Kennedy Krieger Institute

Research Output 1963 2020

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2017

Neurodevelopmental disorders caused by de novo variants in KCNB1 genotypes and phenotypes

De Kovel, C. G. F., Syrbe, S., Brilstra, E. H., Verbeek, N., Kerr, B., Dubbs, H., Bayat, A., Desai, S., Naidu, S., Srivastava, S., Cagaylan, H., Yis, U., Saunders, C., Rook, M., Plugge, S., Muhle, H., Afawi, Z., Klein, K. M., Jayaraman, V., Rajagopalan, R. & 15 others, Goldberg, E., Marsh, E., Kessler, S., Bergqvist, C., Conlin, L. K., Krok, B. L., Thiffault, I., Pendziwiat, M., Helbig, I., Polster, T., Borggraefe, I., Lemke, J. R., Van Den Boogaardt, M. J., Møller, R. S. & Koeleman, B. P. C., Oct 1 2017, In : JAMA Neurology. 74, 10, p. 1228-1236 9 p.

Research output: Contribution to journalArticle

Genotype
Phenotype
Ion Channels
S 6
Neurodevelopmental Disorders

Neurodevelopmental Outcomes in 22 Children with Microcephaly of Different Etiologies

Gordon-Lipkin, E., Gentner, M. B., German, R. & Leppert, M. L., Aug 1 2017, In : Journal of Child Neurology. 32, 9, p. 804-809 6 p.

Research output: Contribution to journalArticle

Microcephaly
Epilepsy
Neonatal Intensive Care Units
Premature Infants
Language

Neuroimaging Abnormalities in a Child With Infantile Spasms on High-Dose Vigabatrin

Sun, L., Bosemani, T. & Smith-Hicks, C. L., Feb 1 2017, In : Pediatric Neurology. 67, p. 109-110 2 p.

Research output: Contribution to journalArticle

Vigabatrin
Infantile Spasms
Neuroimaging

Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study

Charman, T., Young, G. S., Brian, J., Carter, A., Carver, L. J., Chawarska, K., Curtin, S., Dobkins, K., Elsabbagh, M., Georgiades, S., Hertz-Picciotto, I., Hutman, T., Iverson, J. M., Jones, E. J., Landa, R., Macari, S., Messinger, D. S., Nelson, C. A., Ozonoff, S., Saulnier, C. & 5 others, Stone, W. L., Tager-Flusberg, H., Webb, S. J., Yirmiya, N. & Zwaigenbaum, L., Jan 1 2017, In : Autism Research. 10, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

Siblings
Autistic Disorder
Research
Psychological Adaptation
Language Development Disorders

Noncontingent reinforcement for the treatment of severe problem behavior: An analysis of 27 consecutive applications

Phillips, C. L., Iannaccone, J. A., Rooker, G. W. & Hagopian, L. P., Mar 1 2017, In : Journal of Applied Behavior Analysis. 50, 2, p. 357-376 20 p.

Research output: Contribution to journalArticle

reinforcement
Social Reinforcement
Developmental Disabilities
Selection Bias
Reinforcement (Psychology)

Novel automated morphometric and kinematic handwriting assessment: A validity study in children with ASD and ADHD

Dirlikov, B., Younes, L., Nebel, M. B., Martinelli, M. K., Tiedemann, A. N., Koch, C. A., Fiorilli, D., Bastian, A. J., Denckla, M. B., Miller, M. I. & Mostofsky, S. H., Apr 3 2017, In : Journal of Occupational Therapy, Schools, and Early Intervention. 10, 2, p. 185-201 17 p.

Research output: Contribution to journalArticle

Handwriting
handwriting
ADHD
Attention Deficit Disorder with Hyperactivity
autism

One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents

Lock, L. L., Li, Y., Mao, X., Chen, H., Staedtke, V., Bai, R., Ma, W., Lin, R., Li, Y., Liu, G. & Cui, H., Jan 24 2017, In : ACS Nano. 11, 1, p. 797-805 9 p.

Research output: Contribution to journalArticle

Hydrogels
Magnetic resonance
Pemetrexed
magnetic resonance
Labels

Outcome measures for clinical trials in down syndrome

Esbensen, A. J., Hooper, S. R., Fidler, D., Hartley, S. L., Edgin, J., D'Ardhuy, X. L., Capone, G. T., Conners, F. A., Mervis, C. B., Abbeduto, L., Rafii, M., Krinsky-Mchale, S. J., Urv, T., Dykens, E., Esbenson, A., Hartlay, S., Keller, S. & Weir, S., May 1 2017, In : American Journal on Intellectual and Developmental Disabilities. 122, 3, p. 247-281 35 p.

Research output: Contribution to journalArticle

Down Syndrome
Outcome Assessment (Health Care)
Clinical Trials
Developmental Disabilities
National Institutes of Health (U.S.)

Parallel group independent component analysis for massive fMRI data sets

Chen, S., Huang, L., Qiu, H., Nebel, M. B., Mostofsky, S. H., Pekar, J. J., Lindquist, M., Eloyan, A. & Caffo, B. S., Mar 1 2017, In : PLoS One. 12, 3, e0173496.

Research output: Contribution to journalArticle

Independent component analysis
Magnetic Resonance Imaging
computer techniques
Functional Neuroimaging
Functional neuroimaging

Parent-informed test-control functional analysis and treatment of problem behavior related to combined establishing operations

Strohmeier, C. W., Murphy, A. & O'Connor, J. T., May 19 2017, In : Developmental Neurorehabilitation. 20, 4, p. 247-252 6 p.

Research output: Contribution to journalArticle

Research
Problem Behavior

Performance-based and parent ratings of attention in children treated for a brain tumor: The significance of radiation therapy and tumor location on outcome

Raghubar, K. P., Mahone, E. M., Yeates, K. O. & Ris, M. D., Jan 28 2017, (Accepted/In press) In : Child Neuropsychology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Radiotherapy
Neoplasms
Supratentorial Neoplasms
Infratentorial Neoplasms

Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse

Wangler, M. F., Chao, Y. H., Bayat, V., Giagtzoglou, N., Shinde, A. B., Putluri, N., Coarfa, C., Donti, T., Graham, B. H., Faust, J. E., McNew, J. A., Moser, A. B., Sardiello, M., Baes, M. & Bellen, H. J., 2017, In : PLoS Genetics. 13, 6, e1006825.

Research output: Contribution to journalArticle

Carbohydrate Metabolism
carbohydrate metabolism
Drosophila
carbohydrate
peroxisomes

pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI

Pavuluri, K. & Mcmahon, M. T., 2017, (Accepted/In press) In : Israel Journal of Chemistry.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Imaging techniques
Monitoring
Pathology
Tumors

Predictors of Inpatient Psychiatric Hospitalization for Children and Adolescents with Autism Spectrum Disorder

For The Autism And Developmental Disabilities Inpatient Research Collaborative (Addirc), May 23 2017, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-11 11 p.

Research output: Contribution to journalArticle

Psychiatry
Inpatients
Hospitalization
Autistic Disorder
Marital Status
Pediatrics
Traumatic Brain Injury

Priorities for Advancing Research on Youth with Autism Spectrum Disorder and Co-occurring Anxiety

Vasa, R. A., Keefer, A., Reaven, J., South, M. & White, S. W., Nov 21 2017, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-10 10 p.

Research output: Contribution to journalArticle

Anxiety
Research
Anxiety Disorders
Research Personnel
Autism Spectrum Disorder

Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills

For The Autism And Developmental Disorders Inpatient Research Collaborative (Addirc), Jun 8 2017, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-10 10 p.

Research output: Contribution to journalArticle

Aptitude
Psychological Adaptation
Inpatients
Stereotyped Behavior
Self-Injurious Behavior

Quantitative measures of walking and strength provide insight into brain corticospinal tract pathology in multiple sclerosis

Fritz, N. E., Keller, J., Calabresi, P. & Zackowski, K. M., 2017, In : NeuroImage: Clinical. 14, p. 490-498 9 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Multiple Sclerosis
Walking
Pathology
Brain

QUESP and QUEST revisited - fast and accurate quantitative CEST experiments

Zaiss, M., Angelovski, G., Demetriou, E., Mcmahon, M. T., Golay, X. & Scheffler, K., 2017, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Contrast Media
Protons
Water

Randomized open-label trial of dextromethorphan in Rett syndrome

Smith-Hicks, C. L., Gupta, S., Ewen, J. B., Hong, M., Kratz, L., Kelley, R., Tierney, E., Vaurio, R., Bibat, G. M., Sanyal, A., Yenokyan, G., Brereton, N., Johnston, M. V. & Naidu, S., Oct 17 2017, In : Neurology. 89, 16, p. 1684-1690 7 p.

Research output: Contribution to journalArticle

Dextromethorphan
Rett Syndrome
Seizures
Checklist
Electroencephalography

Reading-Related Causal Attributions for Success and Failure: Dynamic Links With Reading Skill

Frijters, J. C., Tsujimoto, K. C., Boada, R., Gottwald, S., Hill, D., Jacobson, L. A., Lovett, M. W., Mahone, E. M., Willcutt, E. G., Wolf, M., Bosson-Heenan, J. & Gruen, J. R., 2017, (Accepted/In press) In : Reading Research Quarterly.

Research output: Contribution to journalArticle

attribution
Reading
Aptitude
ability
Linguistics

Reduced subcortical volumes among preschool-age girls and boys with ADHD

Rosch, K. S., Crocetti, D., Hirabayashi, K., Denckla, M. B., Mostofsky, S. H. & Mahone, E. M., Jan 1 2017, (Accepted/In press) In : Psychiatry Research - Neuroimaging.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Thalamus
Globus Pallidus
Putamen
Caudate Nucleus

Reduced Value-Driven Attentional Capture Among Children with ADHD Compared to Typically Developing Controls

Sali, A. W., Anderson, B. A., Yantis, S., Mostofsky, S. H. & Rosch, K. S., Sep 15 2017, (Accepted/In press) In : Journal of Abnormal Child Psychology. p. 1-14 14 p.

Research output: Contribution to journalArticle

Reward
Color
Short-Term Memory

Response Inhibition Deficits and Altered Motor Network Connectivity in the Chronic Phase of Pediatric Traumatic Brain Injury

Stephens, J. A., Salorio, C. F., Gomes, J. P., Nebel, M. B., Mostofsky, S. H. & Suskauer, S. J. M., Nov 15 2017, In : Journal of Neurotrauma. 34, 22, p. 3117-3123 7 p.

Research output: Contribution to journalArticle

Pediatrics
Motivation
Brain
Task Performance and Analysis
Chronic Brain Injury

Safety, Tolerability, and Sensorimotor Effects of Extended-Release Dalfampridine in Adults With Cerebral Palsy: A Pilot Study

Bethoux, F., Fatemi, A., Fowler, E., Marciniak, C., Mayadev, A., Waksman, J., Zackowski, K., Suarez, G., Blight, A. R., Rabinowicz, A. L. & Carrazana, E., 2017, (Accepted/In press) In : Clinical Therapeutics.

Research output: Contribution to journalArticle

Cerebral Palsy
Placebos
Safety
Hand Strength
Cross-Over Studies

Size of Facial Port-Wine Birthmark May Predict Neurologic Outcome in Sturge-Weber Syndrome

Dymerska, M., Kirkorian, A. Y., Offermann, E. A., Lin, D., Comi, A. M. S. & Cohen, B. A., Sep 1 2017, In : Journal of Pediatrics. 188, p. 205-209.e1

Research output: Contribution to journalArticle

Sturge-Weber Syndrome
Wine
Nervous System
Brain
Magnetic Resonance Imaging

Sleep Problems and Their Relationship to Maladaptive Behavior Severity in Psychiatrically Hospitalized Children with Autism Spectrum Disorder (ASD)

For The Autism And Developmental Disorders Inpatient Research Collaborative (Addirc), Oct 30 2017, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-7 7 p.

Research output: Contribution to journalArticle

Hospitalized Child
Sleep
Checklist
Observation
Autistic Disorder

Sluggish Cognitive Tempo, Processing Speed, and Internalizing Symptoms: the Moderating Effect of Age

Jacobson, L. A., Geist, M. & Mahone, E. M., Feb 18 2017, (Accepted/In press) In : Journal of Abnormal Child Psychology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Physical Exertion
Neurobehavioral Manifestations
Lethargy
Caregivers

Subject-specific regional measures of water diffusion are associated with impairment in chronic spinal cord injury

Choe, A., Sadowsky, C. L., Smith, S. A., Van Zijl, P. C., Pekar, J. J. & Belegu, V., Aug 1 2017, In : Neuroradiology. 59, 8, p. 747-758 12 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Spinal Cord Injuries
Water
Wounds and Injuries
Biomarkers

Talking About Death or Suicide: Prevalence and Clinical Correlates in Youth with Autism Spectrum Disorder in the Psychiatric Inpatient Setting

For The Autism And Developmental Disorders Inpatient Research Collaborative (Addirc), Jun 17 2017, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-9 9 p.

Research output: Contribution to journalArticle

Suicide
Psychiatry
Inpatients
Suicidal Ideation
Anxiety Disorders

Teaching to varied disciplines and educational levels simultaneously: An innovative approach in a neonatal follow-up clinic

Leppert, M. L., Burton, V. J., German, R. A., Gentner, M. B., Yimgang, D. P. & Chen, B. Y., Dec 4 2017, (Accepted/In press) In : Medical Teacher. p. 1-7 7 p.

Research output: Contribution to journalArticle

trainee
Teaching
curriculum
educator
instruction

TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents

Coulter, J. B., Lopez-Bertoni, H., Kuhns, K. J., Lee, R., Laterra, J. J. & Bressler, J., Nov 1 2017, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

DNA Damage
Cyclin B1
Genomic Instability
DNA
Ionizing Radiation

The Arizona cognitive test battery for down syndrome: Test-retest reliability & practice effects

Edgin, J. O., Anand, P., Rosser, T., Pierpont, E. I., Figueroa, C., Hamilton, D., Huddleston, L., Mason, G., Spaǹo, G., Toole, L., Nguyen-Driver, M., Capone, G. T., Abbeduto, L., Maslen, C., Reeves, R. H. & Sherman, S., May 1 2017, In : American Journal on Intellectual and Developmental Disabilities. 122, 3, p. 215-234 20 p.

Research output: Contribution to journalArticle

Down Syndrome
Reproducibility of Results
Intellectual Disability
Clinical Trials
Practice (Psychology)

The cerebellum contributes to proprioception during motion

Weeks, H. M., Therrien, A. S. & Bastian, A. J., Aug 1 2017, In : Journal of Neurophysiology. 118, 2, p. 693-702 10 p.

Research output: Contribution to journalArticle

Proprioception
Cerebellum
Extremities
Hand
Aptitude

The impact of T1 versus EPI spatial normalization templates for fMRI data analyses

Calhoun, V. D., Wager, T. D., Krishnan, A., Rosch, K. S., Seymour, K. E., Nebel, M. B., Mostofsky, S. H., Nyalakanai, P. & Kiehl, K., 2017, (Accepted/In press) In : Human Brain Mapping.

Research output: Contribution to journalArticle

Echo-Planar Imaging
Magnetic Resonance Imaging
Sample Size
Software

The influence of comorbid asthma on the severity of symptoms in children with attention-deficit hyperactivity disorder

Borschuk, A. P., Rodweller, C. & Salorio, C. F., Apr 27 2017, (Accepted/In press) In : Journal of Asthma. p. 1-7 7 p.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Asthma
Behavioral Symptoms
Impulsive Behavior
Anxiety

The kennedy krieger independence scales-sickle cell disease: Executive components of transition readiness

Jones, K. E., Jacobson, L. A. & Tarazi, R. A., Aug 1 2017, In : Rehabilitation Psychology. 62, 3, p. 249-257 9 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Self Care
Caregivers
Episodic Memory
Demography

The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders

Law, K. B., Bronte-Tinkew, D., Di Pietro, E., Snowden, A., Jones, R. O., Moser, A. B., Brumell, J. H., Braverman, N. & Kim, P. K., May 4 2017, In : Autophagy. 13, 5, p. 868-884 17 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphatases
Autophagy
Mutation
Proteins

Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children

THAPCA Trial Investigators & Bhalala, U. S., Jan 26 2017, In : New England Journal of Medicine. 376, 4, p. 318-329 12 p.

Research output: Contribution to journalArticle

Induced Hypothermia
Heart Arrest
Coma
Temperature
Hypothermia

Therapeutische Strategien bei Adrenoleukodystrophie

Translated title of the contribution: Therapeutic strategies in adrenoleukodystrophyTurk, B. R., Moser, A. B. & Fatemi, A., May 10 2017, (Accepted/In press) In : Wiener Medizinische Wochenschrift. p. 1-8 8 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Mutation
Spinal Cord Diseases
Poisons
Hematopoietic Stem Cell Transplantation

Umbilical cord blood NOS1 as a potential biomarker of neonatal encephalopathy

Lei, J., Paules, C., Nigrini, E., Rosenzweig, J. M., Bahabry, R., Farzin, A., Yang, S., Northington, F., Oros, D., McKenney, S., Johnston, M. V., Graham, E. M. & Burd, I., May 22 2017, In : Frontiers in Pediatrics. 5, 112.

Research output: Contribution to journalArticle

Umbilical Cord
Brain Diseases
Fetal Blood
Biomarkers
Endothelial Cells
Mental Health Services
health service
mental health
parents
Therapeutics

Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia

Nemeth, C. L., Drummond, G. T., Mishra, M. K., Zhang, F., Carr, P., Garcia, M. S., Doman, S., Fatemi, A., Johnston, M. V., Rangaramanujam, K., Kannan, S. & Wilson, M. A. A., Oct 1 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 7, p. 2359-2369 11 p.

Research output: Contribution to journalArticle

Hypothermia
Dendrimers
Microglia
Brain Diseases
Hippocampus

Verbal Ability and Psychiatric Symptoms in Clinically Referred Inpatient and Outpatient Youth with ASD

For The Autism And Developmental Disorders Inpatient Research Collaborative (Addirc), Oct 16 2017, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-13 13 p.

Research output: Contribution to journalArticle

Aptitude
Psychiatry
Inpatients
Outpatients
Comorbidity

When Behavioral Health Concerns Present in Pediatric Primary Care: Factors Influencing Provider Decision-Making

Connors, E. H., Arora, P., Blizzard, A. M., Bower, K. M., Coble, K., Harrison, J. N., Pruitt, D., Steinberg, J. & Wissow, L. S., Dec 5 2017, (Accepted/In press) In : Journal of Behavioral Health Services and Research. p. 1-16 16 p.

Research output: Contribution to journalArticle

Primary Health Care
Decision Making
Pediatrics
decision making
present
2016

15N Heteronuclear Chemical Exchange Saturation Transfer MRI

Zeng, H., Xu, J., Yadav, N. N., Mcmahon, M. T., Harden, B., Frueh, D. P. & Van Zijl, P. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11136-11139 4 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Protons
Water
Molecules
Proton transfer

Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes

Edmunds, L. R., Otero, P. A., Sharma, L., D'Souza, S., Dolezal, J. M., David, S., Lu, J., Lamm, L., Basantani, M., Zhang, P., Sipula, I. J., Li, L., Zeng, X., Ding, Y., Ding, F., Beck, M. E., Vockley, J., Monga, S. P. S., Kershaw, E. E., O'Doherty, R. M. & 6 others, Kratz, L., Yates, N. A., Goetzman, E. P., Scott, D., Duncan, A. W. & Prochownik, E. V., May 24 2016, In : Oncotarget. 7, 21, p. 30379-30395 17 p.

Research output: Contribution to journalArticle

Hepatocytes
Lipids
Cytochrome P-450 Enzyme System
Liver
Tyrosinemias

ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism

Ferdinandusse, S., Falkenberg, K. D., Koster, J., Mooyer, P. A., Jones, R. O., van Roermund, C. W. T., Pizzino, A., Schrader, M., Wanders, R. J. A., Vanderver, A. & Waterham, H. R., Oct 31 2016, (Accepted/In press) In : Journal of Medical Genetics.

Research output: Contribution to journalArticle

Protein Deficiency
Acyl Coenzyme A
Fatty Acids
Retinal Dystrophies
Leukoencephalopathies

Adapted resistance training improves strength in eight weeks in individuals with multiple sclerosis

Keller, J. L., Fritz, N., Chiang, C. C., Jiang, A., Thompson, T., Cornet, N., Newsome, S., Calabresi, P. & Zackowski, K., Jan 29 2016, In : Journal of Visualized Experiments. 2016, 107, e53449.

Research output: Contribution to journalArticle

Resistance Training
Multiple Sclerosis
Education
Hip
Direction compound

Adolescent Perceptions of Outgrowing Childhood Attention-Deficit Hyperactivity Disorder: Relationship to Symptoms and Quality of Life

Anixt, J. S., Vaughn, A. J., Powe, N. R. & Lipkin, P. H., Mar 4 2016, (Accepted/In press) In : Journal of Developmental and Behavioral Pediatrics.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Quality of Life
Self Report
Parents
Postal Service