Kennedy Krieger Institute

Research Output 1963 2018

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2018

Accelerating locomotor savings in learning: Compressing four training days to one

Day, K. A., Leech, K. A., Roemmich, R. T. & Bastian, A. J., Jun 1 2018, In : Journal of Neurophysiology. 119, 6, p. 2100-2113 14 p.

Research output: Contribution to journalArticle

Walking
Learning
Space Simulation
Aptitude
Nervous System

Acute kidney injury after out of hospital pediatric cardiac arrest

Cornell, T. T., Selewski, D. T., Alten, J. A., Askenazi, D., Fitzgerald, J. C., Topjian, A., Holubkov, R., Page, K., Slomine, B. S., Christensen, J. R., Dean, J. M. & Moler, F. W., Oct 1 2018, In : Resuscitation. 131, p. 63-68 6 p.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Acute Kidney Injury
Induced Hypothermia
Heart Arrest
Lactates
Dronabinol
Cyclooxygenase 2
Astrocytes
Cannabis
Schizophrenia

A Dual-Learning Paradigm Simultaneously Improves Multiple Features of Gait Post-Stroke

Cherry-Allen, K. M., Statton, M. A., Celnik, P. A. & Bastian, A. J., Jan 1 2018, (Accepted/In press) In : Neurorehabilitation and neural repair.

Research output: Contribution to journalArticle

Gait
Stroke
Learning
Walking
Knee

Altered task-related modulation of long-range connectivity in children with autism

Pillai, A. S., McAuliffe, D., Lakshmanan, B. M., Mostofsky, S. H., Crone, N. E. & Ewen, J. B., Feb 1 2018, In : Autism Research. 11, 2, p. 245-257 13 p.

Research output: Contribution to journalArticle

Autistic Disorder
Task Performance and Analysis
Electroencephalography
Autism Spectrum Disorder

Analysis of KLF4 regulated genes in cancer cells reveals a role of DNA methylation in promoter- enhancer interactions

Oyinlade, O., Wei, S., Kammers, K., Liu, S., Wang, S., Ma, D., Huang, Z. Y., Qian, J., Zhu, H., Wan, J. & Xia, S., Jan 1 2018, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalArticle

Neoplasm Genes
DNA Methylation
Glioblastoma
Gene Expression
Genetic Promoter Regions

Anesthesia and the developing brain: A way forward for laboratory and clinical research

Disma, N., O'Leary, J. D., Loepke, A. W., Brambrink, A. M., Becke, K., Clausen, N. G., De Graaff, J. C., Liu, F., Hansen, T. G., McCann, M. E., Salorio, C. F., Soriano, S., Sun, L. S., Szmuk, P., Warner, D. O., Vutskits, L. & Davidson, A. J., Sep 1 2018, In : Paediatric anaesthesia. 28, 9, p. 758-763 6 p.

Research output: Contribution to journalArticle

Anesthesia
Brain
Research
Anesthetics
Medical Laboratory Science
Attention Deficit Disorder with Hyperactivity
Brain
Frontal Lobe
Temporal Lobe
Parietal Lobe

Anxiety and mood disorder in children with autism spectrum disorder and ADHD

Gordon-Lipkin, E., Marvin, A. R., Law, J. K. & Lipkin, P. H., Apr 1 2018, In : Pediatrics. 141, 4, e20171377

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Anxiety Disorders
Mood Disorders
Autistic Disorder
Autism Spectrum Disorder

Are dopamine receptor and transporter changes in Rett syndrome reflected in Mecp2-deficient mice?

Wong, D. F., Blue, M. E., Brašić, J. R., Nandi, A., Valentine, H., Stansfield, K. H., Rousset, O., Bibat, G., Yablonski, M. E., Johnston, M. V., Gjedde, A. & Naidu, S. B., Sep 1 2018, In : Experimental Neurology. 307, p. 74-81 8 p.

Research output: Contribution to journalArticle

Rett Syndrome
Dopamine Plasma Membrane Transport Proteins
Dopamine Receptors
Positron-Emission Tomography
Autoradiography

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., Zigler, J. S., Kannan, R., Qian, J., Handa, J. T. & Sinha, D., Mar 20 2018, In : Investigative ophthalmology & visual science. 59, 4, p. AMD104-AMD113

Research output: Contribution to journalArticle

Crystallins
Epithelial-Mesenchymal Transition
Macular Degeneration
Vimentin
Cadherins

Association of early postresuscitation hypotension with survival to discharge after targeted temperature management for pediatric out-of-hospital cardiac arrest secondary analysis of a randomized clinical trial

Topjian, A. A. , Moler, F. W. , Telford, R. , Holubkov, R. , Nadkarni, V. M. , Berg, R. A. , Dean, J. M. , Meert, K. L. , Hutchinson, J. S. , Newth, C. J. L. , Bennett, K. S. , Berger, J. T. , Pineda, J. A. , Koch, J. D. , Schleien, C. L. , Dalton, H. J. , Ofori-Amanfo, G. , Goodman, D. M. , Fink, E. L. , McQuillen, P. & 24 others Zimmerman, J. J., Thomas, N. J., Van Der Jagt, E. W., Porter, M. B., Meyer, M. T., Harrison, R., Pham, N., Schwarz, A. J., Nowak, J. E., Alten, J., Wheeler, D. S., Bhalala, U. S., Lidsky, K., Lloyd, E., Mathur, M., Shah, S., Wu, T., Theodorou, A. A., Sanders, R. C., Silverstein, F. S., Christensen, J. R., Slomine, B. S., Pemberton, V. L. & Browning, B., Feb 1 2018, In : JAMA Pediatrics. 172, 2, p. 143-153 11 p.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Pediatric Hospitals
Hypotension
Randomized Controlled Trials
Heart Arrest
Cranial Irradiation
Corpus Callosum
Anisotropy
Irradiation
Prospective Studies

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Wang, J., Zibetti, C., Shang, P., Sripathi, S. R., Zhang, P., Cano, M., Hoang, T., Xia, S., Ji, H., Merbs, S. L., Zack, D. J., Handa, J. T., Sinha, D., Blackshaw, S. & Qian, J., Dec 1 2018, In : Nature Communications. 9, 1, 1364

Research output: Contribution to journalArticle

accessibility
analysis
pathology
risk factor
footprint

Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival

Lopez-Bertoni, H., Kozielski, K. L., Rui, Y., Lal, B., Vaughan, H., Wilson, D. R., Mihelson, N., Eberhart, C. G., Laterra, J. & Green, J. J., Jul 11 2018, In : Nano Letters. 18, 7, p. 4086-4094 9 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
Tumors
delivery
cancer

Brief Report: Self-Injurious Behaviors in Preschool Children with Autism Spectrum Disorder Compared to Other Developmental Delays and Disorders

Soke, G. N., Rosenberg, S. A., Rosenberg, C. R., Vasa, R. A., Lee, L. C. & DiGuiseppi, C., Feb 10 2018, (Accepted/In press) In : Journal of Autism and Developmental Disorders. p. 1-9 9 p.

Research output: Contribution to journalArticle

Self-Injurious Behavior
Developmental Disabilities
Preschool Children
Odds Ratio
Confidence Intervals

Burden of caregiving after a child's in-hospital cardiac arrest

Meert, K., Slomine, B. S., Christensen, J. R., Telford, R., Holubkov, R., Dean, J. M. & Moler, F. W., Jun 1 2018, In : Resuscitation. 127, p. 44-50 7 p.

Research output: Contribution to journalArticle

Heart Arrest
Caregivers
Pediatrics
Induced Hypothermia
Psychological Adaptation
Preschool Children
Caregivers
Post-Concussion Syndrome
Brain Concussion
Enuresis
Loeys-Dietz Syndrome
Carotid Arteries
Kaplan-Meier Estimate
Proportional Hazards Models
Angiography

CEST MRI of 3-O-methyl-D-glucose uptake and accumulation in brain tumors

Sehgal, A. A., Li, Y., Lal, B., Yadav, N. N., Xu, X., Xu, J., Laterra, J. & van Zijl, P. C. M., Jan 1 2018, (Accepted/In press) In : Magnetic resonance in medicine.

Research output: Contribution to journalArticle

3-O-Methylglucose
Brain Neoplasms
Contrast Media
Glucose
Neoplasms

CEST MRI of sepsis-induced acute kidney injury

Liu, J., Han, Z., Chen, G., Li, Y., Zhang, J., Xu, J., van Zijl, P. C. M., Zhang, S. & Liu, G., Aug 1 2018, In : NMR in Biomedicine. 31, 8, e3942

Research output: Contribution to journalArticle

Magnetic resonance imaging
Magnetization
Molecular imaging
Histology
Biomarkers

Clinical and functional characterization of the recurrent TUBA1A p.(ARG2HIS) mutation

Gardner, J. F., Cushion, T. D., Niotakis, G., Olson, H. E., Grant, P. E., Scott, R. H., Stoodley, N., Cohen, J. S., Naidu, S., Attie-Bitach, T., Bonnières, M., Boutaud, L., Encha-Razavi, F., Palmer-Smith, S. M., Mugalaasi, H., Mullins, J. G. L., Pilz, D. T. & Fry, A. E., Aug 7 2018, In : Brain Sciences. 8, 8, 145

Research output: Contribution to journalArticle

Tubulin
Mutation
Microtubules
Brain
Microcephaly

Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection

Renard, M. , Francis, C. , Ghosh, R. , Scott, A. F. , Witmer, P. D. , Adès, L. C. , Andelfinger, G. U. , Arnaud, P. , Boileau, C. , Callewaert, B. L. , Guo, D. , Hanna, N. , Lindsay, M. E. , Morisaki, H. , Morisaki, T. , Pachter, N. , Robert, L. , Van Laer, L. , Dietz, H. C. , Loeys, B. L. & 2 others Milewicz, D. M. & De Backer, J., Aug 7 2018, In : Journal of the American College of Cardiology. 72, 6, p. 605-615 11 p.

Research output: Contribution to journalArticle

Thoracic Aortic Aneurysm
Dissection
Genes
Aortic Diseases
Thoracic Diseases

Comparing fully automated state-of-the-art cerebellum parcellation from magnetic resonance images

Carass, A. , Cuzzocreo, J. L. , Han, S. , Hernandez-Castillo, C. R. , Rasser, P. E. , Ganz, M. , Beliveau, V. , Dolz, J. , Ben Ayed, I. , Desrosiers, C. , Thyreau, B. , Romero, J. E. , Coupé, P. , Manjón, J. V. , Fonov, V. S. , Collins, D. L. , Ying, S. H. , Onyike, C. U. , Crocetti, D. , Landman, B. A. & 3 others Mostofsky, S. H., Thompson, P. M. & Prince, J. L., Dec 1 2018, In : NeuroImage. 183, p. 150-172 23 p.

Research output: Contribution to journalArticle

Cerebellum
Magnetic Resonance Spectroscopy
Pathology
Cerebellar Ataxia
Autistic Disorder

Correction to: Reduced Value-Driven Attentional Capture among Children with ADHD Compared to Typically Developing Control

Sali, A. W., Anderson, B. A., Yantis, S., Mostofsky, S. H. & Rosch, K. S., Apr 11 2018, (Accepted/In press) In : Journal of Abnormal Child Psychology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Child Psychology

Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1)

Magruder, J. T., Fraser, C. D., Grimm, J. C., Crawford, T. C., Beaty, C. A., Suarez-Pierre, A., Hayes, R. L., Johnston, M. V. & Baumgartner, W. A., Jan 1 2018, (Accepted/In press) In : Journal of Cardiothoracic and Vascular Anesthesia.

Research output: Contribution to journalArticle

Ubiquitin Thiolesterase
Nervous System Trauma
Cardiopulmonary Bypass
Biomarkers
Oxygen

Creating flexible motor memories in human walking

Leech, K. A., Roemmich, R. T. & Bastian, A. J., Dec 1 2018, In : Scientific Reports. 8, 1, 94

Research output: Contribution to journalArticle

Walking
Learning
Aptitude
Gait
Nervous System

Crizotinib and erlotinib inhibits growth of c-Met+/EGFRvIII+ primary human glioblastoma xenografts

Goodwin, C. R., Rath, P., Oyinlade, O., Lopez, H., Mughal, S., Xia, S., Li, Y., Kaur, H., Zhou, X., Ahmed, A. K., Ho, S., Olivi, A. & Lal, B., Aug 1 2018, In : Clinical Neurology and Neurosurgery. 171, p. 26-33 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Growth
Epidermal Growth Factor Receptor
Neoplasms

Dendrimer–N-acetyl-L-cysteine modulates monophagocytic response in adrenoleukodystrophy

Turk, B. R., Nemeth, C. L., Marx, J. S., Tiffany, C., Jones, R., Theisen, B., Kambhampati, S., Ramireddy, R., Singh, S., Rosen, M., Kaufman, M. L., Murray, C. F., Watkins, P. A., Kannan, S., Kannan, R. & Fatemi, A., Sep 1 2018, In : Annals of neurology. 84, 3, p. 452-462 11 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Dendrimers
Acetylcysteine
Cysteine
Glutamic Acid
Developmental Disabilities
Intellectual Disability
Epilepsy
Mutation

Detection and differentiation of Cys, Hcy and GSH mixtures by 19F NMR probe

Yang, S., Zeng, Q., Guo, Q., Chen, S., Liu, H., Liu, M., McMahon, M. T. & Zhou, X., Jul 1 2018, In : Talanta. 184, p. 513-519 7 p.

Research output: Contribution to journalArticle

Homocysteine
Cysteine
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Addition reactions

Developmental Trajectory of Motor Deficits in Preschool Children with ADHD

Sweeney, K. L., Ryan, M., Schneider, H., Ferenc, L., Denckla, M. B. & Mark Mahone, E., May 13 2018, (Accepted/In press) In : Developmental Neuropsychology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Preschool Children
Fingers
Neurologic Examination
Physical Examination
Longitudinal Studies

Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study

Raghubar, K. P., Lamba, M., Cecil, K. M., Yeates, K. O., Mahone, E. M., Limke, C., Grosshans, D., Beckwith, T. J. & Ris, M. D., Sep 1 2018, In : Pediatric Blood and Cancer. 65, 9, e27245

Research output: Contribution to journalArticle

Brain Neoplasms
Radiation
Pediatrics
Brain
Learning

Early childhood undernutrition increases risk of hearing loss in young adulthood in rural Nepal

Emmett, S. D., Schmitz, J., Karna, S. L., Khatry, S. K., Wu, L., LeClerq, S. C., Pillion, J. & West, K. P., Feb 1 2018, In : American Journal of Clinical Nutrition. 107, 2, p. 268-277 10 p.

Research output: Contribution to journalArticle

Nepal
Hearing Loss
Malnutrition
Thinness
Growth Disorders

Early detection of hypothermic neuroprotection using T2-weighted magnetic resonance imaging in a mouse model of hypoxic ischemic encephalopathy

Doman, S. E., Girish, A., Nemeth, C. L., Drummond, G. T., Carr, P., Garcia, M. S., Johnston, M. V., Kannan, S., Fatemi, A., Zhang, J. & Wilson, M. A., May 8 2018, In : Frontiers in Neurology. 9, MAY, 304

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Ischemia
Magnetic Resonance Imaging
Hypothermia
Wounds and Injuries

ECT for Self-Injurious Behavior in Autism: A New Indication

Wachtel, L. E., Kellner, C. H. & Fink, M., Feb 1 2018, In : Psychiatric Times. 35, 2, p. 6-9 4 p.

Research output: Contribution to journalArticle

Self-Injurious Behavior
Autistic Disorder

Elevated creatinine in a patient on IVIG-therapy

Knezevic, C. E., Ness, M. A., Kratz, L. E. & Marzinke, M. A., Nov 1 2018, In : Clinica Chimica Acta. 486, p. 94-97 4 p.

Research output: Contribution to journalArticle

Passive Immunization
Intravenous Immunoglobulins
Proline
Creatinine
Sarcosine Oxidase

Engineering functional and histological regeneration of vascularized skeletal muscle

Gilbert-Honick, J., Iyer, S. R., Somers, S. M., Lovering, R. M., Wagner, K., Mao, H. Q. & Grayson, W. L., May 1 2018, In : Biomaterials. 164, p. 70-79 10 p.

Research output: Contribution to journalArticle

Muscle
Regeneration
Skeletal Muscle
Scaffolds
Muscles
Autistic Disorder
Intellectual Disability
Caregivers
Inpatients
Disabled Persons

Exploring Relationships Between Negative Cognitions and Anxiety Symptoms in Youth With Autism Spectrum Disorder

Keefer, A., Kreiser, N. L., Singh, V., Blakeley-Smith, A., Reaven, J. & Vasa, R. A., Jan 1 2018, (Accepted/In press) In : Behavior Therapy.

Research output: Contribution to journalArticle

Cognition
Anxiety
Autism Spectrum Disorder
Uncertainty
Depression

First evidence of maternally inherited mosaicism in TGFBR1 and subtle primary myocardial changes in Loeys-Dietz syndrome: A case report

Baban, A., Magliozzi, M., Loeys, B., Adorisio, R., Alesi, V., Secinaro, A., Corica, B., Vricella, L., Dietz, H. C., Drago, F., Novelli, A. & Amodeo, A., Sep 15 2018, In : BMC Medical Genetics. 19, 1, 170

Research output: Contribution to journalArticle

Loeys-Dietz Syndrome
Mosaicism
Mutation
Cheek
Iris
Tourette Syndrome
gamma-Aminobutyric Acid
Glutamic Acid
Magnetic Resonance Spectroscopy
Motor Cortex

Genetic and genomic stability across lymphoblastoid cell line expansions

Scheinfeldt, L. B., Hodges, K., Pevsner, J., Berlin, D., Turan, N. & Gerry, N. P., Aug 3 2018, In : BMC Research Notes. 11, 1, 558

Research output: Contribution to journalArticle

Genomic Instability
Cells
Cell Line
DNA
Single Nucleotide Polymorphism

Global identification of Small Ubiquitin-related Modifier (SUMO) substrates reveals crosstalk between SUMOylation and phosphorylation promotes cell migration

Uzoma, I., Hu, J., Cox, E., Xia, S., Zhou, J., Rho, H. S., Guzzo, C., Paul, C., Ajala, O., Goodwin, C. R., Jeong, J., Moore, C., Zhang, H., Meluh, P., Blackshaw, S., Matunis, M., Qian, J. & Zhu, H., May 1 2018, In : Molecular and Cellular Proteomics. 17, 5, p. 871-888 18 p.

Research output: Contribution to journalArticle

Sumoylation
Ubiquitin
Cell Movement
Phosphorylation
Rotary engines

GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

Xu, X., Xu, J., Chan, K. W. Y., Liu, J., Liu, H., Li, Y., Chen, L., Liu, G. & van Zijl, P. C. M., Jan 1 2018, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Protons
Glucose
Vascular Tissue Neoplasms
Heterografts
Glioma

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

Wei, S., Wang, J., Oyinlade, O., Ma, D., Wang, S., Kratz, L., Lal, B., Xu, Q., Liu, S., Shah, S. R., Zhang, H., Li, Y., Quiñones-Hinojosa, A., Zhu, H., Huang, Z. Y., Cheng, L., Qian, J. & Xia, S., May 30 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Down-Regulation
Growth
Proteins
Mutation

Home-Based, Therapist-Assisted, Therapy for Young Children With Primary Complex Motor Stereotypies

Singer, H. S., Rajendran, S., Waranch, H. R. & Mahone, E. M., Jan 1 2018, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

Telephone
Lost to Follow-Up
Therapeutics
Attention Deficit Disorder with Hyperactivity
Parents

Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease

Brose, R. D., Lehrmann, E., Zhang, Y., Reeves, R. H., Smith, K. D. & Mattson, M. P., Dec 1 2018, In : Neurobiology of Aging. 72, p. 121-133 13 p.

Research output: Contribution to journalArticle

Hydroxyurea
Alzheimer Disease
Neurons
Amyloid beta-Peptides
Hydrogen Peroxide
Self-Injurious Behavior
behavior analysis
Biomarkers
Therapeutics
physician's care

Improved estimation of subject-level functional connectivity using full and partial correlation with empirical Bayes shrinkage

Mejia, A. F., Nebel, M. B., Barber, A. D., Choe, A. S., Pekar, J. J., Caffo, B. S. & Lindquist, M. A., May 15 2018, In : NeuroImage. 172, p. 478-491 14 p.

Research output: Contribution to journalArticle

Bayes Theorem
Connectome
Research Design
Magnetic Resonance Imaging