Research Output 1994 2017

2017

Beta-cell specific autoantibodies: Are they just an indicator of type 1 diabetes?

Fousteri, G., Ippolito, E., Ahmed, R. & Hamad, A. R. A. 2017 In : Current Diabetes Reviews. 13, 3, p. 322-329 8 p.

Research output: Contribution to journalReview article

Autoantibodies
B-Lymphocytes
Autoantigens
Antigen Presentation
Autoimmunity

Expansion of FasL-expressing CD5+ B cells in type 1 diabetes patients

Saxena, A., Yagita, H., Donner, T. W. & Hamad, A. R. A. Apr 7 2017 In : Frontiers in Immunology. 8, APR, 402

Research output: Contribution to journalArticle

B-Lymphocytes
Interleukin-10
Inbred NOD Mouse
Fas Ligand Protein
Autoantibodies
2016

B cell-targeted immunotherapy for type 1 diabetes: What can make it work?

Hamad, A. R. A., Ahmed, R., Donner, T. & Fousteri, G. 2016 In : Discovery medicine. 21, 115, p. 213-219 7 p.

Research output: Contribution to journalArticle

Immunotherapy
B-Lymphocytes
Autoimmune Diseases
Regulatory B-Lymphocytes
Complementary Therapies

Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney

Martina, M. N., Noel, S., Saxena, A., Bandapalle, S., Majithia, R., Jie, C., Arend, L. J., Allaf, M. E., Rabb, H. & Hamad, A. R. A. Apr 1 2016 In : Journal of the American Society of Nephrology : JASN. 27, 4, p. 1113-1123 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Kidney
Reperfusion Injury
Interleukin-10
Anti-Inflammatory Agents

Sex and the single transplanted kidney

Noel, S., Desai, N. M., Hamad, A. R. A. & Rabb, H. May 2 2016 In : Journal of Clinical Investigation. 126, 5, p. 1643-1645 3 p.

Research output: Contribution to journalReview article

Reperfusion Injury
Kidney
Organ Transplantation
Estrogen Receptors
Transplantation
2015

Double Negative (DN) αβ T Cells: Misperception and overdue recognition

Martina, M. N., Noel, S., Saxena, A., Rabb, H. & Hamad, A. R. A. Mar 19 2015 In : Immunology and Cell Biology. 93, 3, p. 305-310 6 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Apoptosis
Immune System
Autoimmune Lymphoproliferative Syndrome
Homeostasis

Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy

Saxena, A., Khosraviani, S., Noel, S., Mohan, D., Donner, T. & Hamad, A. R. A. Jul 1 2015 In : Cytokine. 74, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Interleukin-10
Immunotherapy
Cytokines
Supravalvular Aortic Stenosis
B-Lymphocytes

Reviving the promise of transcription factor Nrf2-based therapeutics for kidney diseases

Noel, S., Hamad, A. R. A. & Rabb, H. Dec 1 2015 In : Kidney International. 88, 6, p. 1217-1218 2 p.

Research output: Contribution to journalArticle

Kidney Diseases
Transcription Factors
Kidney
Chronic Renal Insufficiency
Acute Kidney Injury

Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells in mice

Dai, H., Rahman, A., Saxena, A., Jaiswal, A. K., Mohamood, A., Ramirez, L., Noel, S., Rabb, H., Jie, C. & Hamad, A. R. A. Nov 1 2015 In : European Journal of Immunology. 45, 11, p. 3045-3051 7 p.

Research output: Contribution to journalArticle

Syndecan-1
Natural Killer T-Cells
Interleukin-17
Heparan Sulfate Proteoglycans
Glycolipids

T lymphocyte-specific activation of Nrf2 protects from AKI

Noel, S., Martina, M. N., Bandapalle, S., Racusen, L. C., Potteti, H. R., Hamad, A. R. A., Reddy, S. P. & Rabb, H. Dec 1 2015 In : Journal of the American Society of Nephrology. 26, 12, p. 2989-3000 12 p.

Research output: Contribution to journalArticle

Lymphocyte Activation
T-Lymphocytes
Ischemia
Gene Expression
Antioxidants

Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease

Noel, S., Martina-Lingua, M. N., Bandapalle, S., Pluznick, J., Hamad, A. R. A., Peterson, D. A. & Rabb, H. Apr 16 2014 In : Nephron - Clinical Practice. 127, 1-4, p. 139-143 5 p.

Research output: Contribution to journalArticle

Microbiota
Chronic Renal Insufficiency
Acute Kidney Injury
Kidney
Kidney Diseases

Isolation of double negative αβ T cells from the kidney

Martina, M. N., Bandapalle, S., Rabb, H. & Hamad, A. R. May 16 2014 In : Journal of Visualized Experiments. 87, e51192

Research output: Contribution to journalArticle

T-Lymphocytes
Kidney
T-cells
Library Catalogs
Tissue

T lymphocytes and acute kidney injury: Update

Martina, M. N., Noel, S., Bandapalle, S., Hamad, A. R. A. & Rabb, H. Apr 16 2014 In : Nephron - Clinical Practice. 127, 1-4, p. 51-55 5 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
T-Lymphocytes
Lymphocytes
Natural Killer T-Cells
Regulatory T-Lymphocytes
2013

Extracellular Matrix Protein Lumican Promotes Clearance and Resolution of Pseudomonas aeruginosa Keratitis in a Mouse Model

Shao, H., Scott, S. G., Nakata, C., Hamad, A. R. & Chakravarti, S. Jan 30 2013 In : PLoS One. 8, 1, e54765

Research output: Contribution to journalArticle

Keratitis
Extracellular Matrix Proteins
Cornea
Pseudomonas aeruginosa
Infection
2012

Extracellular matrix lumican promotes bacterial phagocytosis, and Lum -/- mice show increased Pseudomonas aeruginosa lung infection severity

Shao, H., Lee, S., Gae-Scott, S., Nakata, C., Chen, S., Hamad, A. R. & Chakravarti, S. Oct 19 2012 In : Journal of Biological Chemistry. 287, 43, p. 35860-35872 13 p.

Research output: Contribution to journalArticle

Phagocytosis
Pseudomonas aeruginosa
Extracellular Matrix
Lung
Infection

Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis

Lohr, K., Sardana, H., Lee, S., Wu, F., Huso, D. L., Hamad, A. R. & Chakravarti, S. Jan 2012 In : Inflammatory Bowel Diseases. 18, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Colitis
Inflammation
Innate Immunity
Trinitrobenzenes
Fas Ligand Protein
Insulin
Apoptosis
T-Lymphocytes
Immune System
2011

Blocking fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury

Ko, G. J., Jang, H. R., Huang, Y., Womer, K. L., Liu, M., Higbee, E., Xiao, Z., Yagita, H., Racusen, L., Hamad, A. R. A. & Rabb, H. Apr 2011 In : Journal of the American Society of Nephrology. 22, 4, p. 732-742 11 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Reperfusion Injury
Leukocytes
Kidney
Acute Kidney Injury

Inhibition of fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development

Xiao, Z., Mohamood, A. S., Uddin, S., Gutfreund, R., Nakata, C., Marshall, A., Kimura, H., Caturegli, P., Womer, K. L., Huang, Y., Jie, C., Chakravarti, S., Schneck, J. P., Yagita, H. & Hamad, A. R. A. Aug 2011 In : American Journal of Pathology. 179, 2, p. 725-732 8 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Fas Ligand Protein
Interleukin-10
Mutation
Type 1 Diabetes Mellitus

Subnormal cytokine profile in the tear fluid of keratoconus patients

Jun, A. S., Cope, L., Speck, C., Feng, X., Lee, S., Meng, H., Hamad, A. & Chakravarti, S. 2011 In : PLoS One. 6, 1, e16437

Research output: Contribution to journalArticle

Keratoconus
Tears
Cytokines
Blood Flow Velocity
Amoxicillin
2009

Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to β2 integrin

Lee, S., Bowrin, K., Hamad, A. R. & Chakravarti, S. Aug 28 2009 In : Journal of Biological Chemistry. 284, 35, p. 23662-23669 8 p.

Research output: Contribution to journalArticle

Integrins
Extracellular Matrix
Neutrophils
Enzyme Reactivators
Edema Disease of Swine

Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice

Rhee, K. J., Wu, S., Wu, X., Huso, D. L., Karim, B., Franco, A. A., Rabizadeh, S., Golub, J. E., Mathews, L. E., Shin, J., Balfour Sartor, R., Golenbock, D., Hamad, A. R., Gan, C. M., Housseau, F. & Sears, C. L. Apr 2009 In : Infection and Immunity. 77, 4, p. 1708-1718 11 p.

Research output: Contribution to journalArticle

Bacteroides fragilis
Colitis
Inbred C57BL Mouse
Specific Pathogen-Free Organisms
Cadherins
2008

Fas-mediated apoptosis regulates the composition of peripheral αβ T cell repertoire by constitutively purging out double negative T cells

Mohamood, A. S., Bargatze, D., Xiao, Z., Jie, C., Yagita, H., Ruben, D., Watson, J., Chakravarti, S., Schneck, J. P. & Hamad, A. R. A. Oct 21 2008 In : PLoS One. 3, 10, e3465

Research output: Contribution to journalArticle

Apoptosis
T-Lymphocytes
T-lymphocytes
T-cells
apoptosis
Natural Killer T-Cells
High Fat Diet
Regulatory T-Lymphocytes
Colitis
Colon
2007

A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury

Ma, X., Hua, J., Mohamood, A. R., Hamad, A. R. A., Ravi, R. & Li, Z. Nov 2007 In : Hepatology. 46, 5, p. 1519-1529 11 p.

Research output: Contribution to journalArticle

High Fat Diet
Regulatory T-Lymphocytes
Endotoxins
Liver
Wounds and Injuries

Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically

Mohamood, A. S., Guler, M. L., Xiao, Z., Zheng, D., Hess, A., Wang, Y., Yagita, H., Schneck, J. P. & Hamad, A. R. A. Jul 2007 In : American Journal of Pathology. 171, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
T-Lymphocytes
Mutation
Inbred NOD Mouse
Homeostasis
2006

Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells

Mohamood, A. S., Trujillo, C. J., Zheng, D., Jie, C., Murillo, F. M., Schneck, J. P. & Hamad, A. R. A. Aug 2006 In : International Immunology. 18, 8, p. 1265-1277 13 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Cell Survival
Up-Regulation
Mutation
Genes
2003

B220+ double-negative T cells suppress polyclonal T cell activation by a fas-independent mechanism that involves inhibition of IL-2 production

Hamad, A. R. A., Mohamood, A. S., Trujillo, C. J., Huang, C. T., Yuan, E. & Schneck, J. P. Sep 1 2003 In : Journal of Immunology. 171, 5, p. 2421-2426 6 p.

Research output: Contribution to journalArticle

Interleukin-2
T-Lymphocytes
Fas Ligand Protein
Mutation
Peripheral Tolerance
2001

Antigen-induced T cell death is regulated by CD4 expression

Hamad, A. R. A. & Schneck, J. P. 2001 In : International Reviews of Immunology. 20, 5, p. 535-546 12 p.

Research output: Contribution to journalArticle

Cell Death
T-Lymphocytes
Antigens
CD4 Antigens
Peptides

Lack of coreceptor allows survival of chronically stimulated double-negative α/β T cells: Implications for autoimmunity

Hamad, A. R. A., Srikrishnan, A., Mirmonsef, P., Broeren, C. P. M., June, C. H., Pardoll, D. & Schneck, J. P. May 21 2001 In : Journal of Experimental Medicine. 193, 10, p. 1113-1121 9 p.

Research output: Contribution to journalArticle

Autoimmunity
T-Lymphocytes
Major Histocompatibility Complex
T-Cell Antigen Receptor
Peptides
1999

Soluble, high-affinity dimers of T-cell receptors and class II major histocompatibility complexes: Biochemical probes for analysis and modulation of immune responses

Lebowitz, M. S., O'Herrin, S. M., Hamad, A. R. A., Fahmy, T., Marguet, D., Barnes, N. C., Pardoll, D., Bieler, J. G. & Schneck, J. P. Mar 15 1999 In : Cellular Immunology. 192, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
Immunoglobulin G
Ligands
1998

Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: The role of CD4 coreceptor

Hamad, A. R. A., O'Herrin, S. M., Lebowitz, M. S., Srikrishnan, A., Bieler, J., Schneck, J. & Pardoll, D. Nov 2 1998 In : Journal of Experimental Medicine. 188, 9, p. 1633-1640 8 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Ligands
T-Lymphocytes
Peptides
T-Cell Antigen Receptor
1997

Transcytosis of staphylococcal superantigen toxins

Hamad, A. R. A., Marrack, P. & Kappler, J. W. Apr 21 1997 In : Journal of Experimental Medicine. 185, 8, p. 1447-1454 8 p.

Research output: Contribution to journalArticle

Transcytosis
Superantigens
Enterotoxins
Foodborne Diseases
Septic Shock
1995

Murine Transfer Factors: Dose-Response Relationships and Routes of Administration

Kirkpatrick, C. H., Hamad, A. R. & Morton, L. C. Sep 1995 In : Cellular Immunology. 164, 2, p. 203-206 4 p.

Research output: Contribution to journalArticle

Transfer Factor
Antigens
Delayed Hypersensitivity
Immunologic Factors
Cellular Immunity
1994

Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B

Hamad, A. R. A., Herman, A., Marrack, P. & Kappler, J. W. Aug 1 1994 In : Journal of Experimental Medicine. 180, 2, p. 615-621 7 p.

Research output: Contribution to journalArticle

Superantigens
Enterotoxins
Monoclonal Antibodies
Major Histocompatibility Complex
T-Lymphocytes