Alan Keith Meeker

Associate Professor

1984 …2020

Research output per year

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Research Output

2020

High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer

Gorbounov, M., Carleton, N. M., Asch-Kendrick, R. J., Xian, L., Rooper, L., Chia, L., Cimino-Mathews, A., Cope, L., Meeker, A., Stearns, V., Veltri, R. W., Bae, Y. K. & Resar, L. M. S., Jan 1 2020, In : Breast Cancer Research and Treatment. 179, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

2019

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

Bell, W. R., Meeker, A. K., Rizzo, A., Rajpara, S., Rosenthal, I. M., Flores Bellver, M., Aparicio Domingo, S., Zhong, X., Barber, J. R., Joshu, C. E., Canto-Soler, M. V., Eberhart, C. G. & Heaphy, C. M., Jan 1 2019, In : Brain Pathology. 29, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N. J., London, N. R., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access

Functional loss of ATRX and TERC activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells

Graham, M. K., Kim, J., Da, J., Brosnan-Cashman, J. A., Rizzo, A., Del Valle, J. A. B., Chia, L., Rubenstein, M., Davis, C., Zheng, Q., Cope, L., Considine, M., Haffner, M. C., De Marzo, A. M., Meeker, A. K. & Heaphy, C. M., Jan 1 2019, In : Molecular Cancer Research. 17, 12, p. 2480-2491 12 p.

Research output: Contribution to journalArticle

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Núñez, F. J., Mendez, F. M., Kadiyala, P., Alghamri, M. S., Savelieff, M. G., Garcia-Fabiani, M. B., Haase, S., Koschmann, C., Calinescu, A. A., Kamran, N., Saxena, M., Patel, R., Carney, S., Guo, M. Z., Edwards, M., Ljungman, M., Qin, T., Sartor, M. A., Tagett, R., Venneti, S. & 15 others, Brosnan-Cashman, J., Meeker, A., Gorbunova, V., Zhao, L., Kremer, D. M., Zhang, L., Lyssiotis, C. A., Jones, L., Herting, C. J., Ross, J. L., Hambardzumyan, D., Hervey-Jumper, S., Figueroa, M. E., Lowenstein, P. R. & Castro, M. G., Feb 13 2019, In : Science translational medicine. 11, 479, eaaq1427.

Research output: Contribution to journalArticle

Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities

Trabzonlu, L., Kulac, I., Zheng, Q., Hicks, J. L., Haffner, M. C., Nelson, W. G., Sfanos, K., Ertunc, O., Lotan, T., Heaphy, C. M., Meeker, A. K., Yegnasubramanian, S. & Demarzo, A. M., Apr 1 2019, In : Cold Spring Harbor Perspectives in Medicine. 9, 4

Research output: Contribution to journalReview article

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

Amano, H., Chaudhury, A., Rodriguez-Aguayo, C., Lu, L., Akhanov, V., Catic, A., Popov, Y. V., Verdin, E., Johnson, H., Stossi, F., Sinclair, D. A., Nakamaru-Ogiso, E., Lopez-Berestein, G., Chang, J. T., Neilson, J. R., Meeker, A. K., Finegold, M., Baur, J. A. & Sahin, E., Jun 4 2019, In : Cell Metabolism. 29, 6, p. 1274-1290.e9

Research output: Contribution to journalArticle

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Krueger, T. E., Thorek, D. L. J., Meeker, A. K., Isaacs, J. T. & Brennen, W. N., Feb 15 2019, In : Prostate. 79, 3, p. 320-330 11 p.

Research output: Contribution to journalArticle

2018

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner

Brosnan-Cashman, J. A., Yuan, M., Graham, M. K., Rizzo, A. J., Myers, K. M., Davis, C., Zhang, R., Esopi, D. M., Raabe, E., Eberhart, C. G., Heaphy, C. M. & Meeker, A. K., Sep 1 2018, In : PLoS One. 13, 9, e0204159.

Research output: Contribution to journalArticle

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer

Haffner, M. C., Guner, G., Taheri, D., Netto, G. J., Palsgrove, D. N., Zheng, Q., Guedes, L. B., Kim, K., Tsai, H., Esopi, D. M., Lotan, T., Sharma, R., Meeker, A. K., Chinnaiyan, A. M., Nelson, W. G., Yegnasubramanian, S., Luo, J., Mehra, R., Antonarakis, E., Drake, C. G. & 1 others, Demarzo, A. M., Jun 1 2018, In : American Journal of Pathology. 188, 6, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells

Joshu, C. E., Peskoe, S. B., Heaphy, C. M., Kenfield, S. A., Mucci, L. A., Giovannucci, E. L., Stampfer, M. J., Yoon, G., Lee, T. K., Hicks, J. L., De Marzo, A. M., Meeker, A. K. & Platz, E. A., Feb 15 2018, In : Prostate. 78, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Gallia, G. L., Zhang, M., Ning, Y., Haffner, M. C., Batista, D., Binder, Z. A., Bishop, J. A., Hann, C., Hruban, R. H., Ishii, M., Klein, A., Reh, D. D., Rooper, L., Salmasi, V., Tamargo, R. J., Wang, Q., Williamson, T., Zhao, T., Zou, Y., Meeker, A. K. & 5 others, Agrawal, N., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Bettegowda, C., Dec 1 2018, In : Nature Communications. 9, 1, 5410.

Research output: Contribution to journalArticle

Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer

Boudadi, K., Suzman, D. L., Anagnostou, V., Fu, W., Luber, B., Wang, H., Niknafs, N., White, J. R., Silberstein, J. L., Sullivan, R., Dowling, D., Harb, R., Nirschl, T. R., Veeneman, B. A., Tomlins, S. A., Wang, Y., Jendrisak, A., Graf, R. P., Dittamore, R., Carducci, M. A. & 8 others, Eisenberger, M. A., Haffner, M. C., Meeker, A. K., Eshleman, J. R., Luo, J., Velculescu, V. E., Drake, C. G. & Antonarakis, E. S., Jun 19 2018, In : Oncotarget. 9, 47, p. 28561-28571 11 p.

Research output: Contribution to journalArticle

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer

Baena-Del Valle, J. A., Zheng, Q., Esopi, D. M., Rubenstein, M., Hubbard, G. K., Moncaliano, M. C., Hruszkewycz, A., Vaghasia, A., Yegnasubramanian, S., Wheelan, S., Meeker, A. K., Heaphy, C. M., Graham, M. K. & Demarzo, A. M., Jan 1 2018, In : Journal of Pathology. 244, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

PD-L1 expression in medulloblastoma: An evaluation by subgroup

Martin, A. M., Nirschl, C. J., Polanczyk, M. J., Bell, W. R., Nirschl, T. R., Harris-Bookman, S., Phallen, J., Hicks, J., Martinez, D., Ogurtsova, A., Xu, H., Sullivan, L. M., Meeker, A. K., Raabe, E. H., Cohen, K. J., Eberhart, C. G., Burger, P. C., Santi, M., Taube, J. M., Pardoll, D. M. & 2 others, Drake, C. G. & Lim, M., Apr 10 2018, In : Oncotarget. 9, 27, p. 19177-19191 15 p.

Research output: Contribution to journalArticle

Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations

Weber, K. A., Heaphy, C. M., Joshu, C. E., Lu, J., Rohrmann, S., Bienstock, J. L., Agurs-Collins, T., Meeker, A. K. & Platz, E. A., Aug 1 2018, In : Cancer Causes and Control. 29, 8, p. 759-767 9 p.

Research output: Contribution to journalArticle

TERT promoter mutations in solitary fibrous tumour

Demicco, E. G., Wani, K., Ingram, D., Wagner, M., Maki, R. G., Rizzo, A., Meeker, A. K., Lazar, A. J. & Wang, W. L., Jan 1 2018, (Accepted/In press) In : Histopathology.

Research output: Contribution to journalArticle

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

Diplas, B. H., He, X., Brosnan-Cashman, J. A., Liu, H., Chen, L. H., Wang, Z., Moure, C. J., Killela, P. J., Loriaux, D. B., Lipp, E. S., Greer, P. K., Yang, R., Rizzo, A. J., Rodriguez, F. J., Friedman, A. H., Friedman, H. S., Wang, S., He, Y., McLendon, R. E., Bigner, D. D. & 4 others, Jiao, Y., Waitkus, M. S., Meeker, A. K. & Yan, H., Dec 1 2018, In : Nature Communications. 9, 1, 2087.

Research output: Contribution to journalArticle

2017

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A. K., Jinawath, A., Yeo, C. J., Eshleman, J., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S., May 1 2017, In : Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

Research output: Contribution to journalArticle

Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M., Mar 15 2017, In : Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

Differential long-term stability of microRNAs and RNU6B snRNA in 12-20 year old archived formalin-fixed paraffin-embedded specimens

Peskoe, S. B., Barber, J. R., Zheng, Q., Meeker, A. K., De Marzo, A. M., Platz, E. A. & Lupold, S. E., Jan 6 2017, In : BMC cancer. 17, 1, 32.

Research output: Contribution to journalArticle

Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH

Sharifi-Sanjani, M., Meeker, A. K. & Mourkioti, F., Sep 1 2017, In : Nature Protocols. 12, 9, p. 1855-1870 16 p.

Research output: Contribution to journalArticle

Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm with Features Distinct from Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Boyer, D. F., McKelvie, P. A., De Leval, L., Edlefsen, K. L., Ko, Y. H., Aberman, Z. A., Kovach, A. E., Masih, A., Nishino, H. T., Weiss, L. M., Meeker, A. K., Nardi, V., Palisoc, M., Shao, L., Pittaluga, S., Ferry, J. A., Harris, N. L. & Sohani, A. R., Jan 1 2017, In : American Journal of Surgical Pathology. 41, 3, p. 299-312 14 p.

Research output: Contribution to journalArticle

Immune-checkpoint status in penile squamous cell carcinoma: a North American cohort

Cocks, M., Taheri, D., Ball, M. W., Bezerra, S. M., Del Carmen Rodriguez, M., Ricardo, B. F. P., Bivalacqua, T., Sharma, R. B., Meeker, A. K., Chaux, A., Burnett, A. & Netto, G. J., Jan 1 2017, In : Human Pathology. 59, p. 55-61 7 p.

Research output: Contribution to journalArticle

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate

Brennen, W. N., Zhang, B., Kulac, I., Kisteman, L. N., Antony, L., Wang, H., Meeker, A. K., De Marzo, A. M., Garraway, I. P., Denmeade, S. R. & Isaacs, J. T., Jan 1 2017, In : Oncotarget. 8, 29, p. 46710-46727 18 p.

Research output: Contribution to journalArticle

Mutated chromatin regulatory factors as tumor drivers in cancer

Koschmann, C., Nunez, F. J., Mendez, F., Brosnan-Cashman, J. A., Meeker, A. K., Lowenstein, P. R. & Castro, M. G., Jan 15 2017, In : Cancer Research. 77, 2, p. 227-233 7 p.

Research output: Contribution to journalReview article

PD-L1 expression and the immune microenvironment in primary invasive lobular carcinomas of the breast

Thompson, E., Taube, J. M., Asch-Kendrick, R. J., Ogurtsova, A., Xu, H., Sharma, R., Meeker, A. K., Argani, P., Emens, L. A. & Cimino-Mathews, A. M., Nov 1 2017, In : Modern Pathology. 30, 11, p. 1551-1560 10 p.

Research output: Contribution to journalArticle

Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment

Muroyama, Y., Nirschl, T. R., Kochel, C. M., Lopez-Bujanda, Z., Theodros, D., Mao, W., Carrera-Haro, M. A., Ghasemzadeh, A., Marciscano, A. E., Velarde, E., Tam, A. J., Thoburn, C. J., Uddin, M., Meeker, A. K., Anders, R. A., Pardoll, A. M. & Drake, C. G., Nov 1 2017, In : Cancer immunology research. 5, 11, p. 992-1004 13 p.

Research output: Contribution to journalArticle

Telomeres and telomerase in prostate cancer development and therapy

Graham, M. K. & Meeker, A. K., Oct 1 2017, In : Nature Reviews Urology. 14, 10, p. 607-619 13 p.

Research output: Contribution to journalReview article

Th17 immune microenvironment in Epstein-Barr virus-negative Hodgkin lymphoma: Implications for immunotherapy

Duffield, A. S., Ascierto, M. L., Anders, R. A., Taube, J. M., Meeker, A. K., Chen, S., McMiller, T. L., Phillips, N. A., Xu, H., Ogurtsova, A., Berger, A. E., Pardoll, D. M., Topalian, S. L. & Ambinder, R. F., Jul 25 2017, In : Blood Advances. 1, 17, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

Open Access
2016

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

Hackeng, W. M., Brosens, L. A. A., Poruk, K. E., Noë, M., Hosoda, W., Poling, J. S., Rizzo, A., Campbell-Thompson, M., Atkinson, M. A., Konukiewitz, B., Klöppel, G., Heaphy, C. M., Meeker, A. K. & Wood, L. D., Oct 1 2016, In : Human Pathology. 56, p. 93-100 8 p.

Research output: Contribution to journalArticle

Analysis of potential response predictors to capecitabine/temozolomide in metastatic pancreatic neuroendocrine tumors

Cives, M., Ghayouri, M., Morse, B., Brelsford, M., Black, M., Rizzo, A., Meeker, A. K. & Strosberg, J., 2016, In : Endocrine-Related Cancer. 23, 9, p. 759-767 9 p.

Research output: Contribution to journalArticle

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

Koschmann, C., Calinescu, A. A., Nunez, F. J., Mackay, A., Fazal-Salom, J., Thomas, D., Mendez, F., Kamran, N., Dzaman, M., Mulpuri, L., Krasinkiewicz, J., Doherty, R., Lemons, R., Brosnan-Cashman, J. A., Li, Y., Roh, S., Zhao, L., Appelman, H., Ferguson, D., Gorbunova, V. & 4 others, Meeker, A., Jones, C., Lowenstein, P. R. & Castro, M. G., Mar 2 2016, In : Science translational medicine. 8, 328, 328ra28.

Research output: Contribution to journalArticle

Development and application of a novel model system to study "active" and "passive" tumor targeting

Mukherjee, A., Kumar, B., Hatano, K., Russell, L. M., Trock, B. J., Searson, P. C., Meeker, A. K., Pomper, M. G. & Lupold, S. E., Oct 2016, In : Molecular cancer therapeutics. 15, 10, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

High-resolution telomere fluorescence in situ hybridization reveals intriguing anomalies in germ cell tumors

Shekhani, M. T., Barber, J. R., Bezerra, S. M., Heaphy, C. M., Gonzalez Roibon, N. D., Taheri, D., Reis, L. O., Guner, G., Joshu, C. E., Netto, G. J. & Meeker, A. K., Aug 1 2016, In : Human Pathology. 54, p. 106-112 7 p.

Research output: Contribution to journalArticle

Inactivating ARID1A tumor suppressor enhances TERT transcription and maintains telomere length in cancer cells

Rahmanto, Y. S., Jung, J. G., Wu, R. C., Kobayashi, Y., Heaphy, C. M., Meeker, A. K., Wang, T. L. & Shih, I. M., Jan 1 2016, In : Journal of Biological Chemistry. 291, 18, p. 9690-9699 10 p.

Research output: Contribution to journalArticle

Influence of in Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?

Weber, K. A., Heaphy, C. M., Rohrmann, S., Gonzalez, B., Bienstock, J. L., Agurs-Collins, T., Platz, E. A. & Meeker, A. K., 2016, In : Prostate Cancer. 2016, 3691650.

Research output: Contribution to journalArticle

Low p16INK4a Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone

Graham, M. K., Principessa, L., Antony, L., Meeker, A. K. & Isaacs, J. T., 2016, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

MUC1-ARF - A novel MUC1 protein that resides in the nucleus and is expressed by alternate reading frame translation of MUC1 mRNA

Chalick, M., Jacobi, O., Pichinuk, E., Garbar, C., Bensussan, A., Meeker, A. K., Ziv, R., Zehavi, T., Smorodinsky, N. I., Hilkens, J., Hanisch, F. G., Rubinstein, D. B. & Wreschner, D. H., Oct 1 2016, In : PLoS One. 11, 10, e0165031.

Research output: Contribution to journalArticle

PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas

Cimino-Mathews, A., Thompson, E., Taube, J. M., Ye, X., Lu, Y., Meeker, A., Xu, H., Sharma, R., Lecksell, K., Cornish, T. C., Cuka, N., Argani, P. & Emens, L. A., Jan 1 2016, In : Human pathology. 47, 1, p. 52-63 12 p.

Research output: Contribution to journalArticle

The immune microenvironment of breast ductal carcinoma in situ

Thompson, E., Taube, J. M., Elwood, H., Sharma, R., Meeker, A., Warzecha, H. N., Argani, P., Cimino-Mathews, A. & Emens, L. A., Mar 1 2016, In : Modern Pathology. 29, 3, p. 249-258 10 p.

Research output: Contribution to journalArticle

2015

A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres

Borodovsky, A., Meeker, A. K., Kirkness, E. F., Zhao, Q., Eberhart, C. G., Gallia, G. L. & Riggins, G. J., Jan 1 2015, In : Journal of neuro-oncology. 121, 3, p. 479-487 9 p.

Research output: Contribution to journalArticle

Assessment of tumoral PD-L1 expression and intratumoral CD8+ T cells in urothelial carcinoma

Faraj, S. F., Munari, E., Guner, G., Taube, J. M., Anders, R. A., Hicks, J., Meeker, A. K., Schoenberg, M., Bivalacqua, T., Drake, C. & Netto, G. J., Mar 1 2015, In : Urology. 85, 3

Research output: Contribution to journalArticle

Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer

Julin, B., Shui, I., Heaphy, C. M., Joshu, C. E., Meeker, A. K., Giovannucci, E., De Vivo, I. & Platz, E. A., Feb 17 2015, In : British journal of cancer. 112, 4, p. 769-776 8 p.

Research output: Contribution to journalArticle