Abhay R Moghekar

Associate Professor

20022019
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Research Output 2002 2019

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2019

ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes

Soldan, A., Pettigrew, C., Fagan, A. M., Schindler, S. E., Moghekar, A. R., Fowler, C., Li, Q. X., Collins, S. J., Carlsson, C., Asthana, S., Masters, C. L., Johnson, S., Morris, J. C., Albert, M. & Gross, A. L., Apr 2 2019, In : Neurology. 92, 14, p. e1567-e1579

Research output: Contribution to journalArticle

Amyloid
Biomarkers
National Institute on Aging (U.S.)
Neurofibrillary Tangles
Cognition

Brain oxygen extraction by using MRI in older individuals: Relationship to apolipoprotein e genotype and amyloid burden

Lin, Z., Sur, S., Soldan, A., Pettigrew, C., Miller, M., Oishi, K., Bilgel, M., Moghekar, A. R., Pillai, J., Albert, M. & Lu, H., Jan 1 2019, In : Radiology. 292, 1, p. 140-148 9 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Apolipoproteins
Amyloid
Genotype
Oxygen

Identifying changepoints in biomarkers during the preclinical phase of Alzheimer's disease

Younes, L., Albert, M., Moghekar, A. R., Soldan, A., Pettigrew, C. & Miller, M. I., Jan 1 2019, In : Frontiers in Aging Neuroscience. 11, APR, 74.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
Magnetic Resonance Imaging
Temporal Lobe
Open Access
Receptors, Tumor Necrosis Factor, Type I
Inflammation
Adaptive Immunity
Interleukin-6
Cognitive Dysfunction

Quantitative Proteomic Profiling of Cerebrospinal Fluid to Identify Candidate Biomarkers for Alzheimer's Disease

Sathe, G., Na, C-H., Renuse, S., Madugundu, A. K., Albert, M., Moghekar, A. R. & Pandey, A., Jan 1 2019, (Accepted/In press) In : Proteomics - Clinical Applications. 1800105.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Biomarkers
Proteomics
Cerebrospinal Fluid
Alzheimer Disease
Cerebrospinal Fluid
Proteins
Executive Function
Cognition
Cognitive Reserve

Tau pathology in cognitively normal older adults

Ziontz, J., Bilgel, M., Shafer, A. T., Moghekar, A. R., Elkins, W., Helphrey, J., Gomez, G., June, D., McDonald, M. A., Dannals, R. F., Behnam Azad, B., Ferrucci, L., Wong, D. F. & Resnick, S. M., Dec 1 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 637-645 9 p.

Research output: Contribution to journalArticle

Open Access
Amyloid
Pathology
Positron-Emission Tomography
Alzheimer Disease
Brain

The Occipital Emissary Vein: A Possible Marker for Pseudotumor Cerebri

Hedjoudje, A., Piveteau, A., Gonzalez-Campo, C., Moghekar, A. R., Gailloud, P. & San Millán, D., Jun 1 2019, In : AJNR. American journal of neuroradiology. 40, 6, p. 973-978 6 p.

Research output: Contribution to journalArticle

Pseudotumor Cerebri
Veins
Transverse Sinuses
Stents
Healthy Volunteers
2018

Does Phase-Contrast Imaging through the Cerebral Aqueduct Predict the Outcome of Lumbar CSF Drainage or Shunt Surgery in Patients with Suspected Adult Hydrocephalus?

Blitz, A. M., Shin, J., Balédent, O., Pagé, G., Bonham, L. W., Herzka, D., Moghekar, A. R. & Rigamonti, D., Dec 1 2018, In : AJNR. American journal of neuroradiology. 39, 12, p. 2224-2230 7 p.

Research output: Contribution to journalArticle

Cerebral Aqueduct
Spinal Puncture
Paracentesis
Hydrocephalus
Drainage

Does the Presence or Absence of DESH Predict Outcomes in Adult Hydrocephalus?

Ahmed, A. K., Luciano, M., Moghekar, A. R., Shin, J., Aygun, N., Sair, H., Rigamonti, D. & Blitz, A. M., Nov 1 2018, In : AJNR. American journal of neuroradiology. 39, 11, p. 2022-2026 5 p.

Research output: Contribution to journalArticle

Subarachnoid Space
Hydrocephalus
Neurobehavioral Manifestations
Nonparametric Statistics
Gait

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

Bell, W. R., An, Y., Kageyama, Y., English, C., Rudow, G. L., Pletnikova, O., Thambisetty, M., O'Brien, R., Moghekar, A. R., Albert, M., Rabins, P. V., Resnick, S. M. & Troncoso, J. C., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Tauopathies
Alzheimer Disease
Apolipoprotein E4
Baltimore
Health Planning

Non-contrast MR imaging of blood-brain barrier permeability to water

Lin, Z., Li, Y., Su, P., Mao, D., Wei, Z., Pillai, J., Moghekar, A. R., van Osch, M., Ge, Y. & Lu, H., Jan 1 2018, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Permeability
Water
Hypercapnia
Superior Sagittal Sinus

Phosphotyrosine profiling of human cerebrospinal fluid

Sathe, G., Na, C-H., Renuse, S., Madugundu, A., Albert, M., Moghekar, A. R. & Pandey, A., Sep 12 2018, In : Clinical Proteomics. 15, 1, 29.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Phosphotyrosine
Cerebrospinal Fluid
Tyrosine
Peptides

Predicting progression from normal cognition to mild cognitive impairment for individuals at 5 years

Albert, M., Zhu, Y., Moghekar, A. R., Mori, S., Miller, M. I., Soldan, A., Pettigrew, C., Selnes, O., Li, S. & Wang, M. C., Mar 1 2018, In : Brain. 141, 3, p. 877-887 11 p.

Research output: Contribution to journalArticle

Cognition
Clinical Trials
Alzheimer Disease
Cerebrospinal Fluid
Sensitivity and Specificity

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetics Consortium (Adgc), Jul 2 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Genome-Wide Association Study
Amyloid
Endophenotypes

Toward dynamic lumbar puncture guidance using needle-based single-element ultrasound imaging

Zhang, H. K., Kim, Y., Lin, M., Paredes, M., Kannan, K., Moghekar, A. R., Durr, N. J. & Boctor, E., Apr 1 2018, In : Journal of Medical Imaging. 5, 2, 021224.

Research output: Contribution to journalArticle

Spinal Puncture
Needles
Ultrasonography
Bone and Bones
Computer-Assisted Image Processing
2017

Alpha-2 macroglobulin in Alzheimer's disease: A marker of neuronal injury through the RCAN1 pathway

Varma, V. R., Varma, S., An, Y., Hohman, T. J., Seddighi, S., Casanova, R., Beri, A., Dammer, E. B., Seyfried, N. T., Pletnikova, O., Moghekar, A. R., Wilson, M. R., Lah, J. J., O'Brien, R. J., Levey, A. I., Troncoso, J. C., Albert, M. & Thambisetty, M., Jan 1 2017, In : Molecular Psychiatry. 22, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

alpha-Macroglobulins
Alzheimer Disease
Wounds and Injuries
Calcineurin
Gene Expression

Alzheimer’s disease pathology and shunt surgery outcome in normal pressure hydrocephalus

Yasar, S., Jusue-Torres, I., Lu, J., Robison, J., Patel, M. A., Crain, B., Carson, K. A., Hoffberger, J., Batra, S., Sankey, E., Moghekar, A. R. & Rigamonti, D., Aug 1 2017, In : PLoS One. 12, 8, e0182288.

Research output: Contribution to journalArticle

Normal Pressure Hydrocephalus
hydrocephalus
Amyloid Plaques
Pathology
Alzheimer disease

Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer's disease

the BIOCARD Research Team, Dec 1 2017, In : Neurobiology of Aging. 60, p. 164-172 9 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Cognition
Alzheimer Disease
Biomarkers
Vocabulary

Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetic Consortium (ADGC), May 1 2017, In : Acta Neuropathologica. 133, 5, p. 839-856 18 p.

Research output: Contribution to journalArticle

Endophenotypes
Genome-Wide Association Study
Alzheimer Disease
Cerebrospinal Fluid
Genome

Predictors for venous sinus stent retreatment in patients with idiopathic intracranial hypertension

El Mekabaty, A., Obuchowski, N. A., Luciano, M., John, S., Chung, C. Y., Moghekar, A. R., Jones, S. & Hui, F., Dec 1 2017, In : Journal of NeuroInterventional Surgery. 9, 12, p. 1228-1232 5 p.

Research output: Contribution to journalArticle

Pseudotumor Cerebri
Retreatment
Stents
Body Mass Index
African Americans

Progressive medial temporal lobe atrophy during preclinical Alzheimer's disease

the BIOCARD Research Team, 2017, In : NeuroImage: Clinical. 16, p. 439-446 8 p.

Research output: Contribution to journalArticle

Temporal Lobe
Atrophy
Cerebrospinal Fluid
Alzheimer Disease
Amyloid

The impact of surgical resection on headache disability and quality of life in patients with colloid cyst

Kone, L., Chaichana, K. L., Rincon-Torroella, J., Snyman, C., Moghekar, A. R. & Quiñones-Hinojosa, A., Apr 1 2017, In : Cephalalgia. 37, 5, p. 442-451 10 p.

Research output: Contribution to journalArticle

Colloid Cysts
Headache
Quality of Life
Self Report
Linear Models
Intracranial Hypertension
Skull Base
Cerebrospinal Fluid Pressure
Pathologic Constriction
Intracranial Pressure
2016
dementia
Cerebrospinal Fluid
Paired-Associate Learning
Alzheimer Disease
Biomarkers

Cortical thickness in relation to clinical symptom onset in preclinical AD

the BIOCARD Research Team, 2016, In : NeuroImage: Clinical. 12, p. 116-122 7 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Magnetic Resonance Imaging
Proportional Hazards Models
Cognition
Cerebrospinal Fluid

Hypothetical preclinical Alzheimer disease groups and longitudinal cognitive change

Soldan, A., Pettigrew, C., Cai, Q., Wang, M. C., Moghekar, A. R., O'Brien, R. J., Selnes, O. A., Albert, M. S., Rodzon, B., Gottesman, R., Sacktor, N., McKhann, G., Turner, S., Farrington, L., Grega, M., Rudow, G., D'Agostino, D., Rudow, S., Miller, M., Mori, S. & 21 others, Ratnanather, T., Brown, T., Chi, H., Kolasny, A., Oishi, K., Reigel, T., Younes, L., Spangler, A., Scherer, R., Shade, D., Ervin, A., Jones, J., Toepfner, M., Parlett, L., Patterson, A., Mohammed, A., Lu, D., Troncoso, J., Crain, B., Pletnikova, O. & Fisher, K., Jun 1 2016, In : JAMA Neurology. 73, 6, p. 698-705 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Pathology
Cerebrospinal Fluid
Clinical Trials
Repression (Psychology)

Proteomics in India: A report on a brainstorming meeting at Hyderabad, India

Chatterjee, B., Makarov, A., Clemmer, D. E., Steen, H., Steen, J., Saffell-Clemmer, W., Moghekar, A. R., Rao, C. M., Bradshaw, R. A. & Thakur, S. S., Jul 1 2016, In : Molecular and Cellular Proteomics. 15, 7, p. 2229-2235 7 p.

Research output: Contribution to journalArticle

Proteomics
India
Cytology
Molecular biology
Mass spectrometry
2015

Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects

Toledo, J. B., Zetterberg, H., Van Harten, A. C., Glodzik, L., Martinez-Lage, P., Bocchio-Chiavetto, L., Rami, L., Hansson, O., Sperling, R., Engelborghs, S., Osorio, R. S., Vanderstichele, H., Vandijck, M., Hampel, H., Teipl, S., Moghekar, A. R., Albert, M., Hu, W. T., Monge Argilés, J. A., Gorostidi, A. & 12 others, Teunissen, C. E., De Deyn, P. P., Hyman, B. T., Molinuevo, J. L., Frisoni, G. B., Linazasoro, G., De Leon, M. J., Van Der Flier, W. M., Scheltens, P., Blennow, K., Shaw, L. M. & Trojanowski, J. Q., Sep 1 2015, In : Brain. 138, 9, p. 2701-2715 15 p.

Research output: Contribution to journalArticle

Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
Genotype

Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts

Resnick, S. M., Bilgel, M., Moghekar, A. R., An, Y., Cai, Q., Wang, M. C., Thambisetty, M., Prince, J. L., Zhou, Y., Soldan, A., Wong, D. F., O'Brien, R. J., Ferrucci, L. & Albert, M., 2015, In : Neurobiology of Aging. 36, 8, p. 2333-2339 7 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Biomarkers
Genotype
Positron-Emission Tomography
Apolipoprotein E4

Network neurodegeneration in Alzheimer's disease via MRI based shape diffeomorphometry and high-field atlasing

BIOCARD Research Team, Jan 1 2015, In : Frontiers in Bioengineering and Biotechnology. 3, MAY, 54.

Research output: Contribution to journalArticle

Entorhinal Cortex
Atlases
Magnetic resonance imaging
Alzheimer Disease
Temporal Lobe

Perioperative continuous cerebrospinal fluid pressure monitoring in patients with spontaneous cerebrospinal fluid leaks

Xie, Y. J., Shargorodsky, J., Lane, A. P., Ishii, M., Solomon, D., Moghekar, A. R., Gallia, G. L. & Reh, D. D., Jan 1 2015, In : International Forum of Allergy and Rhinology. 5, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid Pressure
Physiologic Monitoring
Pressure
Intracranial Pressure
Blood Pressure
Amyloid
Episodic Memory
Cognition
Cerebrospinal Fluid
Alzheimer Disease

Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease

the BIOCARD Research Team, Jul 1 2015, In : Human Brain Mapping. 36, 7, p. 2826-2841 16 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Temporal Lobe
Atrophy
Alzheimer Disease
Genotype

Venous sinus stenting is a valuable treatment for fulminant idiopathic intracranial hypertension

Elder, B. D., Rory Goodwin, C., Kosztowski, T. A., Radvany, M. G., Gailloud, P., Moghekar, A. R., Subramanian, P. S., Miller, N. R. & Rigamonti, D., Apr 1 2015, In : Journal of Clinical Neuroscience. 22, 4, p. 685-689 5 p.

Research output: Contribution to journalArticle

Pseudotumor Cerebri
Transverse Sinuses
Cerebrospinal Fluid
Pallor
Therapeutics
2014

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

Semba, R. D., Moghekar, A. R., Hu, J., Sun, K., Turner, R., Ferrucci, L. & O'Brien, R., Jan 13 2014, In : Neuroscience Letters. 558, p. 37-40 4 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Young Adult
Alzheimer Disease
Confidence Intervals
Cognition

Neuro-ophthalmic manifestations in adult hydrocephalus

Moghekar, A. R., 2014, In : International Ophthalmology Clinics. 54, 1, p. 115-121 7 p.

Research output: Contribution to journalArticle

Eye Manifestations
Cerebrospinal Fluid Shunts
Eye Diseases
Hydrocephalus
Magnetic Resonance Imaging

Obesity and headache: Part I-A systematic review of the epidemiology of obesity and headache

Chai, N. C., Scher, A. I., Moghekar, A. R., Bond, D. S. & Peterlin, B. L., Feb 2014, In : Headache. 54, 2, p. 219-234 16 p.

Research output: Contribution to journalArticle

Headache
Epidemiology
Obesity
Migraine Disorders
Secondary Headache Disorders

Obesity and headache: Part II - Potential mechanism and treatment considerations

Cindy Chai, N., Bond, D. S., Moghekar, A. R., Scher, A. I. & Peterlin, B. L., 2014, In : Headache. 54, 3, p. 459-471 13 p.

Research output: Contribution to journalArticle

Headache
Obesity
Migraine Disorders
Pseudotumor Cerebri
Manuscripts

Perceived body weight status of youngsters interferes with headache in obese and non-obese subjects: a response

Cha, N. C. I., Scher, A. I., Moghekar, A. R., Bond, D. S. & Peterlin, B. L., Jun 1 2014, In : Headache. 54, 6, p. 1063-1065 3 p.

Research output: Contribution to journalArticle

Headache
Obesity
Body Weight

Risk factors for failed transverse sinus stenting in pseudotumor cerebri patients

Goodwin, C. R., Elder, B. D., Ward, A., Orkoulas-Razis, D., Kosztowski, T. A., Hoffberger, J., Moghekar, A. R., Radvany, M. & Rigamonti, D., 2014, In : Clinical Neurology and Neurosurgery. 127, p. 75-78 4 p.

Research output: Contribution to journalArticle

Transverse Sinuses
Pseudotumor Cerebri
Stents
Pathologic Constriction
Pressure
2013
Normal Pressure Hydrocephalus
Amyloid
Positron-Emission Tomography
Biopsy
Staining and Labeling

CSF biomarker changes precede symptom onset of mild cognitive impairment

Moghekar, A. R., Li, S., Lu, Y., Li, M., Wang, M. C., Albert, M. & O'Brien, R., Nov 12 2013, In : Neurology. 81, 20, p. 1753-1758 6 p.

Research output: Contribution to journalArticle

Amyloid
Biomarkers
Neurobehavioral Manifestations
Macrophage Colony-Stimulating Factor
Cognition

Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease

Pettigrew, C., Soldan, A., Li, S., Lu, Y., Wang, M. C., Selnes, O. A., Moghekar, A. R., O'Brien, R. & Albert, M., Dec 2013, In : Cognitive Neuroscience. 4, 3-4, p. 136-142 7 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Alzheimer Disease
Cognition
Alleles
Vocabulary
Cognitive Reserve
Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
Amyloid

Visual and neurological outcomes following endovascular stenting for pseudotumor cerebri associated with transverse sinus stenosis

Radvany, M. G., Solomon, D., Nijjar, S., Subramanian, P. S., Miller, N. R., Rigamonti, D., Blitz, A. M., Gailloud, P. & Moghekar, A. R., Jun 2013, In : Journal of Neuro-Ophthalmology. 33, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

Transverse Sinuses
Pseudotumor Cerebri
Pathologic Constriction
Pressure
Tinnitus
2012

Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohort

Moghekar, A. R., Kraut, M. A., Elkins, W., Troncoso, J. C., Zonderman, A. B., Resnick, S. M. & O'Brien, R. J., Oct 2012, In : Alzheimer's and Dementia. 8, SUPPL. 5

Research output: Contribution to journalArticle

Leukoencephalopathies
Pathology
Alzheimer Disease
Magnetic Resonance Imaging
Autopsy

Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort

Moghekar, A. R., Goh, J., Li, M., Albert, M. & O'Brien, R. J., Feb 2012, In : Archives of Neurology. 69, 2, p. 246-250 5 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Biomarkers
Alzheimer Disease
Threonine
Hospital Units

Con: Alzheimer's disease and circadian dysfunction: Chicken or egg?

Moghekar, A. R. & O'Brien, R. J., 2012, In : Alzheimer's Research and Therapy. 4, 4, 26.

Research output: Contribution to journalArticle

Alzheimer Disease
Sleep
Amyloid
Circadian Rhythm
Cerebrospinal Fluid
2011

Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment

Okonkwo, O. C., Mielke, M. M., Griffith, H. R., Moghekar, A. R., O'Brien, R. J., Shaw, L. M., Trojanowski, J. Q. & Albert, M., Jan 2011, In : Archives of Neurology. 68, 1, p. 113-119 7 p.

Research output: Contribution to journalArticle

Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Peptides
Threonine