Howard Hughes Medical Institution

Research Output 1988 2018

Filter
Article
2018

Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase

Morellet, N., Li, X., Wieninger, S. A., Taylor, J. L., Bischerour, J., Moriau, S., Lescop, E., Bardiaux, B., Mathy, N., Assrir, N., Bétermier, M., Nilges, M., Hickman, A. B., Dyda, F., Craig, N. L. & Guittet, E., Jan 1 2018, In : Nucleic acids research. 46, 5, p. 2660-2677 18 p.

Research output: Contribution to journalArticle

Transposases
Braces
Zinc Fingers
Cysteine
DNA
2017

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura

Tischfield, M. A., Robson, C. D., Gilette, N. M., Chim, S. M., Sofela, F. A., DeLisle, M. M., Gelber, A., Barry, B. J., MacKinnon, S., Dagi, L. R., Nathans, J. & Engle, E. C., 2017, (Accepted/In press) In : Developmental Cell.

Research output: Contribution to journalArticle

Cerebral Veins
Bone Morphogenetic Proteins
Skull
Stem Cells
Craniosynostoses

eIF5A Functions Globally in Translation Elongation and Termination

Schuller, A. P., Wu, C. C. C., Dever, T. E., Buskirk, A. R. & Green, R., Apr 20 2017, In : Molecular Cell. 66, 2, p. 194-205.e5

Research output: Contribution to journalArticle

Ribosomes
Proline
Peptide Initiation Factors
Terminator Codon
3' Untranslated Regions

Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain

Zhang, C., Kolodkin, A. L., Wong, R. O. & James, R. E., Jul 25 2017, In : Annual Review of Neuroscience. 40, p. 395-424 30 p.

Research output: Contribution to journalArticle

Retina
Visual Pathways
Brain
Nervous System

Intramembrane proteolysis of astrotactins

Chang, H., Smallwood, P. M., Williams, J. & Nathans, J., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3506-3516 11 p.

Research output: Contribution to journalArticle

Proteolysis
Asialoglycoprotein Receptor
CD4 Antigens
Transferrin Receptors
Hair Follicle

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

Wang, Q., Chiu, S. L., Koropouli, E., Hong, I., Mitchell, S., Easwaran, T. P., Hamilton, N. R., Gustina, A. S., Zhu, Q., Ginty, D. D., Huganir, R. L. & Kolodkin, A. L., Dec 6 2017, In : Neuron. 96, 5, p. 1084-1098.e7

Research output: Contribution to journalArticle

Neuropilin-2
Semaphorins
Neurons
Synapses
AMPA Receptors

Peropsin modulates transit of Vitamin A from retina to retinal pigment epithelium

Cook, J. D., Ng, S. Y., Lloyd, M., Eddington, S., Sun, H., Nathans, J., Bok, D., Radu, R. A. & Travis, G. H., Jan 1 2017, In : Journal of Biological Chemistry. 292, 52, p. 21407-21416 10 p.

Research output: Contribution to journalArticle

Cytology
Ophthalmology
Mammals
Retinal Pigments
Retinal Pigment Epithelium

Rapid generation of hypomorphic mutations

Arthur, L. L., Chung, J. J., Jankirama, P., Keefer, K. M., Kolotilin, I., Pavlovic-Djuranovic, S., Chalker, D. L., Grbic, V., Green, R., Menassa, R., True, H. L., Skeath, J. B. & Djuranovic, S., Jan 20 2017, In : Nature Communications. 8, 14112

Research output: Contribution to journalArticle

mutations
Genes
organisms
genes
Mutation

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

Cho, C., Smallwood, P. M. & Nathans, J., Aug 30 2017, In : Neuron. 95, 5, p. 1056-1073.e5

Research output: Contribution to journalArticle

Blood-Brain Barrier
Leucine
Membrane Proteins
Endothelial Cells
Mutagenesis

Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. Pombe

Guydosh, N. R., Kimmig, P., Walter, P. & Green, R., Sep 25 2017, In : eLife. 6, e29216

Research output: Contribution to journalArticle

Schizosaccharomyces
RNA Stability
Endoplasmic Reticulum
Homeostasis
Ribosomes

Slowed decay of mRNAs enhances platelet specific translation

Mills, E. W., Green, R. & Ingolia, N. T., Apr 27 2017, In : Blood. 129, 17, p. e38-e48

Research output: Contribution to journalArticle

Platelets
Blood Platelets
Messenger RNA
RNA Sequence Analysis
Ribosomes

The laminar organization of the drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections

Xie, X., Tabuchi, M., Brown, M. P., Mitchell, S. P., Wu, M. N. & Kolodkin, A. L., Jun 20 2017, In : eLife. 6, e25328

Research output: Contribution to journalArticle

Semaphorins
Drosophila
Neurons
Axons
Optogenetics

Translation of poly(A) tails leads to precise mRNA cleavage

Guydosh, N. R. & Green, R., May 1 2017, In : RNA. 23, 5, p. 749-761 13 p.

Research output: Contribution to journalArticle

Ribosomes
Messenger RNA
Polyadenylation
RNA Stability
Nucleotides

Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in Drosophila

Jeong, S., Yang, D. S., Hong, Y. G., Mitchell, S. P., Brown, M. P. & Kolodkin, A. L., Sep 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 39, p. E8254-E8263

Research output: Contribution to journalArticle

Semaphorins
Drosophila
Actin Cytoskeleton
Axons
Rho Guanine Nucleotide Exchange Factors
2016

Clarifying the Translational Pausing Landscape in Bacteria by Ribosome Profiling

Mohammad, F., Woolstenhulme, C. J., Green, R. & Buskirk, A. R., Feb 2 2016, In : Cell Reports. 14, 4, p. 686-694 9 p.

Research output: Contribution to journalArticle

Ribosomes
Bacteria
Messenger RNA
Gene expression
Elongation

Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets

Mills, E. W., Wangen, J., Green, R. & Ingolia, N. T., Sep 27 2016, In : Cell Reports. 17, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Erythroid Cells
Platelets
Ribosomes
Blood
Blood Platelets

Epigenomic landscapes of retinal rods and cones

Mo, A., Luo, C., Davis, F. P., Mukamel, E. A., Henry, G. L., Nery, J. R., Urich, M. A., Picard, S., Lister, R., Eddy, S. R., Beer, M. A., Ecker, J. R. & Nathans, J., Mar 7 2016, In : eLife. 5, MARCH2016, e11613

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
Epigenomics
Cones

Frizzled Receptors in Development and Disease

Wang, Y., Chang, H., Rattner, A. & Nathans, J., 2016, (Accepted/In press) In : Current Topics in Developmental Biology.

Research output: Contribution to journalArticle

Frizzled Receptors
Cell Polarity
Central Nervous System
Wnt Receptors
Ventricular Septum

How scientists can reduce their carbon footprint

Nathans, J. & Sterling, P., Mar 31 2016, In : eLife. 5, MARCH2016, e15928

Research output: Contribution to journalArticle

Carbon Footprint
Air Travel
Carbon footprint
Greenhouse gases
Gases

Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A

McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J. C. P., Lu, J., Guo, Z., Ayinde, S., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R. & Liu, J. O., Dec 18 2016, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Biological Products
Ribosomes
agelastatin A
Chemotherapy
Cell proliferation

Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling

Wang, Y., Williams, J., Rattner, A., Wu, S., Bassuk, A. G., Goffinet, A. M. & Nathans, J., Nov 15 2016, In : Developmental Biology. 419, 2, p. 298-310 13 p.

Research output: Contribution to journalArticle

Cell Polarity
Tongue
Alleles
Phenotype
Genes

Ryk controls remapping of motor cortex during functional recovery after spinal cord injury

Hollis, E. R., Ishiko, N., Yu, T., Lu, C. C., Haimovich, A., Tolentino, K., Richman, A., Tury, A., Wang, S. H., Pessian, M., Jo, E., Kolodkin, A. & Zou, Y., May 1 2016, In : Nature Neuroscience. 19, 5, p. 697-705 9 p.

Research output: Contribution to journalArticle

Forelimb
Motor Cortex
Spinal Cord Injuries
Knockout Mice
Rehabilitation

The cellular compass

Adler, P. N. & Nathans, J. Feb 16 2016 In : Scientific American. 314, 3, p. 67-71 5 p.

Research output: Contribution to journalArticle

The cellular compass

Adler, P. N. & Nathans, J., Feb 16 2016, In : Scientific American. 314, 3, p. 67-71 5 p.

Research output: Contribution to journalArticle

Body Patterning
Frizzled Receptors
Cell Physiological Phenomena
Drosophila melanogaster
Cell Communication

The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality

Radhakrishnan, A., Chen, Y. H., Martin, S., Alhusaini, N., Green, R. & Coller, J., Sep 22 2016, In : Cell. 167, 1, p. 122-132.e9

Research output: Contribution to journalArticle

RNA Stability
Protein Biosynthesis
Codon
Ribosomes
Messenger RNA

The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA

Di Santo, R., Aboulhouda, S., Weinberg, D. E. & Green, R., Oct 1 2016, In : eLife. 5, OCTOBER2016, e20069

Research output: Contribution to journalArticle

Unfolded Protein Response
Introns
Messenger RNA
Proteins
Stored Messenger RNA
2015

Avoiding the ends: Internal epitope tagging of proteins using transposon Tn7

Zordan, R. E., Beliveau, B. J., Trow, J. A., Craig, N. L. & Cormack, B. P., Jan 1 2015, In : Genetics. 200, 1, p. 47-58 12 p.

Research output: Contribution to journalArticle

Epitopes
Proteins
Peptides
GPI-Linked Proteins
Saccharomyces cerevisiae Proteins

Axon Dynamics during Neocortical Laminar Innervation

Hand, R. A., Khalid, S., Tam, E. & Kolodkin, A. L., Jul 14 2015, In : Cell Reports. 12, 2, p. 172-182 11 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Cerebral Cortex
Neurons
Axons
Networks (circuits)

Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization

Liu, C. H., Sun, Y., Li, J., Gong, Y., Tian, K. T., Evans, L. P., Morss, P. C., Fredrick, T. W., Saba, N. J., Chen, J. & Nathans, J., Sep 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 39, p. 12163-12168 6 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
MicroRNAs
Endothelial Cells
Physiologic Neovascularization
Retinal Neovascularization

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain

Mo, A., Mukamel, E. A., Davis, F. P., Luo, C., Henry, G. L., Picard, S., Urich, M. A., Nery, J. R., Sejnowski, T. J., Lister, R., Eddy, S. R., Ecker, J. R. & Nathans, J., Jun 17 2015, In : Neuron. 86, 6, p. 1369-1384 16 p.

Research output: Contribution to journalArticle

Epigenomics
DNA Methylation
Brain
Neurons
Chromatin

Functional Assembly of Accessory Optic System Circuitry Critical for Compensatory Eye Movements

Sun, L. O., Brady, C. M., Cahill, H., Al-Khindi, T., Sakuta, H., Dhande, O. S., Noda, M., Huberman, A. D., Nathans, J. & Kolodkin, A. L., May 20 2015, In : Neuron. 86, 4, p. 971-984 14 p.

Research output: Contribution to journalArticle

Semaphorins
Eye Movements
Visual Fields
varespladib methyl
Retinal Ganglion Cells

High-Precision analysis of translational pausing by ribosome profiling in bacteria lacking EFP

Woolstenhulme, C. J., Guydosh, N. R., Green, R. & Buskirk, A. R., Apr 7 2015, In : Cell Reports. 11, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Peptide Elongation Factors
Ribosomes
Proline
Escherichia coli
Elongation

Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles

Chang, H., Cahill, H., Smallwood, P. M., Wang, Y. & Nathans, J., 2015, In : PLoS Genetics. 11, 9, e1005532

Research output: Contribution to journalArticle

hair follicles
modifiers (genes)
Hair Follicle
hair
Hair

Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens

Suwantarat, N., Dalton, J. B., Lee, R., Green, R., Memon, W., Carroll, K. C., Riedel, S. & Zhang, S. X., May 1 2015, In : Diagnostic Microbiology and Infectious Disease. 82, 1, p. 54-56 3 p.

Research output: Contribution to journalArticle

Immunoassay
Cerebrospinal Fluid
Antigens
Serum
Cryptococcosis

MIR retrotransposon sequences provide insulators to the human genome

Wang, J., Vicente-García, C., Seruggia, D., Moltó, E., Fernandez-Miñán, A., Neto, A., Lee, E., Gómez-Skarmeta, J. L., Montoliu, L., Lunyak, V. V., Jordan, I. K. & Craig, N. L., Aug 11 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 32, p. E4428-E4437

Research output: Contribution to journalArticle

Retroelements
Human Genome
Chromatin
T-Lymphocytes
DNA Transposable Elements

Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems

Hua, Z. L., Emiliani, F. E. & Nathans, J., Sep 23 2015, In : Neural Development. 10, 1, 21

Research output: Contribution to journalArticle

Peripheral Nervous System
Axons
Central Nervous System
Motor Neurons
Growth

Ribosomes slide on lysine-encoding homopolymeric A stretches

Koutmou, K. S., Schuller, A. P., Brunelle, J. L., Radhakrishnan, A., Djuranovic, S. & Green, R., Feb 19 2015, In : eLife. 2015, 4

Research output: Contribution to journalArticle

Ribosomes
Codon
Lysine
Proteins
Messenger RNA

Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3′UTRs In Vivo

Young, D. J., Guydosh, N. R., Zhang, F., Hinnebusch, A. G. & Green, R., Aug 17 2015, In : Cell. 162, 4, p. 872-884 13 p., 8356

Research output: Contribution to journalArticle

3' Untranslated Regions
Ribosomes
Recycling
Biochemistry
Mass spectrometry

Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases

Kowalinski, E., Schuller, A., Green, R. & Conti, E., Feb 17 2015, In : Structure. 23, 7, p. 1336-1343 8 p., 3180

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Guanosine Triphosphate
Saccharomyces cerevisiae
Carrier Proteins
Exosomes

Sculpting Neural Circuits by Axon and Dendrite Pruning

Riccomagno, M. M. & Kolodkin, A. L., Nov 13 2015, In : Annual Review of Cell and Developmental Biology. 31, p. 779-805 27 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Mental Disorders
Neuroglia
Synapses
Axons

Sox7, Sox17, and Sox18 cooperatively regulate vascular development in the mouse retina

Zhou, Y., Williams, J., Smallwood, P. M. & Nathans, J., Dec 1 2015, In : PLoS One. 10, 12, 0143650

Research output: Contribution to journalArticle

retina
blood vessels
Blood Vessels
Retina
Genes

Synthesis at the Speed of Codons

Koutmou, K. S., Radhakrishnan, A. & Green, R., 2015, In : Trends in Biochemical Sciences. 40, 12, p. 717-718 2 p.

Research output: Contribution to journalArticle

Codon
Messenger RNA
Protein folding
Protein Folding
Peptides

The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation

Chang, H., Smallwood, P. M., Williams, J. & Nathans, J., Sep 18 2015, (Accepted/In press) In : Developmental Biology.

Research output: Contribution to journalArticle

Hair Follicle
Merkel Cells
Epidermis
Genes
Phenotype

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

Vanhollebeke, B., Stone, O. A., Bostaille, N., Cho, C., Zhou, Y., Maquet, E., Gauquier, A., Cabochette, P., Fukuhara, S., Mochizuki, N., Nathans, J. & Stainier, D. Y. R., Jun 8 2015, In : eLife. 4, JUNE, p. 1-25 25 p., e06489

Research output: Contribution to journalArticle

beta Catenin
Brain
Blood Vessels
Neurology
Central Nervous System
2014

Canonical WNT signaling components in vascular development and barrier formation

Zhou, Y., Wang, Y., Tischfield, M., Williams, J., Smallwood, P. M., Rattner, A., Taketo, M. M. & Nathans, J., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 3825-3846 22 p.

Research output: Contribution to journalArticle

beta Catenin
Blood-Brain Barrier
Low Density Lipoprotein Receptor-Related Protein-1
Blood Vessels
Retina

Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling

Riccomagno, M. M., Sun, L. O., Brady, C. M., Alexandropoulos, K., Seo, S., Kurokawa, M. & Kolodkin, A. L., Feb 19 2014, In : Neuron. 81, 4, p. 779-786 8 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Integrins
Proteins
Laminin
Laminin Receptors

Cellular Resolution Maps of X Chromosome Inactivation: Implications for Neural Development, Function, and Disease

Wu, H., Luo, J., Yu, H., Rattner, A., Mo, A., Wang, Y., Smallwood, P., Erlanger, B., Wheelan, S. & Nathans, J., Jan 8 2014, In : Neuron. 81, 1, p. 103-119 17 p.

Research output: Contribution to journalArticle

X Chromosome Inactivation
Mammals
Retinal Vessels
Mosaicism
X Chromosome

Complete morphologies of basal forebrain cholinergic neurons in the mouse

Wu, H., Williams, J. & Nathans, J., May 7 2014, In : eLife. 2014, 3, e02444

Research output: Contribution to journalArticle

Cholinergic Neurons
Cholinergic Agents
Neurons
Axons
Alzheimer Disease

Cryoelectron microscopic structures of eukaryotic translation termination complexes containing eRF1-eRF3 or eRF1-ABCE1

Preis, A., Heuer, A., Barrio-Garcia, C., Hauser, A., Eyler, D. E., Berninghausen, O., Green, R., Becker, T. & Beckmann, R., Jul 10 2014, In : Cell Reports. 8, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

Terminator Codon
Guanosine Triphosphate
Decoding
Peptidyl Transferases
Ribosomes

Distinct roles for release factor 1 and release factor 2 in translational quality control

Petropoulos, A. D., McDonald, M. E., Green, R. & Zaher, H. S., Jun 20 2014, In : Journal of Biological Chemistry. 289, 25, p. 17589-17596 8 p.

Research output: Contribution to journalArticle

Quality Control
Quality control
Ribosomes
Terminator Codon
Peptide Termination Factors