Akhil Maheshwari

Professor

19992020

Research output per year

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Research Output

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2020

Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction

Whitehead, H. V., Vesoulis, Z. A., Maheshwari, A., Rambhia, A. & Mathur, A. M., Jan 2020, In : Early Human Development. 140, 104891.

Research output: Contribution to journalArticle

2019

A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions

MohanKumar, K., Namachivayam, K., Song, T., Jake Cha, B., Slate, A., Hendrickson, J. E., Pan, H., Wickline, S. A., Oh, J. Y., Patel, R. P., He, L., Torres, B. A. & Maheshwari, A., Dec 1 2019, In : Nature communications. 10, 1, 3494.

Research output: Contribution to journalArticle

Open Access

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F. E., O'Rourke, B. & He, L., Nov 5 2019, In : Cell Reports. 29, 6, p. 1511-1523.e5

Research output: Contribution to journalArticle

Open Access

Platelet transfusions and mortality in necrotizing enterocolitis

Patel, R. M., Josephson, C. D., Shenvi, N., Maheshwari, A., Easley, K. A., Stowell, S., Sola-Visner, M. & Ferrer-Marin, F., Jan 1 2019, (Accepted/In press) In : Transfusion.

Research output: Contribution to journalArticle

2018

Anemia, red blood cell transfusions, and necrotizing enterocolitis

Maheshwari, A., Patel, R. M. & Christensen, R. D., Feb 1 2018, In : Seminars in Pediatric Surgery. 27, 1, p. 47-51 5 p.

Research output: Contribution to journalArticle

Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised?

Whitehead, H. V., Vesoulis, Z. A., Maheshwari, A., Rao, R. & Mathur, A. M., May 8 2018, (Accepted/In press) In : Journal of Perinatology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Changing the paradigm of defining, detecting, and diagnosing NEC: Perspectives on Bell's stages and biomarkers for NEC

Gephart, S. M., Gordon, P. V., Penn, A. H., Gregory, K. E., Swanson, J. R., Maheshwari, A. & Sylvester, K., Feb 1 2018, In : Seminars in Pediatric Surgery. 27, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Dichotomous development of the gut microbiome in preterm infants

Ho, T. T. B., Groer, M. W., Kane, B., Yee, A. L., Torres, B. A., Gilbert, J. A. & Maheshwari, A., Sep 12 2018, In : Microbiome. 6, 1, 157.

Research output: Contribution to journalArticle

Enteric dysbiosis and fecal calprotectin expression in premature infants

Ho, T. T. B., Groer, M. W., Kane, B., Yee, A. L., Torres, B. A., Gilbert, J. A. & Maheshwari, A., Jan 1 2018, (Accepted/In press) In : Pediatric Research.

Research output: Contribution to journalArticle

Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats

Satrom, K. M., Ennis, K., Sweis, B. M., Matveeva, T. M., Chen, J., Hanson, L., Maheshwari, A. & Rao, R., Mar 15 2018, In : Journal of Neuroinflammation. 15, 1, 82.

Research output: Contribution to journalArticle

Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8

Jilling, T., Ambalavanan, N., Cotten, C. M., Martin, C. A., Maheshwari, A., Schibler, K., Levy, J. & Page, G. P., May 1 2018, In : Pediatric Research. 83, 5, p. 943-953 11 p.

Research output: Contribution to journalArticle

2017

Neonatal mice with necrotizing enterocolitis-like injury develop thrombocytopenia despite increased megakaryopoiesis

Namachivayam, K., Krishnan, M., Garg, L., Torres, B. A. & Maheshwari, A., May 1 2017, In : Pediatric Research. 81, 5, p. 817-824 8 p.

Research output: Contribution to journalArticle

Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis

Krishnan, M., Namachivayam, K., Cheng, F., Jiang, R. H. Y., Flores-Torres, J., Torres, B. A. & Maheshwari, A., Jan 1 2017, In : Pediatric Research. 81, 1, p. 99-112 14 p.

Research output: Contribution to journalArticle

2016

Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis

Krishnan, M., Namachivayam, K., Chapalamadugu, K. C., Garzon, S. A., Premkumar, M. H., Tipparaju, S. M. & Maheshwari, A., Jun 1 2016, In : Pediatric Research. 79, 6, p. 951-961 11 p.

Research output: Contribution to journalArticle

Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: Formulating supportive departmental policies

Christou, H., Dizon, M. L. V., Farrow, K. N., Jadcherla, S. R., Leeman, K. T., Maheshwari, A., Rubin, L. P., Stansfield, B. K. & Rowitch, D. H., Nov 1 2016, In : Pediatric Research. 80, 5, p. 635-640 6 p.

Research output: Contribution to journalArticle

2015

All-trans retinoic acid induces TGF-β2 in intestinal epithelial cells via RhoA- and p38α MAPK-mediated activation of the transcription factor ATF2

Namachivayam, K., MohanKumar, K., Arbach, D., Jagadeeswaran, R., Jain, S. K., Natarajan, V., Mehta, D., Jankov, R. P. & Maheshwari, A., Jul 30 2015, In : PloS one. 10, 7, 134003.

Research output: Contribution to journalArticle

Depth of bacterial invasion in resected intestinal tissue predicts mortality in surgical necrotizing enterocolitis

Remon, J. I., Amin, S. C., Mehendale, S. R., Rao, R., Luciano, A. A., Garzon, S. A. & Maheshwari, A., Sep 28 2015, In : Journal of Perinatology. 35, 9, p. 755-762 8 p.

Research output: Contribution to journalArticle

Guidelines: An Exploration and Discussion

Pappas, C., Schwartz, A. & Maheshwari, A., Apr 3 2015, In : Journal of Hospital Librarianship. 15, 2, p. 161-174 14 p.

Research output: Contribution to journalArticle

Red blood cell transfusions increase fecal calprotectin levels in premature infants

Ho, T. T. B., Groer, M. W., Luciano, A. A., Schwartz, A., Ji, M., Miladinovic, B. S., Maheshwari, A. & Ashmeade, T. L., Oct 1 2015, In : Journal of Perinatology. 35, 10, p. 837-841 5 p.

Research output: Contribution to journalArticle

Transforming growth factor–β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycans

Namachivayam, K., Coffing, H. P., Sankaranarayanan, N. V., Jin, Y., Mohankumar, K., Frost, B. L., Blanco, C. L., Patel, A. L., Meier, P. P., Garzon, S. A., Desai, U. R. & Maheshwari, A., Aug 5 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 3, p. G171-G180

Research output: Contribution to journalArticle

VEGF mRNA and protein concentrations in the developing human eye

Ma, I. T., McConaghy, S., Namachivayam, K., Halloran, B. A., Kurundkar, A. R., Mohankumar, K., Maheshwari, A. & Ohls, R. K., Apr 19 2015, In : Pediatric research. 77, 4, p. 500-505 6 p.

Research output: Contribution to journalArticle

2014

Amniotic fluid-borne hepatocyte growth factor protects rat pups against experimental necrotizing enterocolitis

Jain, S. K., Baggerman, E. W., MohanKumar, K., Namachivayam, K., Jagadeeswaran, R., Reyes, V. E. & Maheshwari, A., Mar 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 5, p. G361-G369

Research output: Contribution to journalArticle

Cytokines associated with necrotizing enterocolitis in extremely-low-birth- weight infants

Maheshwari, A., Schelonka, R. L., Dimmitt, R. A., Carlo, W. A., Munoz-Hernandez, B., Das, A., McDonald, S. A., Thorsen, P., Skogstrand, K., Hougaard, D. M. & Higgins, R. D., Jul 2014, In : Pediatric research. 76, 1, p. 100-108 9 p.

Research output: Contribution to journalArticle

Intestinal epithelial apoptosis initiates gut mucosal injury during extracorporeal membrane oxygenation in the newborn piglet

Mohankumar, K., Killingsworth, C. R., Britt McIlwain, R., Timpa, J. G., Jagadeeswaran, R., Namachivayam, K., Kurundkar, A. R., Kelly, D. R., Garzon, S. A. & Maheshwari, A., Feb 1 2014, In : Laboratory Investigation. 94, 2, p. 150-160 11 p.

Research output: Contribution to journalArticle

Maternal breast milk transforming growth factor-beta and feeding intolerance in preterm infants

Frost, B. L., Jilling, T., Lapin, B., Maheshwari, A. & Caplan, M. S., Oct 1 2014, In : Pediatric Research. 76, 4, p. 386-393 8 p.

Research output: Contribution to journalArticle

The relationship between reticulated platelets, intestinal alkaline phosphatase, and necrotizing enterocolitis

Kampanatkosol, R., Thomson, T., Habeeb, O., Glynn, L., Dechristopher, P. J., Yong, S., Jeske, W., Maheshwari, A. & Muraskas, J., Feb 1 2014, In : Journal of pediatric surgery. 49, 2, p. 273-276 4 p.

Research output: Contribution to journalArticle

2013

Preterm human milk contains a large pool of latent TGF-β, which can be activated by exogenous neuraminidase

Namachivayam, K., Blanco, C. L., Frost, B. L., Reeves, A. A., Jagadeeswaran, R., Mohankumar, K., Safarulla, A., Mandal, P., Garzon, S. A., Raj, J. U. & Maheshwari, A., Jun 16 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12, p. G1055-G1065

Research output: Contribution to journalArticle

Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis

Namachivayam, K., Blanco, C. L., Mohankumar, K., Jagadeeswaran, R., Vasquez, M., Mcgill-Vargas, L., Garzon, S. A., Jain, S. K., Gill, R. K., Freitag, N. E., Weitkamp, J. H., Seidner, S. R. & Maheshwari, A., Jan 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 2, p. G167-G180

Research output: Contribution to journalArticle

TGF-β2, a protective intestinal cytokine, is abundant in maternal human milk and human-derived fortifiers but not in donor human milk

Reeves, A. A., Johnson, M. C., Vasquez, M. M., Maheshwari, A. & Blanco, C. L., Dec 1 2013, In : Breastfeeding Medicine. 8, 6, p. 496-502 7 p.

Research output: Contribution to journalArticle

The many faces of B Cells: From generation of antibodies to immune regulation

Schelonka, R. L. & Maheshwari, A., Sep 1 2013, In : NeoReviews. 14, 9, p. e438-e447

Research output: Contribution to journalArticle

2012

Absence of gastrointestinal pathogens in ileum tissue resected for necrotizing enterocolitis

Ullrich, T., Tang, Y. W., Correa, H., Garzon, S. A., Maheshwari, A., Hill, M., Matta, P., Krishnan, M. K. & Weitkamp, J. H., Apr 1 2012, In : Pediatric Infectious Disease Journal. 31, 4, p. 413-414 2 p.

Research output: Contribution to journalArticle

Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells

Sawant, A., Hensel, J. A., Chanda, D., Harris, B. A., Siegal, G. P., Maheshwari, A. & Ponnazhagan, S., Nov 1 2012, In : Journal of Immunology. 189, 9, p. 4258-4265 8 p.

Research output: Contribution to journalArticle

Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: Evidence from an animal model

MohanKumar, K., Kaza, N., Jagadeeswaran, R., Garzon, S. A., Bansal, A., Kurundkar, A. R., Namachivayam, K., Remon, J. I., Rekha Bandepalli, C., Feng, X., Weitkamp, J. H. & Maheshwari, A., Jul 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 1, p. G93-G102

Research output: Contribution to journalArticle

Haematological abnormalities in neonatal necrotizing enterocolitis

Song, R., Subbarao, G. C. & Maheshwari, A., Oct 1 2012, In : Journal of Maternal-Fetal and Neonatal Medicine. 25, SUPPL.4, p. 14-17 4 p.

Research output: Contribution to journalArticle

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function

Patel, R. M., Myers, L. S., Kurundkar, A. R., Maheshwari, A., Nusrat, A. & Lin, P. W., Feb 1 2012, In : American Journal of Pathology. 180, 2, p. 626-635 10 p.

Research output: Contribution to journalArticle

The role of CX3CL1/CX3CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental hepatopulmonary syndrome

Zhang, J., Yang, W., Luo, B., Hu, B., Maheshwari, A. & Fallon, M. B., Oct 2012, In : Journal of Hepatology. 57, 4, p. 752-758 7 p.

Research output: Contribution to journalArticle

2011

Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling

Honavar, J., Samal, A. A., Bradley, K. M., Brandon, A., Balanay, J., Squadrito, G. L., MohanKumar, K., Maheshwari, A., Postlethwait, E. M., Matalon, S. & Patel, R. P., Aug 1 2011, In : American journal of respiratory cell and molecular biology. 45, 2, p. 419-425 7 p.

Research output: Contribution to journalArticle

Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: Role of TGFβ signaling pathway

Walsh, S. B., Xu, J., Xu, H., Kurundkar, A. R., Maheshwari, A., Grizzle, W. E., Timares, L., Huang, C. C., Kopelovich, L., Elmets, C. A. & Athar, M., Jul 1 2011, In : Molecular Carcinogenesis. 50, 7, p. 516-527 12 p.

Research output: Contribution to journalArticle

T cell cytokines and the risk of blood stream infection in extremely low birth weight infants

Schelonka, R. L., Maheshwari, A., Carlo, W. A., Taylor, S., Hansen, N. I., Schendel, D. E., Thorsen, P., Skogstrand, K., Hougaard, D. M. & Higgins, R. D., Feb 1 2011, In : Cytokine. 53, 2, p. 249-255 7 p.

Research output: Contribution to journalArticle

TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine

Maheshwari, A., Kelly, D. R., Nicola, T., Ambalavanan, N., Jain, S. K., Murphyullrich, J., Athar, M., Shimamura, M., Bhandari, V., Aprahamian, C., Dimmitt, R. A., Serra, R. & Ohls, R. K., Jan 2011, In : Gastroenterology. 140, 1, p. 242-253 12 p.

Research output: Contribution to journalArticle

2010

Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages

Smythies, L. E., Roger White, C., Maheshwari, A., Palgunachari, M. N., Anantharamaiah, G. M., Chaddha, M., Kurundkar, A. R. & Datta, G., Jun 1 2010, In : American Journal of Physiology - Cell Physiology. 298, 6, p. C1538-C1548

Research output: Contribution to journalArticle

Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs

Stoll, B., Horst, D. A., Cui, L., Chang, X., Ellis, K. J., Hadsell, D. L., Suryawan, A., Kurundkar, A., Maheshwari, A., Davis, T. A. & Burrin, D. G., Dec 1 2010, In : Journal of Nutrition. 140, 12, p. 2193-2200 8 p.

Research output: Contribution to journalArticle

Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants?

Josephson, C. D., Wesolowski, A., Bao, G., Sola-Visner, M. C., Dudell, G., Castillejo, M. I., Shaz, B. H., Easley, K. A., Hillyer, C. D. & Maheshwari, A., Dec 2010, In : Journal of Pediatrics. 157, 6, p. 972-978.e3

Research output: Contribution to journalArticle

Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis

Maynard, A. A., Dvorak, K., Khailova, L., Dobrenen, H., Arganbright, K. M., Halpern, M. D., Kurundkar, A. R., Maheshwari, A. & Dvorak, B., Sep 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 3, p. G614-G622

Research output: Contribution to journalArticle

Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet

Kurundkar, A. R., Killingsworth, C. R., McIlwain, R. B., Timpa, J. G., Hartman, Y. E., He, D., Karnatak, R. K., Neel, M. L., Clancy, J. P., Anantharamaiah, G. M. & Maheshwari, A., Aug 2010, In : Pediatric research. 68, 2, p. 128-133 6 p.

Research output: Contribution to journalArticle

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine

McIlwain, R. B., Timpa, J. G., Kurundkar, A. R., Holt, D. W., Kelly, D. R., Hartman, Y. E., Neel, M. L., Karnatak, R. K., Schelonka, R. L., Anantharamaiah, G. M., Killingsworth, C. R. & Maheshwari, A., Jan 1 2010, In : Laboratory Investigation. 90, 1, p. 128-139 12 p.

Research output: Contribution to journalArticle

Reference ranges for blood concentrations of eosinophils and monocytes during the neonatal period defined from over 63 000 records in a multihospital health-care system

Christensen, R. D., Jensen, J., Maheshwari, A. & Henry, E., Aug 1 2010, In : Journal of Perinatology. 30, 8, p. 540-545 6 p.

Research output: Contribution to journalArticle

2009

Developmental changes in circulating IL-8/CXCL8 isoforms in neonates

Maheshwari, A., Voitenok, N. N., Akalovich, S., Shaik, S. S., Randolph, D. A., Sims, B., Patel, R. P., Killingsworth, C. R., Fallon, M. B. & Ohls, R. K., Apr 2009, In : Cytokine. 46, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

Epithelial cells in fetal intestine produce chemerin to recruit macrophages

Maheshwari, A., Kurundkar, A. R., Shaik, S. S., Kelly, D. R., Hartman, Y., Zhang, W., Dimmitt, R., Saeed, S., Randolph, D. A., Aprahamian, C., Datta, G. & Ohls, R. K., Jul 1 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 297, 1, p. G1-G10

Research output: Contribution to journalArticle

Immune-mediated neutropenia in the neonate

Vandy Black, L. & Maheshwari, A., Dec 1 2009, In : NeoReviews. 10, 9, p. e446-e453

Research output: Contribution to journalArticle