Kennedy Krieger Institute

Research Output 1963 2020

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2019

Sturge-Weber Syndrome Patient Registry: Delayed Diagnosis and Poor Seizure Control

Cho, S., Maharathi, B., Ball, K. L., Loeb, J. A. & Pevsner, J. A., Jan 1 2019, (Accepted/In press) In : Journal of Pediatrics.

Research output: Contribution to journalArticle

Sturge-Weber Syndrome
Delayed Diagnosis
Registries
Seizures
Wine
Pediatrics
Neurologic Examination
Physical Examination
Trail Making Test
Executive Function

Subtle Motor Signs in Children with Chronic Traumatic Brain Injury

Crasta, J. E., Sibel, J., Slomine, B. S., Mahone, E. M., Mostofsky, S. H. & Suskauer, S. J. M., Sep 1 2019, In : American Journal of Physical Medicine and Rehabilitation. 98, 9, p. 737-744 8 p.

Research output: Contribution to journalArticle

Chronic Brain Injury
Neurologic Examination
Physical Examination
Wounds and Injuries
Continuing Medical Education
Biopolymers
Molecular Imaging
Magnetic resonance
Sugars
Magnetic Resonance Imaging

Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS

Ross, P. J., Zhang, W. B., Mok, R. S. F., Zaslavsky, K., Deneault, E., D'Abate, L., Rodrigues, D. C., Yuen, R. K. C., Faheem, M., Mufteev, M., Piekna, A., Wei, W., Pasceri, P., Landa, R., Nagy, A., Varga, B., Salter, M. W., Scherer, S. W. & Ellis, J., Jan 1 2019, (Accepted/In press) In : Biological psychiatry.

Research output: Contribution to journalArticle

Open Access
Autistic Disorder
Neurons
Induced Pluripotent Stem Cells
Exons
Long Noncoding RNA

TET1 regulates DNA repair in human glial cells

Kuhns, K. J., Lopez-Bertoni, H., Coulter, J. B. & Bressler, J., Oct 1 2019, In : Toxicology and Applied Pharmacology. 380, 114646.

Research output: Contribution to journalArticle

Neuroglia
DNA Repair
Repair
DNA
Ionizing radiation

The association of early post-resuscitation hypotension with discharge survival following targeted temperature management for pediatric in-hospital cardiac arrest

for the Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trial Investigators, Aug 2019, In : Resuscitation. 141, p. 24-34 11 p.

Research output: Contribution to journalArticle

Extracorporeal Membrane Oxygenation
Pediatric Hospitals
Heart Arrest
Resuscitation
Hypotension

The capacity to learn new motor and perceptual calibrations develops concurrently in childhood

Rossi, C., Chau, C. W., Leech, K. A., Statton, M. A., Gonzalez, A. J. & Bastian, A. J., Dec 1 2019, In : Scientific reports. 9, 1, 9322.

Research output: Contribution to journalArticle

Open Access
Calibration
Walking
Aptitude
Learning

The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma

Xu, X., Xu, J., Knutsson, L., Liu, J., Liu, H., Li, Y., Lal, B., Laterra, J. J., Artemov, D., Liu, G., Van Zijl, P. C. & Chan, K. W. Y., Jan 1 2019, In : Magnetic resonance in medicine.

Research output: Contribution to journalArticle

Sirolimus
Glioblastoma
Glucose
Neoplasms
Heterografts

The NIH Toolbox for cognitive surveillance in Duchenne muscular dystrophy

Thangarajh, M., Kaat, A. J., Bibat, G. M., Mansour, J., Summerton, K., Gioia, A., Berger, C., Hardy, K. K. & Wagner, K. R., Jan 1 2019, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access
Duchenne Muscular Dystrophy
Cognition
Mothers
National Institutes of Health (U.S.)
Equipment and Supplies

The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood

Yang, K., Kondo, M. A., Jaaro-Peled, H., Cash-Padgett, T., Kano, S. I., Ishizuka, K., Pevsner, J. A., Tomoda, T., Sawa, A. & Niwa, M., Jan 1 2019, In : Schizophrenia Research.

Research output: Contribution to journalArticle

Transcriptome
Psychiatry
Schizophrenia
Psychotic Disorders
Biological Psychiatry

The Validity of a Frustration Paradigm to Assess the Effect of Frustration on Cognitive Control in School-Age Children

Seymour, K. E., Rosch, K. S., Tiedemann, A. & Mostofsky, S. H., Jan 1 2019, (Accepted/In press) In : Behavior Therapy.

Research output: Contribution to journalArticle

Frustration
Behavioral Research
Anger
Attention Deficit Disorder with Hyperactivity
Psychopathology

Trading Symmetry for Energy Cost During Walking in Healthy Adults and Persons Poststroke

Roemmich, R. T., Leech, K. A., Gonzalez, A. J. & Bastian, A. J., Jan 1 2019, In : Neurorehabilitation and neural repair.

Research output: Contribution to journalArticle

Gait
Walking
Costs and Cost Analysis
Rehabilitation
Stroke

Treatment patterns in children with autism in the United States

Monz, B. U., Houghton, R., Law, J. K. & Loss, G., Mar 1 2019, In : Autism Research. 12, 3, p. 517-526 10 p.

Research output: Contribution to journalArticle

Open Access
Autistic Disorder
Caregivers
Geography
Medicaid
Delivery of Health Care
2018

Accelerating locomotor savings in learning: Compressing four training days to one

Day, K. A., Leech, K. A., Roemmich, R. T. & Bastian, A. J., Jun 1 2018, In : Journal of Neurophysiology. 119, 6, p. 2100-2113 14 p.

Research output: Contribution to journalArticle

Walking
Learning
Space Simulation
Aptitude
Nervous System

Achievement attributions are associated with specific rather than general learning delays

Tsujimoto, K. C., Frijters, J. C., Boada, R., Gottwald, S., Hill, D., Jacobson, L. A., Lovett, M. W., Mahone, E. M., Willcutt, E. G., Wolf, M., Bosson-Heenan, J. & Gruen, J. R., May 1 2018, In : Learning and Individual Differences. 64, p. 8-21 14 p.

Research output: Contribution to journalArticle

attribution
Reading
Aptitude
Learning
Vocabulary

Acute kidney injury after out of hospital pediatric cardiac arrest

Cornell, T. T., Selewski, D. T., Alten, J. A., Askenazi, D., Fitzgerald, J. C., Topjian, A., Holubkov, R., Page, K., Slomine, B. S., Christensen, J. R., Dean, J. M. & Moler, F. W., Oct 1 2018, In : Resuscitation. 131, p. 63-68 6 p.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Acute Kidney Injury
Induced Hypothermia
Heart Arrest
Lactates

Addressing Medical Students' Negative Bias Toward Patients With Obesity Through Ethics Education

Geller, G. & Watkins, P. A., Oct 1 2018, In : AMA journal of ethics. 20, 10, p. E948-E959

Research output: Contribution to journalArticle

Medical Students
Ethics
Obesity
Education
Students
Attention Deficit Disorder with Hyperactivity
Sex Characteristics
Prefrontal Cortex
Gyrus Cinguli
Amygdala

Adipose-derived Stem/Stromal Cells on Electrospun Fibrin Microfiber Bundles Enable Moderate Muscle Reconstruction in a Volumetric Muscle Loss Model

Gilbert-Honick, J., Ginn, B., Zhang, Y., Salehi, S., Wagner, K. R., Mao, H. Q. & Grayson, W. L., Nov 1 2018, In : Cell Transplantation. 27, 11, p. 1644-1656 13 p.

Research output: Contribution to journalArticle

Stromal Cells
Stem cells
Fibrin
Muscle
Stem Cells
Dronabinol
Astrocytes
Cannabis
Schizophrenia
Parvalbumins

A Dual-Learning Paradigm Simultaneously Improves Multiple Features of Gait Post-Stroke

Cherry-Allen, K. M., Statton, M. A., Celnik, P. A. & Bastian, A. J., Jan 1 2018, (Accepted/In press) In : Neurorehabilitation and Neural Repair.

Research output: Contribution to journalArticle

Gait
Stroke
Learning
Walking
Knee

Altered functional connectivity between sub-regions in the thalamus and cortex in schizophrenia patients measured by resting state BOLD fMRI at 7T

Hua, J., Blair, N. I. S., Paez, A., Choe, A., Barber, A. D., Brandt, A., Lim, I. A. L., Xu, F., Kamath, V., Pekar, J. J., Van Zijl, P. C., Ross, C. A. & Margolis, R. L., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Thalamus
Schizophrenia
Magnetic Resonance Imaging
Brain
Magnetic Fields

Altered task-related modulation of long-range connectivity in children with autism

Pillai, A. S., McAuliffe, D., Lakshmanan, B. M., Mostofsky, S. H., Crone, N. E. & Ewen, J. B., Feb 1 2018, In : Autism Research. 11, 2, p. 245-257 13 p.

Research output: Contribution to journalArticle

Autistic Disorder
Task Performance and Analysis
Electroencephalography
Autism Spectrum Disorder

Altered trajectories of neurodevelopment and behavior in mouse models of Rett syndrome

Smith, E. S., Smith, D. R., Eyring, C., Braileanu, M., Smith-Connor, K. S., Ei Tan, Y., Fowler, A. Y., Hoffman, G. E., Johnston, M. V., Kannan, S. & Blue, M. E., Jan 1 2018, (Accepted/In press) In : Neurobiology of Learning and Memory.

Research output: Contribution to journalArticle

Rett Syndrome
Neuroglia
Phenotype
Inborn Genetic Diseases
Genetic Models

A metabolomic map of Zellweger spectrum disorders reveals novel disease biomarkers

Wangler, M. F., Hubert, L., Donti, T. R., Ventura, M. J., Miller, M. J., Braverman, N., Gawron, K., Bose, M., Moser, A. B., Jones, R. O., Rizzo, W. B., Sutton, V. R., Sun, Q., Kennedy, A. D. & Elsea, S. H., Oct 1 2018, In : Genetics in Medicine. 20, 10, p. 1274-1283 10 p.

Research output: Contribution to journalArticle

Zellweger Syndrome
Peroxisomes
Metabolomics
Biomarkers
Sphingomyelins

Analysis of copy number variants on chromosome 21 in down syndrome-associated congenital heart defects

Rambo-Martin, B. L., Mulle, J. G., Cutler, D. J., Bean, L. J. H., Rosser, T. C., Dooley, K. J., Cua, C., Capone, G. T., Maslen, C. L., Reeves, R. H., Sherman, S. L. & Zwick, M. E., Jan 1 2018, In : G3: Genes, Genomes, Genetics. 8, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 21
Congenital Heart Defects
Down Syndrome
African Americans
Atrioventricular Septal Defect

Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter- enhancer interactions

Oyinlade, O., Wei, S., Kammers, K., Liu, S., Wang, S., Ma, D., Huang, Z. Y., Qian, J., Zhu, H., Wan, J. & Xia, S., Jan 1 2018, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalArticle

Neoplasm Genes
DNA Methylation
Glioblastoma
Gene Expression
Genetic Promoter Regions

Anesthesia and the developing brain: A way forward for laboratory and clinical research

Disma, N., O'Leary, J. D., Loepke, A. W., Brambrink, A. M., Becke, K., Clausen, N. G., De Graaff, J. C., Liu, F., Hansen, T. G., McCann, M. E., Salorio, C. F., Soriano, S., Sun, L. S., Szmuk, P., Warner, D. O., Vutskits, L. & Davidson, A. J., Sep 1 2018, In : Paediatric Anaesthesia. 28, 9, p. 758-763 6 p.

Research output: Contribution to journalArticle

Anesthesia
Brain
Research
Anesthetics
Medical Laboratory Science
Attention Deficit Disorder with Hyperactivity
Brain
Frontal Lobe
Temporal Lobe
Parietal Lobe

Anxiety and mood disorder in children with autism spectrum disorder and ADHD

Gordon-Lipkin, E., Marvin, A. R., Law, J. K. & Lipkin, P. H., Apr 1 2018, In : Pediatrics. 141, 4, e20171377.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Anxiety Disorders
Mood Disorders
Autistic Disorder
Autism Spectrum Disorder

A PIGH mutation leading to GPI deficiency is associated with developmental delay and autism

Nguyen, T. T. M., Mahida, S., Smith-Hicks, C. L. & Campeau, P. M., Jan 1 2018, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Autistic Disorder
Mutation
Febrile Seizures
Muscle Hypotonia

Are dopamine receptor and transporter changes in Rett syndrome reflected in Mecp2-deficient mice?

Wong, D. F., Blue, M. E., Brasic, J. R., Nandi, A., Valentine, H., Stansfield, K. H., Rousset, O., Bibat, G. M., Yablonski, M. E., Johnston, M. V., Gjedde, A. & Naidu, S., Sep 1 2018, In : Experimental Neurology. 307, p. 74-81 8 p.

Research output: Contribution to journalArticle

Rett Syndrome
Dopamine Plasma Membrane Transport Proteins
Dopamine Receptors
Positron-Emission Tomography
Autoradiography

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD104-AMD113

Research output: Contribution to journalArticle

Crystallins
Epithelial-Mesenchymal Transition
Macular Degeneration
Vimentin
Cadherins

Association of early postresuscitation hypotension with survival to discharge after targeted temperature management for pediatric out-of-hospital cardiac arrest secondary analysis of a randomized clinical trial

Topjian, A. A., Moler, F. W., Telford, R., Holubkov, R., Nadkarni, V. M., Berg, R. A., Dean, J. M., Meert, K. L., Hutchinson, J. S., Newth, C. J. L., Bennett, K. S., Berger, J. T., Pineda, J. A., Koch, J. D., Schleien, C. L., Dalton, H. J., Ofori-Amanfo, G., Goodman, D. M., Fink, E. L., McQuillen, P. & 24 others, Zimmerman, J. J., Thomas, N. J., Van Der Jagt, E. W., Porter, M. B., Meyer, M. T., Harrison, R., Pham, N., Schwarz, A. J., Nowak, J. E., Alten, J., Wheeler, D. S., Bhalala, U. S., Lidsky, K., Lloyd, E., Mathur, M., Shah, S., Wu, T., Theodorou, A. A., Sanders, R. C., Silverstein, F. S., Christensen, J. R., Slomine, B. S., Pemberton, V. L. & Browning, B., Feb 1 2018, In : JAMA Pediatrics. 172, 2, p. 143-153 11 p.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Pediatric Hospitals
Hypotension
Randomized Controlled Trials
Heart Arrest
Cranial Irradiation
Corpus Callosum
Anisotropy
Prospective Studies
Radiation

Associations between medical history, cognition, and behavior in youth with down syndrome: A report from the down syndrome cognition project

Rosser, T. C., Edgin, J. O., Capone, G. T., Hamilton, D. R., Allen, E. G., Dooley, K. J., Anand, P., Strang, J. F., Armour, A. C., Frank-Crawford, M. A., Channell, M. M., Pierpont, E. I., Feingold, E., Maslen, C. L., Reeves, R. H. & Sherman, S. L., Nov 1 2018, In : American Journal on Intellectual and Developmental Disabilities. 123, 6, p. 514-528 15 p.

Research output: Contribution to journalArticle

Down Syndrome
Cognition
Congenital Heart Defects
Social Class
Medical Records

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Wang, J., Zibetti, C., Shang, P., Sripathi, S. R., Zhang, P., Cano, M., Hoang, T., Xia, S., Ji, H. K., Merbs, S. L., Zack, D. J., Handa, J., Sinha, D., Blackshaw, S. & Qian, J., Dec 1 2018, In : Nature Communications. 9, 1, 1364.

Research output: Contribution to journalArticle

chromatin
degeneration
Macular Degeneration
Chromatin
epithelium

A transition toolkit for Duchenne muscular dystrophy

Trout, C. J., Case, L. E., Clemens, P. R., McArthur, A., Noritz, G., Ritzo, M., Wagner, K. R., Vroom, E. & Kennedy, A., Oct 1 2018, In : Pediatrics. 142, p. S110-S117

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Young Adult
Delivery of Health Care
Patient Transfer
Equipment and Supplies

Best practices in fragile X syndrome treatment development

Erickson, C. A., Kaufmann, W. E., Budimirovic, D. B., Lachiewicz, A., Haas-Givler, B., Miller, R. M., Dixon Weber, J., Abbeduto, L., Hessl, D., Hagerman, R. J. & Berry-Kravis, E., Dec 2018, In : Brain Sciences. 8, 12, 224.

Research output: Contribution to journalArticle

Open Access
Fragile X Syndrome
Practice Guidelines
Animal Models
Therapeutics
Clinical Trials

Biological scaffold-mediated delivery of myostatin inhibitor promotes a regenerative immune response in an animal model of Duchenne muscular dystrophy

Estrellas, K. M., Chung, L., Cheu, L. A., Sadtler, K., Majumdar, S., Mula, J., Wolf, M. T., Elisseeff, J. H. & Wagner, K. R., Jan 1 2018, In : Journal of Biological Chemistry. 293, 40, p. 15594-15605 12 p.

Research output: Contribution to journalArticle

Myostatin
Duchenne Muscular Dystrophy
Hydrogel
Scaffolds
Muscle

Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival

Lopez-Bertoni, H., Kozielski, K. L., Rui, Y., Lal, B., Vaughan, H., Wilson, D. R., Mihelson, N., Eberhart, C. G., Laterra, J. J. & Green, J., Jul 11 2018, In : Nano Letters. 18, 7, p. 4086-4094 9 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
MicroRNAs
Tumors
delivery

Brief Report: Self-Injurious Behaviors in Preschool Children with Autism Spectrum Disorder Compared to Other Developmental Delays and Disorders

Soke, G. N., Rosenberg, S. A., Rosenberg, C. R., Vasa, R. A., Lee, L-C. & DiGuiseppi, C., Feb 10 2018, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-9 9 p.

Research output: Contribution to journalArticle

Self-Injurious Behavior
Developmental Disabilities
Preschool Children
Odds Ratio
Confidence Intervals

Burden of caregiving after a child's in-hospital cardiac arrest

Meert, K., Slomine, B. S., Christensen, J. R., Telford, R., Holubkov, R., Dean, J. M. & Moler, F. W., Jun 1 2018, In : Resuscitation. 127, p. 44-50 7 p.

Research output: Contribution to journalArticle

Heart Arrest
Caregivers
Pediatrics
Induced Hypothermia
Psychological Adaptation

Cardiac management of the patient with Duchenne muscular dystrophy

Buddhe, S., Cripe, L., Friedland-Little, J., Kertesz, N., Eghtesady, P., Finder, J., Hor, K., Judge, D. P., Kinnett, K., McNally, E. M., Raman, S., Thompson, R., Wagner, K. R. & Olson, A. K., Oct 1 2018, In : Pediatrics. 142, p. S72-S81

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Heart Failure
Dystrophin
Heart-Assist Devices
Defibrillators
Preschool Children
Caregivers
Post-Concussion Syndrome
Brain Concussion
Enuresis

Causal Attribution Profiles as a Function of Reading Skills, Hyperactivity, and Inattention

Tsujimoto, K. C., Boada, R., Gottwald, S., Hill, D., Jacobson, L. A., Lovett, M., Mahone, E. M., Willcutt, E., Wolf, M., Bosson-Heenan, J., Gruen, J. R. & Frijters, J. C., Jan 1 2018, (Accepted/In press) In : Scientific Studies of Reading.

Research output: Contribution to journalArticle

attribution
Reading
motivation research
Learning
Aptitude

CEST MRI of 3-O-methyl-D-glucose uptake and accumulation in brain tumors

Sehgal, A. A., Li, Y., Lal, B., Yadav, N. N., Xu, X., Xu, J., Laterra, J. J. & Van Zijl, P. C., Jan 1 2018, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

3-O-Methylglucose
Brain Neoplasms
Contrast Media
Glucose
Neoplasms

CEST MRI of sepsis-induced acute kidney injury

Liu, J., Han, Z., Chen, G., Li, Y., Zhang, J., Xu, J., Van Zijl, P. C., Zhang, S. & Liu, G., Aug 1 2018, In : NMR in Biomedicine. 31, 8, e3942.

Research output: Contribution to journalArticle

Acute Kidney Injury
Magnetic resonance imaging
Sepsis
Kidney
Lipopolysaccharides