes 81%
  • Prostatic Neoplasms 67%
  • Genes 34%

• Downregulation of 5-hydroxymethylcytosine is an early event in pancreatic tumorigenesis

  Fujikura, K., Alruwaii, Z. I., Haffner, M. C., Trujillo, M. A., Roberts, N. J., Hong, S. M., Macgregor-Das, A., Goggins, M. G., Roy, S., Meeker, A. K., Ding, D., Wright, M., He, J., Hruban, R. H. & Wood, L. D., Jul 2021, In: Journal of Pathology. 254, 3, p. 279-288 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 5-hydroxymethylcytosine 100%
  • Dioxygenases 71%
  • Carcinogenesis 50%
  • Down-Regulation 46%
  • Epigenomics 28%

• Monoallelic IDH1 R132H mutation mediates glioma cell response to anticancer therapies via induction of senescence

  Zhan, D., Ma, D., Wei, S., Lal, B., Fu, Y., Eberhart, C., Laterra, J., Ying, M., Li, Y., Meeker, A., Lopez-Bertoni, H. & Xia, S., Nov 2021, In: Molecular Cancer Research. 19, 11, p. 1878-1888 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioma 100%
  • Mutation 60%
  • Cellular Senescence 47%
  • Isocitrate Dehydrogenase 29%
  • DNA Damage 18%

• Obesity is associated with shorter telomere length in prostate stromal cells in men with aggressive prostate cancer

  Joshu, C. E., Heaphy, C. M., Barber, J. R., Lu, J., Zarinshenas, R., Davis, C., Han, M., Lotan, T. L., Sfanos, K. S., de Marzo, A. M., Meeker, A. K. & Platz, E. A., 2021, In: Cancer Prevention Research. 14, 4, p. 463-470 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere 100%
  • Stromal Cells 91%
  • Prostate 75%
  • Prostatic Neoplasms 72%
  • Obesity 63%

• Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer

  Shrestha, E., Coulter, J. B., Guzman, W., Ozbek, B., Hess, M. M., Mummert, L., Ernst, S. E., Maynard, J. P., Meeker, A. K., Heaphy, C. M., Haffner, M. C., de Marzo, A. M. & Sfanos, K. S., Aug 10 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 32, e2018976118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gene Fusion 100%
  • Bacterial Infections 82%
  • Prostatic Neoplasms 70%
  • Atrophy 57%
  • Prostate 55%

• Proteomic characterization of primary and metastatic prostate cancer reveals reduced proteinase activity in aggressive tumors

  Li, Q. K., Chen, J., Hu, Y., Höti, N., Lih, T. S. M., Thomas, S. N., Chen, L., Roy, S., Meeker, A., Shah, P., Chen, L., Bova, G. S., Zhang, B. & Zhang, H., Dec 2021, In: Scientific reports. 11, 1, 18936.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteomics 100%
  • Peptide Hydrolases 91%
  • Prostatic Neoplasms 86%
  • Dipeptidyl Peptidase 4 36%
  • Neoplasms 35%

• Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer

  Brennen, W. N., Zhu, Y., Coleman, I. M., Dalrymple, S. L., Antony, L., Patel, R. A., Hanratty, B., Chikarmane, R., Meeker, A. K., Zheng, S. L., Hooper, J. E., Luo, J., de Marzo, A. M., Corey, E., Xu, J., Yegnasubramanian, S., Haffner, M. C., Nelson, P. S., Nelson, W. G., Isaacs, W. B., & 1 othersIsaacs, J. T., Apr 1 2021, In: JCI Insight. 6, 8, e146827.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Androgen Receptors 100%
  • Prostatic Neoplasms 73%
  • Sequence Deletion 53%
  • Castration 51%
  • Phenotype 27%

• SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma

  Brosnan-Cashman, J. A., Davis, C. M., Diplas, B. H., Meeker, A. K., Rodriguez, F. J. & Heaphy, C. M., Oct 2021, In: Modern Pathology. 34, 10, p. 1810-1819 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere Homeostasis 100%
  • Glioblastoma 66%
  • X-linked Nuclear Protein 31%
  • Telomere 18%
  • Immunohistochemistry 15%
• 2020

  High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer

  Gorbounov, M., Carleton, N. M., Asch-Kendrick, R. J., Xian, L., Rooper, L., Chia, L., Cimino-Mathews, A., Cope, L., Meeker, A., Stearns, V., Veltri, R. W., Bae, Y. K. & Resar, L. M. S., Jan 1 2020, In: Breast Cancer Research and Treatment. 179, 1, p. 25-35 11 p.

  Research output: Contribution to journal › Article › peer-review

  • High Mobility Group Proteins 100%
  • Estrogen Receptors 64%
  • Breast Neoplasms 44%
  • Gene Expression 41%
  • Neoplasms 18%
  4 Scopus citations

• In vivo anti-MUC1⁺ tumor activity and sequences of high-affinity anti-MUC1-SEA antibodies

  Pichinuk, E., Chalik, M., Benhar, I., Ginat-Koton, R., Ziv, R., Smorodinsky, N. I., Haran, G., Garbar, C., Bensussan, A., Meeker, A., Guillaume, T., Rubinstein, D. B. & Wreschner, D. H., Jul 1 2020, In: Cancer Immunology, Immunotherapy. 69, 7, p. 1337-1352 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Antibodies 100%
  • Neoplasms 58%
  • Monoclonal Antibodies 33%
  • Exotoxins 30%
  • Immunotoxins 30%
  3 Scopus citations

• Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

  Esopi, D., Graham, M. K., Brosnan-Cashman, J. A., Meyers, J., Vaghasia, A., Gupta, A., Kumar, B., Haffner, M. C., Heaphy, C. M., De Marzo, A. M., Meeker, A. K., Nelson, W. G., Wheelan, S. J. & Yegnasubramanian, S., Oct 1 2020, In: Cellular Oncology. 43, 5, p. 847-861 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alleles 100%
  • Neoplasms 44%
  • hydrogen sulfite 19%
  • CpG Islands 18%
  • Gene Expression 18%
  2 Scopus citations

• Racial difference in prostate cancer cell telomere lengths in men with higher grade prostate cancer: A clue to the racial disparity in prostate cancer outcomes

  Heaphy, C. M., Joshu, C. E., Barber, J. R., Davis, C., Zarinshenas, R., de Marzo, A. M., Lotan, T. L., Sfanos, K. S., Meeker, A. K. & Platz, E. A., 2020, In: Cancer Epidemiology Biomarkers and Prevention. 29, 3, p. 676-680 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere 100%
  • Prostatic Neoplasms 72%
  • Stromal Cells 24%
  • African Continental Ancestry Group 24%
  • European Continental Ancestry Group 22%
  3 Scopus citations

• Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors

  Zhu, Y., Dalrymple, S. L., Coleman, I., Zheng, S. L., Xu, J., Hooper, J. E., Antonarakis, E. S., De Marzo, A. M., Meeker, A. K., Nelson, P. S., Isaacs, W. B., Denmeade, S. R., Luo, J., Brennen, W. N. & Isaacs, J. T., Nov 5 2020, In: Oncogene. 39, 45, p. 6935-6949 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Androgen Receptors 100%
  • MDV 3100 85%
  • Prostatic Neoplasms 73%
  • Heterografts 20%
  • Abiraterone Acetate 18%
  4 Scopus citations

• Stromal CAVIN1 controls prostate cancer microenvironment and metastasis by modulating lipid distribution and inflammatory signaling

  Low, J. Y., Brennen, W. N., Meeker, A. K., Ikonen, E., Simons, B. W. & Laiho, M., Sep 1 2020, In: Molecular Cancer Research. 18, 9, p. 1414-1426 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Caveolae 100%
  • Tumor Microenvironment 80%
  • Prostatic Neoplasms 61%
  • Lipids 50%
  • Neoplasm Metastasis 47%
  1 Scopus citations

• Telomere lengths differ significantly between small-cell neuroendocrine prostate carcinoma and adenocarcinoma of the prostate

  Heaphy, C. M., Haffner, M. C., Graham, M. K., Lim, D., Davis, C., Corey, E., Epstein, J. I., Eisenberger, M. A., Wang, H., De Marzo, A. M., Meeker, A. K. & Lotan, T. L., Jul 2020, In: Human pathology. 101, p. 70-79 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Carcinoma 100%
  • Telomere 85%
  • Prostate 64%
  • Adenocarcinoma 60%
  • Missense Mutation 7%
  1 Scopus citations
• 2019

  Adding the team into T1 translational research: A case study of multidisciplinary team science in the evaluation of biomarkers of prostate cancer risk and prognosis

  Marrone, M. T., Joshu, C. E., Peskoe, S. B., De Marzo, A. M., Heaphy, C. M., Lupold, S. E., Meeker, A. K. & Platz, E. A., Jan 2019, In: Clinical chemistry. 65, 1, p. 189-198 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interdisciplinary Research 100%
  • Translational Medical Research 83%
  • Biological Marker 66%
  • Telomere 60%
  • MicroRNA 60%
  2 Scopus citations

• A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

  Bell, W. R., Meeker, A. K., Rizzo, A., Rajpara, S., Rosenthal, I. M., Flores Bellver, M., Aparicio Domingo, S., Zhong, X., Barber, J. R., Joshu, C. E., Canto-Soler, M. V., Eberhart, C. G. & Heaphy, C. M., Jan 2019, In: Brain Pathology. 29, 1, p. 45-52 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Retinal Rod Photoreceptor Cells 100%
  • Telomere 82%
  • Phenotype 45%
  • DNA 41%
  • Retina 39%
  3 Scopus citations

• Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

  Tomasetti, C., Poling, J., Roberts, N. J., London, N. R., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deceleration 100%
  • Cell Division 79%
  • Incidence 40%
  • Stem Cells 30%
  • Mutation Accumulation 28%
  13 Scopus citations

• Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

  Graham, M. K., Kim, J., Da, J., Brosnan-Cashman, J. A., Rizzo, A., Del Valle, J. A. B., Chia, L., Rubenstein, M., Davis, C., Zheng, Q., Cope, L., Considine, M., Haffner, M. C., De Marzo, A. M., Meeker, A. K. & Heaphy, C. M., 2019, In: Molecular Cancer Research. 17, 12, p. 2480-2491 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere Homeostasis 100%
  • telomerase RNA 99%
  • Telomerase 65%
  • Telomere 63%
  • Prostatic Neoplasms 53%
  8 Scopus citations

• IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

  Núñez, F. J., Mendez, F. M., Kadiyala, P., Alghamri, M. S., Savelieff, M. G., Garcia-Fabiani, M. B., Haase, S., Koschmann, C., Calinescu, A. A., Kamran, N., Saxena, M., Patel, R., Carney, S., Guo, M. Z., Edwards, M., Ljungman, M., Qin, T., Sartor, M. A., Tagett, R., Venneti, S., & 15 othersBrosnan-Cashman, J., Meeker, A., Gorbunova, V., Zhao, L., Kremer, D. M., Zhang, L., Lyssiotis, C. A., Jones, L., Herting, C. J., Ross, J. L., Hambardzumyan, D., Hervey-Jumper, S., Figueroa, M. E., Lowenstein, P. R. & Castro, M. G., Feb 13 2019, In: Science translational medicine. 11, 479, eaaq1427.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-Thalassemia 100%
  • X-Linked Genes 93%
  • Tumor Suppressor Proteins 69%
  • Intellectual Disability 68%
  • Glioma 67%
  49 Scopus citations

• Molecular pathology of high-grade prostatic intraepithelial neoplasia: Challenges and opportunities

  Trabzonlu, L., Kulac, I., Zheng, Q., Hicks, J. L., Haffner, M. C., Nelson, W. G., Sfanos, K. S., Ertunc, O., Lotan, T. L., Heaphy, C. M., Meeker, A. K., Yegnasubramanian, S. & De Marzo, A. M., Apr 2019, In: Cold Spring Harbor Perspectives in Medicine. 9, 4, a030403.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prostatic Intraepithelial Neoplasia 100%
  • Molecular Pathology 79%
  • Fuel 57%
  • Prostatic Neoplasms 55%
  • Carcinoma in Situ 52%
  5 Scopus citations

• Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

  Amano, H., Chaudhury, A., Rodriguez-Aguayo, C., Lu, L., Akhanov, V., Catic, A., Popov, Y. V., Verdin, E., Johnson, H., Stossi, F., Sinclair, D. A., Nakamaru-Ogiso, E., Lopez-Berestein, G., Chang, J. T., Neilson, J. R., Meeker, A., Finegold, M., Baur, J. A. & Sahin, E., Jun 4 2019, In: Cell Metabolism. 29, 6, p. 1274-1290.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sirtuins 100%
  • Telomere 81%
  • Sirtuin 1 49%
  • Telomere Shortening 24%
  • NAD 19%
  32 Scopus citations

• Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

  Krueger, T. E., Thorek, D. L. J., Meeker, A. K., Isaacs, J. T. & Brennen, W. N., Feb 15 2019, In: Prostate. 79, 3, p. 320-330 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Microenvironment 100%
  • Mesenchymal Stem Cells 86%
  • Immunosuppressive Agents 80%
  • Prostatic Neoplasms 76%
  • Neoplasms 31%
  19 Scopus citations
• 2018

  Association between statin drug use and peripheral blood leukocyte telomere length in the National Health and Nutrition Examination Survey 1999–2002: a cross-sectional study

  Tran, P. T., Meeker, A. K. & Platz, E. A., Aug 2018, In: Annals of epidemiology. 28, 8, p. 529-534 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Telomere 100%
  • Nutrition Surveys 99%
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors 88%
  • Leukocytes 71%
  • Cross-Sectional Studies 59%
  3 Scopus citations

• ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

  Brosnan-Cashman, J. A., Yuan, M., Graham, M. K., Rizzo, A. J., Myers, K. M., Davis, C., Zhang, R., Esopi, D. M., Raabe, E. H., Eberhart, C. G., Heaphy, C. M. & Meeker, A. K., Sep 2018, In: PloS one. 13, 9, e0204159.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere Homeostasis 100%
  • Glioma 62%
  • Phenotype 40%
  • Cell Line 39%
  • Telomerase 17%
  14 Scopus citations

• Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer

  Haffner, M. C., Guner, G., Taheri, D., Netto, G. J., Palsgrove, D. N., Zheng, Q., Guedes, L. B., Kim, K., Tsai, H., Esopi, D. M., Lotan, T. L., Sharma, R., Meeker, A. K., Chinnaiyan, A. M., Nelson, W. G., Yegnasubramanian, S., Luo, J., Mehra, R., Antonarakis, E. S., Drake, C. G., & 1 othersDe Marzo, A. M., Jun 2018, In: American Journal of Pathology. 188, 6, p. 1478-1485 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prostatic Neoplasms 100%
  • Ligands 89%
  • Programmed Cell Death 1 Receptor 30%
  • Adenocarcinoma 24%
  • Antibodies 11%
  54 Scopus citations

• Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells

  Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Feb 15 2018, In: Prostate. 78, 3, p. 233-238 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere 100%
  • Stromal Cells 91%
  • Prostate 75%
  • Prostatic Neoplasms 72%
  • Smoking 65%
  2 Scopus citations

• Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

  Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C. L., Hruban, R. H., Ishii, M., Klein, A. P., Reh, D. D., Rooper, L. M., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K., & 5 othersAgrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In: Nature communications. 9, 1, 5410.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • deletion 92%
  • Dystrophin 82%
  • Nucleotide 54%
  • genes 51%
  • tumors 42%
  7 Scopus citations

• Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer

  Boudadi, K., Suzman, D. L., Anagnostou, V., Fu, W., Luber, B., Wang, H., Niknafs, N., White, J. R., Silberstein, J. L., Sullivan, R., Dowling, D., Harb, R., Nirschl, T. R., Veeneman, B. A., Tomlins, S. A., Wang, Y., Jendrisak, A., Graf, R. P., Dittamore, R., Carducci, M. A., & 8 othersEisenberger, M. A., Haffner, M. C., Meeker, A. K., Eshleman, J. R., Luo, J., Velculescu, V. E., Drake, C. G. & Antonarakis, E. S., Jun 19 2018, In: Oncotarget. 9, 47, p. 28561-28571 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ipilimumab 100%
  • Nivolumab 96%
  • DNA Repair 65%
  • Progression-Free Survival 64%
  • Prostatic Neoplasms 56%
  66 Scopus citations

• MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

  Baena-Del Valle, J. A., Zheng, Q., Esopi, D. M., Rubenstein, M., Hubbard, G. K., Moncaliano, M. C., Hruszkewycz, A., Vaghasia, A., Yegnasubramanian, S., Wheelan, S. J., Meeker, A. K., Heaphy, C. M., Graham, M. K. & De Marzo, A. M., Jan 2018, In: Journal of Pathology. 244, 1, p. 11-24 14 p.

  Research output: Contribution to journal › Article › peer-review

  • telomerase RNA 100%
  • Prostatic Neoplasms 54%
  • Telomerase 12%
  • Telomere 12%
  • Cell Line 10%
  24 Scopus citations

• PD-L1 expression in medulloblastoma: An evaluation by subgroup

  Martin, A. M., Nirschl, C. J., Polanczyk, M. J., Bell, W. R., Nirschl, T. R., Harris-Bookman, S., Phallen, J., Hicks, J., Martinez, D., Ogurtsova, A., Xu, H., Sullivan, L. M., Meeker, A. K., Raabe, E. H., Cohen, K. J., Eberhart, C. G., Burger, P. C., Santi, M., Taube, J. M., Pardoll, D. M., & 2 othersDrake, C. G. & Lim, M., Apr 10 2018, In: Oncotarget. 9, 27, p. 19177-19191 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Medulloblastoma 100%
  • Hedgehog Proteins 34%
  • Interferon-gamma 24%
  • Biomarkers 17%
  • Cell Line 16%
  14 Scopus citations

• Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations

  Weber, K. A., Heaphy, C. M., Joshu, C. E., Lu, J., Rohrmann, S., Bienstock, J. L., Agurs-Collins, T., Meeker, A. K. & Platz, E. A., Aug 1 2018, In: Cancer Causes and Control. 29, 8, p. 759-767 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere 100%
  • Fetal Blood 89%
  • Leukocytes 71%
  • Mothers 57%
  • European Continental Ancestry Group 31%
  3 Scopus citations

• TERT promoter mutations in solitary fibrous tumour

  Demicco, E. G., Wani, K., Ingram, D., Wagner, M., Maki, R. G., Rizzo, A., Meeker, A., Lazar, A. J. & Wang, W. L., Nov 2018, In: Histopathology. 73, 5, p. 843-851 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Solitary Fibrous Tumors 100%
  • Mutation 39%
  • Neoplasm Metastasis 13%
  • Neoplasms 10%
  • Necrosis 4%
  16 Scopus citations

• The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

  Diplas, B. H., He, X., Brosnan-Cashman, J. A., Liu, H., Chen, L. H., Wang, Z., Moure, C. J., Killela, P. J., Loriaux, D. B., Lipp, E. S., Greer, P. K., Yang, R., Rizzo, A. J., Rodriguez, F. J., Friedman, A. H., Friedman, H. S., Wang, S., He, Y., McLendon, R. E., Bigner, D. D., & 4 othersJiao, Y., Waitkus, M. S., Meeker, A. K. & Yan, H., Dec 1 2018, In: Nature communications. 9, 1, 2087.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • telomeres 100%
  • dehydrogenases 84%
  • Isocitrate Dehydrogenase 80%
  • Glioblastoma 58%
  • Telomere Homeostasis 58%
  50 Scopus citations

• Tumor-associated macrophages and the tumor immune microenvironment of primary and recurrent epithelial ovarian cancer

  Ojalvo, L. S., Thompson, E. D., Wang, T. L., Meeker, A. K., Shih, I. M., Fader, A. N., Cimino-Mathews, A. & Emens, L. A., Apr 2018, In: Human pathology. 74, p. 135-147 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Ovarian Epithelial Carcinoma 100%
  • Tumor Microenvironment 89%
  • Macrophages 60%
  • Neoplasms 27%
  • Recurrence 11%
  21 Scopus citations
• 2017

  Absence of cytomegalovirus in glioblastoma and other high-grade gliomas by real-time PCR, immunohistochemistry, and in situ hybridization

  Holdhoff, M., Guner, G., Rodriguez, F. J., Hicks, J. L., Zheng, Q., Forman, M. S., Ye, X., Grossman, S. A., Meeker, A. K., Heaphy, C. M., Eberhart, C. G., De Marzo, A. M. & Arav-Boger, R., Jun 15 2017, In: Clinical Cancer Research. 23, 12, p. 3150-3157 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytomegalovirus 100%
  • Glioblastoma 99%
  • Glioma 92%
  • In Situ Hybridization 91%
  • Real-Time Polymerase Chain Reaction 79%
  27 Scopus citations

• Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

  Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A. P., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A., Jinawath, A., Yeo, C. J., Eshleman, J. R., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S., May 1 2017, In: Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cadherins 100%
  • Adenocarcinoma 77%
  • Loss of Heterozygosity 42%
  • Pancreatic Neoplasms 23%
  • Chromosome Breakpoints 19%
  4 Scopus citations

• Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

  Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Mar 15 2017, In: Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Telomere Homeostasis 100%
  • Neuroendocrine Tumors 76%
  • Survival 37%
  • Neoplasm Metastasis 15%
  • X-linked Nuclear Protein 11%
  55 Scopus citations