Howard Hughes Medical Institution

Research output

Research output per year 1976 1992 1993 1995 1996 1997 2000 2001 2004 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 1031 Article
• 76 Review article
• 36 Comment/debate
• 22 Short survey
• 39 More
  • 17 Chapter
  • 17 Letter
  • 5 Editorial

Research output per year

Research output per year

Search results

• 2024

  B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage

  Park, E. N., Mackens-Kiani, T., Berhane, R., Esser, H., Erdenebat, C., Burroughs, A. M., Berninghausen, O., Aravind, L., Beckmann, R., Green, R. & Buskirk, A. R., Feb 15 2024, In: EMBO Journal. 43, 4, p. 484-506 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ribosome Subunits 100%
  • Ribosomes 75%
  • Cleavage 49%
  • Collision 47%
  • Messenger RNA 41%

• Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells

  Board, N. L., Yuan, Z., Wu, F., Moskovljevic, M., Ravi, M., Sengupta, S., Mun, S. S., Simonetti, F. R., Lai, J., Tebas, P., Lynn, K., Hoh, R., Deeks, S. G., Siliciano, J. D., Montaner, L. J. & Siliciano, R. F., 2024, (Accepted/In press) In: Nature Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bispecific Antibodies 100%
  • Natural Killer Cells 65%
  • HIV-1 61%
  • human IL15 protein 21%
  • Human Immunodeficiency Virus env Gene Products 19%

• CD4+ T cells with latent HIV-1 have reduced proliferative responses to T cell receptor stimulation

  Kufera, J. T., Armstrong, C., Wu, F., Singhal, A., Zhang, H., Lai, J., Wilkins, H. N., Simonetti, F. R., Siliciano, J. D. & Siliciano, R. F., Mar 4 2024, In: The Journal of experimental medicine. 221, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proviruses 100%
  • T-Cell Antigen Receptor 77%
  • HIV-1 66%
  • T-Lymphocytes 47%
  • Virion 36%

• Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary

  Sanders-Beer, B. E., Archin, N. M., Brumme, Z. L., Busch, M. P., Deleage, C., O’Doherty, U., Hughes, S. H., Jerome, K. R., Jones, R. B., Karn, J., Kearney, M. F., Keele, B. F., Kulpa, D. A., Laird, G. M., Li, J. Z., Lichterfeld, M. D., Nussenzweig, M. C., Persaud, D., Yukl, S. A., Siliciano, R. F., & 1 othersMellors, J. W., Jan 1 2024, In: AIDS research and human retroviruses. 40, 1, p. 7-21 15 p.

  Research output: Contribution to journal › Article › peer-review

  • National Institute of Allergy and Infectious Diseases (U.S.) 100%
  • HIV 44%
  • Education 40%
  • Clinical Trial Protocols 16%
  • Clinical Trials 14%

• HIV cure: The daunting scale of the problem

  Siliciano, J. D. & Siliciano, R. F., Feb 16 2024, In: Science. 383, 6684, p. 703-705 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Machine learning to detect the SINEs of cancer

  Douville, C., Lahouel, K., Kuo, A., Grant, H., Avigdor, B. E., Curtis, S. D., Summers, M., Cohen, J. D., Wang, Y., Mattox, A., Dudley, J., Dobbyn, L., Popoli, M., Ptak, J., Nehme, N., Silliman, N., Blair, C., Romans, K., Thoburn, C., Gizzi, J., & 18 othersSchoen, R. E., Tie, J., Gibbs, P., Ho-Pham, L. T., Tran, B. N. H., Tran, T. S., Nguyen, T. V., Goggins, M., Wolfgang, C., Wang, T-L., Shih, I. M., O'Broin-Lennon, A. M. L., Hruban, R., Bettegowda, C., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Tomasetti, C., Jan 24 2024, In: Science translational medicine. 16, 731, eadi3883.

  Research output: Contribution to journal › Article › peer-review

• P-body-like condensates in the germline

  Cassani, M. & Seydoux, G., Apr 2024, In: Seminars in Cell and Developmental Biology. 157, p. 24-32 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Germ Cells 100%
  • Ribonucleoproteins 24%
  • RNA Stability 22%
  • Protein Biosynthesis 22%
  • Embryonic Structures 16%
• 2023

  A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design

  Sengupta, S., Zhang, J., Reed, M. C., Yu, J., Kim, A., Boronina, T. N., Board, N. L., Wrabl, J. O., Shenderov, K., Welsh, R. A., Yang, W., Timmons, A. E., Hoh, R., Cole, R. N., Deeks, S. G., Siliciano, J. D., Siliciano, R. F. & Sadegh-Nasseri, S., Jul 3 2023, In: Journal of Experimental Medicine. 220, 7, e20221654.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antigen Presentation 100%
  • HIV-1 79%
  • Epitopes 78%
  • Vaccines 68%
  • Antigens 19%

• Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques

  Wu, H. L., Busman-Sahay, K., Weber, W. C., Waytashek, C. M., Boyle, C. D., Bateman, K. B., Reed, J. S., Hwang, J. M., Shriver-Munsch, C., Swanson, T., Northrup, M., Armantrout, K., Price, H., Robertson-LeVay, M., Uttke, S., Kumar, M. R., Fray, E. J., Taylor-Brill, S., Bondoc, S., Agnor, R., & 23 othersJunell, S. L., Legasse, A. W., Moats, C., Bochart, R. M., Sciurba, J., Bimber, B. N., Sullivan, M. N., Dozier, B., MacAllister, R. P., Hobbs, T. R., Martin, L. D., Panoskaltsis-Mortari, A., Colgin, L. M. A., Siliciano, R. F., Siliciano, J. D., Estes, J. D., Smedley, J. V., Axthelm, M. K., Meyers, G., Maziarz, R. T., Burwitz, B. J., Stanton, J. J. & Sacha, J. B., Jul 11 2023, In: Immunity. 56, 7, p. 1649-1663.e5

  Research output: Contribution to journal › Article › peer-review

  • Macaca 100%
  • Allogeneic Cells 96%
  • Hematopoietic Stem Cell Transplantation 95%
  • Stem Cell Transplantation 93%
  • Immunity 73%

• Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants

  Fray, E. J., Wu, F., Simonetti, F. R., Zitzmann, C., Sambaturu, N., Molina-Paris, C., Bender, A. M., Liu, P. T., Ventura, J. D., Wiseman, R. W., O'Connor, D. H., Geleziunas, R., Leitner, T., Ribeiro, R. M., Perelson, A. S., Barouch, D. H., Siliciano, J. D. & Siliciano, R. F., Mar 8 2023, In: Cell Host and Microbe. 31, 3, p. 356-372.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Simian immunodeficiency virus 100%
  • Simian Immunodeficiency Virus 87%
  • deterioration 54%
  • therapeutics 53%
  • Genome 46%

• Author Correction: 14-3-3σ is required to prevent mitotic catastrophe after DNA damage (Nature, (1999), 401, 6753, (616-620), 10.1038/44188)

  Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W. & Vogelstein, B., Sep 7 2023, In: Nature. 621, 7977, p. E28-E29

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • DNA Damage 100%
  • Cyclin B1 50%
  • Staining and Labeling 49%
  • Fluorescence Microscopy 37%
  • Doxorubicin 35%

• Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

  Wang, J., Rattner, A. & Nathans, J., 2023, In: eLife. 12, e86130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Chemoattractant 88%
  • Bacterial Meningitides 74%
  • Endothelial Cells 44%
  • Escherichia coli Infections 30%

• Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir

  Kumar, M. R., Fray, E. J., Bender, A. M., Zitzmann, C., Ribeiro, R. M., Perelson, A. S., Barouch, D. H., Siliciano, J. D. & Siliciano, R. F., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 43, e2313209120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Simian Immunodeficiency Virus 100%
  • HIV 53%
  • Genome 52%
  • HIV-1 29%
  • Proviruses 14%

• Bursting translation on single mRNAs in live cells

  Livingston, N. M., Kwon, J., Valera, O., Saba, J. A., Sinha, N. K., Reddy, P., Nelson, B., Wolfe, C., Ha, T., Green, R., Liu, J. & Wu, B., Jul 6 2023, In: Molecular cell. 83, 13, p. 2276-2289.e11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Kinetics 100%
  • Single Molecule Imaging 94%
  • Trans-Activators 84%
  • 5' Untranslated Regions 80%
  • Messenger RNA 78%

• CD8⁺ lymphocytes do not impact SIV reservoir establishment under ART

  Statzu, M., Jin, W., Fray, E. J., Wong, A. K. H., Kumar, M. R., Ferrer, E., Docken, S. S., Pinkevych, M., McBrien, J. B., Fennessey, C. M., Keele, B. F., Liang, S., Harper, J. L., Mutascio, S., Franchitti, L., Wang, H., Cicetti, D., Bosinger, S. E., Carnathan, D. G., Vanderford, T. H., & 9 othersMargolis, D. M., Garcia-Martinez, J. V., Chahroudi, A., Paiardini, M., Siliciano, J., Davenport, M. P., Kulpa, D. A., Siliciano, R. S. & Silvestri, G., Feb 2023, In: Nature microbiology. 8, 2, p. 299-308 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Simian Immunodeficiency Virus 100%
  • Lymphocytes 53%
  • Cytotoxic T-Lymphocytes 41%
  • Infections 37%
  • T-Lymphocytes 36%

• Clonally expanded HIV-1 proviruses with 5'-leader defects can give rise to nonsuppressible residual viremia

  White, J. A., Wu, F., Yasin, S., Moskovljevic, M., Varriale, J., Dragoni, F., Camilo-Contreras, A., Duan, J., Zheng, M. Y., Tadzong, N. F., Patel, H. B., Quiambao, J. M. C., Rhodehouse, K., Zhang, H., Lai, J., Beg, S. A., Delannoy, M., Kilcrease, C., Hoffmann, C. J., Poulin, S., & 10 othersChano, F., Tremblay, C., Cherian, J., Barditch-Crovo, P., Chida, N., Moore, R. D., Summers, M. F., Siliciano, R. F., Siliciano, J. D. & Simonetti, F. R., Mar 15 2023, In: Journal of Clinical Investigation. 133, 6, e165245.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proviruses 100%
  • Viremia 86%
  • HIV-1 66%
  • Clone Cells 22%
  • National Institute of Dental and Craniofacial Research (U.S.) 17%

• Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules

  Wang, Y., Douville, C., Cohen, J. D., Mattox, A., Curtis, S., Silliman, N., Popoli, M., Ptak, J., Dobbyn, L., Nehme, N., Dudley, J. C., Summers, M., Zhang, M., Ho-Pham, L. T., Tran, B. N. H., Tran, T. S., Nguyen, T. V., Bettegowda, C., Papadopoulos, N., Kinzler, K. W., & 1 othersVogelstein, B., Apr 11 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 15, e2220704120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 5-Methylcytosine 100%
  • Methylation 95%
  • Epigenomics 61%
  • Mutation 59%
  • DNA 58%

• Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis

  Laky, K., Kinard, J. L., Li, J. M., Moore, I. N., Lack, J., Fischer, E. R., Kabat, J., Latanich, R., Zachos, N. C., Limkar, A. R., Weissler, K. A., Thompson, R. W., Wynn, T. A., Dietz, H. C., Guerrerio, A. L. & Frischmeyer-Guerrerio, P. A., Jan 2023, In: Science Immunology. 8, 79, eabp9940.

  Research output: Contribution to journal › Article › peer-review

  • Eosinophilic Esophagitis 100%
  • Growth Factor Receptors 82%
  • Transforming Growth Factors 73%
  • Inflammation 41%
  • Adaptive Immunity 17%

• HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

  Benner, S. E., Zhu, X., Hussain, S., Florman, S., Eby, Y., Fernandez, R. E., Ostrander, D., Rana, M., Ottmann, S., Hand, J., Price, J. C., Pereira, M. R., Wojciechowski, D., Simkins, J., Stosor, V., Mehta, S. A., Aslam, S., Malinis, M., Haidar, G., Massie, A., & 11 othersSmith, M. L., Odim, J., Morsheimer, M., Quinn, T. C., Laird, G. M., Siliciano, R., Balagopal, A., Segev, D. L., Durand, C. M., Redd, A. D. & Tobian, A. A. R., Nov 1 2023, In: Journal of Infectious Diseases. 228, 9, p. 1274-1279 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proviruses 100%
  • Liver Transplantation 93%
  • HIV 70%
  • Liver 26%
  • HIV-1 22%

• Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen

  Wright, K. M., DiNapoli, S. R., Miller, M. S., Aitana Azurmendi, P., Zhao, X., Yu, Z., Chakrabarti, M., Shi, W. X., Douglass, J., Hwang, M. S., Hsiue, E. H. C., Mog, B. J., Pearlman, A. H., Paul, S., Konig, M. F., Pardoll, D. M., Bettegowda, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., & 2 othersZhou, S. & Gabelli, S. B., Dec 2023, In: Nature communications. 14, 1, 5063.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hydrophobic and Hydrophilic Interactions 100%
  • peptides 99%
  • mutations 84%
  • HLA-A Antigens 67%
  • antibodies 64%

• Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos

  Nkoula, S. N., Velez-Aguilera, G., Ossareh-Nazari, B., Hove, L. V., Ayuso, C., Legros, V., Chevreux, G., Thomas, L., Seydoux, G., Askjaer, P. & Pintard, L., Jul 2023, In: Science Advances. 9, 29, eadf7826.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • C elegans plk-1 protein 100%
  • Nuclear Pore 52%
  • polo-like kinase 1 43%
  • Nuclear Pore Complex Proteins 43%
  • Nuclear Envelope 33%

• Midterm outcomes of aortic root surgery in patients with Marfan syndrome: A prospective, multicenter, comparative study

  Aortic Valve Operative Outcomes in Marfan Patients Study Group, May 2023, In: Journal of Thoracic and Cardiovascular Surgery. 165, 5, p. 1790-1799.e12

  Research output: Contribution to journal › Article › peer-review

  • Marfan Syndrome 100%
  • Aortic Valve 76%
  • Multicenter Studies 67%
  • Survival Rate 14%
  • Hemorrhage 12%

• Normal and Sjogren's syndrome models of the murine lacrimal gland studied at single-cell resolution

  Rattner, A., Heng, J. S., Winer, B. L., Goff, L. A. & Nathans, J., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 42, e2311983120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lacrimal Apparatus 100%
  • Sjogren's Syndrome 93%
  • Acinar Cells 17%
  • Tears 14%
  • Gene Expression 13%

• Nucleoporin foci are stress-sensitive condensates dispensable for C. elegans nuclear pore assembly

  Thomas, L., Taleb Ismail, B., Askjaer, P. & Seydoux, G., Jul 3 2023, In: EMBO Journal. 42, 13, e112987.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nuclear Pore Complex Proteins 100%
  • Nuclear Pore 90%
  • Pore 44%
  • Condensation 32%
  • Cytoplasm 22%

• Radiologists' Expectations of Artificial Intelligence in Pancreatic Cancer Imaging: How Good Is Good Enough?

  Chu, L. C., Ahmed, T., Blanco, A., Javed, A., Weisberg, E. M., Kawamoto, S., Hruban, R. H., Kinzler, K. W., Vogelstein, B. & Fishman, E. K., Nov 1 2023, In: Journal of computer assisted tomography. 47, 6, p. 845-849 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Artificial Intelligence 100%
  • Pancreatic Neoplasms 71%
  • Radiologists 69%
  • Motivation 60%
  • Radiology 6%

• RNA granules: functional compartments or incidental condensates?

  Putnam, A., Thomas, L. & Seydoux, G., May 1 2023, In: Genes & development. 37, 9-10, p. 354-376 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • RNA 100%
  • Ribonucleoproteins 50%
  • Single Molecule Imaging 28%
  • Solubility 20%
  • Biochemistry 18%

• RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

  Zhao, S., Cordes, J., Caban, K. M., Götz, M. J., Mackens-Kiani, T., Veltri, A. J., Sinha, N. K., Weickert, P., Kaya, S., Hewitt, G., Nedialkova, D. D., Fröhlich, T., Beckmann, R., Buskirk, A. R., Green, R. & Stingele, J., Dec 7 2023, In: Molecular cell. 83, 23, p. 4290-4303.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitination 100%
  • Aldehydes 66%
  • RNA 64%
  • Ribosomes 57%
  • Proteins 33%

• Saving ribosomal proteins for later

  Black, J. J. & Green, R., Nov 2023, In: Nature cell biology. 25, 11, p. 1568-1569 2 p.

  Research output: Contribution to journal › Article › peer-review

• Seeing is believing: The development of optical coherence tomography

  Nathans, J., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 39, e2311129120.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid

  Douville, C., Curtis, S., Summers, M., Azad, T. D., Rincon-Torroella, J., Wang, Y., Mattox, A., Avigdor, B., Dudley, J., Materi, J., Raj, D., Nair, S., Bhanja, D., Tuohy, K., Dobbyn, L., Popoli, M., Ptak, J., Nehme, N., Silliman, N., Blair, C., & 20 othersJudge, K., Gallia, G. L., Groves, M., Jackson, C. M., Jackson, E. M., Laterra, J., Lim, M., Mukherjee, D., Weingart, J., Naidoo, J., Koschmann, C., Smith, N., Schreck, K. C., Pardo, C. A., Glantz, M., Holdhoff, M., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Bettegowda, C., Aug 15 2023, In: Cell Reports Medicine. 4, 8, 101148.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Central Nervous System Neoplasms 100%
  • Aneuploidy 86%
  • Cerebrospinal Fluid 70%
  • Plasma 49%
  • Cell-Free Nucleic Acids 25%

• Structural characterization of mRNA-tRNA translocation intermediates

  Agirrezabala, X., Liao, H. Y., Schreiner, E., Fu, J., Ortiz-Meoz, R. F., Schulten, K., Green, R. & Frank, J., Oct 6 2023, Novel Developments in Cryo-EM of Biological Molecules: Resolution in Time and State Space. Taylor and Francis, p. 87-107 21 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Transfer RNA 100%
  • Ribosomes 95%
  • ribosomes 86%
  • Brownian Motion 64%
  • Messenger RNA 52%

• Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae

  Chang, T. H., Hsieh, F. L., Gu, X., Smallwood, P. M., Kavran, J. M., Gabelli, S. B. & Nathans, J., Apr 4 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2221103120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diaphragm 100%
  • Blood Vessels 57%
  • Protein Domains 49%
  • Circular Dichroism 40%
  • Sulfur 38%

• Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein

  Hsieh, F. L., Chang, T. H., Gabelli, S. B. & Nathans, J., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 20, e2217096120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenomatous Polyposis Coli 100%
  • Carrier Proteins 68%
  • Lipids 53%
  • palmitoleic acid 24%
  • Proteins 11%

• Systemic artery to pulmonary artery aneurysm malformations associated with variants at MCF2L

  Mitchell, S. E., Martin, R. P., Terry, P., Drant, S. E., Valle, D., Dietz, H. & Sobreira, N., May 2023, In: American Journal of Medical Genetics, Part A. 191, 5, p. 1250-1260 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pulmonary Artery 100%
  • Aneurysm 96%
  • Arteries 81%
  • Hereditary Hemorrhagic Telangiectasia 51%
  • Exome 43%

• The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy

  McMyn, N. F., Varriale, J., Fray, E. J., Zitzmann, C., MacLeod, H., Lai, J., Singhal, A., Moskovljevic, M., Garcia, M. A., Lopez, B. M., Hariharan, V., Rhodehouse, K., Lynn, K., Tebas, P., Mounzer, K., Montaner, L. J., Benko, E., Kovacs, C., Hoh, R., Simonetti, F. R., & 6 othersLaird, G. M., Deeks, S. G., Ribeiro, R. M., Perelson, A. S., Siliciano, R. F. & Siliciano, J. M., Sep 1 2023, In: Journal of Clinical Investigation. 133, 17, e171554.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HIV-1 100%
  • Proviruses 49%
  • Therapeutics 18%
  • T-Lymphocytes 15%
  • Virus Replication 12%

• The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

  Koller, T. O., Scheid, U., Kösel, T., Herrmann, J., Krug, D., Boshoff, H. I. M., Beckert, B., Evans, J. C., Schlemmer, J., Sloan, B., Weiner, D. M., Via, L. E., Moosa, A., Ioerger, T. R., Graf, M., Zinshteyn, B., Abdelshahid, M., Nguyen, F., Arenz, S., Gille, F., & 13 othersSiebke, M., Seedorf, T., Plettenburg, O., Green, R., Warnke, A. L., Ullrich, J., Warrass, R., Barry, C. E., Warner, D. F., Mizrahi, V., Kirschning, A., Wilson, D. N. & Müller, R., Jan 18 2023, In: Journal of the American Chemical Society. 145, 2, p. 851-863 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bactericides 100%
  • Biosynthesis 93%
  • Antibiotics 84%
  • Antibacterial Agent 65%
  • Total Synthesis 51%

• The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer

  Mattox, A. K., Douville, C., Wang, Y., Popoli, M., Ptak, J., Silliman, N., Dobbyn, L., Schaefer, J., Lu, S., Pearlman, A. H., Cohen, J. D., Tie, J., Gibbs, P., Lahouel, K., Bettegowda, C., Hruban, R. H., Tomasetti, C., Jiang, P., Chan, K. C. A., Lo, Y. M. D., & 3 othersPapadopoulos, N., Kinzler, K. W. & Vogelstein, B., 2023, In: Cancer discovery. 13, 10, p. 2166-2179 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell-Free Nucleic Acids 100%
  • Pancreatic Neoplasms 75%
  • Ovarian Neoplasms 72%
  • Colorectal Neoplasms 63%
  • Lung Neoplasms 62%

• The rapid and highly parallel identification of antibodies with defined biological activities by SLISY

  Lu, S., Mattox, A. K., Aitana Azurmendi, P., Christodoulou, I., Wright, K. M., Popoli, M., Chen, Z., Sur, S., Li, Y., Bonifant, C. L., Bettegowda, C., Papadopoulos, N., Zhou, S., Gabelli, S. B., Vogelstein, B. & Kinzler, K. W., Dec 2023, In: Nature communications. 14, 1, 17.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sequencing 100%
  • Immunosorbent 99%
  • Immunosorbents 95%
  • activity (biology) 93%
  • antibodies 86%

• The spectrum of foot deformities in Loeys-Dietz syndrome

  Badin, D., Dietz, H. C. & Sponseller, P. D., Jan 1 2023, In: Journal of Pediatric Orthopaedics Part B. 32, 1, p. 21-26 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Loeys-Dietz Syndrome 100%
  • Foot Deformities 81%
  • Clubfoot 16%
  • Orthopedic Surgeons 13%
  • Foot 9%

• Transitions in the framework of condensate biology

  Seydoux, G., Zhang, M., Forman-Kay, J. D., McStay, B., Liu, K. F. & Li, P., Apr 6 2023, In: Molecular cell. 83, 7, p. 1016-1021 6 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Research Personnel 100%
• 2022

  Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials

  The Marfan Treatment Trialists’ Collaboration, Sep 10 2022, In: The Lancet. 400, 10355, p. 822-831 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Marfan Syndrome 100%
  • Angiotensin Receptor Antagonists 87%
  • Data Analysis 58%
  • Meta-Analysis 58%
  • Fibrillin-1 7%

• An isogenic cell line panel for sequence-based screening of targeted anticancer drugs

  Cook, A. L., Wyhs, N., Sur, S., Ptak, B., Popoli, M., Dobbyn, L., Papadopoulos, T., Bettegowda, C., Papadopoulos, N., Vogelstein, B., Zhou, S. & Kinzler, K. W., Jun 17 2022, In: iScience. 25, 6, 104437.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Line 100%
  • MK-1775 77%
  • Pharmaceutical Preparations 69%
  • Biochemical Phenomena 55%
  • Growth Inhibitors 55%

• A Possible Sterilizing Cure of HIV-1 Infection Without Stem Cell Transplantation

  Turk, G., Seiger, K., Lian, X., Sun, W., Parsons, E. M., Gao, C., Rassadkina, Y., Polo, M. L., Czernikier, A., Ghiglione, Y., Vellicce, A., Varriale, J., Lai, J., Yuki, Y., Martin, M., Rhodes, A., Lewin, S. R., Walker, B. D., Carrington, M., Siliciano, R., & 4 othersSiliciano, J., Lichterfeld, M., Laufer, N. & Yu, X. G., Jan 1 2022, In: Annals of internal medicine. 175, 1, p. 95-100 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem Cell Transplantation 100%
  • HIV Infections 84%
  • HIV-1 83%
  • Proviruses 27%
  • Genome 10%

• Assessment of pleural pressure during sleep in Marfan syndrome

  Sowho, M., Jun, J., Sgambati, F., Potocki, M., Schneider, H., Smith, P., Schwartz, A., Dietz, H., MacCarrick, G. & Neptune, E., Jun 2022, In: Journal of Clinical Sleep Medicine. 18, 6, p. 1583-1592 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Marfan Syndrome 100%
  • Continuous Positive Airway Pressure 68%
  • Sleep 60%
  • Pressure 50%
  • Snoring 48%

• Cardiovascular Outcomes in Aortopathy: GenTAC Registry of Genetically Triggered Aortic Aneurysms and Related Conditions

  GenTAC Investigators, May 31 2022, In: Journal of the American College of Cardiology. 79, 21, p. 2069-2081 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aortic Aneurysm 100%
  • Loeys-Dietz Syndrome 80%
  • Registries 68%
  • Bicuspid Aortic Valve 65%
  • Marfan Syndrome 61%

• Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

  for the DYNAMIC Investigators, Jun 16 2022, In: New England Journal of Medicine. 386, 24, p. 2261-2272 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Circulating Tumor DNA 100%
  • Colonic Neoplasms 62%
  • Adjuvant Chemotherapy 37%
  • Recurrence 21%
  • Survival 14%

• Classification of pancreatic cystic neoplasms using radiomic feature analysis is equivalent to an experienced academic radiologist: a step toward computer-augmented diagnostics for radiologists

  Chu, L. C., Park, S., Soleimani, S., Fouladi, D. F., Shayesteh, S., He, J., Javed, A. A., Wolfgang, C., Vogelstein, B., Kinzler, K. W., Hruban, R. H., Afghani, E., O'Broin-Lennon, A. M. L., Fishman, E. K. & Kawamoto, S., Dec 2022, In: Abdominal Radiology. 47, 12, p. 4139-4150 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pancreatic Cyst 100%
  • Pancreatic Neoplasms 65%
  • Radiologists 63%
  • Machine Learning 31%
  • Pancreas 23%

• Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy

  White, J. A., Simonetti, F. R., Beg, S., McMyn, N. F., Dai, W., Bachmann, N., Lai, J., Ford, W. C., Bunch, C., Jones, J. L., Ribeiro, R. M., Perelson, A. S., Siliciano, J. D. & Siliciano, R. F., Feb 8 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 6, e2120326119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proviruses 100%
  • Virion 73%
  • HIV 52%
  • Half-Life 27%
  • HIV-1 26%

• Distinct Contribution of Global and Regional Angiotensin II Type 1a Receptor Inactivation to Amelioration of Aortopathy in Tgfbr1^M318R/+ Mice

  Bramel, E. E., Bagirzadeh, R., Saqib, M., Creamer, T. J., Espinoza Camejo, W. A., Roker, L. T. A., Pardo Habashi, J., Dietz, H. C. & Gallo MacFarlane, E., Jun 22 2022, In: Frontiers in Cardiovascular Medicine. 9, 936142.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Loeys-Dietz Syndrome 100%
  • Angiotensin Type 1 Receptor 72%
  • Aortic Diseases 55%
  • Heart 19%
  • Aortic Aneurysm 17%

• Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

  Veltri, A. J., D'orazio, K. N., Lessen, L. N., Loll-Krippleber, R., Brown, G. W. & Green, R., Jul 2022, In: eLife. 11, e76038.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Stability 100%
  • Codon 74%
  • Messenger RNA 25%
  • Ribosomes 15%
  • Eukaryota 15%