Kennedy Krieger Institute

Research Output 1963 2020

2020

Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex

Chu, C., Jablonska, A., Lesniak, W. G., Thomas, A. M., Lan, X., Linville, R. M., Li, S., Searson, P. C., Liu, G., Pearl, M., Pomper, M. G., Janowski, M., Magnus, T. & Walczak, P., Jan 10 2020, In : Journal of Controlled Release. 317, p. 312-321 10 p.

Research output: Contribution to journalArticle

Open Access
Blood-Brain Barrier
Pharmaceutical Preparations
Intra Arterial Infusions
Brain
Rhodamines

Stem cell-based therapies for Duchenne muscular dystrophy

Sun, C., Serra, C., Lee, G. & Wagner, K. R., Jan 2020, In : Experimental Neurology. 323, 113086.

Research output: Contribution to journalReview article

Pluripotent Stem Cells
Duchenne Muscular Dystrophy
Cell- and Tissue-Based Therapy
Stem Cells
Stem Cell Research
2019

AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice

Nance, M. E., Shi, R., Hakim, C. H., Wasala, N. B., Yue, Y., Pan, X., Zhang, T., Robinson, C. A., Duan, S. X., Yao, G., Yang, N. N., Chen, S. J., Wagner, K. R., Gersbach, C. A. & Duan, D., Jan 1 2019, In : Molecular Therapy.

Research output: Contribution to journalArticle

Dependovirus
Muscle Cells
Stem Cells
Dystrophin
Clustered Regularly Interspaced Short Palindromic Repeats

A Coupled Manifold Optimization Framework to Jointly Model the Functional Connectomics and Behavioral Data Spaces

D’Souza, N. S., Nebel, M. B., Wymbs, N., Mostofsky, S. H. & Venkataraman, A., Jan 1 2019, Information Processing in Medical Imaging - 26th International Conference, IPMI 2019, Proceedings. Bao, S., Chung, A. C. S., Gee, J. C. & Yushkevich, P. A. (eds.). Springer Verlag, p. 605-616 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11492 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Functional Magnetic Resonance Imaging
Optimization
Optimise
Distinct
Manifold Learning

Acute flaccid myelitis: Rehabilitation challenges and outcomes in a pediatric cohort

Melicosta, M. E., Dean, J., Hagen, K., Oppenheimer, K., Porter, C., Rybczynski, S., Salorio, C. & Sadowsky, C., Jan 1 2019, In : Journal of pediatric rehabilitation medicine. 12, 3, p. 245-253 9 p.

Research output: Contribution to journalArticle

Myelitis
Pediatrics
Rehabilitation
Paralysis
Recovery of Function

A fluorinated aza-BODIPY derivative for NIR fluorescence/PA/ 19 F MR tri-modality: In vivo imaging

Liu, L., Yuan, Y., Yang, Y., Mcmahon, M. T., Chen, S. & Zhou, X., Jan 1 2019, In : Chemical Communications. 55, 42, p. 5851-5854 4 p.

Research output: Contribution to journalArticle

Photoacoustic effect
Contrast Media
Tumors
Fluorescence
Infrared radiation

Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population

Pediatric Imaging, Neurocognition, and Genetics (PING) Study Consortium, Jan 1 2019, In : Biological psychiatry.

Research output: Contribution to journalArticle

Corpus Striatum
Population
Attention Deficit Disorder with Hyperactivity
Psychotic Disorders
Depression

An Evaluation of Operant Behavioural Economics in Functional Communication Training for Severe Problem Behaviour

Gilroy, S. P., Ford, H. L., Boyd, R. J., O'Connor, J. T. & Kurtz, P. F., Nov 17 2019, In : Developmental Neurorehabilitation. 22, 8, p. 553-564 12 p.

Research output: Contribution to journalArticle

Behavioral Economics
Communication
Therapeutics
Caregivers
Problem Behavior

An exploration of concomitant psychiatric disorders in children with autism spectrum disorder

Lecavalier, L., McCracken, C. E., Aman, M. G., McDougle, C. J., McCracken, J. T., Tierney, E., Smith, T., Johnson, C., King, B., Handen, B., Swiezy, N. B., Eugene Arnold, L., Bearss, K., Vitiello, B. & Scahill, L., Jan 1 2019, In : Comprehensive Psychiatry. 88, p. 57-64 8 p.

Research output: Contribution to journalArticle

Psychiatry
Attention Deficit and Disruptive Behavior Disorders
Attention Deficit Disorder with Hyperactivity
Anxiety Disorders
Conduct Disorder
Cerebral Palsy
Hip
Hip Dislocation
Pain
Postoperative Pain

Assessment of functional outcomes of an interdisciplinary inpatient pediatric pain rehabilitation program

Robinson, M., Ward, C. M., Shieh, B. S., Armstrong, B., Docimo, M. A., Celedon, X., Rybczynski, S., Levey, E. & Slifer, K. J., Jun 1 2019, In : Clinical Practice in Pediatric Psychology. 7, 2, p. 116-126 11 p.

Research output: Contribution to journalArticle

Inpatients
Rehabilitation
Outcome Assessment (Health Care)
Pediatrics
Pain
Parents
Patient Education
Search Engine
Neoplasms
Names

Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort

Hassiotis, A., Brown, E., Harris, J., Helm, D., Munir, K., Salvador-Carulla, L., Bertelli, M., Baghdadli, A., Wieland, J., Novell-Alsina, R., Cid, J., Vergés, L., Martínez-Leal, R., Mutluer, T., Ismayilov, F. & Emerson, E., Dec 5 2019, In : BMC psychiatry. 19, 1, 387.

Research output: Contribution to journalArticle

Open Access
Psychiatry
Parturition
Morbidity
Economics
Equipment and Supplies

Behavioral Assessment and Treatment of Pica in a Typically Developing 3-Year-Old

Ness, E., Strohmeier, C. W., Ramazon, N. & O'Connor, J. T., Jan 1 2019, (Accepted/In press) In : Clinical Practice in Pediatric Psychology.

Research output: Contribution to journalArticle

Pica
Therapeutics
Developmental Disabilities
Intellectual Disability
Caregivers

Benign tumors in myotonic dystrophy type I target disease-related cancer sites

Alsaggaf, R., St. George, D. M. M., Zhan, M., Pfeiffer, R. M., Wang, Y., Anderson, L. A., Liu, Z., Koshiol, J., Bauer, A. J., Wagner, K. R., Greene, M. H., Amr, S. & Gadalla, S. M., Jan 1 2019, In : Annals of Clinical and Translational Neurology. 6, 8, p. 1510-1518 9 p.

Research output: Contribution to journalArticle

Open Access
Myotonic Dystrophy
Neoplasms
Confidence Intervals
Polyps
Brain Neoplasms
Magnetic resonance imaging
Contrast Media
Carbon
Magnetic resonance
Imaging techniques

Cardiac Arrest Outcomes in Children With Preexisting Neurobehavioral Impairment

Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) Trial Investigators, Jun 1 2019, In : Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 20, 6, p. 510-517 8 p.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Psychological Adaptation
Heart Arrest
Induced Hypothermia
Pediatrics

Caregivers' perception of and experience with variants of uncertain significance from whole exome sequencing for children with undiagnosed conditions

Li, X., Nusbaum, R., Smith-Hicks, C. L., Jamal, L., Dixon, S. & Mahida, S., Apr 1 2019, In : Journal of Genetic Counseling. 28, 2, p. 304-312 9 p.

Research output: Contribution to journalArticle

Exome
Caregivers
Child Care
Legal Guardians
Emotions

CEST MRI monitoring of tumor response to vascular disrupting therapy using high molecular weight dextrans

Chen, H., Liu, D., Li, Y., Xu, X., Xu, J., Yadav, N. N., Zhou, S., Van Zijl, P. C. & Liu, G., Jan 1 2019, In : Magnetic resonance in medicine.

Research output: Contribution to journalArticle

Dextrans
Blood Vessels
Molecular Weight
Neoplasms
Therapeutics

Characteristics Associated with Autism Spectrum Disorder Risk in Individuals with Down Syndrome

The Down Syndrome Cognition Project, Sep 15 2019, In : Journal of Autism and Developmental Disorders. 49, 9, p. 3543-3556 14 p.

Research output: Contribution to journalArticle

Down Syndrome
Psychological Adaptation
Autism Spectrum Disorder
Therapeutics
Psychiatry
Hospital Emergency Service
Attention Deficit Disorder with Hyperactivity
Ambulatory Care
Hospitalization
Open Access
Self-Injurious Behavior
Tuberous Sclerosis
Diffusion Tensor Imaging
Basal Ganglia
Globus Pallidus
Appointments and Schedules
Parents
African Americans
Sample Size
Autism Spectrum Disorder

Clinical trial readiness to solve barriers to drug development in FSHD (ReSolve): Protocol of a large, international, multi-center prospective study

Lorusso, S., Johnson, N. E., McDermott, M. P., Eichinger, K., Butterfield, R. J., Carraro, E., Higgs, K., Lewis, L., Mul, K., Sacconi, S., Sansone, V. A., Shieh, P., Van Engelen, B., Wagner, K., Wang, L., Statland, J. M., Tawil, R., Dimachkie, M., Pasnoor, M., Roath, K. & 32 others, McCalley, A., Currence, M., Herbelin, L., Hamel, J., Arnold, W. D., Alexander, T., Yankie, M., Kelly, K., Holmberg, B., Diaz, L., Jones, A., Butler, A., Moldt, S., Wilson, A., McIntyre, M., Leung, D., Bibat, G., Yep, M., Stinson, N., Jaworek, A., Sissons-Ross, L., Johnstone, L., Skura, C., Deguzman, D., Cornelissen, Y., Villa, L., Puma, A., Gambella, M., Shi, Y., Garcia, J., Beshiri, F. & Mauro, L., Sep 10 2019, In : BMC neurology. 19, 1, 224.

Research output: Contribution to journalArticle

Open Access
Facioscapulohumeral Muscular Dystrophy
Clinical Trials
Prospective Studies
Pharmaceutical Preparations
Outcome Assessment (Health Care)
Open Access
Electrophysiology
Biomarkers
Aptitude
Brain
Drug Discovery

Cornelia de Lange syndrome, related disorders, and the Cohesin complex: Abstracts from the 8th biennial scientific and educational symposium 2018

Kline, A. D., Krantz, I. D., Bando, M., Shirahige, K., Chea, S., Sakata, T., Rao, S., Dorsett, D., Singh, V. P., Gerton, J. L., Horsfield, J. A., Calof, A. L., Katz, O., Grados, M., Raible, S., Baranano, K., Lyon, G., Musio, A., Carrico, C. S., Clemens, D. K. & 6 others, Caudill, P., Massa, V., McGill, B. E., Dommestrup, A., O'Connor, J. T. & Haaland, R. E., Jun 1 2019, In : American Journal of Medical Genetics, Part A. 179, 6, p. 1080-1090 11 p.

Research output: Contribution to journalArticle

De Lange Syndrome
Mutation
Microcephaly
Ethics Committees
Baltimore

Correction: Brain structure in pediatric Tourette syndrome (Molecular Psychiatry, (2017), 22, 7, (972-980), 10.1038/mp.2016.194)

The Tourette Association of America Neuroimaging Consortium, Jan 1 2019, In : Molecular psychiatry.

Research output: Contribution to journalComment/debate

Open Access
Tourette Syndrome
Los Angeles
Psychiatry
Baltimore
Pediatrics
Open Access
Authorship
Autistic Disorder
Caregivers
Research
Publications

Correction to: Psychometric Validation of the Autism Impact Measure (AIM) (Journal of Autism and Developmental Disorders, (2019), 49, 6, (2559-2570), 10.1007/s10803-019-04011-2)

Houghton, R., Monz, B., Law, J. K., Loss, G., Le Scouiller, S., de Vries, F. & Willgoss, T., Jun 15 2019, In : Journal of Autism and Developmental Disorders. 49, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Autistic Disorder
Psychometrics
Internet

Correlation Between White Matter Injury Identified by Neonatal Diffusion Tensor Imaging and Neurodevelopmental Outcomes Following Term Neonatal Asphyxia and Therapeutic Hypothermia: An Exploratory Pilot Study

Gerner, G. J., Newman, E. I., Burton, V. J., Roman, B., Cristofalo, E. A., Leppert, M. L., Johnston, M. V., Northington, F., Huisman, T. A. G. M. & Poretti, A., Jan 1 2019, In : Journal of child neurology.

Research output: Contribution to journalArticle

Induced Hypothermia
Diffusion Tensor Imaging
Asphyxia
Brain Hypoxia-Ischemia
Wounds and Injuries

CT and CEST MRI bimodal imaging of the intratumoral distribution of iodinated liposomes

Chen, Z., Li, Y., Airan, R., Han, Z., Xu, J., Chan, K. W. Y., Xu, Y., Bulte, J. W. M., Van Zijl, P. C. M., McMahon, M. T., Zhou, S. & Liu, G., Jan 1 2019, In : Quantitative Imaging in Medicine and Surgery. 9, 9, p. 1579-1591 13 p.

Research output: Contribution to journalArticle

Liposomes
Contrast Media
Rhodamines
Neoplasms
X Ray Computed Tomography
Executive Function
Attention Deficit Disorder with Hyperactivity
Emotions
National Institute of Mental Health (U.S.)
Short-Term Memory

De Novo Variants in MAPK8IP3 Cause Intellectual Disability with Variable Brain Anomalies

Platzer, K., Sticht, H., Edwards, S. L., Allen, W., Angione, K. M., Bonati, M. T., Brasington, C., Cho, M. T., Demmer, L. A., Falik-Zaccai, T., Gamble, C. N., Hellenbroich, Y., Iascone, M., Kok, F., Mahida, S., Mandel, H., Marquardt, T., McWalter, K., Panis, B., Pepler, A. & 12 others, Pinz, H., Ramos, L., Shinde, D. N., Smith-Hicks, C. L., Stegmann, A. P. A., Stöbe, P., Stumpel, C. T. R. M., Wilson, C., Lemke, J. R., Di Donato, N., Miller, K. G. & Jamra, R., Feb 7 2019, In : American Journal of Human Genetics. 104, 2, p. 203-212 10 p.

Research output: Contribution to journalArticle

Exome
Intellectual Disability
Clustered Regularly Interspaced Short Palindromic Repeats
Axonal Transport
Corpus Callosum

Depression in Youth with Autism Spectrum Disorder

Pezzimenti, F., Han, G. T., Vasa, R. A. & Gotham, K., Jan 1 2019, In : Child and Adolescent Psychiatric Clinics of North America.

Research output: Contribution to journalReview article

Depression
Autistic Disorder
Public Health
Guidelines
Population
Phosphatases
Magnetic resonance
Acid Phosphatase
Phenol
Contrast Media

Developmental Trajectories of Infants with Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study

McDonald, N. M., Senturk, D., Scheffler, A., Brian, J. A., Carver, L. J., Charman, T., Chawarska, K., Curtin, S., Hertz-Piccioto, I., Jones, E. J. H., Klin, A., Landa, R., Messinger, D. S., Ozonoff, S., Stone, W. L., Tager-Flusberg, H., Webb, S. J., Young, G., Zwaigenbaum, L. & Jeste, S. S., Jan 1 2019, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticle

Autistic Disorder
Siblings
Research
Aptitude
Incidence

Development of the frontal lobe

Rosch, K. S. & Mostofsky, S. H., Jan 1 2019, Handbook of Clinical Neurology. Elsevier B.V., p. 351-367 17 p. (Handbook of Clinical Neurology; vol. 163).

Research output: Chapter in Book/Report/Conference proceedingChapter

Frontal Lobe
Choice Behavior
Avoidance Learning
Animal Behavior
Precision Medicine

Differential Changes in Functional Connectivity of Striatum-Prefrontal and Striatum-Motor Circuits in Premanifest Huntington's Disease

Kronenbuerger, M., Hua, J., Bang, J. Y. A., Ultz, K. E., Miao, X., Zhang, X., Pekar, J. J., Van Zijl, P. C., Duan, W., Margolis, R. L. & Ross, C. A., Jan 1 2019, (Accepted/In press) In : Neurodegenerative Diseases.

Research output: Contribution to journalArticle

Huntington Disease
Networks (circuits)
Motor Cortex
Cytosine
Guanine

Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission

Guo, H., Li, Y., Shen, L., Wang, T., Jia, X., Liu, L., Xu, T., Ou, M., Hoekzema, K., Wu, H., Gillentine, M. A., Liu, C., Ni, H., Peng, P., Zhao, R., Zhang, Y., Phornphutkul, C., Stegmann, A. P. A., Prada, C. E., Hopkin, R. J. & 53 others, Shieh, J. T., McWalter, K., Monaghan, K. G., van Hasselt, P. M., van Gassen, K., Bai, T., Long, M., Han, L., Quan, Y., Chen, M., Zhang, Y., Li, K., Zhang, Q., Tan, J., Zhu, T., Liu, Y., Pang, N., Peng, J., Scott, D. A., Lalani, S. R., Azamian, M., Mancini, G. M. S., Adams, D. J., Kvarnung, M., Lindstrand, A., Nordgren, A., Pevsner, J., Osei-Owusu, I. A., Romano, C., Calabrese, G., Galesi, O., Gecz, J., Haan, E., Ranells, J., Racobaldo, M., Nordenskjold, M., Madan-Khetarpal, S., Sebastian, J., Ball, S., Zou, X., Zhao, J., Hu, Z., Xia, F., Liu, P., Rosenfeld, J. A., de Vries, B. B. A., Bernier, R. A., Xu, Z. Q. D., Li, H., Xie, W., Hufnagel, R. B., Eichler, E. E. & Xia, K., Sep 25 2019, In : Science Advances. 5, 9, eaax2166.

Research output: Contribution to journalArticle

Open Access
synapses
disabilities
seizures
proteins
Drosophila

Does Increased Consolidated Nighttime Sleep Facilitate Attentional Control? A Pilot Study of Nap Restriction in Preschoolers

Lam, J. C., Koriakin, T. A., Scharf, S. M., Mason, T. B. A. & Mahone, E. M., Feb 1 2019, In : Journal of Attention Disorders. 23, 4, p. 333-340 8 p.

Research output: Contribution to journalArticle

Sleep
Cognition
Actigraphy
Preschool Children

Early Antibiotics and Childhood Obesity: Do Future Risks Matter to Parents and Physicians?

Lipstein, E. A., Block, J. P., Dodds, C., Forrest, C. B., Heerman, W. J., Law, J. K., Lunsford, D., Winkler, P. & Finkelstein, J. A., Feb 1 2019, In : Clinical Pediatrics. 58, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

Pediatric Obesity
Parents
Anti-Bacterial Agents
Physicians
Obesity

Early motor abilities in infants at heightened versus low risk for ASD: A Baby Siblings Research Consortium (BSRC) study

Iverson, J. M., Shic, F., Wall, C. A., Chawarska, K., Curtin, S., Estes, A., Gardner, J. M., Hutman, T., Landa, R., Levin, A. R., Libertus, K., Messinger, D. S., Nelson, C. A., Ozonoff, S., Sacrey, L. A. R., Sheperd, K., Stone, W. L., Tager-Flusberg, H. B., Wolff, J. J., Yirmiya, N. & 1 others, Young, G. S., Jan 1 2019, In : Journal of Abnormal Psychology. 128, 1, p. 69-80 12 p.

Research output: Contribution to journalArticle

Aptitude
Siblings
Research
Motor Skills
Autism Spectrum Disorder
Sex Chromosomes
Aneuploidy
Epigenomics
Alcohols
Phenotype
Electroconvulsive Therapy
Obsessive-Compulsive Disorder

Elopement Patterns and Caregiver Strategies

Andersen, A. M., Law, J. K., Marvin, A. R. & Lipkin, P. H., Jan 1 2019, In : Journal of Autism and Developmental Disorders.

Research output: Contribution to journalArticle

Caregivers
Autistic Disorder
Insurance
Equipment and Supplies
Surveys and Questionnaires

Engineering 3D skeletal muscle primed for neuromuscular regeneration following volumetric muscle loss

Gilbert-Honick, J., Wagner, K. R., Mao, H. Q. & Grayson, W. L., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Agrin
Muscle
Regeneration
Skeletal Muscle
Cholinergic Receptors
Epigenomics
Health
Environmental Exposure
Malnutrition
Type 2 Diabetes Mellitus

Epilepsy and Autism Severity: A Study of 6,975 Children

Ewen, J. B., Marvin, A. R., Law, J. K. & Lipkin, P. H., Jan 1 2019, In : Autism Research.

Research output: Contribution to journalArticle

Autistic Disorder
Epilepsy
Intellectual Disability
Autism Spectrum Disorder
Sex Factors
Research
Population
Mentoring

Evaluating Motor Control Improves Discrimination of Adolescents with and without Sports Related Concussion

Stephens, J. A., Davies, P. L., Gavin, W. J., Mostofsky, S. H., Slomine, B. S. & Suskauer, S. J. M., Jan 1 2019, In : Journal of Motor Behavior.

Research output: Contribution to journalArticle

Sports
Gait
Wounds and Injuries
Therapeutics